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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=32045
Proper Citation: RRID:MMRRC_032045-JAX
Description: Mus musculus with name B6J.129S2-Ifnar1tm1Agt/Mmjax from MMRRC.
Species: Mus musculus
Notes: Research areas: ; Mutation Type: Targeted Mutation ; Collection:
Phenotype: decreased bone mineral density [MP:0000063]| abnormal spleen morphology [MP:0000689]| enlarged spleen [MP:0000691]| enlarged lymph nodes [MP:0000702]| abnormal skin condition [MP:0001191]| anemia [MP:0001577]| postnatal growth retardation [MP:0001732]| altered susceptibility to infection [MP:0001793]| decreased IgG level [MP:0001805]| abnormal inflammatory response [MP:0001845]| salivary gland inflammation [MP:0001870]| small lymph nodes [MP:0002217]| abnormal dendritic cell physiology [MP:0002376]| abnormal lymphopoiesis [MP:0002401]| decreased susceptibility to viral infection [MP:0002410]| increased susceptibility to viral infection [MP:0002418]| abnormal macrophage morphology [MP:0002446]| abnormal immunoglobulin level [MP:0002490]| increased IgG level [MP:0002493]| increased IgM level [MP:0002494]| increased IgA level [MP:0002495]| glomerulonephritis [MP:0002743]| joint inflammation [MP:0002933]| increased urine protein level [MP:0002962]| abnormal cytokine secretion [MP:0003009]| abnormal leukocyte migration [MP:0003156]| rheumatoid arthritis [MP:0003561]| increased tumor growth/size [MP:0003721]| increased autoantibody level [MP:0003725]| decreased autoantibody level [MP:0003726]| decreased fetal size [MP:0004200]| abnormal CD8-positive [MP:0004392]| alpha-beta T cell physiology [MP:0004762]| increased anti-double stranded DNA antibody level [MP:0004794]| increased anti-nuclear antigen antibody level [MP:0004795]| decreased anti-nuclear antigen antibody level [MP:0004801]| increased susceptibility to systemic lupus erythematosus [MP:0004802]| decreased susceptibility to systemic lupus erythematosus [MP:0004952]| increased spleen weight [MP:0004982]| abnormal osteoclast morphology [MP:0005025]| abnormal response to infection [MP:0005027]| increased susceptibility to parasitic infection [MP:0005070]| impaired natural killer cell mediated cytotoxicity [MP:0005542]| corneal vascularization [MP:0008476]| increased spleen red pulp amount [MP:0008501]| increased IgG2b level [MP:0008502]| increased IgG3 level [MP:0008553]| increased circulating tumor necrosis factor level [MP:0008559]| abnormal interferon-gamma secretion [MP:0008561]| decreased tumor necrosis factor secretion [MP:0008563]| decreased interferon-alpha secretion [MP:0008565]| decreased interferon-beta secretion [MP:0008593]| increased circulating interleukin-10 level [MP:0008617]| increased circulating interleukin-12 level [MP:0008635]| increased circulating interleukin-18 level [MP:0008706]| decreased interleukin-6 secretion [MP:0008713]| abnormal cytokine level [MP:0009642]| abnormal blood homeostasis [MP:0009788]| increased susceptibility to bacterial infection induced morbidity/mortality [MP:0009790]| decreased susceptibility to viral infection induced morbidity/mortality [MP:0009791]| increased susceptibility to viral infection induced morbidity/mortality [MP:0010750]| increased susceptibility to parasitic infection induced morbidity/mortality [MP:0010766]| abnormal NK cell physiology [MP:0011089]
Affected Gene: Ifnar1
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Source: Mutant Mouse Resource and Research Center (RRID:SCR_002953)
Description: National public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.
URL: http://www.mmrrc.org/
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
The NIDDK Information Network (dkNET) serves the needs of basic and clinical investigators by providing seamless access to large pools of data and research resources relevant to the mission of The National Institute of Diabetes Digestive and Kidney Diseases (NIDDK). dkNET is hosted at University of California San Diego, and is supported by NIH NIDDK grant U24DK097771.
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