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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
Core laboratory for nucleic acid sequencing and bioinformatics. Mission includes research support, education, and training.Services encompass range of genomic techniques and applications, sequencing technologies, and bioinformatics analyses. GGBC operates multiple platforms for short-, long-, and single-molecule sequencing reads (i.e., Illumina MiSeq and NextSeq, PacBio Sequel, and Oxford Nanopore MinIon). We also write letters of support (LOS) to offer our capabilities and expertise for grant applications submitted to funding agencies.
Proper citation: University of Georgia Georgia Genomics and Bioinformatics Core Facility (RRID:SCR_022880) Copy
https://www.cincinnatichildrens.org/service/p/pathology/mass-spectrometry
Provides analytical resource focusing on application of mass spectrometry and allied chromatographies to analysis of small molecules, generally of less than 1,000 daltons molecular weight, in complex clinical and biological samples.
Proper citation: Cincinnati Children's Hospital Mass Spectrometry Core Facility (RRID:SCR_022638) Copy
https://research.wayne.edu/proteomics
Protein identification and proteome analysis using Orbitrao Eclipse,Fusion and Q Exactive LC-MS/MS platforms. Affinity selection for phosphopeptides with analysis using HCD, CID and ETD. Validation and quantitation of proteins using MRM with a TSQ Vantage triple quad.
Proper citation: Wayne State University Proteomics Core Facility (RRID:SCR_022879) Copy
https://www.cincinnatichildrens.org/service/c/clinical-trials/biobank
Provides access to services for standardized and centralized acquisition, processing, storage and distribution of biospecimens for research.
Proper citation: Cincinnati Children's Hospital Discover Together Biobank Core Facility (RRID:SCR_022632) Copy
https://www.cincinnatichildrens.org/research/cores/imaging
Provides access to advanced analytical imaging and image post-processing methods for collaborators involved in basic and clinical research.
Proper citation: Cincinnati Children's Hospital Imaging Research Center Core Facility (RRID:SCR_022631) Copy
SOCR designs, validates and freely disseminates knowledge. The Resource develops AI/ML tools, mathematical models, and end-to-end data analytic protocols for biomedical and health studies. It provides portable online aids for probability, statistics and health science education, promotes technology enhanced instruction, supports efficient statistical computing, supports AI-services, and advances predictive big data analytics. The SOCR platform includes repository of interactive apps, datasets and case-studies, computational tools, visualization approaches, instructional resources, learning materials, and curricular components. SOCR faculty, staff, and students support data and information science collaborations and analytic partnerships involving biomedical, healthcare, and biostatistical investigations.
Proper citation: University of Michigan Statistics Online Computational Resource Core Facility (RRID:SCR_022917) Copy
https://vivariumandtransgenicscore.vai.org/
Provides genetically modified animal models for our collaborators. For preexisting models provides rederivation or reconstitution for purpose of importing animals into Vivarium barrier. In the absence of preexisting models core works closely with partnering labs to generate their ideal mutation de novo, often using CRISPR technology. Usually beginning with a brief consultation, this process involves discussing factors such as ideal background strain, molecular methods for optimizing the intended genetic change, mutation induction strategies, screening approaches and eventual QC of the new mutant line with the overall goal of giving our collaborators a fully informed, realistic picture of their projects timeframe, pitfalls and workflow. Core provides mouse sperm and embryo cryopreservation services for purpose of archiving and distributing valuable lines. Institute is an AAALAC-accredited facility. All procedures are conducted according to the NIH Guide for the Care and Use of Laboratory Animals.
Proper citation: Van Andel Institute Transgenic Core Facility (RRID:SCR_022914) Copy
https://www.med.uvm.edu/vigr/mpsf
Provides support for design, execution, and analysis of experiments involving Next Generation Sequencing through access and use of Illumina HiSeq 1500. Sequencer performs wide range of analysis including target preparation for RNAseq, Exome Seq, ChIP seq, Methyl Seq, whole genome sequencing, and small RNA sequencing.Core is involved in all aspects of Nanopore sequencing.
Proper citation: University of Vermont Larner College of Medicine Advanced Genome Technologies Massively Parallel Sequencing Core Facility (RRID:SCR_022696) Copy
https://www.janelia.org/support-team/flow-cytometry
Provides range of instrumentation and expertise for cell sorting and analysis that can support experimental needs related to single cells, cell line production, biosensor development, and dye analysis. Offers expertise in flow cytometry experimental design, operation of instruments, distribution of raw data and sort reports, interpretation of results, and preparation of graphics for presentation and publication.
Proper citation: Howard Hughes Medical Institute at Janelia Research Campus Flow Cytometry Shared Resource Core Facility (RRID:SCR_022690) Copy
https://www.fredhutch.org/en/research/shared-resources/core-facilities/therapeutic-products.html
Provides facilities and services in process development and manufacturing of Good Manufacturing Practice grade biologic and cellular therapeutic products for Phase 1/2 clinical trials. Supports the translation of ideas from academic laboratories to clinical trials.
