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URL: https://web.expasy.org/cellosaurus/CVCL_0579
Proper Citation: Coriell Cat# AG06814-M, RRID:CVCL_0579
Description: Cell line WI-38 is a Finite cell line with a species of origin Homo sapiens (Human)
Sex: Female
Defining Citation: PMID:211143, PMID:352912, PMID:535915, PMID:656543, PMID:699332, PMID:1031681, PMID:1249414, PMID:1756776, PMID:3016668, PMID:4203458, PMID:4329447, PMID:4695793, PMID:4817727, PMID:5347639, PMID:5668122, PMID:5801069, PMID:5834207, PMID:5956336, PMID:6256643, PMID:6409440, PMID:6538202, PMID:6887978, PMID:7065527, PMID:7972006, PMID:14064953, PMID:14218592, PMID:14315085, PMID:17395773, PMID:17792436, PMID:19896956, PMID:20215515, PMID:22984048, PMID:25063771, PMID:25903999, PMID:29546209
Comments: Anecdotal: Have been flown in space on Skylab-3 to study growth in microgravity (PubMed=352912)., Anecdotal: Leonard Hayflick when numbering diploid cell strains 'jumped' directly from WI-27 (which failed) to WI-38 (CelloPub=CLPUB00391)., Senescence: Life expectancy of 50 +- 10 population doublings. Senesces at 38 PDL (PubMed=17395773)., Characteristics: Used in many context such as senescence and aging studies., Biotechnology: Was used in the early 1970's for the production of the Human Diploid Cell Vaccine (HDCV) vaccine against rabies by Institut Merieux., Biotechnology: Used for the production of live oral adenovirus type 4 and type 7 vaccine used by the US military. Produced first by Wyeth Laboratories from 1971 to 1999 and from 2011 onward by Barr Pharmaceuticals., Biotechnology: Used for the production of RA27/3 - the first rubella virus vaccine., Population: Caucasian; Swedish., Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982)., Group: Vaccine production cell line., Group: Space-flown cell line (cellonaut).
Category: Finite cell line
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No rating or validation information has been found for WI-38.
Discontinued
Discontinued: ATCC; CRL-7728
Discontinued
Discontinued: JCRB; JCRB9017
Possibly Discontinued
Discontinued: KCLB; 10075
Source: Cellosaurus
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