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Norway

PMID:22452792  

Loss of HLTF function promotes intestinal carcinogenesis.

Sumit Sandhu | Xiaoli Wu | Zinnatun Nabi | Mojgan Rastegar | Sam Kung | Sabine Mai | Hao Ding
Molecular cancer | 2012

HLTF (Helicase-like Transcription Factor) is a DNA helicase protein homologous to the SWI/SNF family involved in the maintenance of genomic stability and the regulation of gene expression. HLTF has also been found to be frequently inactivated by promoter hypermethylation in human colon cancers. Whether this epigenetic event is required for intestinal carcinogenesis is unknown.

Pubmed ID: 22452792

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Associated grants

  • Agency: Canadian Institutes of Health Research, Canada
    Id: MOP 77783

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