Proper citation: Fred Hutchinson Cancer Center Therapeutic Products Core Facility (RRID:SCR_022725) Copy
https://www.mayo.edu/research/core-resources/immune-monitoring-core/overview
Provided services include Designing assays to identify and quantify immune cell subpopulations; Characterizing and measuring immune function; Monitoring immunological changes in response to both specific and nonspecific stimulation; Mass Cytometry (CyTOF, Helios); Imaging Mass Cytometry (IMC, Hyperion). Supports experimental systems to study human and mouse models by providing expertise and standardized assays to evaluate immune functions in broad range of diseases and therapies in models as well as in healthy human subjects with variable demographics.Provides services to all Mayo Clinic faculty and staff engaged in research. Selective services are available to investigators outside Mayo Clinic.
Proper citation: Mayo Clinic Immune Monitoring Core Facility (RRID:SCR_022724) Copy
Leica Microsystems and Fred Hutch established Leica Center of Excellence in Pacific Northwest to provide researchers with advanced microscopy technologies, support generating scientific discoveries and developing new approaches to preventing and treating cancer and related diseases.
Proper citation: Fred Hutchinson Cancer Center Leica Center of Excellence Core Facility (RRID:SCR_022720) Copy
Provides services including sequencing library preparation and sequencing on Illumina MiSeq and NovaSeq 6000 platforms. Supports single cell sequencing on 10X Genomics Chromium Controller. Provides Illumina Infinium Beadchips, which includes variety of whole genome genotyping arrays as well as Infinium MethylationEPIC BeadChip.
Proper citation: University of California at San Diego Institute for Genomic Medicine Genomics Center Core Facilitiy (RRID:SCR_022740) Copy
https://www.unmc.edu/publichealth/centers/ccorda/index.html
Provides advance clinical, translational and public health research at UNMC and in the community and region. Provides expertise in quantitative sciences, including biostatistics, epidemiology, and health services research, and coordinates collaborative design, planning, conduct, analysis and interpretation of laboratory, clinical, and public health research studies.Provides educational training opportunities for graduate students and educational opportunities for public health, clinical, and translational investigators.
Proper citation: University of Nebraska Medical Center Center for Collaboration on Research Design and Analysis Core Facility (RRID:SCR_022860) Copy
Supports leading edge research with free access to advanced computing hardware and software.
Proper citation: University of Pittsburgh Center for Research Computing Core Facility (RRID:SCR_022735) Copy
Provides support with technologies for cell and animal model needs. Services are ranging from CRISPR reagents with or without validation, to cancer/iPS cell line modification or animal model creation. Works closely with mouse cores from design, reagent validation to genotyping, process improvement and troubleshooting, when necessary. Provides next-generation sequencing (NGS) based human cell authentication and NGS-based genotyping services and general molecular biology assistance. Offers to culture, bank and store primary fibroblasts and renal epithelial cells from patient samples for investigators, and iPSC reprogramming service is provided from fibroblasts, RECs as well as peripheral blood mononuclear cells. Provides differentiation services on growing list of cell types.
Proper citation: Washington University School of Medicine Genome Engineering and Stem Cell Center Core Facility (RRID:SCR_023243) Copy
https://asrc.gc.cuny.edu/neuroscience/facilities/live-imaging-bioenergetics-facility/
Provides Zeiss LSM880 upright two photon confocal microscope with Airyscan, FAST model and CLARITY lens; LSM880 inverted live cell imaging confocal microscope with Airyscan and FAST model; Agilent Seahorse XFe24 live cell metabolic analyzer.Supported applications include in vivo imaging of live animals, time lapse live cell imaging with high resolution optical sectioning, deep imaging of fixed CLARITY tissues, calcium imaging, photo switching and photo uncaging, Fluorescence Recovery After Photobleaching, Forster Resonance Energy Transfer, laser ablation, and measuring mitochondrial respiration and glycolysis in live cells in real time.Provides advanced imaging analysis software Imaris for data processing.
Proper citation: City University of New York Advanced Science Research Center Live Imaging and Bioenergetics Core Facility (RRID:SCR_022945) Copy
Provides light stable isotope ratio analysis services to scientists from UCSC and from around the world.
Proper citation: University of California at Santa Cruz Stable Isotope Laboratory Core Facility (RRID:SCR_022947) Copy
Facility is equipped with JEOL JXA-8230 SuperProbe electron microprobe. Electron microprobe measures elemental compositions of solid samples by detecting the X-rays emitted on excitation by focused electron beam, down to spatial resolution of about 1 micron. All elements heavier than beryllium can be detected, at concentrations as low as 10s of ppm. Highly quantitative analyses are made using 5 wavelength dispersive X-ray spectrometers (WDS) with calibrations based on known standard materials. Compositional images (maps) can readily be obtained with backscattered electrons (sensitive primarily to mean atomic number), or with WDS or EDS X-ray data. The instrument is adjacent to the Stanford Nanocharacterization Laboratory (SNL), at the west end of the first floor of the McCullough Building.
Proper citation: Stanford Microchemical Analysis Core Facility (RRID:SCR_023256) Copy
Provides instruments for solid, aquouse and gas sample analyses, quantitative analysis, technical expertise to members of Stanford community.
Proper citation: Stanford Environmental Measurements Core Facility (RRID:SCR_023255) Copy
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