Type 1 Diabetes Knowledge Portal (T1DKP)

WHAT IS IT?

The Type 1 Diabetes Knowledge Portal (T1DKP) enables browsing, searching, and analysis of human genetic information linked to type 1 diabetes and related traits.​ T1DKP integrates and visualizes genetic and genomic data relevant to T1D and its complications in order to spark insights into the molecular bases of disease risk and progression. The T1DKP aggregates three types of data: genetic associations, epigenomic annotations, and results from bioinformatic methods. Genetic association data are obtained from all available studies and consortia, including the Type 1 Diabetes Genetics Consortium (T1DGC), The Environmental Determinants of Diabetes in the Young (TEDDY), the TrialNet Pathway to Prevention, and the JDRF Diabetic Nephropathy Collaborative Research Initiative. The T1DKP resource provides researchers access to integrated and distilled genome-wide data, allowing researchers to explore genomic regions that are linked to T1D risk and to generate hypotheses about causal genes and pathways.

WHO CAN USE IT?

Scientists who are interested in finding genetic and genomic information for studying the mechanisms and treatment of type 1 diabetes and its complications.

WHAT TYPE OF QUESTIONS CAN IT ANSWER?

1. What are the genomic-wide associations for T1D and related traits from the definitive T1D genetic community datasets?

2. What are the most up to date and curated list of predicted T1D effector genes, along with the supporting lines for evidence?

3. What is the credible set of variants to study for functional follow up from any GWAS locus for T1D?

4. What are the results of computational approaches and relevant genomic annotations to assist in prioritization of a variant or gene from a GWAS loci?