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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=152975964
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 152975964
Notes: Full gene inversion of the rat F8 gene introduced by CRISPR/Cas9, to DahlSS background rats. This inversion causes a premature stop codon 3 amino acids into the protein. F8 activity in rats, homozygous for the mutation, is undetectable. Contact MCW Rat Distribution at [email protected]
Proper citation: RRID:RGD_152975964 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=10054459
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2017-01-26)
Alternate IDs: 10054459
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Sirt3 gene of T2DN/Mcwi rat embryos. The resulting mutation is a 31-bp deletion in the Sirt3 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_10054459 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=10054292
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2017-01-26)
Alternate IDs: 10054292
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Arhgef11 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 17-bp deletion in the Arhgef11 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_10054292 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=152985526
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 152985526
Notes: A 7-bp deletion in exon 1 of the Cdkn2a (p16) gene was introduced by the CRISPR/Cas9. Genetic background is Iar:Wistar-Imamichi (Institute for Animal Reproduction) (RGD:125097496). Introducing the deletion mutation in the Cdkn2a (p16) gene into the background of DMD rats (muscular dystrophy model rats) improves muscle pathology. National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_152985526 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=155663559
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2022-11-28)
Alternate IDs: 155663559
Notes: CRISPR/Cas9 technology was used to insert an IRES for iCre expression after the final coding sequence of exon 6 of the rat Gcg gene, before the 3' UTR. Strain has been deposited to RRRC(RRRC:00983, RGD:155663560)
Proper citation: RRID:RGD_155663559 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=10002782
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 10002782
Notes: Spontaneous mutation in the colony of SHR/OlaIpcv in Prague.
Proper citation: RRID:RGD_10002782 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=1302678
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2024-09-24)
Alternate IDs: 1302678
Notes: Strain originated from Japan SLC, Inc, Shizuoka, Japan. National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_1302678 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=629459
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 629459
Notes: Obtained from Louisiana Sate University Medical Center, New Orleans by the Department of Physiology.
Proper citation: RRID:RGD_629459 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=629462
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 629462
Notes: This recessive fatty Zucker rat carries a mutation that occurred spontaneously in the 13M stock and was reported by Lois Zucker and Theodore Zucker in 1960. This was observed during genetic experiments related to coat color and body size.
Proper citation: RRID:RGD_629462 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=639699398
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 639699398
Notes: Cas9 protein and sgRNA targeting the sequence CCTTTTTGCAGAGCACGAAA within exon 2 of Adcy3 were injected into embryos of the WKY/NCrl strain. A 1-bp deletion resulted (rn7: chr6:27,126,062).The homozygous mutant was lethal shortly after birth, so the heterozygous +/- (RGD:19165366) was used for breeding and study. Contact Dr. Solberg-Woods at Wake Forest University School of Medicine, Email: [email protected]
Proper citation: RRID:RGD_639699398 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=329849114
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 329849114
Notes: The CRISPR/SpCas9 system was used to introduce a 10-bp deletion (rn6: chr3:153,453,801-153,453,810) in exon 3 of the Ghrh gene in Crl:SD Sprague Dawley embryos.
Proper citation: RRID:RGD_329849114 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=632518357
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2026-02-06)
Alternate IDs: 632518357
Notes: The endonuclease mediated knock in of the transgenic cassette, CAG-LSL-tdTomato in mouse (ROSA)26Sor, was created in Crl:CD (SD) rats. Cyagen
Proper citation: RRID:RGD_632518357 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=629006637
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 629006637
Notes: ANTXR2 knock-out rats were generated using CRISPR/Cas9-mediated genome editing. Specifically, a 67 base pairs deletion in exon 1 of ANTXR2 was induced by 2 guide RNAs targeting sequences within exon 1. The guide RNA targeting vectors and Cas9 were co-injected into the fertilized Sprague Dawley eggs to generate ANTXR2 knock-out rats. The pups were genotyped by PCR and confirmed by sequencing (forward primer: 5′-TTGGGTGGCTCTGAGCTTGGA-3′, reverse primer: 5′-AGGGGTCTAGGGGAGTGTGATAAAGA-3′).
