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Center mission is to advance medical and biological research by providing the scientific community with standardized, high quality metabolic and physiologic phenotyping services for mouse models of diabetes, diabetic complications, obesity and related disorders.
Proper citation: National Mouse Metabolic Phenotyping Centers (RRID:SCR_008997) Copy
THIS RESOURCE IS NO LONGER IN SERVICE, documented October 13, 2014. The resource has moved to the NIDDKInformation Network (dkNET) project. Contact them at info_at_dknet.org with any questions. Database of large pools of data relevant to the mission of NIDDKwith the goal of developing a community-based network for integration across disciplines to include the larger DKuniverse of diseases, investigators, and potential users. The focus is on greater use of this data with the objective of adding value by breaking down barriers between sites to facilitate linking of different datasets. To date (2013/06/10), a total of 1,195 resources have been associated with one or more genes. Of 11,580 total genes associated with resources, the ten most represented are associated with 359 distinct resources. The main method by which they currently interconnect resources between the providers is via EntrezGene identifiers. A total of 780 unique genes provide the connectivity between 3,159 resource pairs across consortia. To further increase interconnectivity, the groups have been further annotating their data with additional gene identifiers, publications, and ontology terms from selected Open Biological and Biomedical Ontologies (OBO).
Proper citation: dkCOIN (RRID:SCR_004438) Copy
http://mmpc.ucdavis.edu/index.php
Center that provides the scientific community with metabolic and physiologic phenotyping tests, services, and procedures for mouse models of diabetes, diabetic complications, obesity and related disorders in order to advance medical and biological research.
Proper citation: MMPC-University of California Davis (RRID:SCR_015357) Copy
Research center which provides various research techniques for investigating mouse models of human disease to advance medical and biological research by providing the scientific community with comprehensive, standardized, and high quality metabolic phenotyping services for mouse models of diabetes, diabetic complications, obesity and related disorders.
Proper citation: MMPC-University of Massachusetts Medical School (RRID:SCR_015366) Copy
Research center which aims to contribute to a national database of metabolic phenotyping data in wild-type mouse strains and a broad range of mouse models relevant to the pathogenesis and treatment of diabetes, obesity and associated metabolic disorders. It also aims to foster continued technical development, refinement of assay sensitivity and specificity, data reproducibility, and transmission of best research practices within the areas of fundamental and applied diabetes and obesity research.
Proper citation: MMPC-University of Michigan Medical School (RRID:SCR_015373) Copy
http://animalcare.umich.edu/business-services/germ-free-mouse-facility
Core that provides services to the University of Michigan community and can also ship germ-free mice to locations worldwide. Its projects include studies investigating inflammatory bowel disease and cancer, host microbiome interactions, infectious disease pathogenesis, and mammalian and bacterial metabolism.
Proper citation: MMPC-University of Michigan Medical School Animal Care and Germ-Free Mouse Core (RRID:SCR_015344) Copy
https://labnodes.vanderbilt.edu/resource/view/id/10800/community_id/1418
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 6th,2023. Core whose objective is to provide investigators at Vanderbilt and outside institutions a means to accurately assess cardiovascular phenotypes in mouse models of diabetes and metabolic disease. The CPC uses validated approaches and state-of-the-art instrumentation that allow for sensitive screening of phenotypic variations.
Proper citation: MMPC-Vanderbilt University School of Medicine Cardiovascular Pathophysiology Core (RRID:SCR_015353) Copy
https://labnodes.vanderbilt.edu/resource/view/id/10822/community_id/1418
Core that ensures the health and welfare of mouse models by assuring that mice admitted to the MMPC meet defined health criteria and that post-quarantine protocol assignment. It diagnoses disease and identifies unique metabolic or cardiovascular phenotypes of mice through interaction with the Comparative Pathology Subcore.
Proper citation: MMPC-Vanderbilt University School of Medicine Animal Health and Welfare Core (RRID:SCR_015380) Copy
http://www.mmpc.org/shared/showCenterCore.aspx?id=30
Core that provides investigators with services to accurately measure the major components of energy balance in their mouse models and tests that allow investigators to examine physiological factors that may influence food intake or energy expenditure.
Proper citation: MMPC-University of California Davis Energy Balance Exercise and Behavior Core (RRID:SCR_015364) Copy
http://www.umassmed.edu/umpc/cores/metabolism/
Core that conducts specialized and non-invasive metabolic experiments to measure insulin sensitivity, glucose/lipid/protein metabolism, pancreatic beta-cell function, body composition and energy balance. Its services include access to hyperglycemic clamps to assess insulin secretion and pancreatic beta cell function in awake mice and exercise studiesl with acute, chronic endurance, and exhaustive exercise protocols and using in-house cage wheels.
