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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=404976873
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2024-03-18)
Alternate IDs: 404976873
Notes: Four single guide RNAs and SpCas9 targeting sequences CTTCATTGTATGAGCAGCCG, TTTGAAAGAGACAGCTGCCT, ACGCACGTCGGACAGTTCCA, and GGCTTATTGCGCACGCACGT flanking a chromosome 1 region were targeted in SS/JrHsdMcwi embryos. An 82-bp deletion in chromosome 1 (rn7: chr1:255,749,164-255,749,245) resulted. Please contact: [email protected]
Proper citation: RRID:RGD_404976873 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=156420152
Source Database: Rat Genome Database (RGD)
Genetic Background: outbred
Availability: Unknown
Alternate IDs: 156420152
Notes: This outbred Wistar was maintained at National Laboratory Animal Center (NLAC), Thailand. All animals were housed at the Chulalongkorn University Laboratory Animal Center (CULAC) . National Laboratory Animal Center, Mahidol University Thailand
Proper citation: RRID:RGD_156420152 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=404976871
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Availability: Live Animals (as of 2024-03-18)
Alternate IDs: 404976871
Notes: A closed colony of DA/MolTac (RRID:RGD_1566438) has been maintained at the Medical College of Wisconsin for more than 30 generations. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_404976871 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=5688037
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Genomic Alteration: (null)
Availability: Unknown
Source References: (null)
Alternate IDs: 5688037
Notes: ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders.
Proper citation: RRID:RGD_5688037 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=5688034
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Genomic Alteration: (null)
Availability: Live Animals (as of 2017-07-18)
Source References: (null)
Alternate IDs: 5688034
Notes: ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders.
Proper citation: RRID:RGD_5688034 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=405855876
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 405855876
Notes: This Foxo4 mutant strain was created in zygotes from Holtzman Sprague-Dawley. Guided RNAs targeting exon 2 (target sequence: CCAGATATACGAATGGATGGTCC; nucleotides 517-539) and exon 3 (target sequence: GTTCATCAAGGTACATAACGAGG; nucleotides 631-653) of the Foxo4 gene (NM_001106943.1)) were injected to the embryos to create a 3096-bp deletion including the 3' part of exon 2 and 5' part of exon 3, and resulting a premature stop of the protein.
Proper citation: RRID:RGD_405855876 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12790615
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals; Cryorecovery (as of 2017-02-17)
Alternate IDs: 12790615
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Chrna4 gene of LEW/Crl rat embryos. The resulting mutation is a 4-bp deletion in the Chrna4 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_12790615 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=401901202
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Availability: Unknown
Alternate IDs: 401901202
Notes: The obese SHHFcp/cp are homozygous for the corpulent allele. The Breeding stock for this colony was transferred to Dr. Sylvia McCune at the University of Chicago Medical School in 1983 from the laboratory of J.E. Miller at G.D. Searle and Company. The animals were developed by backcrossing the SHROB rat to the SHR/N rat. Dr. McCune obtained the colony after the seventh backcross and continued to inbreed past 20 generations to fix the congestive heart failure trait.
Proper citation: RRID:RGD_401901202 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=6484582
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2021-11-03)
Alternate IDs: 6484582
Notes: This strain was produced by injecting ZFNs targeting the sequence CTCGCCTGCATCCTTCAAGtgcagtTCCCAGGAGCAGGTAAGG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 11-bp frameshift deletion in exon 1.
Proper citation: RRID:RGD_6484582 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=405100226
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 405100226
Notes: Colony founders were produced by SAGE (Sigma Advanced Genetic Engineering) Labs using ZFN-mediated disruption of Fmr1 with a targeted construct containing coding sequence for eGFP; resulting founders did not express FMRP or eGFP. Simons Initiative for the Developing Brain (SIDB), Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh EH8 9XD, UK. Contact SIDB Scientific Officer for enquiries on rat distribution ([email protected]).
Proper citation: RRID:RGD_405100226 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=401901201
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Availability: Unknown
Alternate IDs: 401901201
Notes: The lean SHHFcp/+ is heterozygous for the corpulent allele and is the control model for the obese SHHFcp/cp. The Breeding stock for this colony was transferred to Dr. Sylvia McCune at the University of Chicago Medical School in 1983 from the laboratory of J.E. Miller at G.D. Searle and Company. The animals were developed by backcrossing the SHROB rat to the SHR/N rat. Dr. McCune obtained the colony after the seventh backcross and continued to inbreed past 20 generations to fix the congestive heart failure trait.
