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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=288084582
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 288084582
Notes: This CRISPR/Cas9 induced mutation Phe54Leu is induced in embryos of F344/NSlc. The genome editing system targeting exon 3 of Txn1 gene ( (c. 160 T > C) was delivered into embryos by electroporation. The two-cell stage embryos were transferred into the oviducts of pseudopregnant females. The rat called Txn1-F54L rat, replicates Adem rats (RGD:288084580) which carried Phe54Leu mutation in the same gene.These two strains exhibit similar phenotype.
Proper citation: RRID:RGD_288084582 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=151665772
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Embryo; Cryopreserved Sperm (as of 2022-04-01)
Alternate IDs: 151665772
Notes: The targeting vector was designed to replace the stop codon of Tfap2c with T2A-tdTomato. The adeno-associated virus carrying the targeting vector was infected to Crlj:WI (RGD ID: 2312504) rat 1 cell zygotes followed by the introduction of CRISPR/Cas9 ribonucleoprotein complex by electroporation. After incubation overnight, the zygotes were transferred into oviducts of pseudo-pregnant rats. The pups were judged correct gene-targeting by genomic PCR. These rat strains are being maintained by crossing the founder rats with Crlj:WI rats. The tdTomato fluorescence faithfully label Tfap2c expressing cells. Section of Mammalian Transgenesis Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki Aichi 444-8787, Japan. or Division of Mammalian Embryology, Center for Stem Cell Biology and Regenerative Medicine, The Institute for Medical Science, The University of Tokyo, Tokyo108-8639, Japan.
Proper citation: RRID:RGD_151665772 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13800848
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 13800848
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Nlrp3 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 10-bp deletion of exon 1 in the Nlrp3 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13800848 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=25394532
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 25394532
Notes: The rat strain was produced by injecting CRISPR/Cas9 targeting rat Scn2a into Crl:LE embryos. The result is a 6-bp deletion in exon 5 of the gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_25394532 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=155631261
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 155631261
Notes: CRISPR/Cas9 system was used to generate this mutant; sgRNA+Cas9 targeting exon 4 of rat Brca1was injected to fertilized eggs of Jcl:SD rats (Clea Japan). The founder animal carried c.188T>A (p.L63X) was mated to closed-colony Jcl:SD rats.
Proper citation: RRID:RGD_155631261 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=155791438
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 155791438
Notes: Immunodeficient subcongenic line developed by intercross SS-Chr 3BN.SS-(D3Rat222-D3Rat218).Il2rgem1Mcwi/Mcwi (RGD:155791433) heterozygous congenic, Il2rg null mutant (X-SCID) lines. Contact MCW rat distribution at [email protected] for availability.
Proper citation: RRID:RGD_155791438 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=329849010
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2023-06-09)
Alternate IDs: 329849010
Notes: A congenic strain in which a chromosome 17 fragment of LEA rats (provided by Dr. Tadashi Okamura) was introduced into the F344-TyrC KitH (NBRP Rat No. 0768). National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_329849010 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=401938653
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2025-03-31)
Alternate IDs: 401938653
Notes: The Ctns gen was deleted by oocyte injection of the CRISPER/Cas9 system (PolyGene AG, Zurich,Switzer-land). Two single guideRNAs(sgRNAs) targeting exon3 of Ctns were selected :CRISPR1a: ACCAACGTCAGCATTAC-CCT(TGG), CRISPR1b: CCATTTACCAGCTTCACAGT(GGG). This Ctns rat line harboring a deletion of 12bp and insertion of 8bp resultingin a premature stop codon in the exon3 of Ctns. Contact Olivier Devuyst at Email: [email protected], National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_401938653 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=329955459
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 329955459
Notes: A global P2RX7KO on a WKYbackground was created at Imperial College London using zinc finger nuclease
(ZFN) technology to generate a 2 base pair insertion in exon 10 of P2rx7
Proper citation: RRID:RGD_329955459 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=4139876
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Genomic Alteration: (null)
Availability: Extinct (as of 2017-01-26)
Source References: (null)
Alternate IDs: 4139876
Notes: This strain was produced by injecting ZFNs targeting the sequence aaccacaaccaactacgatgatgaccggaagtggggc into SS/JrHsdMcwi rat embryos. The resulting mutation is a 10-bp frameshift deletion in exon 7.
Proper citation: RRID:RGD_4139876 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=405850241
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 405850241
Notes: Sprague Dawley rats by microinjection of TALENs in fertilized eggs (Cyagen Biosciences). Briefly, the rno-mir-500 gene (Gene ID: 100314112; MirBase accession no. MIMAT0005321), which was located on rat chromosome X, was selected as the TALEN target site. TALENs were constructed using the Golden Gate Assembly and confirmed by sequencing. The founder, which carried 8- bp deletion (GCACCTGG) in the both strands compared with the wild-type (WT) DNA sequence, were genotyped by PCR followed by DNA-sequencing analysis. After that, heterozygous F1 were produced by mating F0 with WT rats. Heterozygous F1 rats were determined and mated to produce homozygote mutant (mir-500−/−) and WT (mir-500+/+).
