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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
http://www.bioconductor.org/packages/devel/bioc/html/RUVSeq.html
Software package that implements the remove unwanted variation (RUV) methods for the normalization of RNA-Seq read counts between samples.
Proper citation: RUVSeq (RRID:SCR_006263) Copy
http://www.bioconductor.org/packages/devel/bioc/html/CGHnormaliter.html
Software for normalization and centralization of array comparative genomic hybridization (aCGH) data with imbalanced aberrations. The algorithm uses an iterative procedure that effectively eliminates the influence of imbalanced copy numbers. This leads to a more reliable assessment of copy number alterations (CNAs).
Proper citation: CGHnormaliter (RRID:SCR_002936) Copy
http://www.bioconductor.org/packages/release/bioc/html/flowWorkspace.html
Software package that facilitates comparison of automated gating methods against manual gating done in flowJo. This package allows you to import basic flowJo workspaces into BioConductor and replicate the gating from flowJo using the flowCore functionality. Gating hierarchies, groups of samples, compensation, and transformation are performed so that the output matches the flowJo analysis.
Proper citation: flowWorkspace (RRID:SCR_001155) Copy
http://www.bioconductor.org/packages/release/bioc/html/wateRmelon.html
Software package for Illumina 450 methylation array normalization and metrics including 15 flavors of betas and three performance metrics, with methods for objects produced by methylumi, minfi and IMA packages.
Proper citation: wateRmelon (RRID:SCR_001296) Copy
https://rdrr.io/bioc/spotSegmentation/
Model-based software package for processing microarray images so as to estimate foreground and background intensities. The method starts with a very simple but effective automatic gridding method, and then proceeds in two steps. The first step applies model-based clustering to the distribution of pixel intensities, using the Bayesian Information Criterion (BIC) to choose the number of groups up to a maximum of three. The second step is spatial, finding the large spatially connected components in each cluster of pixels. The method thus combines the strengths of the histogram-based and spatial approaches. It deals effectively with inner holes in spots and with artifacts. It also provides a formal inferential basis for deciding when the spot is blank, namely when the BIC favors one group over two or three.
Proper citation: spotSegmentation (RRID:SCR_001298) Copy
http://www.bioconductor.org/packages/release/bioc/html/ARRmNormalization.html
Software package to perform the Adaptive Robust Regression method (ARRm) for the normalization of methylation data from the Illumina Infinium HumanMethylation 450k assay.
Proper citation: ARRmNormalization (RRID:SCR_001292) Copy
https://www.bioconductor.org/packages//2.10/bioc/html/oneChannelGUI.html
Software library that provides a graphical interface for microarray gene and exon level analysis as well as miRNA/mRNA-seq data analysis. The package was developed to simplify the use of Bioconductor tools for beginners having limited or no experience in writing R code.
Proper citation: oneChannelGUI (RRID:SCR_001325) Copy
https://www.bioconductor.org/packages//2.12/bioc/html/LMGene.html
Software package for Data Transformation and Identification of Differentially Expressed Genes in Gene Expression Arrays.
Proper citation: LMGene (RRID:SCR_001329) Copy
http://bioinf.wehi.edu.au/affylmGUI/
R software package providing a Graphical User Interface for analysis of Affymetrix microarray data, using the limma package (Linear Models for MicroArray data). While not as powerful as limma to the expert user, it offers a simple point-and-click interface to many of the commonly-used limma and affy functions. You need to have R 1.9.0 or later, Tcl/Tk 8.3 or later (ActiveTcl for Windows, Tcl/Tk Source for Linux/Unix, or X11 Tcl/Tk for MacOSX) and the limma, affylmGUI, and tkrplot R packages. It has been succesfully tested on Windows 2000, Windows XP, RedHat/Fedora Linux, and on Mac OSX with X11.
Proper citation: affylmGUI (RRID:SCR_001320) Copy
https://www.bioconductor.org/packages//2.10/bioc/html/ArrayTools.html
Software package for quality assessment and to detect differentially expressed genes for the Affymetrix GeneChips, including both 3' -arrays and gene 1.0-ST arrays. The package generates comprehensive analysis reports in HTML format. Hyperlinks on the report page will lead to a series of QC plots, processed data, and differentially expressed gene lists. Differentially expressed genes are reported in tabular format with annotations hyperlinked to online biological databases.
Proper citation: ArrayTools (RRID:SCR_001313) Copy
http://www.bioconductor.org/packages/release/bioc/html/affyPLM.html
Software for fitting probe-level models and tools using these models. Probe-level models (PLM) based quality assessment tools.
Proper citation: affyPLM (RRID:SCR_001319) Copy
http://www.bioconductor.org/packages/release/bioc/html/genArise.html
An easy to use software tool for dual color microarray data. Its GUI-Tk based environment lets any non-experienced user perform a basic, but not simple, data analysis just following a wizard. In addition it provides some tools for the developer.
Proper citation: genArise (RRID:SCR_001346) Copy
http://www.bioconductor.org/packages/release/bioc/html/Harshlight.html
Software package used to detect extended, diffuse and compact blemishes on microarray chips. It automatically marks the areas in a collection of chips (affybatch objects) and a corrected AffyBatch object is returned, in which the defected areas are substituted with NAs or the median of the values of the same probe in the other chips in the collection.
Proper citation: Harshlight (RRID:SCR_001340) Copy
http://www.bioconductor.org/packages/release/bioc/html/MiChip.html
Software package that takes the MiChip miRNA microarray .grp scanner output files and parses these out, providing summary and plotting functions to analyse MiChip hybridizations. A set of hybridizations is packaged into an ExpressionSet allowing it to be used by other BioConductor packages.
Proper citation: MiChip (RRID:SCR_001341) Copy
http://www.bioconductor.org/packages/release/bioc/html/frma.html
Preprocessing and analysis software for single microarrays and microarray batches.
Proper citation: fRMA (RRID:SCR_001345) Copy
https://bioconductor.org/packages//2.13/bioc/html/virtualArray.html
Software package that permits the user to combine raw data of different microarray platforms into one virtual array. It consists of several functions that act subsequently in a semi-automatic way. Doing as much of the data combination and letting the user concentrate on analyzing the resulting virtual array.
Proper citation: virtualArray (RRID:SCR_001361) Copy
http://www.bioconductor.org/packages/release/bioc/html/stepNorm.html
Software for stepwise normalization functions for cDNA microarray data.
Proper citation: stepNorm (RRID:SCR_001359) Copy
http://www.bioconductor.org/packages/release/bioc/html/rama.html
Software package for robust estimation of cDNA microarray intensities with replicates. It uses a Bayesian hierarchical model for the robust estimation. Outliers are modeled explicitly using a t-distribution, and the model also addresses classical issues such as design effects, normalization, transformation, and nonconstant variance.
Proper citation: RAMA (RRID:SCR_001358) Copy
http://www.bioconductor.org/packages/release/bioc/html/MANOR.html
Software packqge for importation, normalization, visualization, and quality control functions to correct identified sources of variability in array-CGH (Comparative genomic hybridization) experiments.
Proper citation: MANOR (RRID:SCR_001305) Copy
http://www.bioconductor.org/packages/release/bioc/html/dyebias.html
Software package using the GASSCO method for correcting for slide-dependent gene-specific dye bias.
Proper citation: dyebias (RRID:SCR_001308) Copy
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