Nuclear Receptor Signaling Atlas (NURSA) Hub Open Competition for NURSA Data Source Projects (NDSP)
- 04:37pm July 6, 2016
- Ko-Wei Lin
The nuclear receptor (NR) community has generated a large number of discovery-scale transcriptomic datasets that collectively document the tissue-specific regulation of gene expression by NR signaling pathways. Despite their potential for affording insight into unknown or unfamiliar NR signaling pathway biology, these datasets have been poorly exposed for re-use by the research community. In response to this, the NURSA Hub is aggregating, curating and processing these datasets to enhance their discoverability, accessibility and citability. The full current list of datasets can be browsed on the NURSA Dataset home page or the 30,000,000+ data points in the entire resource can be mined via the Transcriptomine search engine. To fully leverage this significant investment of knowledge and expertise, this fourth NDSP announcement solicits applications based on the existing collection of NURSA transcriptomic data points. Examples of responsive applications include: Demonstrating how the Transcriptomine knowledgebase can be leveraged to identify novel gene-tissue-NR signaling pathway relationships that have not been previously characterized in the published research literature, and that can be then validated in a bench research component. Development of data visualization and analysis tools that interface with Transcriptomine to extend its utility. Interoperability and/or integration between NURSA and external resources with complementary ‘omics-scale datasets, or biocuration activites to support such integration (e.g. integration of ChIP-Seq datasets).