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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
http://www.oracle.com/us/sun/index.htm
Oracle''s complete, open, and integrated product strategy provides flexibility and choice to our customers across their IT infrastructure. Now, with Sun server, storage, operating-system, and virtualization technology, Oracle is the only vendor able to offer a complete technology stack in which every layer is integrated to work together as a single system. Oracle''s open architecture and multiple operating-system options gives our customers unmatched benefits, including excellent system availability, scalability, energy efficiency, powerful performance, and low total cost of ownership Starting more than 30 years ago with Oracle''s innovative relational database, the Oracle stack today includes Oracle Enterprise Linux, Oracle VM, Oracle Fusion Middleware, and the largest and most complete set of industry and business applications software on the market. The addition of Sun storage and systems technology makes the Oracle stack complete. Oracle integrates every layer of the IT stack to deliver compelling value, based on high system availability and security, stunning performance, and low TCO. Only Oracle can offer this stack advantage to its customers through deep and seamless integration between the tiers that our competitors cannot match.
Proper citation: SUN Interface Engine (RRID:SCR_008659) Copy
http://portal.ncibi.org/gateway/bcde.html
Biological Concept Diagram Editor (BCDE) is a conceptual relationship diagramming tool specifically designed for biomedical researchers. It allows for efficient knowledge and data capture, fast diagram creation, easy data retrieval, and flexible exporting. The BCDE application is the main diagramming tool in the system. Through it, users can create, modify, load, and save BCDE diagrams. The diagrams created with BCDE application are network oriented. Each BCDE figure can be annotated using fields from the BioPAX level II format. In addition, a user can add URL links and attachments to a BCDE figure. Diagrams generated in BCDE are stored in the BCDE XML format for better database integration and better data extraction.
Proper citation: Biological Concept Diagram Editor (RRID:SCR_008654) Copy
http://www.alz.org/research/alzheimers_grants/overview.asp
An organization that funds research for Alzheimer's disease, provides information on new treatment strategies, provides information on caring for afflicted people, and generally increases public knowledge of disease prevention. This program financially supports new Alzheimer's studies. These research projects are selected by the Medical and Scientific Advisory Council. The council chooses which studies to address based on their potential uses in diagnostics, genetics, treatments, prevention, early detection and general enhancement of lifestyle.
Proper citation: Alzheimer's Association International Research Grant Program (RRID:SCR_008775) Copy
An endowment that offers funding for neuroscience research, especially as it may apply to Minnesota, agriculture, or if the researchers are based in Minnesota. The McKnight Foundation, a Minnesota-based family foundation, seeks to improve the quality of life for present and future generations through grantmaking, collaboration, and strategic policy reform in the following areas: arts, education and learning, environment, the region and communities, agricultural research, and neuroscience research. The McKnight Foundation assists nonprofit organizations and public agencies to improve the quality of life for all people, particularly those in need. Through grantmaking, coalition-building, and encouragement of strategic policy reform, we aim to build and maintain vibrant communities; enrich people''s lives through the arts; encourage protection of the natural environment; and promote research in selected fields. The Foundation had assets of approximately $1.8 billion and gave about $98 million in grants in 2009. Generally speaking, McKnight supports nonprofit organizations in Minnesota, U.S., only. McKnight''s primary geographic focus in grantmaking is to nonprofit organizations located within the state of Minnesota. We do not provide funding outside Minnesota, with five important programmatic exceptions: * Collaborative Crop research: International. * East Africa: Tanzania and Uganda only. * Mississippi River: 10 states bordering or encompassing the Mississippi River. * Neuroscience research: National. * Southeast Asia: Cambodia, Laos, and Vietnam only. Each program is different. Please consult the specific guidelines appropriate to your project or organization for funding details. With very few exceptions, McKnight funds nonprofit organizations only. To be eligible for a grant, applicants must be classified by the Internal Revenue Service as tax-exempt, nonprofit organizations. We discourage the use of fiscal agents.
Proper citation: McKnight Foundation (RRID:SCR_008776) Copy
http://www.mcknight.org/neuroscience/
An endowment that offers funding for memory research. The McKnight Endowment Fund for Neuroscience is an independent charitable organization established by The McKnight Foundation to carry out the wishes of its founder, William L. McKnight (1887-1979). Currently, the Endowment Fund for Neuroscience administers four awards which support young and established neuroscientists and encourage interdisciplinary collaboration: * Memory and Cognitive Disorders Awards * Neuroscience of Brain Disorders Awards * Scholar Awards * Technological Innovations in Neuroscience Awards Mr. McKnight, who led the 3M company for three decades, had a personal interest in memory and its diseases. He chose to set aside part of his legacy to bring hope to those suffering from brain injury or disease and cognitive impairment.
