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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
https://www.mmrrc.org/catalog/sds.php?mmrrc_id=68113
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
Genetic Background: Transgenic
Affected Genes: |Trbv15|Trav7-3
Source References: PMID: 30737355
Alternate IDs: MMRRC_68113-MU, MMRRC_068113, MMRRC_68113
Notes: Research areas: Immunology and Inflammation; Mutation Type: Transgenic ; Collection:
Proper citation: RRID:MMRRC_068113-MU Copy
https://www.mmrrc.org/catalog/sds.php?mmrrc_id=68122
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
Genetic Background: Transgenic
Affected Genes: |cre|Tshb
Alternate IDs: MMRRC_68122-JAX, MMRRC_068122, MMRRC_68122
Notes: Research areas: Endocrine Deficiency, Research Tools; Mutation Type: Transgenic ; Collection:
Proper citation: RRID:MMRRC_068122-JAX Copy
https://www.mmrrc.org/catalog/sds.php?mmrrc_id=68121
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
Genetic Background: Transgenic
Alternate IDs: MMRRC_68121-MU, MMRRC_068121, MMRRC_68121
Notes: Research areas: Cell Biology, Metabolism, Models for Human Disease, Neurobiology; Mutation Type: Transgenic ; Collection:
Proper citation: RRID:MMRRC_068121-MU Copy
https://www.mmrrc.org/catalog/sds.php?mmrrc_id=68099
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
Genetic Background: Transgenic
Affected Genes: |Igkv3-5|MYC
Source References: PMID: 18242516, PMID: 32954360
Alternate IDs: MMRRC_68099-MU, MMRRC_068099, MMRRC_6899
Notes: Research areas: Cancer, Models for Human Disease; Mutation Type: Transgenic ; Collection:
Proper citation: RRID:MMRRC_068099-MU Copy
https://www.mmrrc.org/catalog/sds.php?mmrrc_id=68100
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
Genetic Background: Transgenic
Affected Genes: GFP|cre/ERT2||FEZF2
Alternate IDs: MMRRC_68100-UCD, MMRRC_068100, MMRRC_681
Notes: Research areas: Developmental Biology, Models for Human Disease, Neurobiology; Mutation Type: Transgenic ; Collection:
Proper citation: RRID:MMRRC_068100-UCD Copy
https://www.mmrrc.org/catalog/sds.php?mmrrc_id=68216
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
Genetic Background: Transgenic
Affected Genes: mCerulean
Alternate IDs: MMRRC_68216-UNC, MMRRC_068216, MMRRC_68216
Notes: Research areas: Apoptosis, Cancer, Cell Biology, Models for Human Disease, Neurobiology, Research Tools; Mutation Type: Transgenic ; Collection:
Proper citation: RRID:MMRRC_068216-UNC Copy
https://www.mmrrc.org/catalog/sds.php?mmrrc_id=69545
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
Genetic Background: Transgenic
Affected Genes: RHO
Source References: PMID: 9751768, PMID: 23646198
Alternate IDs: MMRRC_69545-UNC, MMRRC_069545, MMRRC_69545
Notes: Research areas: Neurobiology; Mutation Type: Transgenic ; Collection:
Proper citation: RRID:MMRRC_069545-UNC Copy
https://www.mmrrc.org/catalog/sds.php?mmrrc_id=69544
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
Genetic Background: Transgenic
Affected Genes: RHO
Source References: PMID: 17460245, PMID: 22289036
Alternate IDs: MMRRC_69544-UNC, MMRRC_069544, MMRRC_69544
Notes: Research areas: Sensorineural; Mutation Type: Transgenic ; Collection:
Proper citation: RRID:MMRRC_069544-UNC Copy
https://www.mmrrc.org/catalog/sds.php?mmrrc_id=69595
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
Genetic Background: Transgenic
Affected Genes: cre|Lrat|
Source References: PMID: 24264436
Alternate IDs: MMRRC_69595-JAX, MMRRC_069595, MMRRC_69595
Notes: Research areas: Research Tools; Mutation Type: Transgenic ; Collection:
Proper citation: RRID:MMRRC_069595-JAX Copy
https://www.mmrrc.org/catalog/sds.php?mmrrc_id=69613
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
Genetic Background: Transgenic
Affected Genes: Irgm1
Source References: PMID: 31825834
Alternate IDs: MMRRC_69613-JAX, MMRRC_069613, MMRRC_69613
Notes: Research areas: Immunology and Inflammation; Mutation Type: Transgenic ; Collection:
Proper citation: RRID:MMRRC_069613-JAX Copy
https://www.mmrrc.org/catalog/sds.php?mmrrc_id=69749
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
Genetic Background: Transgenic
Affected Genes: SFTPA2||SFTPC|Sftpa1|
Source References: PMID: 20048345
Alternate IDs: MMRRC_69749-JAX, MMRRC_069749, MMRRC_69749
Notes: Research areas: Cell Biology, Immunology and Inflammation, Models for Human Disease; Mutation Type: Transgenic ; Collection:
Proper citation: RRID:MMRRC_069749-JAX Copy
https://www.mmrrc.org/catalog/sds.php?mmrrc_id=69738
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
Genetic Background: Transgenic
Affected Genes: |Tek|Gja5|EGFP
Source References: PMID: 23471232, PMID: 25547341
Alternate IDs: MMRRC_69738-UCD, MMRRC_069738, MMRRC_69738
Notes: Research areas: Cardiovascular, Diabetes; Mutation Type: Transgenic ; Collection:
Proper citation: RRID:MMRRC_069738-UCD Copy
https://www.mmrrc.org/catalog/sds.php?mmrrc_id=69745
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
Genetic Background: Transgenic
Affected Genes: GFP|Cd5||
Alternate IDs: MMRRC_69745-MU, MMRRC_069745, MMRRC_69745
Notes: Research areas: Diabetes, Immunology and Inflammation; Mutation Type: Transgenic ; Collection:
Proper citation: RRID:MMRRC_069745-MU Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=155663368
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 155663368
Notes: This transgenic model line 737 was made by injecting bacterial artificial chromosome (BAC) RNECO-180E22, into Crl:CD(SD) strain embryos. The BAC clone RNECO-180E22, a kind gift of Helen Skaletsky, is derived from Rattus norvegicus strain SHR chromosome Y.
