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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=14398825
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 14398825
Notes: This strain was produced by injecting Sprague Dawley embryo with CRISPR/Cas9 system targeting the exon 2 of rat Fah gene. The resulting mutation is line 15 with a frameshift deletion causing Fah null in homozygotes. None of the Fah-/- newborns survived longer than three days after birth in the absence of NTBC. Upon NTBC addition to the drinking water, the Fah-/- rats underwent normal growth and were indistinguishable from their WT littermates.
Proper citation: RRID:RGD_14398825 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13825196
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2018-11-21)
Alternate IDs: 13825196
Notes: CRISPR/Cas9 and two ssODNs (single-stranded oligodeoxynucleotide) were used to insert loxP sites flanking multiple exons
Proper citation: RRID:RGD_13825196 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=39128172
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Cryopreserved Sperm (as of 2020-09-23)
Alternate IDs: 39128172
Notes: This strain was established by Bac transgenic method (construct: Kazuhiro Yamakawa, phD) in 2014 and maintained at Jikei University School of Medicine. Background: Crlj:WI. Transgene: VGAT（Slc32a1: mouse, Kanamycin resistance gene（E. coli）, Cre（P1 phage), polyA signal（SV40 virus). Mouse BAC clone: RP23-392-P11 National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_39128172 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=150520211
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown (as of 2021-11-09)
Alternate IDs: 150520211
Notes: Using CRISPR/Cas9, a 568bp region of the Pvt1 gene was deleted from the ACI genome including all of exon 3. This strain is maintained at Rat Resource and Research Center.
Proper citation: RRID:RGD_150520211 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=150520212
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2021-11-05)
Alternate IDs: 150520212
Notes: using CRISPR/Cas9, exon 8 of the pvt1 gene was deleted from the ACI genome. Resulting in a total excision of 588bp.
Proper citation: RRID:RGD_150520212 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=150520213
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2021-11-05)
Alternate IDs: 150520213
Notes: using CRISPR/Cas9, exon 8 of the pvt1 gene was deleted from the ACI genome. Resulting in a total excision of 588bp. This strain is maintained at Rat Resource and Research Center.
Proper citation: RRID:RGD_150520213 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=150520214
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2021-11-05)
Alternate IDs: 150520214
Notes: CRISPR/Cas9 was used to delete miR1208 in a 763bp excision in ACI rat embryos.
Proper citation: RRID:RGD_150520214 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=38456008
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Availability: Unknown
Alternate IDs: 38456008
Notes: Bazin and Beckers from rats of presumed Wistar origin kept at the Universite Catholique de Louvain. LOU/C was selected among 28 parallel sublines for its high incidence of immunocytomas, and LOU/M for its low incidence. The two are histocomaptible (Bazin 1977, Bazin and Beckers 1978).
Proper citation: RRID:RGD_38456008 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=126925756
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 126925756
Notes: This spontaneous mutation was identified in the offspring of pregnant Sprague-Dawley rats purchased from Taconic Farms. This mutant exhibited abnormal eye phenotype including nuclear cataracts and was called Nuc1 rat. Sequencing of the mutant allele revealed a 27 base pair insertion in exon 6 of Cryba1.
Proper citation: RRID:RGD_126925756 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=150520205
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 150520205
Notes: This strain is derived from SHR/OlaIpcv where a spontaneous mutation was observed in the NH2-terminal cytosolic domain of Cx50, L7Q. The connexin50 mutation in heterozygous state affects significantly the lipid profile and the oxidative stress parameters in SHR rats.
Proper citation: RRID:RGD_150520205 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=127285380
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 127285380
Notes: CRISPR/Cas9 system was used to introduce the gene knockout of Mir31 in the Sprague Dawley embryos.
Proper citation: RRID:RGD_127285380 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=150520206
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 150520206
Notes: Generated by microinjecting SHR/OlaIpcv zygotes with wild type Folr1 cDNA from BN-Lx/Cub under control of EF-1α (human EEF1A1) universal promoter
Proper citation: RRID:RGD_150520206 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=150520207
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2021-11-05)
Alternate IDs: 150520207
Notes: The CRISPR/Cas9 system was used to introduce 2 AttP landing sites in the ROSA26 locus of F344/NHsd rat embryos. ROSA26 is a synonym for rat Thumpd3-as1 (RGD:6491660) and is used as an official symbol for rat strain nomenclature. Rat Resource and Research Center (RRRC)
Proper citation: RRID:RGD_150520207 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=150520208
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2021-11-05)
Alternate IDs: 150520208
Notes: Using CRISPR/Cas9, exon 1b of the Pvt1 gene was excised from the ACI/SegHsd genome in a 1165bp deletion.
Proper citation: RRID:RGD_150520208 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=150520209
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 150520209
Notes: The ACI-Pvt1em1Shul was created using CRISPR/Cas9 by Shull laboratory at UW madison. The exon 1b of the Pvt1 gene was excised from the ACI/SegHsd genome in a 1165bp deletion. This strain is now maintained at Rat Resource and Research Center.
Proper citation: RRID:RGD_150520209 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=25330089
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 25330089
Notes: The rat strain was produced by injecting CRISPR/Cas9 targeting rat Nrxn1 into Crl:LE embryos. The result is a 4-bp deletion in exon 1. Autism Rat Model Resource. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_25330089 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=150520049
Source Database: Rat Genome Database (RGD)
Genetic Background: congenic
Availability: Unknown
Alternate IDs: 150520049
Notes: The hairless rat was orginially found in JCL:Wistar rats at Ishikawa Laboratory Animal company, Saitama, Japan. Thereafter, hairless rats were backcrossed with WBN rats for 8 generations and the congenic strain of hairless rats has been established with a background of WBN at the company.
Proper citation: RRID:RGD_150520049 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=149735530
Source Database: Rat Genome Database (RGD)
Genetic Background: recombinant_inbred
Availability: Unknown
Alternate IDs: 149735530
Notes: These are re-derived rats of BXH2/Cub now maintained at Medical College of Wisconsin. The parent strain was derived from founder strains BN-Lx/Cub and SHR/OlaIpcv RGD HRDP, contact HRDP
Proper citation: RRID:RGD_149735530 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=14394496
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2021-11-03)
Alternate IDs: 14394496
Notes: CRISPR/Cas9 system was used to introduce a 2-bp deletion mutation in exon 1 of the Kcnj2 gene of SS/JrHsdMcwi rat embryos. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_14394496 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=14995941
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 14995941
Notes: The wpk mutation was first recognized in 1994 in a colony of outbred Wistar rats at Utrecht University (Utrecht, The Netherlands). In 1996, a breeding pair of test-proven heterozygotes were transferred to the University of Rotterdam (Rotterdam, The Netherlands), and a new subcolony was initiated. This colony has been maintained by brother-sister matings for more than five generations. Individuals heterozygous for the mutant allele were identified in each generation by test-crossing phenotypically normal offspring from known heterozygotes. A single C to T substitution in exon 12 was identified as the mutated allele in the Wpk rat. This mutation converts a proline to a leucine in the protein products(P394L). This mutation was not present in the parental Wistar strain.
Proper citation: RRID:RGD_14995941 Copy
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