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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12790947
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2017-02-22)
Alternate IDs: 12790947
Notes: This strain was produced by injecting ZFNs targeting the sequence of Sorcs2 into SS/JrHsdMcwi rat embryos. The resulting mutation is a 33-bp frameshift deletion in exon 15.
Proper citation: RRID:RGD_12790947 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12790702
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2021-11-03)
Alternate IDs: 12790702
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Pon3 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 16-bp deletion of exon 4 in the Pon1 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_12790702 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12879432
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Embryo (as of 2017-04-19)
Alternate IDs: 12879432
Notes: This strain was established by CRISPR/Cas9 system at Kyoto University and introduced to the Institute of Environmental Toxicology. Background strain: Jcl:Wistar. This line 1 (em1) has 2-bp insertion (c.23_24insGG) in the exon 1 of Ift140 (intraflagellar transport 140) gene. National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_12879432 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12879434
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Embryo (as of 2017-04-19)
Alternate IDs: 12879434
Notes: This strain was established by CRISPR/Cas9 system at Kyoto University and introduced to the Institute of Environmental Toxicology. Background strain: Jcl:Wistar. This line 2 (em2) has 2-bp deletion (c.23_24del) in the exon 1 of Ift140 (intraflagellar transport 140) gene. National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_12879434 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12904905
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Embryo (as of 2017-05-24)
Alternate IDs: 12904905
Notes: This ZFN model carries a 2 bp deletion within exon 3 of the Rag2 gene.on chromosome 3 Rag2 knockout rats completely lack B and T cells. Horizon Discovery
Proper citation: RRID:RGD_12904905 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12904907
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2017-05-24)
Alternate IDs: 12904907
Notes: This ZFN induced knockout rats carrying a shorter truncated gene, 872 by PCR vs 1627 in wild type, have severe combined immunodeficiency (SCID) and lack of both B and T cells Horizon Discovery
Proper citation: RRID:RGD_12904907 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=11553916
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2017-01-25)
Alternate IDs: 11553916
Notes: ZFN system was used to introduce a T>G transversion mutation in the Shc1 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a substitution to generate S36A in Exon 2 of theShc1 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_11553916 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12904908
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2017-05-24)
Alternate IDs: 12904908
Notes: In this ZFN induced model, a total of 337 bp were deleted at the junction of intron 3 and exon 4 (on chromosome 8), and 4 bp ccgt were inserted rat Ldlr gene on chromosome 8. Homozygous knockout rats display loss of LDLR protein via Western blot. Homozygous knockout rats have increased body weight as compared to wild type. Homozygous knockout rats show significantly elevated serum cholesterol levels. Horizon Discovery
Proper citation: RRID:RGD_12904908 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13207501
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2021-11-03)
Alternate IDs: 13207501
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Nlrp10 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 11-bp deletion of exon 2 in the Nlrp10 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13207501 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12743611
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals; Cryopreserved Sperm (as of 2018-09-05)
Alternate IDs: 12743611
Notes: ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous
Proper citation: RRID:RGD_12743611 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12903250
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2017-05-10)
Alternate IDs: 12903250
Notes: This ZFN model contains a 760-bp deletion in the rat Ahr gene. Horizon Discovery
Proper citation: RRID:RGD_12903250 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12905033
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2017-05-31)
Alternate IDs: 12905033
Notes: This model expresses cre-recombinase under the control of the endogenous solute carrier family 32 member 1 (Vgat) promoter enabling specific expression in Vgat positive GABAergic neurons. This model possesses a targeted insertion of (IRES)-cre immediately after the translational stop in the open reading frame of the Vgat gene. The Vgat-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines. Horizon Discovery
Proper citation: RRID:RGD_12905033 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12905034
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown (as of 2017-05-31)
Alternate IDs: 12905034
Notes: This model expresses cre-recombinase under the control of the endogenous vasoactive intestinal peptide (VIP) promoter enabling specific expression in VIP positive GABAergic interneurons. This model possesses a targeted insertion of (T2A)-cre immediately before the translational stop in the open reading frame of the VIP gene. The VIP-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines. Horizon Discovery
Proper citation: RRID:RGD_12905034 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12905031
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2017-05-31)
Alternate IDs: 12905031
Notes: This model expresses cre-recombinase under the control of the endogenous dopamine transporter promoter enabling specific expression in dopaminergic neurons. This model possesses a targeted insertion of (IRES)-cre immediately after the translational stop in the open reading frame of DAT. The DAT-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines. Horizon Discovery
Proper citation: RRID:RGD_12905031 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12905032
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2017-05-31)
Alternate IDs: 12905032
Notes: This model expresses cre-recombinase under the control of the endogenous camkIIa promoter enabling specific expression in excititory neurons. This model possesses a targeted insertion of (IRES)-cre immediately after the translational stop in the open reading frame of CamkIIa. The CamkIIa-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines. Horizon Discovery
Proper citation: RRID:RGD_12905032 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13207507
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2021-11-03)
Alternate IDs: 13207507
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Nlrp12 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 2-bp deletion of exon 3 in the Nlrp12 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13207507 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12905037
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2017-05-31)
Alternate IDs: 12905037
Notes: This CRISPR knock in model possesses the fluorophore tdTomato, sitting behind a floxed stop codon in the ROSA26 locus under control of the CAG promoter. By introducing Cre-recombinase through viral transduction or crossing with one of our Cre-driver rats, tdTomato fluorescence will be observed anywhere Cre- is expressed. The tdTomato Reporter rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with Cre-driver lines. ROSA26 is a synonym for rat Thumpd3-as1 (RGD:6491660) and is used as an official symbol for rat strain nomenclature. Horizon Discovery
Proper citation: RRID:RGD_12905037 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12905038
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2017-05-31)
Alternate IDs: 12905038
Notes: This CRISPR knock in model possesses the Halorhodopsin fused to TdTomato, sitting behind a floxed stop codon in the ROSA26 locus under the control of the CAG promoter. By introducing Cre-recombinase by crossing with one of our Cre-driver rats, neuronal subtype-specific expression of halorhodopsin and TdTomato will be observed anywhere Cre- is expressed. The Halorhodopsin rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with Cre-driver lines. ROSA26 is a synonym for rat Thumpd3-as1 (RGD:6491660) and is used as an official symbol for rat strain nomenclature. Horizon Discovery
Proper citation: RRID:RGD_12905038 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12905035
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2017-05-31)
Alternate IDs: 12905035
Notes: This model expresses cre-recombinase under the control of the endogenous Tryptophan Hydroxylase 2 (Tph2) promoter enabling specific expression in Tph2 positive serotonergic neurons. This model possesses a targeted insertion of (T2A)-cre immediately before the translational stop in the open reading frame of the Tph2 gene. The Tph2-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines. Horizon Discovery
Proper citation: RRID:RGD_12905035 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13207503
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2021-11-03)
Alternate IDs: 13207503
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Nlrp10 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 10-bp deletion of exon 2 in the Nlrp10 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13207503 Copy
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