Proper citation: MMPC-University of Massachusetts Medical School Metabolism Core (RRID:SCR_015369) Copy
http://www.mmpc.org/shared/showCenterCore.aspx?id=37
Core that offers measurement of gut permeability, plasma lipopolysaccharide binding protein (LBP) assay, and inflammatory profiling.
Proper citation: MMPC-University of California Davis Microbiome and Host Response Core (RRID:SCR_015361) Copy
http://www.mmpc.org/shared/showCenterCore.aspx?id=48
Core which provides a complete range of microvascular phenotyping of murine models of diabetes, obesity and metabolic disease, including validated, reproducible and standardized phenotyping of the three major microvascular complications: diabetic polyneuropathy, nephropathy and retinopathy.
Proper citation: MMPC-University of Michigan Medical School Microvascular Complications Core (RRID:SCR_015376) Copy
https://labnodes.vanderbilt.edu/resource/view/id/10810/community_id/1418
Core whose services include determining the components of energy balance with high precision and time resolution, providing robust imaging technology to monitor the dynamics of cellular process, and providing innovative mouse bariatric surgery models with application to basic and translational research.
Proper citation: MMPC-Vanderbilt University School of Medicine Metabolic Regulation Core (RRID:SCR_015377) Copy
http://umassmed.edu/umpc/animal/humanized-mouse-core/
Core which provides humanized mice that enable clinically relevant in vivo studies of human cells, tissues, and immune system without putting patients at risk and expert in vivo functional analysis of transplanted human islets and stem cell-derived b-cells in immunodeficient mice that are highly valuable to the mouse research community.
Proper citation: MMPC-University of Massachusetts Medical School Humanized Mouse Cell Transplantation and Assessment Core (RRID:SCR_015372) Copy
http://umassmed.edu/umpc/cores/islet-core/
Core which provides comprehensive in vivo, ex vivo, and in vitro analysis of pancreatic function and islet structure. Its services include mouse pancreas preparation for histological experiments, surgical isolation of mouse islets, and islet structural analysis.
Proper citation: MMPC-University of Massachusetts Medical School Islet Core (RRID:SCR_015370) Copy
The NIDDK Information Network (dkNET) is a community-based network to serve needs of basic and clinical investigators that includes large pools of data and research resources relevant to mission of National Institute of Diabetes and Digestive and Kidney Disease.
Proper citation: NIDDK Information Network (dkNET) (RRID:SCR_001606) Copy
http://www.uc.edu/labs/mmpc.html
Research center that provides metabolic and physiologic phenotyping services for mouse models of diabetes, diabetic complications, obesity and related disorders. It specializes in the immunological aspects of Type I diabetes, measurement of various glucose and lipid metabolism parameters relevant to Type II diabetes as well as diabetic complications such as heart disease and obesity.
Proper citation: MMPC-University of Cincinnati Medical Center (RRID:SCR_015367) Copy
https://labnodes.vanderbilt.edu/mmpc
Research center whose mission is to advance research in the area of diabetes by providing experimental tools to the scientific community for phenotyping mouse transgenic models of diabetes and related disorders.
Proper citation: MMPC-Vanderbilt University School of Medicine (RRID:SCR_015374) Copy
http://www.mmpc.org/shared/showCenterCore.aspx?id=47
Core whose services include in vivo physiological assessments encompassing glucose homeostasis (glucose tolerance, insulin tolerance, hyperinsulinemic/euglycemic clamps), energy homeostasis (indirect calorimetry by CLAMS, dietary challenge), ultradian hormone secretion (Culex platform for serial biological fluid sampling from unrestrained mice), behavioral measurements (locomotor activity, meal pattern analysis, operant conditioning) and generation of bariatric surgery models.
Proper citation: MMPC-University of Michigan Medical School Metabolism Bariatric Surgery and Behavior Core (RRID:SCR_015354) Copy
http://mmpc.ucdavis.edu/core.php?coreID=29
Core that provides phenotyping services for the assessment of endocrine function and metabolic pathways in mouse models of obesity, diabetes, and related metabolic diseases including dyslipidemia and fatty liver disease.
Proper citation: MMPC-University of California Davis Endocrinology and Metabolism Core (RRID:SCR_015359) Copy
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