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Project Team


Maryann Martone, dkNET PI


Dr. Martone has a BA from Wellesley College in biological psychology and a Ph. D. in neuroscience from the University of California, San Diego, where she is currently a Professor in the Department of Neuroscience. Her background is in neuroanatomy, particularly light and electron microscopy, but she spends most of her time now in the field of neuroinformatics. She is the principal investigator of the Neuroinformatics Framework project, a national project to establish a uniform resource description framework for neuroscience. Her recent work has focused on building ontologies for neuroscience for data integration. She heads the International Neuroinformatics Coordinating Facility (INCF) program on ontologies. She is the president of FORCE11, an organization dedicated to advancing scholarly communication and e-scholarship.                         




Jeffrey Grethe, dkNET PI


Dr. Grethe has a BS from the University of California Irvine in Applied Mathematics and a Ph.D. in Neuroscience, with a focus on bioinformatics, from the University of Southern California. Throughout his career, his primary focus has been on enabling collaborative research, data sharing and discovery through the application of advanced informatics approaches. Before coming to UCSD he was one of the core members responsible for bringing the fMRI Data Center online, the first publicly accessible repository of peer-reviewed fMRI studies. He is currently leading a number of large scale biological and biomedical informatics projects (i.e. PI for the NIDDK Interconnectivity Network Coordinating Center, co-PI for the Neuroscience Information Framework, and Technical Lead for the Community Cyberinfrastructure for Advanced Microbial Ecology Research and Analysis) in the Center for Research in Biological Systems at the University of California, San Diego.          


Ko-Wei Lin, Project Manager


Dr. Lin has a DVM from National Taiwan University and a PhD in Comparative Biomedical Sciences, focusing on Cell Biology, from North Carolina State University. Her post-doctoral training at University of California San Diego were both in Biomedical Sciences focusing on inflammatory and immune pathways, and in Biomedical Informatics.  She also has extensive experience in bridging the biomedical sciences and informatics -e.g. through information model development and validation, user outreach, and user requirement analysis for developing information retrieval tools. 


James Go, Web Developer


James has a BS in Cell and Molecular Biology from Cal State Northridge. He previously worked as a researcher and web developer at UCLA where he analyzed epigenetic and proteomic data and created web interfaces for collaborating researchers to access their data.                         



Sean Penticoff, Systems Support

Sean is a systems engineer working for the Center for Research in Biological Systems at the University of California, San Diego. He has 10+ years of experience working on system integration and configuration management.

NIH Advisors


Ron Margolis, Ph.D.


As senior advisor of the Endocrinology and Hormone Signaling program, I am responsible for the scientific oversight and management of approximately 100 grants relating to the nuclear hormone receptor superfamily, a unique class of proteins that helps regulate an array of molecular functions, such as homeostasis, reproduction, development, and metabolism, through the interaction and control of gene expression. Diseases affected by members of the nuclear receptor superfamily include those of the thyroid, lipid, and xenobiotic metabolism; osteoporosis; type 2 diabetes; breast and prostate cancer; and obesity. I am interested in supporting research that advances control over these major diseases through manipulation of gene expression and transcription factors using drug therapy. Some research topics covered under my portfolio include signal transduction and regulation of gene expression, structure and function of the steroid hormones, receptor structure, interaction with cytoplasmic chaperones and ligands, nuclear translocation, and mediator proteins.I also serve as project scientist for the Nuclear Receptor Signaling Atlas (NURSA) initiative. The NURSA initiative is a web-accessible bioinformatics resource that provides current and emerging data on nuclear receptor structure, function, and role in disease that is organized into user-mineable forms.I am a member of the NIH Big Data to Knowledge Executive Committee and co-lead for the Data Discovery Index designed to improve the ability to discover, access, and cite biomedical big data. I am also co-lead for the NIH Common Fund project to "Illuminate the Druggable Genome" designed to expand the druggable genome by identifying new potential therapeutic targets.                        



Kristin Abraham, Ph.D.


My portfolio includes research grants focused on the role of inflammation in diabetes and projects developing animal models to enhance basic and preclinical research in diabetes, endocrinology, and metabolic diseases. I also play an active role in the Mouse Metabolic Phenotyping Centers Program, the Diabetic Complications Consortium, and in the second phase of the KOMP2 Knockout Mouse Project. In addition, I am a member of the Common Fund High-Risk High-Reward working group that assists with oversight of the NIH Director's HRHR portfolio including the Pioneer, New Innovator, Early Investigator, and Transformative R01 programs.                        

External Scientific Advisory Panel

Lauren Becnel, Ph.D.

Director of Biomedical Informatics & Alliances, Clinical Data Interchange Standards Consortium (CDISC), and Assistant Professor, Baylor College of Medicine

Eugene Kolker, Ph.D.

Chief Data Officer Children's Hospital and Regional Medical Center

W. Lee Kraus, Ph.D.

Department of Obstetrics and Gynecology, UT Southwestern Medical Center

Richard Mclndoe, Ph.D.

Associate Director, Center for Biotechnology and Genomic Medicine, Augusta University

Andrea de Souza, Ph.D.

Director, Informatics & Data AnalysisBroad Institute, Broad Institute


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