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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
http://www.wormbase.org/db/get?name=WBStrain00054912
Source Database: WormBase (WB)
Affected Genes: WBGene00009304(eva-1)
Genomic Alteration: WBGene00009304(eva-1)
Availability: unknown
Source References: EMPTY
Synonyms: eva-1(qy114[eva-1::mNG + LoxP]) I.
Notes: mNG tag inserted into the endogenous eva-1 locus (internal tag). Reference: Jayadev R, et al. Sci Adv. 2022 May 20;8(20):eabn2265. doi: 10.1126/sciadv.abn2265. PMID: 35584218.
Proper citation: RRID:WB-STRAIN:WBStrain00054912 Copy
http://www.wormbase.org/db/get?name=WBStrain00054911
Source Database: WormBase (WB)
Affected Genes: WBGene00004729(sax-3)
Genomic Alteration: WBGene00004729(sax-3)
Availability: unknown
Source References: EMPTY
Synonyms: sax-3(qy113[sax-3::mNG + LoxP]) X.
Notes: mNG tag inserted into the endogenous sax-3 locus (internal tag). Reference: Jayadev R, et al. Sci Adv. 2022 May 20;8(20):eabn2265. doi: 10.1126/sciadv.abn2265. PMID: 35584218.
Proper citation: RRID:WB-STRAIN:WBStrain00054911 Copy
http://www.wormbase.org/db/get?name=WBStrain00054914
Source Database: WormBase (WB)
Availability: unknown
Source References: EMPTY
Synonyms: C48E7.6(qy116[C48E7.6::mNG + LoxP]) I.
Notes: mNG tag inserted into the endogenous C48E7.6 locus. Reference: Jayadev R, et al. Sci Adv. 2022 May 20;8(20):eabn2265. doi: 10.1126/sciadv.abn2265. PMID: 35584218.
Proper citation: RRID:WB-STRAIN:WBStrain00054914 Copy
http://www.wormbase.org/db/get?name=WBStrain00054913
Source Database: WormBase (WB)
Affected Genes: WBGene00003555(nas-39)
Genomic Alteration: WBGene00003555(nas-39)
Availability: unknown
Source References: EMPTY
Synonyms: nas-39(qy115[nas-39::mNG + LoxP]) X.
Notes: mNG tag inserted into the endogenous nas-39 locus. Reference: Jayadev R, et al. Sci Adv. 2022 May 20;8(20):eabn2265. doi: 10.1126/sciadv.abn2265. PMID: 35584218.
Proper citation: RRID:WB-STRAIN:WBStrain00054913 Copy
http://www.wormbase.org/db/get?name=WBStrain00054877
Source Database: WormBase (WB)
Affected Genes: WBGene00001803(lite-1)|WBGene00001864(him-5)
Genomic Alteration: WBGene00001803(lite-1), WBGene00001864(him-5)
Availability: unknown
Source References: EMPTY
Synonyms: him-5(e1490) V; lite-1(ce314) X; fsIs22; ljIs114.
Notes: fsIs22 [osm-5p::fem-3::mCherry + unc-122p::GFP]. ljIs114 [gpa-13pFLPase + sra-6pFRT::mCherry::StopCodon::FRTChR2YFP]. Him. Pan-ciliated masculinization with ChR2 specifically in ASH. Reference: Pechuk V., et al. 2022, Current Biology 32, 114. https:|"Made_by: Vladyslava Pechuk"
Proper citation: RRID:WB-STRAIN:WBStrain00054877 Copy
http://www.wormbase.org/db/get?name=WBStrain00054876
Source Database: WormBase (WB)
Affected Genes: WBGene00002004(hsf-1)
Genomic Alteration: WBGene00002004(hsf-1)
Availability: unknown
Source References: EMPTY
Synonyms: hsf-1(sy441) I; risIs33.
