Foundation For the NIH (FNIH) Accelerating Medicines Partnership: Type 2 Diabetes Project (AMP T2D) Request For Proposals

The open access AMP T2D Knowledge Portalhas been built to generate new biologic and disease state understanding by maximizing the ability to explore rare and common genetic variants across quantitative and qualitative phenotypes related to the many indications related to T2D and its complications. FNIH is seeking proposals from organizations to contribute high-quality human genome sequence, clinical, and molecular phenotypic data for Nonalcoholic Steatohepatitis (NASH), Diabetic Nephropathy (DN), Type 2 Diabetes (T2D), T2D-related quantitative traits, and for T2D microvascular, cardiovascular, renal, and hepatic complications to the AMP T2D Knowledge Portal. Proposals to contribute existing data sets as well as proposals to derive new genotyping data from readily available and appropriately consented samples will be considered. The consortium is expanding the KP to federated sites outside the U.S. in order to facilitate inclusion of global data in order to accommodate regional requirements. By participating in this global collaborative effort, awardees will help advance translational science and help identify new treatments for T2D and its complications. Data of interest include those derived from whole exome sequencing, whole genome sequencing, exome chip, or genome wide association analyses of large cohorts with corresponding and relevant individual level phenotypic data. Data from any and all geographic regions, races, and ethnicities are of great value to the knowledge portal and will contribute toward building the single most powerful resource for understanding the genetics of Type 2 Diabetes and its complications. In the interest of attaining critical scale, applications from consortia representing multiple cohorts are encouraged. Awardees will become active members of a growing AMP T2D collaborative group, which includes experts from multiple private, public, and non-profit institutions. Awardees will benefit from access to state of the art computational tools facilitated by harmonization and integration with extensive, well-phenotyped data from other sources. Application due on December 31, 2016. For more information, please check http://fnih.org/what-we-do/current-research-programs/amp-t2d-project. Contact: Dr. Sanya Whitaker (swhitaker@fnih.org).