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All organisms depend on food digestion for survival, yet the brain-gut signaling mechanisms that regulate this process are not fully understood. Here, using an established C. elegans digestion model, we uncover a pathway in which neuronal ROS (free radicals) signal the intestine to suppress digestion. Genetic screening reveals that reducing genes responsible for maintaining ROS balance increases free radicals and decreases digestion. PRDX-2 knockout in olfactory neurons (AWC) elevates ROS and reduces digestive capacity, mediated by the neuropeptide NLP-1 and activation of the mitochondrial unfolded protein response (UPRmt) in the intestine. Additionally, over-expressing nlp-1 or ablating AWC neurons both trigger UPRmt and inhibit digestion. These findings reveal a brain-gut connection in which neuronal PRDX-2-mediated ROS signaling modulates food digestion, highlighting a critical role of free radicals in shutting down digestion to alleviate stress and reduce food consumption.
Pubmed ID: 39632952
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Web application that helps design, evaluate and clone guide sequences for the CRISPR/Cas9 system. This sgRNA design tool assists with guide selection in a variety of genomes and pre-calculated results for all human coding exons as a UCSC Genome Browser track.
View all literature mentionsCenter that acquires, maintains, and distributes genetic stocks and information about stocks of the small free-living nematode Caenorhabditis elegans for use by investigators initiating or continuing research on this genetic model organism. A searchable strain database, general information about C. elegans, and links to key Web sites of use to scientists, including WormBase, WormAtlas, and WormBook are available.
View all literature mentionsCaenorhabditis elegans with name sod-3(tm760) X. from WB.
View all literature mentionsCaenorhabditis elegans with name Caenorhabditis elegans wild isolate. from WB.
View all literature mentionsCaenorhabditis elegans with name ctl-3(ok2042) II. from WB.
View all literature mentionsCaenorhabditis elegans with name prdx-2(gk169) II. from WB.
View all literature mentionsCaenorhabditis elegans with name zcIs4 V. from WB.
View all literature mentionsCaenorhabditis elegans with name pmk-1(km25) IV. from WB.
View all literature mentionsCaenorhabditis elegans with name ctl-1(ok1242) II. from WB.
View all literature mentionsCaenorhabditis elegans with name ctl-2(ok1137) II. from WB.
View all literature mentionsCaenorhabditis elegans with name atfs-1(et18) V. from WB.
View all literature mentionsCaenorhabditis elegans with name zcIs13 V. from WB.
View all literature mentionsCaenorhabditis elegans with name gpIs1. from WB.
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