Notes: Made_by: Fabian Fischer|"risIs33 [K03A1.5p::3xFLAG::SV40-NLS::dCas9::SV40-NLS::VP64::HA + unc-119(+)]. risIs33 transgene stably expresses a 171 kDa dCas9::VP64 fusion protein suitable for for CRISPR activation (CRISPRa) in C. elegans, as described in Fischer F, et al. J Biol Chem. 2022 May 27;102085. doi: 10.1016/j.jbc.2022.102085. PMID: 35636511. Derived by crossing parental strains MIR249 and PS3551."
Proper citation: RRID:WB-STRAIN:WBStrain00054876 Copy
http://www.wormbase.org/db/get?name=WBStrain00054919
Source Database: WormBase (WB)
Affected Genes: WBGene00000535(cpi-1)
Genomic Alteration: WBGene00000535(cpi-1)
Availability: unknown
Source References: EMPTY
Synonyms: cpi-1(qy127[cpi-1::mNG + LoxP]) IV.
Notes: mNG tag inserted into the endogenous nas-39 locus. Reference: Jayadev R, et al. Sci Adv. 2022 May 20;8(20):eabn2265. doi: 10.1126/sciadv.abn2265. PMID: 35584218.
Proper citation: RRID:WB-STRAIN:WBStrain00054919 Copy
http://www.wormbase.org/db/get?name=WBStrain00054918
Source Database: WormBase (WB)
Availability: unknown
Source References: EMPTY
Synonyms: qySi569 I.
Notes: qySi569 [cdh-3p::fdgt-2::mNG + loxP] I. Superficially wild type animal expressing a single copy insertion of glucose transporter fdgt-2 in the anchor cell. fdgt-2 formerly known as fgt-2. Reference: Garde A, et. al. Dev. Cell. 2022 Mar 28;57(6):732-749.e7. PMID: 35316617|"qySi569 [cdh-3p::fgt-2::mNG + loxP] I. Superficially wild type animal expressing a single copy insertion of glucose transporter fgt-2 in the anchor cell. Reference: Garde A, et. al. Dev. Cell. 2022 Mar 28;57(6):732-749.e7. PMID: 35316617"
Proper citation: RRID:WB-STRAIN:WBStrain00054918 Copy
http://www.wormbase.org/db/get?name=WBStrain00054917
Source Database: WormBase (WB)
Affected Genes: WBGene00000674(col-99)
Genomic Alteration: WBGene00000674(col-99)
Availability: unknown
Source References: EMPTY
Synonyms: col-99(qy119[col-99::mNG + LoxP]) IV.
Notes: mNG tag inserted into the endogenous col-99 locus. Reference: Jayadev R, et al. Sci Adv. 2022 May 20;8(20):eabn2265. doi: 10.1126/sciadv.abn2265. PMID: 35584218.
Proper citation: RRID:WB-STRAIN:WBStrain00054917 Copy
http://www.wormbase.org/db/get?name=WBStrain00054862
Source Database: WormBase (WB)
Affected Genes: WBGene00004795(sid-1)
Genomic Alteration: WBGene00004795(sid-1)
Availability: unknown
Source References: PMID:38177330, PMID:39395417
Synonyms: sid-1(qt9) V; sqIs71.