Proper citation: RRID:RGD_405850241 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=401827145
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryorecovery (as of 2025-01-27)
Alternate IDs: 401827145
Notes: The CRISPR-Cas9 system was used to delete the coding region (exons 1-8) of the Pink1 gene in NTac:SD embryos. The rat is deposited at Rat Resource and Research Center (RRRC).
Rat Resource and Research Center
Proper citation: RRID:RGD_401827145 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=329845599
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 329845599
Notes: Genome editing was performed using the rGONAD method to produce three different lines of KO rats due to three different genome mutations thus different in protein expression predication. The genetic background is WKY/NCrlCrlj (Charles River Laboratories Japan) (RGD:61119). Tandem STOP codons were designed to integrate into 27 bases after the first ATG in the rat Col4a5 gene This em2 mutant carries a premature stop coden after 15 amino acids due to insertion of a 42bp stop codon. Col4α5 em2 rats have urinary protein and hematuria from early on, and males begin to die at 18 weeks of age and all die by 28 weeks of age. National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_329845599 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=401940198
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 401940198
Notes: The Ahr wild type littermates from the cross of heterozygous Ahr rats. The Ahr mutants were created using CRISPR/Cas9 gene editing to delete a portion of exon 2 of Ahr in Sprague Dawley rats .
Proper citation: RRID:RGD_401940198 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=329845597
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Embryo (as of 2023-05-30)
Alternate IDs: 329845597
Notes: Genome editing was performed using the rGONAD method to produce three different lines of KO rats due to three different genome mutations thus different in protein expression predication. The genetic background is WKY/NCrlCrlj (Charles River Laboratories Japan) (RGD:61119). Tandem STOP codons were designed to integrate into 27 bases after the first ATG in the rat Col4a5 gene This em1 mutant carries a premature stop coden after 9 amino acids due to the insertion of a 20 bp stop codon. Col4a5 KO rats have urinary protein and hematuria from early on, and males begin to die at 18 weeks of age and all die by 28 weeks of age. National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_329845597 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=155630631
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 155630631
Notes: The mutant rat was produced by injecting Crl:CD(SD) zygotes with gRNA +Cas9 ribonucleoprotein complex targeting exon 3 of rat Ctns. The founder of this strain possessed a 2-bp insertion which results in frameshift and pre-mature stop truncated protein.
Proper citation: RRID:RGD_155630631 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=405649860
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 405649860
Notes: Two target sequences (GCCGTGTTCAACTACCCCGAGGG and
GCTGCGCAAGTGTTACGAAGTGG) within the second and third exon, respectively, of the
coding sequence of Esr1 (the rat gene encoding ERα) were selected. gRNAs targeting these
sequences were synthesized via in vitro transcription. gRNAs (25 ng/ul each) were co-
microinjected with Cas9 protein (40 ng/ul) into Sprague-Dawley rat embryos, and embryos were
transferred into pseudo-pregnant recipients. Animals heterozygous for a 25 base pair deletion in Esr1 exon 3 were used to establish an ER alpha mutant colony and subsequent homozygous mutant offspring were obtained for study. Department of Medicine, Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Proper citation: RRID:RGD_405649860 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=329845586
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2023-12-28)
Alternate IDs: 329845586
Notes: Izumo1 KO strain was established by CRISPR/Cas9 system using inbred WIAR (RGD:2304222) (SLC, Inc.). sgRNA:GGTGGCTGCAATAAAGACTT, PAM sequence：TGG. A 7-bp deletion（CTTTGGA）after start codon (Met) in exon2 of Izumo1 gene was detected. After establishment of WIAR background KO rats, this strain was mated with Slc:Wistar (RGD:2314928), hence this mutant is in mix background.Izumo1-deficient male rats are infertile. In female rats, no specific phenotype is observed. National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_329845586 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=329955557
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2023-07-17)
Alternate IDs: 329955557
Notes: CRISPR/Cas9 knock-in of the human ACE2 transgene into the endogenous locus of the rat Ace2 gene. Single integration of hACE2, with expression driven by the endogenous rat Ace2 promoter. Provides a more natural expression pattern (versus abundant overexpression as seen in prior models). Deposited this strain with the Rat Resource and Research Center: (RRRC), 4011 Discovery Drive, Columbia, MO 65201. Phone: (573) 884-6076 Fax: 573-882-9857
Proper citation: RRID:RGD_329955557 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=405849411
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 405849411
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Krtcap3 gene of WKY/Ncrlrat embryos. This is the wild type littermate (from heterozygous breeders) carrying wild type Krtcap3. This wild type mutant usually is used as an experimental control. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_405849411 Copy
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