Nuclear Receptor Signaling Atlas (NURSA) Hub: Consensome Validation NURSA Data Source Projects (NDSPs)

The mission of the Nuclear Receptor Signaling Atlas (NURSA) Hub is to improve the accessibility and re-usability of publicly-archived datasets of relevance to the nuclear receptor (NR) signaling research community.  To arrive at consensus physiological system- and organ-specific transcriptomic signatures of NR pathways, the NURSA Hub has added a new module to its Transcriptomine data analysis platform, called Consensome. In this feature, genes are ranked according to the frequency with which they are significantly differentially expressed in publicly archived datasets involving manipulation of a given NR pathway in a specific organ or physiological system. The rankings, or Consensomes, are available at https://www.nursa.org/nursa/transcriptomine/index.jsf. In addition to validating well-characterized NR target genes, many Consensomes contain highly ranked genes that represent potentially important, but currently underappreciated, transcriptional targets of NR signaling pathways. In this NDSP solicitation, we invite applications proposing bench validation of relationships between NR signaling pathways and gene(s) predicted by the Consensomes, but that are previously unpublished in the research literature. Letter of Intent due date: May 31, 2017.