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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=38599242
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Cryopreserved Sperm (as of 2020-09-16)
Alternate IDs: 38599242
Notes: Mutant human amyloid beta (APP*) combined Thy1 promoter which is specifically expressed in neurons, was induced to ES cells from DA strain rats, and chimera rats obtained from the ES cells. The F1 rats were backcrossed with Crl:CD (SD) strain rats and F3 rats was deposited to NBRP. The expression levels of mutant human APP mRNA are difficult among Lines (12>1>14>6). National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_38599242 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=39131285
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 39131285
Notes: This Cre recombinase reporter rat expressing mCherry was generated by backcrossing Sprague-Dawley to LE-Tg(DIO-mCherry)2Ottc (RGD:8693598).
The transgene contains Cre recombinase reporter rat expressing mCherry driven by the EF1 alpha promoter. Optogenetics and Transgenic Technology Core
Proper citation: RRID:RGD_39131285 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=38599244
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Cryopreserved Sperm (as of 2020-09-16)
Alternate IDs: 38599244
Notes: Mutant human amyloid beta (APP*) combined Thy1 promoter which is specifically expressed in neurons, was induced to ES cells from DA strain rats, and chimera rats obtained from the ES cells. The F1 rats were backcrossed with Crl:CD (SD) strain rats and F3 rats was deposited to NBRP. The expression levels of mutant human APP mRNA are difficult among Lines (12>1>14>6). National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_38599244 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=155663368
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 155663368
Notes: This transgenic model line 737 was made by injecting bacterial artificial chromosome (BAC) RNECO-180E22, into Crl:CD(SD) strain embryos. The BAC clone RNECO-180E22, a kind gift of Helen Skaletsky, is derived from Rattus norvegicus strain SHR chromosome Y.
Proper citation: RRID:RGD_155663368 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=155260364
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Cryopreserved Sperm (as of 2022-10-06)
Alternate IDs: 155260364
Notes: rat strain in which the rat Cyp3a1 gene (Cyp3a23-3a1, RGD:628626) was inactivated by insertion of a human CYP3A4 minigene (Cyp3A4*) and the linked rat Cyp3a2 locus was simultaneously mutated by CRISPR-mediated indel introduction. Strain contains Indel 8 at the Rat 3A2 locus (55 kb away), The CYP3A4 minigene included a CRISPR/Cas9 gene drive element to enable super-Mendelian inheritance. Strain contains and Active Genetic cassette which encodes a gRNA targeting the Rat 3A1 and 3A2 translation initiation site. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin URL: Doi:10.1101/2022.08.30.505951 URL: Doi:10.1101/2022.08.30.505951
URL: URL: Doi:10.1101/2022.08.30.505951 RRRC
Proper citation: RRID:RGD_155260364 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=155260365
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Cryopreserved Sperm (as of 2022-10-06)
Alternate IDs: 155260365
Notes: This project entailed generation of a novel rat strain in which a P2A-Cas9-T2A-EGFP coding sequence was inserted at the stop codon of the rat Sycp1 gene for co-expression of Cas9 and EGFP under the control of the Sycp1 regulatory elements. Animals express Cas9 in the testis in the spermatogonial layer and in meiosis stages with 4N DNA content. Strain catalyzes high levels of Active Genetic Gene conversion when paired with certain Active Genetic cassettes. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin
URL: Doi:10.1101/2022.08.30.505951 Donated to Rat Resource & Research Center
Proper citation: RRID:RGD_155260365 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=329955364
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 329955364
Notes: Transgene insertion (human CD68-GFP) using Sleeping Beauty transposon system on Wistar Kyoto rats. Rat monocyte/macrophage reporter strain on a WKY background which has susceptibility to experimental glomerulonephritis. GFP expression occurs exclusively within blood monocytes and tissue macrophages.
Proper citation: RRID:RGD_329955364 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=404976872
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Cryopreserved Sperm (as of 2024-03-18)
Alternate IDs: 404976872
Notes: CD-Tg(RNECO-180E22)733Arno, RGD:155663367 was backcrossed at the Medical College of Wisconsin to DA/MolTacMcwi for 6-7 generations before cryopreservation of sperm. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_404976872 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=598092606
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Cryopreserved Sperm (as of 2025-03-28)
Alternate IDs: 598092606
Notes: This strain was established by a use of the BAC transgenic method with a technical support from the C.B.S.N resource (Dr. Kazuto Kobayashi, Fukushima Medical University, Dr. Yuchio Yanagawa, Gunma University Graduate School of Medicine). This transgenic rat was transported to The Jikei University School of Medicine, and cre recombinase expression was confirmed by crossing it with a reporter rat (NBRP Rat No: 0734). These rats are maintained in The Jikei University School of Medicine. Background strain: Crlj:WI.
