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http://www.informatics.jax.org

International database for laboratory mouse. Data offered by The Jackson Laboratory includes information on integrated genetic, genomic, and biological data. MGI creates and maintains integrated representation of mouse genetic, genomic, expression, and phenotype data and develops reference data set and consensus data views, synthesizes comparative genomic data between mouse and other mammals, maintains set of links and collaborations with other bioinformatics resources, develops and supports analysis and data submission tools, and provides technical support for database users. Projects contributing to this resource are: Mouse Genome Database (MGD) Project, Gene Expression Database (GXD) Project, Mouse Tumor Biology (MTB) Database Project, Gene Ontology (GO) Project at MGI, and MouseCyc Project at MGI.

Proper citation: Mouse Genome Informatics (MGI) (RRID:SCR_006460) Copy   

•   Source: SciCrunch Registry

http://jaxmice.jax.org/list/ra56.html

This Resource maintains and distributes mouse models for neural tube defects. Current Neural Tube Defect stains include: * Repository- Live: 129(Cg)-Foxg1/J, B6.129P2(Cg)-Foxg1/J, B6.129P2-Apob/J, B6.129S7-Twist1/J, B6.129X1(Cg)-Shh/J, B6.Cg-Lootl/GrsrJ, B6.D2-Kitl/J, B6;129-Pax3/J, B6;129-Shh/J, B6;SJL-Tg(Sox10-cre)507Mcln/J, C57BL/6J-Pax3/J, STOCK Ptch1/J, STOCK Sec24b/J, STOCK Smo/J, STOCK Tgfb3/J, WCB6F1/J-Kitl/Kitl, * Cryopreserved - Ready for recovery: 129-Ski/J, 129-Tulp3/Pjn, 129/Sv-Csk/J, 129P4.Cg-Axin1/J, 129S-Dvl2/J, 129S-Dvl3/J, 129S-Nog/J, 129S1/Sv-Sufu/J, 129X1-Smo/J, A.129P-Ski/J, A/WySnJ-ctl/GrsrJ, B6-Pax3.Cg-N/J, B6.129-Dll1/J, B6.129-Kif3a/J, B6.129-Ski/J, B6.129-Tulp3/Pjn, B6.129S1-Twist1/J, B6.129S2-Mgat1/J, B6.129S4-Shroom3/J, B6.129S4-Strap/J, B6.129S6-Crebbp/Jm, B6.129S6-Dnmt3l/J, B6.C3 Pde6bHps4/+ +-Lmx1a/J, B6.C3-Gli3/J, B6;129-Apob Apoe/J, B6;129S-Ldlr Apob/J, B6;129S-Twist1/J, B6;129S6-Apaf1/J, B6;129S7-Apob/J, B6C3Fe a/a-Lmx1a/J, B6C3Fe a/a-Wnt1/J, B6CBACa A/A-we a Mafb/J, B6EiC3Sn a/A-Egfr Wnt3a/J, BNT/LeJ, C3H/HeSn-Gpr161/J, C3HeB/FeJ x STX/Le-Mc1r Gli3 Tw/J, C57BL/6J-Pax3/J, FL/1Re-Kit/J, FL/1ReJ, JE/LeJ, LPT/LeJ, STOCK Apaf1/J, STOCK Grhl3/J, STOCK Mttp Ldlr Apob Tg(Mx1-cre)1Cgn/J, STOCK Pax3 Mlph/J, STOCK Shh/J, STOCK T/J, STOCK a/a Egfr/J, STOCK t tf/J, WB.Cg-f/J, WB.D2-Kitl/J, 129S1.B6-Shroom3/J * Under Development - Now Accepting Orders: 129S1.B6-Shroom3/J, 129S1.B6-Zic2/J, STOCK Nog/J, STOCK Tg(TCF/Lef1-cre/ERT2)1Dje/J First time users are required to fill out a request form for mice. Information on individual strains is also available through links on the Web site.

Proper citation: JAX Mice: Neural Tube Defects (RRID:SCR_007333) Copy   

•   Source: SciCrunch Registry

http://www.jax.org/imr/index.html

THIS RESOURCE IS NO LONGER IN SERVICE, documented on June 08, 2012. The function of the IMR is to select, import, cryopreserve, maintain, and distribute these important strains of mice to the research community. To improve their value for research, the IMR also undertakes genetic development of stocks, such as transferring mutant genes or transgenes to defined genetic backgrounds and combining transgenes and/or targeted mutations to create new mouse models for research. The function of the IMR is to: * select biomedically important stocks of transgenic, chemically induced, and targeted mutant mice * import these stocks into the Jackson Laboratory by rederivation procedures that rid them of any pathogens they might carry * cryopreserve embryos from these stocks to protect them against accidental loss and genetic contamination * backcross the mutation onto an inbred strain, if necessary * distribute them to the scientific community More than 1000 mutant stocks have been accepted by the IMR from 1992 through December 2006. Current holdings include models for research on cancer; breast cancer; immunological and inflammatory diseases; neurological diseases; behavioral, cardiovascular and heart diseases; developmental, metabolic and other diseases; reporter (e.g., GFP) and recombinase (e.g., cre/loxP) strains. About eight strains a month are being added to the IMR holdings. Research is being conducted on improved methods for assisted reproduction and speed congenic production. Most of the targeted mutants arrive on a mixed 129xC57BL/6 genetic background, and as many of these as possible are backcrossed onto an inbred strain (usually C57BL/6J). In addition, new mouse models are being created by intercrossing carriers of specific transgenes and/or targeted mutations. Simple sequence length polymorphism DNA markers are being used to characterize and evaluate differences between inbred strains, substrains, and embryonic stem cell lines.

Proper citation: Induced Mutant Resource (RRID:SCR_008366) Copy   

•   Source: SciCrunch Registry

https://www.jax.org/news-and-insights/2004/june/app-mouse-models-for-alzheimers-disease-research

An information resource about several models for mice to develop Alzheimer's-related characteristics as they age.

Proper citation: Mouse Models For Alzheimer's Disease Research (RRID:SCR_000708) Copy   

•   Source: SciCrunch Registry

http://hearingimpairment.jax.org/screening.html

The fairly common occurrence of hearing-loss or deafness in both humans and mice, and the anatomical and functional similarities of their inner ears, attest to the potential of mice as models to study hereditary hearing loss. Hundreds of standard inbred, recombinant inbred, and congenic strains are maintained at The Jackson Laboratory, as well as hundreds of inbred strains with spontaneous or induced mutations. To assess hearing impairment in inbred and mutant strains of mice we measure auditory-evoked brainstem response (ABR) thresholds.

Proper citation: The Jackson Laboratory Hearing Research Program (RRID:SCR_007196) Copy   

•   Source: SciCrunch Registry