Proper citation: RRID:RGD_155663368 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=155260364
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Cryopreserved Sperm (as of 2022-10-06)
Alternate IDs: 155260364
Notes: rat strain in which the rat Cyp3a1 gene (Cyp3a23-3a1, RGD:628626) was inactivated by insertion of a human CYP3A4 minigene (Cyp3A4*) and the linked rat Cyp3a2 locus was simultaneously mutated by CRISPR-mediated indel introduction. Strain contains Indel 8 at the Rat 3A2 locus (55 kb away), The CYP3A4 minigene included a CRISPR/Cas9 gene drive element to enable super-Mendelian inheritance. Strain contains and Active Genetic cassette which encodes a gRNA targeting the Rat 3A1 and 3A2 translation initiation site. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin URL: Doi:10.1101/2022.08.30.505951 URL: Doi:10.1101/2022.08.30.505951
URL: URL: Doi:10.1101/2022.08.30.505951 RRRC
Proper citation: RRID:RGD_155260364 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=155260365
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Cryopreserved Sperm (as of 2022-10-06)
Alternate IDs: 155260365
Notes: This project entailed generation of a novel rat strain in which a P2A-Cas9-T2A-EGFP coding sequence was inserted at the stop codon of the rat Sycp1 gene for co-expression of Cas9 and EGFP under the control of the Sycp1 regulatory elements. Animals express Cas9 in the testis in the spermatogonial layer and in meiosis stages with 4N DNA content. Strain catalyzes high levels of Active Genetic Gene conversion when paired with certain Active Genetic cassettes. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin
URL: Doi:10.1101/2022.08.30.505951 Donated to Rat Resource & Research Center
Proper citation: RRID:RGD_155260365 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=329955364
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 329955364
Notes: Transgene insertion (human CD68-GFP) using Sleeping Beauty transposon system on Wistar Kyoto rats. Rat monocyte/macrophage reporter strain on a WKY background which has susceptibility to experimental glomerulonephritis. GFP expression occurs exclusively within blood monocytes and tissue macrophages.
Proper citation: RRID:RGD_329955364 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=404976872
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Cryopreserved Sperm (as of 2024-03-18)
Alternate IDs: 404976872
Notes: CD-Tg(RNECO-180E22)733Arno, RGD:155663367 was backcrossed at the Medical College of Wisconsin to DA/MolTacMcwi for 6-7 generations before cryopreservation of sperm. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_404976872 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=598092606
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Cryopreserved Sperm (as of 2025-03-28)
Alternate IDs: 598092606
Notes: This strain was established by a use of the BAC transgenic method with a technical support from the C.B.S.N resource (Dr. Kazuto Kobayashi, Fukushima Medical University, Dr. Yuchio Yanagawa, Gunma University Graduate School of Medicine). This transgenic rat was transported to The Jikei University School of Medicine, and cre recombinase expression was confirmed by crossing it with a reporter rat (NBRP Rat No: 0734). These rats are maintained in The Jikei University School of Medicine. Background strain: Crlj:WI.
Transgene: Dbh (dopamine beta-hydroxylase: rat), TetR (E.coli), VP16 protein minimal“F”-type activation domain (Herpes simplex virus), 2A (Thosea asigna virus), cre recombinase (P1 Phage), bGlobin polyA (rabbit), loxP (P1 phage). Detailed method (BAC transgenic method): a rat BAC clone was used (CH230-211J22). Combined mRNA for tTA and cre recombinase sequences is transcribed under the control of Dbh promoter. In translation step, the transcript is cut at the 2A peptide sequence, resulting in a separate protein production of tTA and Cre. National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_598092606 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=598154611
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 598154611
Notes: The full length humanTOR1A wild type gene including upstream and downstream flanking regions were inserted into a pUC19 vector. Following linearization and purification the transgenes were used to generate transgenic rats by microinjection of the DNA construct into the pronucleus of rat zygotes. Transgenic rats were kept on Sprague–Dawley background and bred as hemizygotes using standard procedures. Genotypes of offspring were determined by PCR and sequencing of DNA extracted from ear biopsies. Primer pair 5′-TAAAAATGTGTATCCGAGTGGAAAT (forward) and 5′-AAGGACTGAGTGTTGTTTCTTTTC (reverse) amplified a 230 bp segment within the coding sequence of exon 5 under the following conditions: 94 °C for 1 min, 60 °C for 1 min and 72 °C for 1 min, 40 cycles. Only lines that showed stable germline transmission of the transgenes were used for further analyses.
Proper citation: RRID:RGD_598154611 Copy
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