Transgene: Dbh (dopamine beta-hydroxylase: rat), TetR (E.coli), VP16 protein minimal“F”-type activation domain (Herpes simplex virus), 2A (Thosea asigna virus), cre recombinase (P1 Phage), bGlobin polyA (rabbit), loxP (P1 phage). Detailed method (BAC transgenic method): a rat BAC clone was used (CH230-211J22). Combined mRNA for tTA and cre recombinase sequences is transcribed under the control of Dbh promoter. In translation step, the transcript is cut at the 2A peptide sequence, resulting in a separate protein production of tTA and Cre. National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_598092606 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=598154611
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 598154611
Notes: The full length humanTOR1A wild type gene including upstream and downstream flanking regions were inserted into a pUC19 vector. Following linearization and purification the transgenes were used to generate transgenic rats by microinjection of the DNA construct into the pronucleus of rat zygotes. Transgenic rats were kept on Sprague–Dawley background and bred as hemizygotes using standard procedures. Genotypes of offspring were determined by PCR and sequencing of DNA extracted from ear biopsies. Primer pair 5′-TAAAAATGTGTATCCGAGTGGAAAT (forward) and 5′-AAGGACTGAGTGTTGTTTCTTTTC (reverse) amplified a 230 bp segment within the coding sequence of exon 5 under the following conditions: 94 °C for 1 min, 60 °C for 1 min and 72 °C for 1 min, 40 cycles. Only lines that showed stable germline transmission of the transgenes were used for further analyses.
Proper citation: RRID:RGD_598154611 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=598154612
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 598154612
Notes: The 16.25 kbps full length human DYT1 allele of TOR1A gene including upstream and downstream flanking regions were inserted into a pUC19 vector. Following linearization and purification the transgenes were used to generate transgenic rats by microinjection of the DNA construct into the pronucleus of rat zygotes. Transgenic rats were kept on Sprague–Dawley background and bred as hemizygotes using standard procedures. Genotypes of offspring were determined by PCR and sequencing of DNA extracted from ear biopsies. Primer pair 5′-TAAAAATGTGTATCCGAGTGGAAAT (forward) and 5′-AAGGACTGAGTGTTGTTTCTTTTC (reverse) amplified a 230 bp segment within the coding sequence of exon 5 under the following conditions: 94 °C for 1 min, 60 °C for 1 min and 72 °C for 1 min, 40 cycles. Only lines that showed stable germline transmission of the transgenes were used for further analyses.
Proper citation: RRID:RGD_598154612 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=598092579
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Cryopreserved Sperm (as of 2025-03-27)
Alternate IDs: 598092579
Notes: Background strain: Long-Evans rat (Iar:Long-Evans). This strain was established by injection of modified BAC (cre gene was inserted into the exon 2 of rat Tac1 gene) into Long-Evans rat's fertiled eggs. National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_598092579 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=405849385
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 405849385
Notes: The hDNMT3A transgenic rats were established using zygote microinjection of a bacterial artificial chromosome (BAC). The RP11-159D24 BAC (NCBI-ID:223335, Homo sapiens, GRCh38.p2: Chr. 2: 25,202,642-25,410,145, total length: 207,504 bp) containing DNMT3A (GRCh38.p2: 25,232,961,25,342,590, total length: 109,630 bp) was injected into rat zygotes (Rattus norvegicus, Sprague-Dawley, SD). The offspring were identified with 8 PCR primer-pairs that were specific for the RP11-159D24 sequence to detect positive transgenic ones.
Proper citation: RRID:RGD_405849385 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=632522750
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 632522750
Notes: This is the wild type littermate of the transgenic rat strain carrying human NR3C2 (RGD:632522749).
Proper citation: RRID:RGD_632522750 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=626168247
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 626168247
Notes: A chimeric AVP-hM3Dq-mCherry BAC clone transgene construct was
purified for microinjections. hM3Dq is a modified form of the human M3 muscarinic receptor (hM3; CHRM3*). It can be activated by the inert clozapine metabolite clozapine-N-oxide (CNO), engaging the Gq signaling pathway.The hM3Dq-mCherry sequence from the hM3Dq-mCherry cassette (Plasmid
#44361, Addgene, Cambridge, MA, USA) was used for the transgene. Next, SV40 poly A sequence was framed to the hM3Dq-mCherry sequence. Finally, this
hM3Dq-mCherry-SV40 poly A cassette was introduced into the rat Avp gene in place of the genomic start
codon. Thus, hM3Dq-mCherry should be specifically expressed under the Avp promoter in the transgenic rat
brain.
Proper citation: RRID:RGD_626168247 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=1357175
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 1357175
Notes: Wild type allele of Gimap5 from BN was microinjected into the pronuclei of fertilized eggs from a T cell lymphopenic congenic strain F344.DR-(D4Mit6-D4Mit24)
Proper citation: RRID:RGD_1357175 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=1566459
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 1566459
Notes: F344 embryos were microinjected with R26-EGFP trangene which comprises of 0.8 kb genomic sequence of ROSA 26 promoter fused to enhanced green fluorescent protein (EGFP).
Proper citation: RRID:RGD_1566459 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=1358299
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 1358299
Notes: This transgenic strain carries a copy of mouse Rhodopsin gene with a proline to histidine substitution at codon 23 (c.68C>A). Retinal Degeneration Rat Model Resource
Proper citation: RRID:RGD_1358299 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=1302921
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 1302921
Notes: hDTR (HBEGF) cDNA was inserted at the 3' of the 2.5 kb human podocin (NPHS2) promoter. This transgenic construct was released by XbaI/HindIII digestion and injected into the pronuclei of fertilized eggs.
Proper citation: RRID:RGD_1302921 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=1600341
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 1600341
Notes: This is a transgenic hypertensive rat strain, the mouse Ren2, renin gene is microinjected into fertilized eggs of LEW/Crl rats
Proper citation: RRID:RGD_1600341 Copy
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