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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=617154642
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 617154642
Notes: The CRISPR/Cas9 genetic editing approach was used to generate .a heterozygous Long-Evans rat model of human SCA34. The human Cas9 D10A (hCas9-D10A) nickase was used to knock-in the c.736T>G mutation by targeting exon 6 of the rat Elovl4 (Ensembl: ENSRNOG00000009773) located on rat chromosome 8. The hCas9 mRNA, sgRNA(CCTTCCCCAAGTGGATGCAC), and single-strand oligonucleotide donor (ssODN: TTCCATGTGACCATTGGGCACACAGCACTGTCTCTCTACACCGACTGCCCCTTCCCCAAGGGGATGCACTGGGCTCTGATCGCCTATGCCATCAGCTTCATCTTCCTCTTCCTCAACTTCTAC) were co-injected into Long-Evans rat zygotes at the laboratories of Cyagen Bioscience Inc.The heterozygous F0 rats carrying c.736T>G, p.W246G, mutation were bred with with WT Long-Evans rats over several generations to breed out any potential off-target effects and to establish the heterozygous SCA34 Long-Evans rat model. Successfully generation of homozygous SCA34 rats (MUT) by breeding heterozygous rats from the different F0 lines.
Proper citation: RRID:RGD_617154642 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=156431061
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2026-01-15)
Alternate IDs: 156431061
Notes: The CRISPR/Cas9 system was used to introduce a T insertion in exon 1 of C17h6orf52 gene causing a frameshift and predicated early truncation of the translated protein in an embryo from LH/MavRrrcAek (RGD:10755352) through electroporation. Currently live colony with Dr. Anne Kwitek at the Medical College of Wisconsin. Being cryopreserved and the live colony will not be available.
Proper citation: RRID:RGD_156431061 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=626168261
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2025-08-29)
Alternate IDs: 626168261
Notes: Crispr/Cas9 genome editing of the Peg3 gene The strain is deposit at RRRC - University of Missouri
Proper citation: RRID:RGD_626168261 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13506177
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2018-01-31)
Alternate IDs: 13506177
Notes: CRISPR/SpCas9 targeting was used to introduce an 11-bp putative frame-shift deletion in exon 3. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13506177 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=626170595
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2025-09-02)
Alternate IDs: 626170595
Notes: This allele has a deletion of the C2/GAP domain of Syngap1 and was generated by Sigma Advanced Genetic Engineering (SAGE) Labs (St. Louis, MO, US). Zinc-finger nucleases (ZFNs) designed to target Syngap1 exons 8–12 were microinjected into the pronucleus of fertilized, single-cell Long Evans (LE) embryos. A 3,584-bp selective deletion and 3-bp insertion were confirmed by sequencing, which resulted in a mutant protein that was 377 amino acids smaller than endogenous SYNGAP1. Simons Initiative for the Developing Brain (SIDB), Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh EH8 9XD, UK. Contact SIDB Scientific Officer for enquiries on rat distribution ([email protected]).
Proper citation: RRID:RGD_626170595 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=632518398
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2026-02-12)
Alternate IDs: 632518398
Notes: The CRISPR/Cas9 system was multiplexed to introduce a double strand brake at exon 3 and 14 to promote the removal of majority of the MPO gene in rat embryos. Animal Modeling Core at the University of Missouri. Availability Contact Email: [email protected]
Proper citation: RRID:RGD_632518398 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=153297754
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2022-07-21)
Alternate IDs: 153297754
Notes: This strain was produced at the Medical College of Wisconsin using CRISPR Cas9 mutagenesis in the Crl:SD strain. A CRISPR SpCas9/sgRNA targeting the GTCCTTTGCAGTCCCTGCCG sequence within exon 15 of Gsap and a 5-bp indel (rn72: chr4:13,849,488-13,849,492) was identified.