Notes: Made_by: Yongzhi Yang|"sqIs71 [rgef-1p::GFP + rgef-1p::sid-1]. Pan-neuronal expression of sid-1 driven by the rgef-1 promoter. Expression remains neuron-specific until at least Day 10. Animals respond to feeding RNAi against gfp and neuronal genes snb-1 and unc-13. In contrast, animals are resistant to phenotypes induced by feeding RNAi constructs targeting non-neuronal genes pept-1, unc-112, bli-1 and die-1. Reference: Yang Y, et al. Nat Aging 2024 Jan 4. doi: 10.1038/s43587-023-00548-1. PMID: 38177330. MAH677 effectively replaces strain TU3401 sid-1(pk3321) uIs69 [pCFJ90 (myo-2p::mCherry) + unc-119p::sid-1] V., which was found to show RNAi response in non-neuronal tissues."|"sqIs71 [rgef-1p::GFP + rgef-1p::sid-1]. Pan-neuronal expression of sid-1 driven by the rgef-1 promoter. Expression remains neuron-specific until at least Day 10. Animals respond to feeding RNAi against gfp and neuronal genes snb-1 and unc-13. In contrast, animals are resistant to phenotypes induced by feeding RNAi constructs targeting non-neuronal genes pept-1, unc-112, bli-1 and die-1. This strain effectively replaces strain TU3401 sid-1(pk3321) uIs69 V, which was found to show RNAi response in non-neuronal tissues. Reference: Yang et al., bioRxiv 2022.12.12.520171; doi: https:"
Proper citation: RRID:WB-STRAIN:WBStrain00054862 Copy
http://www.wormbase.org/db/get?name=WBStrain00054867
Source Database: WormBase (WB)
Affected Genes: WBGene00001170(egl-1)|WBGene00003598(nhl-2)|WBGene00006331(sup-26)
Genomic Alteration: WBGene00001170(egl-1), WBGene00003598(nhl-2), WBGene00006331(sup-26)
Availability: unknown
Source References: EMPTY
Synonyms: sup-26(cdb99) nhl-2(cdb100) III; egl-1(cdb97) V.
Notes: nhl-2(cdb100) contains engineered mutations in the mir-35 binding site in the nhl-2 3UTR region making the sequence complementary to the mir-35(cdb4) variant. egl-1(cdb97) contains engineered mutations in mir-35 binding site in the egl-1 3UTR region making the sequence complementary to the mir-35(cdb4) variant. Slightly reduced brood size at 25C. Reference: Donnelly BF, et al. (2022). Cell Reports.
Proper citation: RRID:WB-STRAIN:WBStrain00054867 Copy
http://www.wormbase.org/db/get?name=WBStrain00054900
Source Database: WormBase (WB)
Affected Genes: WBGene00001403(fbl-1)|WBGene00003020(lin-35)
Genomic Alteration: WBGene00001403(fbl-1), WBGene00003020(lin-35)
Availability: unknown
Source References: EMPTY
Synonyms: lin-35(n745) I; fbl-1(qy62[mNG+loxP::fbl-1]) IV.
Notes: CRISPR/Cas9 insertion of mNeonGreen into the endogenous fbl-1 locus in an RNAi-sensitized background. Reference: Gianakas CA, et al. J Cell Biol. 2023 Jan 2;222(1):e202112096. doi: 10.1083/jcb.202112096. PMID: 36282214.
Proper citation: RRID:WB-STRAIN:WBStrain00054900 Copy
http://www.wormbase.org/db/get?name=WBStrain00054903
Source Database: WormBase (WB)
Availability: unknown
Source References: EMPTY
Synonyms: F26E4.7(qy103[F26E4.7::mNG + LoxP]) I.
Notes: mNG tag inserted into the endogenous F26E4.7 locus. Reference: Jayadev R, et al. Sci Adv. 2022 May 20;8(20):eabn2265. doi: 10.1126/sciadv.abn2265. PMID: 35584218.
Proper citation: RRID:WB-STRAIN:WBStrain00054903 Copy
http://www.wormbase.org/db/get?name=WBStrain00054864
Source Database: WormBase (WB)
Affected Genes: WBGene00003263(mir-35)
Genomic Alteration: WBGene00003263(mir-35)
Availability: unknown
Source References: EMPTY
Synonyms: mir-35(cdb2 cdb6) II.
Notes: The seed region of the mature mir-35 is replaced with random nucleotides in mir-35(cdb2 cdb6). This mutant mir-35 has little impact on embryonic mir-35 abundance but strongly inhibits its decay at embryo to L1. Superficially wild-type. Reference: Donnelly BF, et al. (2022). Cell Reports.
Proper citation: RRID:WB-STRAIN:WBStrain00054864 Copy
http://www.wormbase.org/db/get?name=WBStrain00054865
Source Database: WormBase (WB)
Affected Genes: WBGene00003263(mir-35)
Genomic Alteration: WBGene00003263(mir-35)
Availability: unknown
Source References: EMPTY
Synonyms: mir-35(cdb2 cdb72) II.
