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Monarch Initiative

Repository of information about model organisms, in vitro models, genes, pathways, gene expression, protein and genetic interactions, orthology, disease, phenotypes, publications, and authors, and the the ability to navigate multi-scale spatial and temporal phenotypes across in vivo and in vitro model systems in the context of genetic and genomic data, using semantics and statistics. The discovery system provides basic and clinical science researchers, informaticists, and medical professionals with an integrated interface and set of discovery tools to reveal the genetic basis of disease, facilitate hypothesis generation, and identify novel candidate drug targets. The aim for this system is to promote true translational research, in that clinicians can connect with model systems researchers with expertise in related phenotypes, assays, or models. In addition to providing easy-to-use tools to navigate the model-disease data landscape, it also provides services for other resources, and educational outreach regarding the production of structured data for biomedical discovery. Model systems are the cornerstone of biomedical research to investigate biological processes, test gene-based disease hypotheses, and develop and test disease treatments. The vast knowledge about model systems can be better utilized if semantically aggregated and made queryable based on any number of facets, such as phenotypic similarity, network analysis, gene expression and function, and genomics.


Details

  • Related Condition:
  • Funding Agency: NIH Office of the Director
  • Relation: related to: Lifespan Observations Database, PhenoGen Informatics, Ancora, openSNP, Mouse Neuronal Expression Database, WikiPathways, dbSNP, GeneNetwork, Aging Genes and Interventions Database, NCBI database of Genotypes and Phenotypes, miRBase, PubChem, Pfam, Pain Genes database, Knockout Mouse Project, International Knockout Mouse Consortium, CMHD - Centre for Modeling Human Disease, SNPedia, Australian Phenomics Network, Leiden Open Variation Database, HPA, HGVS Locus Specific Mutation Databases, Human Genome Variation Society: Databases and Other Tools, HPID - Human Protein Interaction database, Olfactory Receptor DataBase, Search Tool for Interactions of Chemicals, Human Variation DB, Digital Ageing Atlas, International Mouse Strain Resource, Expression Patterns for C. elegans promoter GFP fusions, Human Gene Mutation Database, AnimalTFDB, MouseCyc, PhosphoSitePlus: Protein Modification Site, Bgee: a dataBase for Gene Expression Evolution, Rat Resource and Research Center, DOMINE: Database of Protein Interactions, PharmGKB, Phenoscape Knowledgebase, Database of Interacting Proteins (DIP), Reactome, UniProtKB, NCBI Sequence Read Archive (SRA), MOPED - Model Organism Protein Expression Database , European Mouse Mutant Archive, modENCODE, Sanger Mouse Resources Portal, Rat Genome Database (RGD), Gene Expression Database, InterPro, National Swine Resource and Research Center, Europhenome Mouse Phenotyping Resource, IntAct, VISTA Enhancer Browser, Gemma, PiGenome, used by: NIF Data Federation, uses: Ensembl Variation, Animal QTLdb, Xenbase, elements of morphology, STRING, Clinical Genomic Database, ENCODE, UBERON, Ensembl, Entrez Gene, Zebrafish Information Network (ZFIN), T3DB, DrugBank, Gene Ontology, WormBase, Mouse Phenome Database (MPD), PANTHER, International Mouse Phenotyping Consortium (IMPC), ClinVar, Human Phenotype Ontology Annotations, OMIA - Online Mendelian Inheritance in Animals, OMIM, Mouse Genome Informatics (MGI), Comparative Toxicogenomics Database, FlyBase, GeneReviews, Caenorhabditis Genetics Center, Biological General Repository for Interaction Datasets (BioGRID), GWAS: Catalog of Published Genome-Wide Association Studies, KEGG, Coriell Cell Repositories, SciGraph, listed by: Neuroscience Information Framework, lists: ClinicalTrials.gov, Gene Expression Omnibus, AutDB, Kawasaki Disease Dataset
  • Reference:
  • Website Status: Last checked up
  • Alternate IDs: nlx_152525
  • Alternate URLs:
  • Old URLs:
  • v_uuid: 437c6dcd-6dc1-5a71-a1d3-261712bd3a6d
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