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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12904900
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Embryo (as of 2017-05-24)
Alternate IDs: 12904900
Notes: This ZFN model carries a 29 bp deletion within exon 2 of the Rag1 gene on chromosome 3. Homozygous animals display loss of Rag1 protein and loss of B and T cells by FACS analysis. Horizon Discovery
Proper citation: RRID:RGD_12904900 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12904730
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2017-05-19)
Alternate IDs: 12904730
Notes: This ZFN induced knockout model contains biallelic 8-bp deletion within Abcb11 gene. The homozygous knockout rats display total loss of protein via Western blot. Horizon Discovery
Proper citation: RRID:RGD_12904730 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12905029
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2017-05-31)
Alternate IDs: 12905029
Notes: This ZFN knock in model expresses cre-recombinase under the control of the endogenous tyrosine hydroxylase promoter enabling specific expression in dopaminergic neurons. This model possesses a targeted insertion of (IRES)-cre immediately after the translational stop in the open reading frame of Th. The TH-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines. Horizon Discovery
Proper citation: RRID:RGD_12905029 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13506176
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm; Cryorecovery (as of 2018-11-12)
Alternate IDs: 13506176
Notes: Breeding together of SS-Nox4em2Mcwi (RGDID: 4139883) and SS-Ncf2em1Mcwi (RGDID: 5144104), both models were generated by ZFN mutagenesis. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13506176 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13451538
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 13451538
Notes: This strain was produced by injecting ZFNs targeting the following sequence CAGGGCAGCCGC-CACtggcaGAAGCTGCGGGAGGA in exon 1 of the rat Dusp5 gene into FHH-Chr 1BN/Mcwi embryos. The resulting mutation is a 14 bp deletion and a 3 bp insertion between nucleotides 449 and 464 in Dusp5 mRNA that creates a frame shift mutation which is predicted to introduce a premature stop codon at amino acid 121.
Proper citation: RRID:RGD_13451538 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13207525
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2021-11-03)
Alternate IDs: 13207525
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Spp1 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 4-bp deletion in Exon 3 of the Spp1 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13207525 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13208844
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2021-11-03)
Alternate IDs: 13208844
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Ptgs2 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 7-bp deletion of exon 4 in the Ptgs2 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13208844 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13207516
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2021-11-03)
Alternate IDs: 13207516
Notes: This strain was produced by crossing of SD-Rag2em3Mcwi and SD-Il2rgem2Mcwi. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13207516 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12904912
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Embryo (as of 2017-05-24)
Alternate IDs: 12904912
Notes: This ZFN model possesses a 151 bp deletion spanning exon 1/intron 1 junction of Leptin gene. Homozygous knockout rats display loss of Leptin protein via Western blot. Homozygous knockout rats demonstrate significant weight gain compared to wild type littermates. Homozygous knockout rats show significantly elevated serum cholesterol levels Inotiv
Proper citation: RRID:RGD_12904912 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13506832
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2021-11-03)
Alternate IDs: 13506832
Notes: CRISPR/Cas9 system was used to introduce a mutation in the P2rx7 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is an 10-bp putative frame-shift deletion in exon 2 Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13506832 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13506831
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2018-02-21)
Alternate IDs: 13506831
Notes: CRISPR/Cas9 system was used to introduce a mutation in the P2rx7 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is an 11-bp putative frame-shift deletion in exon 2 Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13506831 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12904891
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2017-05-24)
Alternate IDs: 12904891
Notes: This ZFN model carries the knockout of the rat Slc22a2. Horizon Discovery
Proper citation: RRID:RGD_12904891 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12904892
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Embryo (as of 2017-05-24)
Alternate IDs: 12904892
Notes: This ZFN model carries the knockout of the rat Slc22a6. Horizon Discovery
Proper citation: RRID:RGD_12904892 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12904897
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Extinct (as of 2024-04-16)
Alternate IDs: 12904897
Notes: This ZFN model carries the monoallelic 11 base pair deletion in Tp53 gene. Animals exhibit broad tumor spectrum with high degree of tumor malignancy. Horizon Discovery
Proper citation: RRID:RGD_12904897 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13210578
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 13210578
Notes: This CRISPR/Cas9 model possesses a 3 bp(ATC) deletion resulting in the deletion of isoleucine at position 14. The Lep mutant rats exhibited similar mutant phenotypes to Lep and Lepr null rats.
Proper citation: RRID:RGD_13210578 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13800845
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2023-06-21)
Alternate IDs: 13800845
Notes: CRISPR/Cas9 system was used to introduce a 2-bp deletion in exon 1 of rat Mybphl gene in the FHH/EurMcwi embryos. embryos. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13800845 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13792803
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2023-06-21)
Alternate IDs: 13792803
Notes: This allele was made by CRISPR/Cas9 system. The resulting mutation is a 10-bp deletion in Exon 2 of the P2rx7 gene.
Proper citation: RRID:RGD_13792803 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13792801
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2018-09-28)
Alternate IDs: 13792801
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Nlrp3 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 14-bp deletion of exon 1 in the Nlrp3 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13792801 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12910101
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 12910101
Notes: This model possesses a 19-bp deletion in the seventh exon of the ldlr gene by ZFN method.
Proper citation: RRID:RGD_12910101 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12907570
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 12907570
Notes: This model contains one 19- bp deletion and one 428-bp deletion within Abcba1 gene. The homozygous knockout rats display total loss of protein via Western blot.
Proper citation: RRID:RGD_12907570 Copy
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