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Hypothesis Center
Type 1 Diabetes Knowledge Portal (T1DKP) Tutorial
Introduction:
The Type 1 Diabetes Knowledge Portal (T1DKP) enables browsing, searching, and analysis of human genetic information linked to type 1 diabetes and related traits. T1DKP integrates and visualizes genetic and genomic data relevant to T1D and its complications in order to spark insights into the molecular bases of disease risk and progression. The T1DKP aggregates three types of data: genetic associations, epigenomic annotations, and results from bioinformatic methods. Genetic association data are obtained from all available studies and consortia, including the Type 1 Diabetes Genetics Consortium (T1DGC), The Environmental Determinants of Diabetes in the Young (TEDDY), the TrialNet Pathway to Prevention, and the JDRF Diabetic Nephropathy Collaborative Research Initiative. The T1DKP resource provides researchers access to integrated and distilled genome-wide data, allowing researchers to explore genomic regions that are linked to T1D risk and to generate hypotheses about causal genes and pathways.
Type 1 Diabetes Knowledge Portal Tutorial
This tutorial teaches you how to navigate the T1DKP and find genetic and genomic information about Type 1 Diabetes.
Tutorial That Has Been Selected For You:
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What hypothesis are you developing or what information are you looking for? Human genetic and genomic information linked to a phenotype or disease |
The hypothesis generation examples that you selected: Human genetic and genomic information linked to type 1 diabetes and related traits |
Learning Goals:
How to navigate the portal
How to find information of available T1D datasets at T1DKP
How to navigate phenotype page to find top single-variant associations, top common variant gene-level associations for T1D, datasets used in meta-analysis, and globally enriched annotations for T1D.
How to navigate variant page to find closed gene, predicted variant consequences, PheWAS plot, binding motifs, annotated regions
How to find the variant associations in the region
Tutorial Lesson:
This is an external tutorial provided by Type 1 Diabetes Knowledge Portal. You will be directed to an external page for this tutorial.
About
The NIDDK Information Network (dkNET) serves the needs of basic and clinical investigators by providing seamless access to large pools of data and research resources relevant to the mission of The National Institute of Diabetes Digestive and Kidney Diseases (NIDDK). dkNET is hosted at University of California San Diego, and is supported by NIH NIDDK grant 2U24DK097771-09.
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