Introduction:

The Mouse Metabolic Phenotyping Centers (MMPC) is a National Institutes of Diabetes and Digestive and Kidney Diseases-Sponsored resource that provides state-of-the-art technologies to investigators for a fee. Their services include characterization of mouse metabolism, blood composition (including hormones), energy balance, eating and exercise, organ function and morphology, physiology and histology. MMPC provides data search tools that assist researchers in finding a gene list in association with phenotypes, phenotypes in association with gene-specific KO mice, or finding mouse experimental test results in association with genes, phenotypes, or MMPC test catalog.

dkNET Webinar: The Mouse Metabolic Phenotyping Centers: Services and Data

Dr. Richard McIndoe reviewed the structure of the MMPC, the services it provides and the data generated by the consortium for public use.

Tutorial That Has Been Selected For You:

Learning Goals:

STEP 1: First let’s open a new window with the MMPC (National Mouse Metabolic Phenotyping Center)

To make it easier to walk through the tutorial, please launch a new window

STEP 2: Go to Search Data and then select MMPC Data from the drop-down list

STEP 3: The first thing one needs to do within the MMPC Data Search is to let MMPC Data Search tool know "What would you like to search for" from the drop-down list. In this tutorial we will be selecting Phenotype.

STEP 4: Next, you will need to select a Phenotype based on your interest from the drop-down list. For this tutorial, please select MP:0001260 - increased body weight. Click Search

STEP 5: This is the example results page that you will see if you pick up the phenotype “increased body weight”. The results will be changed if you change it to another phenotype.

Now you can find a list of mouse genes that are associated with the phenotype “increased body weight”.

Hover the mouse cursor over the links to get more information, including

• Experimental name

• Mouse strains used in the experiment

• Assay measurements captured in the experiment

• Significance (P value) for this assay between the Control and Experimental groups

• Effect size for that assay in the experiments