Proper citation: RRID:RGD_153297754 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=626419679
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Embryo (as of 2025-09-05)
Alternate IDs: 626419679
Notes: Crl:CD(SD)-KO(Gnal*135)44-178Hpng/Hpng rats were generated by CRISPR/Cas9 technology. A deletion of 135 base pairs, corresponding to position 44-178, downstream of the translation initiation start ATG of the Gnal splicing variant 2, results in a deletion mutation. CRISPR technology details: self-synthesized Cas9 mRNA using px 330 vector, applying T7 transcription kit followed by Poly-Adenylation and Capping. No sequencing performed, whether Cas9 has been inserted into the rat genome is unknown. European Mouse Mutant Archive(EMMA)
Proper citation: RRID:RGD_626419679 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=405100724
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 405100724
Notes: This mutant rat was produced by targeted knocking adding in IRES-iCre to the 3' end of Pdyn in LE rat using CRISPR/Cas9 method. Optogenetics and Transgenic Technology Core
Proper citation: RRID:RGD_405100724 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=616572761
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 616572761
Notes: This is the wild type littermate of SD-CdCSem1Bcgen+/- (RGD:616390066). The mutant CdCS rat has the 5p15.2 deletion in the genome and it a rat model for human Cri du Chat Syndrome .
Proper citation: RRID:RGD_616572761 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13441560
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 13441560
Notes: CRISPR/Cas9 system was used to introduce a 2-base pair insertion mutation into exon 6 in the rat Galt gene of Crl:SD embryos
Proper citation: RRID:RGD_13441560 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=625777904
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 625777904
Notes: To produce Pxr KO rats, A pair of TALEN mRNAs targeting Nr1i2 (Pxr) was injected into rat fertilized eggs.This strain was derived from a founder harbouring a16 bp deletion (rPxr-KO).
Proper citation: RRID:RGD_625777904 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=625777901
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 625777901
Notes: To produce Cyp3a (∼560-kb) KO rats, A pair of TALEN mRNAs targeting exon 5 of rat Cyp3a23/3a1 and Cyp3a2 were injected into rat fertilized eggs. A founder with homozygous big deletion (BD) mutation from No. 58 line selected.
Proper citation: RRID:RGD_625777901 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=19165366
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2026-03-03)
Alternate IDs: 19165366
Notes: Cas9 protein and sgRNA targeting the sequence CCTTTTTGCAGAGCACGAAA within exon 2 of Adcy3 were injected into embryos of the WKY/NCrl strain. A 1-bp deletion resulted (rn7: chr6:27,126,062).The homozygous mutant was lethal shortly after birth, so the heterozygous +/- was used for study. Contact Dr. Solberg-Woods at Wake Forest University School of Medicine, Email: [email protected]
Proper citation: RRID:RGD_19165366 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=625777902
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 625777902
Notes: To produce Cyp3a (∼560-kb) KO rats, A pair of TALEN mRNAs targeting exon 5 of rat Cyp3a23/3a1 and Cyp3a2 were injected into rat fertilized eggs. A founder with 9-bp deletion mutation from No. 65 line selected.
Proper citation: RRID:RGD_625777902 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=629459
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 629459
Notes: Obtained from Louisiana Sate University Medical Center, New Orleans by the Department of Physiology.
Proper citation: RRID:RGD_629459 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=629462
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 629462
Notes: This recessive fatty Zucker rat carries a mutation that occurred spontaneously in the 13M stock and was reported by Lois Zucker and Theodore Zucker in 1960. This was observed during genetic experiments related to coat color and body size.
Proper citation: RRID:RGD_629462 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=10054420
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2017-01-26)
Alternate IDs: 10054420
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Mprl28 gene of LEW/NCrl rat embryos. The resulting mutation is a 7-bp insertion in the 2-bp deletion site in the Mrpl28 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_10054420 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=10054405
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2018-10-22)
Alternate IDs: 10054405
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Helz2 gene of FHH-Chr 3BN/Mcwi rat embryos.The resulting mutation is a 1-bp insertion in the Helz2 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_10054405 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=10054408
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2021-11-03)
Alternate IDs: 10054408
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Kcnj10 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 1-bp insertion in the Kcnj10 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_10054408 Copy
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