Proper citation: RRID:RGD_401901201 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=405878047
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Availability: Unknown
Alternate IDs: 405878047
Notes: D. F. Kohn, Inst. of Comparative Medicine,Columbia University established this strain from institutional albino rats of unknown origin at University of Texas. This HTX is the parent to HTX substrains maintained in other institutions.
Proper citation: RRID:RGD_405878047 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=405878046
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Availability: Unknown
Alternate IDs: 405878046
Notes: This strain derived by Heston 1946 from Buffalo stock of H. Morris, to. It is the parental strains to several BUF substrains maintained in other institutions.
Proper citation: RRID:RGD_405878046 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=405878045
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Availability: Unknown
Alternate IDs: 405878045
Notes: Curtiss and Dunning 1926 at the Columbia University Institute for Cancer Research, after accidental mating between an August male with an Irish coat and a COP (Copenhagen2331)female. This is the parent to ACI substrains sent to Heston 1945 at F30, to National Institutes of Health 1950 at F41. Subsequent sublines from Dunning or NIH.
Proper citation: RRID:RGD_405878045 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=155791439
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 155791439
Notes: Immunodeficient subcongenic line developed by intercross SS-Chr 3BN.SS-(D3Rat222-D3Rat218).Il2rgem1Mcwi/Mcwi (RGD:155791433) heterozygous congenic, Il2rg null mutant (X-SCID) lines. Contact MCW rat distribution at [email protected] for availability.
Proper citation: RRID:RGD_155791439 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=329849011
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2023-06-09)
Alternate IDs: 329849011
Notes: SD rats (Slc:SD) in which the c-Fos gene (ENSRNOG00000008015) was disrupted by the CRISPR/Cas9 system. Two guide RNAs and Cas9 protein were injected into the pronucleus of fertilized eggs of SD rats. After injection, they were transferred into the oviducts of the recipient rats and born. The founder rat (line 12) showed abnormal teeth, and PCR and sequencing analysis revealed that 1,067 bases including Exon 1 were deleted. The founder rat were mated with SD rats and bred. National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_329849011 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=401938647
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2023-12-18)
Alternate IDs: 401938647
Notes: Crispr-Cas was used to introduce a 2bp insertion of TT to create a stop codon in exon 7 of SLC9a6 gene, causing termination of translation. The strain was rederived at RRRC. deposited at RRRC
Proper citation: RRID:RGD_401938647 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=155791435
Source Database: Rat Genome Database (RGD)
Genetic Background: congenic
Availability: Unknown
Alternate IDs: 155791435
Notes: Immunodeficient subcongenic line developed by intercross SS-Chr 3BN.SS-(D3Rat222-D3Rat218).Il2rgem1Mcwi/Mcwi (RGD:155791433) heterozygous congenic, Il2rg null mutant (X-SCID) lines. Contact MCW rat distribution at [email protected] for availability.
Proper citation: RRID:RGD_155791435 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=155791437
Source Database: Rat Genome Database (RGD)
Genetic Background: congenic
Availability: Unknown
Alternate IDs: 155791437
Notes: Immunodeficient subcongenic line developed by intercross SS-Chr 3BN.SS-(D3Rat222-D3Rat218).Il2rgem1Mcwi/Mcwi (RGD:155791433) heterozygous congenic, Il2rg null mutant (X-SCID) lines. Contact MCW rat distribution at [email protected] for availability.
Proper citation: RRID:RGD_155791437 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=329849009
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2023-06-09)
Alternate IDs: 329849009
Notes: F344-TyrC KitH/Kyo (Black F344, NBRP Rat No. 0768, aka RGD:11040971), carrying 1) point mutation in the exon 2 (896G>A, p.R229H) of Tyrosinase (Tyr) gene (albino phenotype) and 2) retrotransposon insertion (7-bp) in kit gene (hooded phenotype) induced was crossed with F344/NSlc (Japan SLC, Inc.). Then, from the F2 generation, Tyr as a wild-type homozygous (confirmed by sequence) and Kit as a hooded homozygous (confirmed by phenotype) were selected. National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_329849009 Copy
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