Proper citation: RRID:RGD_629006637 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=25394534
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 25394534
Notes: LE-ROSA26em1(CAG-tdTomato)1Sage (RGDID: 12905037) was backcrossed to SS/JrHsdMcwi for more than 8 generations. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_25394534 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=152998996
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2022-07-15)
Alternate IDs: 152998996
Notes: This model was generated at the Medical College of Wisconsin by CRISPR/Cas9 mutagenesis in Crl:SD strain and harbors a 16-bp deletion in exon 3 of Adh5. rn6.0:chr2:226,979,096-226,979,111. contact MCW Rat Distribution at [email protected]
Proper citation: RRID:RGD_152998996 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=152998993
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2022-07-15)
Alternate IDs: 152998993
Notes: This model was produced at the Medical College of Wisconsin using CRISPR/Cas9 in the Crl:SD strain. The resulting mutation is a 1-bp insertion in the third exon of the Ager gene. rn6.0:chr20:4,150,403-4,150,403 ins T contact MCW Rat Distribution at [email protected]
Proper citation: RRID:RGD_152998993 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=632645231
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 632645231
Notes: This is a heterozygous Galt mutant rat carries one copy of CRISPR/Cas9 system induced 2-base pair insertion mutation into exon 6 in the rat Galt gene of Crl:SD embryos.
Proper citation: RRID:RGD_632645231 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=625777899
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 625777899
Notes: To produce Ugt2 cluster (∼762-kb) KO rats, two gRNAs with target sites upstream of Ugt2a1 and the coding region of Ugt2b31-like were injected into rat fertilized eggs.
A knockout strain with Ugt2 cluster mutation carried concatenation of the genomic sequence upstream of Ugt2a1, a 102-bp insertion, and the Ugt2b31-like region.
The F2 homozygous rats showed decreased gemfibrozil glucuronidation activity in the liver.
The result suggested the functional deletion of rat Ugt2 genes in the Ugt2-KO rats.
Proper citation: RRID:RGD_625777899 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=626170603
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2025-09-02)
Alternate IDs: 626170603
Notes: In collaboration with Horizon Discovery, CRISPR/Cas9 technology was used in Long Evans (LE) embryos to introduce a 10bp deletion in exon 8 of the Cdkl5 gene (Ensembl coordinates X:35,674,763–35,674,772, in the Rnor_6.0 genome assembly) which results in the introduction of an early stop codon in constitutive exon 9, leading to lack of CDKL5 protein expression. Simons Initiative for the Developing Brain (SIDB), Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh EH8 9XD, UK. Contact SIDB Scientific Officer for enquiries on rat distribution ([email protected]).
Proper citation: RRID:RGD_626170603 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=617154644
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 617154644
Notes: The CRISPR/Cas9 genetic editing approach was used to generate .a homozygous Long-Evans rat model of human SCA34. The human Cas9 D10A (hCas9-D10A) nickase was used to knock-in the c.736T>G mutation by targeting exon 6 of the rat Elovl4 (Ensembl: ENSRNOG00000009773) located on rat chromosome 8. The hCas9 mRNA, sgRNA(CCTTCCCCAAGTGGATGCAC), and single-strand oligonucleotide donor (ssODN: TTCCATGTGACCATTGGGCACACAGCACTGTCTCTCTACACCGACTGCCCCTTCCCCAAGGGGATGCACTGGGCTCTGATCGCCTATGCCATCAGCTTCATCTTCCTCTTCCTCAACTTCTAC) were co-injected into Long-Evans rat zygotes at the laboratories of Cyagen Bioscience Inc.The heterozygous F0 rats carrying c.736T>G, p.W246G, mutation were bred with with WT Long-Evans rats over several generations to breed out any potential off-target effects and to establish the heterozygous SCA34 Long-Evans rat model. Successfully generation of homozygous SCA34 rats (MUT) by breeding heterozygous rats from the different F0 lines.
Proper citation: RRID:RGD_617154644 Copy
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