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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=13592604
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Sperm; Cryorecovery (as of 2018-05-14)
Alternate IDs: RGD_13592604, 13592604, RRRC_785, RRRC_0785, RRRC_00785
Notes: These rats were created using BAC constructs consisting of the entire 144kb human LRRK2 locus containing the G2019S mutation and fused to a YPet reporter tag. Rat Resource and Research Center
Proper citation: RRID:RRRC_00785 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=11667094
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Sperm (as of 2017-01-26)
Alternate IDs: RGD_11667094, 11667094, RRRC_705, RRRC_0705, RRRC_00705
Notes: micro-injected with a ~6 kb transgenic cassette, which contained a CMV enhancer, chicken beta-actin promoter, the full-length cDNA encoding human complement factor H, and a rabbit beta-globin poly(A) sequence that had been isolated and purified from plasmid pCAGGS-human fH. Rat Resource and Research Center
Proper citation: RRID:RRRC_00705 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=13462044
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: RGD_13462044, 13462044, RRRC_829, RRRC_0829, RRRC_00829
Notes: Pronuclear injection was used to introduce an expression cassette containing the Thy-1 enhancer and GCaMP6f protein coding sequence. GCaMP6f is a genetically encoded calcium indicator. It is a synthetic fusion of green fluorescent protein, calmodulin, and M13, a peptide sequence from myosin light-chain kinase. Rat Resource & Research Center
Proper citation: RRID:RRRC_00829 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=126781839
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery (as of 2024-01-05)
Alternate IDs: RGD_126781839, 126781839, RRRC_870, RRRC_0870, RRRC_00870
Notes: The 'docking site ready (DSR)' rat strain, or TARGAT /TM rat strain was generated using CRISPR/Cas9. With integrase, these TARGAT/DSR rats are used as embryo donors. TARGATT rat embryos will be microinjected with a mixture of TARGATT Cre DNA constructs containing mouse Olfr16 (MOR23) promoter, a fluorescent reporter mCherry in the Cre cassette linked by a T2A sequence. The Olfactory sensory neuronal lineage tissue-specific expression of a CreERT2 is also tamoxifen-dependent. Rat Resource and Research Center
Proper citation: RRID:RRRC_00870 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=9588593
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryorecovery (as of 2025-01-27)
Alternate IDs: RGD_9588593, 9588593, RRRC_751, RRRC_0751, RRRC_00751
Notes: The transgene expresses BAC transgenic using rat GAD1 promoter to express Cre recombinase in GABAergic neurons Optogenetics and Transgenic Technology Core, Rat Resource and Research Center
Proper citation: RRID:RRRC_00751 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=126781841
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Embryo; Cryorecovery (as of 2024-01-10)
Alternate IDs: RGD_126781841, 126781841, RRRC_872, RRRC_0872, RRRC_00872
Notes: The CRISPR/Cas9 system was injected to the Crl:CD(SD)embryo to induce the knock-in Cre-ERT2 cassette at the 3' end of Mnx1 (HB9) gene linked by 2A peptide. This model is used to lineage tracing of motor neurons by tissue specific expression of creERT2 Rat Resource and Research Center
Proper citation: RRID:RRRC_00872 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=126781842
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Embryo; Cryorecovery (as of 2024-01-05)
Alternate IDs: RGD_126781842, 126781842, RRRC_873, RRRC_0873, RRRC_00873
Notes: The CRISPR/Cas9 system was injected to the Crl:CD(SD)embryo to induce the knock-in Cre-ERT2 cassette at the 3' end of Drd1 (Drd1a) gene linked by 2A peptide. This model is used to lineage tracing of dopamine D1 receptor expressing neurons Rat Resource and Research Center
Proper citation: RRID:RRRC_00873 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=11084925
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Sperm (as of 2017-01-26)
Alternate IDs: RGD_11084925, 11084925, RRRC_754, RRRC_0754, RRRC_00754
Notes: Transgene: human CD59 gene (cDNA) under control of alpha-globin regulatory elements (alpha-globin promoter and alpha hemoglobin locus control region). Upon administration of intermedilysin (ILY), cells expressing human CD59 will be selectively ablated Rat Resource and Research Center
Proper citation: RRID:RRRC_00754 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=56677892
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Live Animals (as of 2024-01-05)
Alternate IDs: RGD_56677892, 56677892, RRRC_876, RRRC_0876, RRRC_00876
Notes: The 'docking site ready (DSR)' rat strain, or TARGAT /TM rat strain was generated using CRISPR/Cas9. With integrase, these TARGAT/DSR rats are used as embryo donors. TARGATT rat embryos will be microinjected with a mixture of TARGATT Cre DNA constructs containing human GFAP promoter, a fluorescent reporter mCherry in the Cre cassette linked by a T2A sequence. The astrocyte tissue-specific expression of a CreERT2 is also tamoxifen-dependent. Rat Resource and Research Center
Proper citation: RRID:RRRC_00876 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=9588578
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Live Animals (as of 2017-05-31)
Alternate IDs: RGD_9588578, 9588578, RRRC_758, RRRC_0758, RRRC_00758
Notes: The transgene contains BAC transgenic using rat dopamine transporterSlc6a3 (DAT) promoter to express Cre recombinase in dopaminergic neurons Optogenetics and Transgenic Technology Core, Rat Resource and Research Center
Proper citation: RRID:RRRC_00758 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=10401208
