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Norway

PMID:21957448  

Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity.

Maryla Krajewska | Zerong You | Juan Rong | Christina Kress | Xianshu Huang | Jinsheng Yang | Tiffany Kyoda | Ricardo Leyva | Steven Banares | Yue Hu | Chia-Hung Sze | Michael J Whalen | Leonardo Salmena | Razqallah Hakem | Brian P Head | John C Reed | Stan Krajewski
PloS one | 2011

Acute brain injury is an important health problem. Given the critical position of caspase 8 at the crossroads of cell death pathways, we generated a new viable mouse line (Ncasp8(-/-)), in which the gene encoding caspase 8 was selectively deleted in neurons by cre-lox system.

Pubmed ID: 21957448

Research resources used in this publication

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Antibodies used in this publication

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Associated grants

  • Agency: NINDS NIH HHS, United States
    Id: R01 NS036821
  • Agency: NINDS NIH HHS, United States
    Id: R01 NS064545
  • Agency: NCI NIH HHS, United States
    Id: P01 CA069381
  • Agency: NINDS NIH HHS, United States
    Id: NS36821
  • Agency: NCI NIH HHS, United States
    Id: CA69381

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STATISTICA (tool)

RRID:SCR_014213

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RRID:SCR_014311

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FVB/NJ (tool)

RRID:IMSR_JAX:001800

Mus musculus with name FVB/NJ from IMSR.

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