Notes: cdb2 cdb72 is a mutation to the 3' end of the mature mir-35 creating a 3 end containing nucleotides that are not present or rare among all mir-35 family members at a given position, while preserving overall GC content. This mir-35 mutant strongly impacts embryonic abundance of mir-35 but does not affect its decay at embryo to L1. Superficially wild-type. Reference: Donnelly BF, et al. (2022). Cell Reports.|"Made_by: Bridget Donnelly"
Proper citation: RRID:WB-STRAIN:WBStrain00054865 Copy
http://www.wormbase.org/db/get?name=WBStrain00054904
Source Database: WormBase (WB)
Availability: unknown
Source References: EMPTY
Synonyms: C16E9.1(qy104[C16E9.1::mNG + LoxP]) X.
Notes: mNG tag inserted into the endogenous C16E9.1 locus. Reference: Jayadev R, et al. Sci Adv. 2022 May 20;8(20):eabn2265. doi: 10.1126/sciadv.abn2265. PMID: 35584218.
Proper citation: RRID:WB-STRAIN:WBStrain00054904 Copy
http://www.wormbase.org/db/get?name=WBStrain00054907
Source Database: WormBase (WB)
Affected Genes: WBGene00006745(unc-5)
Genomic Alteration: WBGene00006745(unc-5)
Availability: unknown
Source References: PMID:38345070
Synonyms: unc-5(qy70[unc-5::2xmNG + LoxP]) IV.
Notes: 2x mNG tag inserted into the endogenous unc-5 locus. Reference: Jayadev R, et al. Sci Adv. 2022 May 20;8(20):eabn2265. doi: 10.1126/sciadv.abn2265. PMID: 35584218.|"Made_by: Eric Hastie"
Proper citation: RRID:WB-STRAIN:WBStrain00054907 Copy
http://www.wormbase.org/db/get?name=WBStrain00054851
Source Database: WormBase (WB)
Availability: unknown
Source References: EMPTY
Synonyms: lqIs221 V.
Notes: lqIs221 [egl-17p::mab-5::GFP + gcy-32p::CFP]. AQR migration defects. AQR in the tail in the normal position of PQR. CFP expression in AQR, PQR and URXL/R. Reference: Tamayo JV, et al. BMC Genomics. 2013 May 4;14:304. doi: 10.1186/1471-2164-14-304. PMID: 23642123.
Proper citation: RRID:WB-STRAIN:WBStrain00054851 Copy
http://www.wormbase.org/db/get?name=WBStrain00054850
Source Database: WormBase (WB)
Availability: unknown
Source References: EMPTY
Synonyms: ayIs9 II; lqIs220 X.
Notes: ayIs9 [egl-17p::GFP + dpy-20(+)]. Reference: Tamayo JV, et al. BMC Genomics. 2013 May 4;14:304. doi: 10.1186/1471-2164-14-304. PMID: 23642123.lqIs221 is a Pegl-17::mab-5::gfp transgene. ayIs9 is a Pegl-17::gfp transgene. AQR migration defects. AQR in the tail in the normal position of PQR.|"Made_by: Dr. Erik Lundquist"
Proper citation: RRID:WB-STRAIN:WBStrain00054850 Copy
http://www.wormbase.org/db/get?name=WBStrain00054857
Source Database: WormBase (WB)
Affected Genes: WBGene00000913(daf-18)
Genomic Alteration: WBGene00000913(daf-18)
Availability: unknown
Source References: EMPTY
Synonyms: daf-18(syb1615) IV.
Notes: D137A. Daf-d. L1 starvation sensitive. M-cell arrest defective. daf-18(D137A) corresponds to human allele PTEN(D92A). Reference: Chen J, et al. G3 (Bethesda). 2022 12(6):jkac092. doi: 10.1093/g3journal/jkac092. PMID: 35451480.|"Made_by: Suny Biotech; Jingxian Chen"
Proper citation: RRID:WB-STRAIN:WBStrain00054857 Copy
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