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Live Animals; Cryopreserved Sperm (as of 2019-02-20)
Alternate IDs: RGD_10401208, 10401208, RRRC_699, RRRC_0699, RRRC_00699
Notes: The strain was coinjected with two transgenes: one contains the human amyloid beta (A4) precursor protein (hAPP) gene with the Swedish mutation (K595N/M596L) driven by mouse prion promoter (Prp). The other contains the human presenilin 1 gene (PS1) with a deletion of exon 9, also driven by the mouse prion promoter (Prp). Based on segregation patterns, it is believed that the two transgenes have integrated at the same chromosomal site. Rat Resource and Research Center
Proper citation: RRID:RRRC_00699 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14700890
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Live Animals (as of 2021-02-12)
Alternate IDs: RGD_14700890, 14700890, RRRC_862, RRRC_0862, RRRC_00862
Notes: This strain was generated by microinjection of Sprague-Dawley embyos with a BAC DNA containing the Cx3cr1-cre/ERT2 transgene which is composed of cre/ERT2 recombinase gene driven by the rat genomic Cx3cr1promoter. Rat Resource & Research Center
Proper citation: RRID:RRRC_00862 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=11081153
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Live Animals (as of 2019-02-26)
Alternate IDs: RGD_11081153, 11081153, RRRC_748, RRRC_0748, RRRC_00748
Notes: The transgene contains Cre recombinase reporter rat expressing the red fluorescent protein gene (iRFP) driven by the EF1 alpha promoter. Optogenetics and Transgenic Technology Core, Rat Resource and Research Center
Proper citation: RRID:RRRC_00748 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=126781838
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery (as of 2024-01-10)
Alternate IDs: RGD_126781838, 126781838, RRRC_869, RRRC_0869, RRRC_00869
Notes: The 'docking site ready (DSR)' rat strain, or TARGAT /TM rat strain was generated using CRISPR/Cas9. With integrase, these TARGAT/DSR rats are used as embryo donors. TARGATT rat embryos will be microinjected with a mixture of TARGATT Cre DNA constructs containing human PDGFB promoter, a fluorescent reporter mCherry in the Cre cassette linked by a T2A sequence. The brain tissue-specific expression of a CreERT2 is also tamoxifen-dependent. Rat Resource and Research Center
Proper citation: RRID:RRRC_00869 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=2292527
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Embryo; Cryopreserved Sperm
Alternate IDs: RGD_2292527, 2292527, RRRC_308, RRRC_0308, RRRC_00308
Notes: Dahl Sensitive rats were microinjected with AngII/AVP receptor gene and SV40 PolyA signal. Rat Resource and Research Center
Proper citation: RRID:RRRC_00308 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=4143165
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Embryo; Cryopreserved Sperm
Alternate IDs: RGD_4143165, 4143165, RRRC_427, RRRC_0427, RRRC_00427
Notes: This rat model was developed by perivitelline injection of one cell SD embryos with packaged lentiviral particles containing the pFUGW vector containing the Aqp5 promoter and the EGFP gene. Resulting transgenic founders with mated to wild-type SD rats and heterozygous offspring were obtained. Rat Resource and Research Center
Proper citation: RRID:RRRC_00427 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=401959229
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: RGD_401959229, 401959229, RRRC_1010, RRRC_01010
Notes: Pronuclear injection was used to introduce an expression cassette containing the Thy-1 enhancer and GCaMP6f protein coding sequence. GCaMP6f is a genetically encoded calcium indicator. It is a synthetic fusion of green fluorescent protein, calmodulin, and M13, a peptide sequence from myosin light-chain kinase. Reference ID: https://doi.org/10.1101/2023.08.17.553594 Rat Resource & Research Center
Proper citation: RRID:RRRC_01010 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=155260361
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Sperm (as of 2022-10-06)
Alternate IDs: RGD_155260361, 155260361, RRRC_968, RRRC_0968, RRRC_00968
Notes: This project entailed generation of a novel rat strain in which a P2A-Cas9-T2A-EGFP coding sequence was inserted at the stop codon of the rat Sycp1 gene for co-expression of Cas9 and EGFP under the control of the Sycp1 regulatory elements. Animals express Cas9 in the testis in the spermatogonial layer and in meiosis stages with 4N DNA content. Strain catalyzes high levels of Active Genetic Gene conversion when paired with certain Active Genetic cassettes. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin
URL: Doi:10.1101/2022.08.30.505951 Rat Resource and Research Center
Proper citation: RRID:RRRC_00968 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=1554309
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Embryo; Cryopreserved Sperm
Alternate IDs: RGD_1554309, 1554309, RRRC_259, RRRC_0259, RRRC_00259
Notes: These transgenic rats are produced by the intracytoplasmic sperm injection (ICSI) using a Piezo-driven micromanipulator. National BioResource Project for the Rat in Japan, Rat Resource and Research Center
Proper citation: RRID:RRRC_00259 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=6482252
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Embryo; Cryopreserved Sperm
Alternate IDs: RGD_6482252, 6482252, RRRC_53, RRRC_053, RRRC_0053, RRRC_00053
Notes: Multiple random integration of EGFP gene under the control of the PGK promoter. Rat Resource and Research Center
Proper citation: RRID:RRRC_00053 Copy
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