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Profilins are actin binding proteins essential for regulating cytoskeletal dynamics, however, their function in the mammalian nervous system is unknown. Here, we provide evidence that in mouse brain profilin1 and profilin2 have distinct roles in regulating synaptic actin polymerization with profilin2 preferring a WAVE-complex-mediated pathway. Mice lacking profilin2 show a block in synaptic actin polymerization in response to depolarization, which is accompanied by increased synaptic excitability of glutamatergic neurons due to higher vesicle exocytosis. These alterations in neurotransmitter release correlate with a hyperactivation of the striatum and enhanced novelty-seeking behavior in profilin2 mutant mice. Our results highlight a novel, profilin2-dependent pathway, regulating synaptic physiology, neuronal excitability, and complex behavior.
Pubmed ID: 17541406
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A video tracking system that takes automated recordings and analyzes animal activity through various arena and maze systems. It can track multiple arenas using one camera, and an unlimited number of zones of interest can be generated for performing spatial analyses or controlling data acquisition. Features include 3-point detection, 3D measurements, access to raw data, and reanalysis of tracking data.
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