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| Resource Name | Proper Citation | Abbreviations | Resource Type |
Description |
Keywords | Resource Relationships | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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Duke O'Brien Center for Kidney Research Animal Models Core Resource Report Resource Website |
Duke O'Brien Center for Kidney Research Animal Models Core (RRID:SCR_015267) | service resource, core facility, access service resource, resource | Core facility that provides access to a range of experimental models of kidney, heart and vascular diseases. It also provides comprehensive phenotyping services for kidney functions, blood pressure and other cardiovascular functions. | animal model, experimental kidney model, experimental heart model, experimental vascular model |
is listed by: NIDDK Information Network (dkNET) has parent organization: Duke O'Brien Center for Kidney Research has parent organization: Duke University School of Medicine; North Carolina; USA has parent organization: Duke University; North Carolina; USA is organization facet of: Duke O'Brien Center for Kidney Research |
kidney disease, heart disease, hypertension, muscle disease | NIDDK P30DK096493 | Available to the research community | SCR_015267 | 2026-08-11 09:43:00 | 0 | ||||||||
|
Duke O'Brien Center for Kidney Research Resource Report Resource Website |
Duke O'Brien Center for Kidney Research (RRID:SCR_015268) | portal, topical portal, service resource, data or information resource, access service resource, resource, disease-related portal | Research center which investigates the mechanisms underlying the impact kidney disease has on cardiovascular morbidity and mortality using genetic and basic science approaches. | kidney disease, cardiovascular disease, kidney research |
is listed by: NIDDK Information Network (dkNET) has parent organization: Duke University School of Medicine; North Carolina; USA has parent organization: Duke University; North Carolina; USA is parent organization of: Duke O'Brien Center for Kidney Research Clinical and Translational Core is parent organization of: Duke O'Brien Center for Kidney Research Renal Genomics Core is parent organization of: Duke O'Brien Center for Kidney Research Animal Models Core has organization facet: Duke O'Brien Center for Kidney Research Animal Models Core has organization facet: Duke O'Brien Center for Kidney Research Renal Genomics Core has organization facet: Duke O'Brien Center for Kidney Research Clinical and Translational Core is organization facet of: O'Brien Kidney Centers |
kidney disease, heart disease, hypertension, muscle disease | NIDDK P30DK096493 | Available to the research community | SCR_015268 | 2026-08-11 09:42:59 | 0 | ||||||||
|
Duke O'Brien Center for Kidney Research Renal Genomics Core Resource Report Resource Website |
Duke O'Brien Center for Kidney Research Renal Genomics Core (RRID:SCR_015269) | service resource, core facility, access service resource, resource | Core facility that provides resources for investigators researching the genetic mechanisms of chronic kidney disease, cardiovascular disease, and hypertension. Its services include pre-study consultation, standardized services for DNA isolation and storage, and assisstance in carrying out molecular genetic studies. | chronic kidney disease research service, cardiovascular disease research service, hypertensions research service, experimental consultation |
is listed by: NIDDK Information Network (dkNET) has parent organization: Duke O'Brien Center for Kidney Research has parent organization: Duke University School of Medicine; North Carolina; USA has parent organization: Duke University; North Carolina; USA is organization facet of: Duke O'Brien Center for Kidney Research |
kidney disease, heart disease, hypertension, muscle disease | NIDDK P30DK096493 | Available to the research community | SCR_015269 | 2026-08-11 09:43:07 | 0 | ||||||||
|
Duke O'Brien Center for Kidney Research Clinical and Translational Core Resource Report Resource Website |
Duke O'Brien Center for Kidney Research Clinical and Translational Core (RRID:SCR_015272) | service resource, core facility, access service resource, resource | Core facility which investigates the connections between chronic kidney disease, cardiovascular disease, and hypertension. It focuses specifically on investigating the pathophysiology, epidemiology, and therapeutic response in on-going studies or existing datasets of one of the three diseases with the aim of relating data from individual diseases to each other. | translational kidney research, translational cardiovascular research, translational hypertension research |
is listed by: NIDDK Information Network (dkNET) has parent organization: Duke O'Brien Center for Kidney Research has parent organization: Duke University School of Medicine; North Carolina; USA has parent organization: Duke University; North Carolina; USA is organization facet of: Duke O'Brien Center for Kidney Research |
kidney disease, heart disease, hypertension, muscle disease | NIDDK P30DK096493 | Available to the research community | SCR_015272 | 2026-08-11 09:43:07 | 0 | ||||||||
|
AASK Clinical Trial and Cohort Study Resource Report Resource Website |
AASK Clinical Trial and Cohort Study (RRID:SCR_006985) | AASK Cohort Study | portal, topical portal, clinical trial, research forum portal, data or information resource, resource, disease-related portal | Clinical trial investigating whether a specific class of antihypertensive drugs (beta-adrenergic blockers, calcium channel blockers, or angiotensin converting enzyme inhibitors) and/or the level of blood pressure would influence progression of hypertensive kidney disease in African Americans. The initiative consisting of 21 clinical centers and a data-coordinating center is followed by a Continuation of AASK Cohort Study to investigate the environmental, socio-economic, genetic, physiologic, and other co-morbid factors that influence progression of kidney disease in a well-characterized cohort of African Americans with hypertensive kidney disease. Only patients who were previously in the randomized trial are eligible for the cohort study. A significant discovery was made in the treatment strategy for slowing kidney disease caused by hypertension. Angiotensin-converting enzyme (ACE) inhibitors, compared with calcium channel blockers, were found to slow kidney disease progression by 36 percent, and they drastically reduced the risk of kidney failure by 48 percent in patients who had at least one gram of protein in the urine, a sign of kidney failure. ACE inhibitors have been the preferred treatment for hypertension caused by diabetes since 1994; however, calcium channel blockers have been particularly effective in controlling blood pressure in African Americans. The AASK study now recommends ACE inhibitors to protect the kidneys from the damaging effects of hypertension. The Continuation of AASK Cohort Study will be followed at the clinical centers. The patients will be provided with the usual clinical care given to all such patients at the respective centers. Baseline demographic information, selected laboratory tests, and other studies are being obtained at the initiation of the Continuation Study. The patients will be seen quarterly at the centers, and some selected studies done at these visits. Samples will be obtained and stored for additional studies and analyses at a later date. | african american, blood pressure, beta-adrenergic blocker, calcium channel blocker, angiotensin converting enzyme inhibitor, environment, socio-economic, genetic, physiology, co-morbid factor, gene, adult human, antihypertensive drug, clinical, treatment, longitudinal, demographics, laboratory test, biospecimen, biomaterial supply resource |
is listed by: One Mind Biospecimen Bank Listing is related to: NIDDK Information Network (dkNET) is related to: Chronic Renal Insufficiency Cohort Study |
End-stage renal disease, Kidney failure, Kidney disease, Hypertension, Hypertensive kidney disease | NIDDK | nlx_152750 | SCR_006985 | African American Study of Kidney Disease and Hypertension (AASK) Clinical Trial and Cohort Study, African American Study of Kidney Disease and Hypertension Clinical Trial and Cohort Study, Continuation of AASK Cohort Study, African American Study of Kidney Disease and Hypertension | 2026-08-11 09:41:29 | 0 |
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The NIDDK Information Network (dkNET) serves the needs of basic and clinical investigators by providing seamless access to large pools of data and research resources relevant to the mission of The National Institute of Diabetes Digestive and Kidney Diseases (NIDDK). dkNET is hosted at University of California San Diego, and is supported by NIH NIDDK grant U24DK097771.
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