Proper citation: McKnight Endowment Fund for Neuroscience (RRID:SCR_008771) Copy
http://genome.ufl.edu/rivalab/pasta/
A complete pipeline for the analysis of alternative splicing using RNA-Sequencing data.
Proper citation: PASTA (RRID:SCR_008770) Copy
Many science fairs have a group of people called a Scientific Review Committee (or SRC) that reviews each project application to ensure that all safety and legal requirements will be met and that the appropriate forms have been completed. The committee also reviews the completed project displays. Typically, a Scientific Review Committee is composed of at least three people: a biomedical scientist, a physical scientist, and a science teacher. Some fairs also have an Institutional Review Board (IRB), which reviews all proposed projects that in any way involve human beings. An IRB''s purpose is to ensure that the project will not present undue risk to the subjects.
Proper citation: Scientific Review Committee (RRID:SCR_008652) Copy
https://www.stat.auckland.ac.nz/~paul/plaudits/Iobion.htm
GeneTraffic is a web-based microarray data analysis and management software developed by Iobion Informatics that allows users to log onto a server, upload their microarray data and perform analysis and project management remotely. GeneTraffic was made by Iobion Informatics (now under Stratagene) and can be accessed thorough Internet Explorer 6.0 or greater on Windows XP.
Proper citation: GeneTraffic (RRID:SCR_008651) Copy
Platform for sharing data, with very large storage capability for electrophysiological data, EEG data is included. This service is provided for neuroscientists to facilitate data access, data storage, data analysis and data sharing. This service is developed and maintained by the German Node of the International Neuroinformatics Coordinating Facility. The global scale of neuroinformatics offers unprecedented opportunities for scientific collaborations between and among experimental and theoretical neuroscientists. To fully harvest these possibilities, coordinated activities are required to improve key ingredients of neuroscience: data access, data storage, and data analysis, together with supporting activities for teaching and training. Focusing on the development and free distribution of tools for handling and analyzing neurophysiological data, G-Node aims at addressing these aspects as part of the International Neuroinformatics Coordination Facility (INCF) and the German Bernstein Network for Computational Neuroscience (NNCN). G-Node also serves as an international forum for Computational Neuroscientists that are interested in sharing experimental data and tools for data analysis and modeling. G-Node is funded through the German Federal Ministry of Education and Research and hosted by Ludwig-Maximilians-Universit-Munchen.
Proper citation: G-node portal electrophysiology data sharing (RRID:SCR_008893) Copy
http://human-phenotype-ontology.github.io/
The Disease Ontology group has developed a set of standard representations of phenotypes associated with diseases useful in bioinformatics applications. These are formalized into an ontological structure and are encoded in OWL. Neurodegenerative diseases have a wide and complex range of biological and clinical symptoms. While neurodegenerative diseases share many pathological features in common, they also contain unique signatures. Animal models of these disorders are key to translational research. However, animal models typically replicate only a subset of disease features or display features that are only indirectly related to a given disorder, whose relationship to the human condition may be across several diseases. Matching animal models to human diseases is therefore a significant informatics challenge. We have been working to develop ontologies that capture essential features of neurodegenerative diseases and associated animal models in a way that allows more flexible matching of animal models to human disorders and in a way that makes explicit commonalities and differences among animal models and human neurodegenerative disease. Creating ontologies for diseases and disorders is a very challenging task (Gupta et al., 2003) because of the complexity of the disorders and because of the limitations of current ontology formalisms. In order to simplify the approach and make it practical for use in information systems, we have focused on formal descriptions of phenotypes associated with diseases and animal models rather than on a formal model of the disease process itself. We employ the modular ontologies developed as part of the Neuroscience Information Framework (NIF: http://nif.nih.gov) and the Phenotype and Trait Ontology (PATO), an ontology of qualities associated with biological phenotypes, to create a flexible template for creating phenotypic statements at the class and instance levels. We show how these phenotypes can be used to look for commonalities across multiple neurodegenerative conditions and animal models.
Proper citation: Disease Phenotype Ontology (RRID:SCR_008687) Copy
http://www.opentox.org/dev/apis/api-1.1/structure
Tools for the integration of data from various sources (public and confidential), for the generation and validation of computer models for toxic effects, libraries for the development and seamless integration of new algorithms, and scientifically sound validation routines. The goal of OpenTox is to develop an interoperable predictive toxicology framework which may be used as an enabling platform for the creation of predictive toxicology applications. OpenTox is relevent for users from a variety of research areas: Toxicological and chemical experts (e.g. risk assessors, drug designers, researchers) computer model developers and algorithm developers non specialists requiring access to Predictive Toxicology models and data OpenTox applications can combine multiple web services providing users access to distributed toxicological resources including data, computer models, validation and reporting. Applications are based on use cases that satisfy user needs in predictive toxicology. OpenTox was initiated as a collaborative project involving a combination of different enterprise, university and government research groups to design and build the initial OpenTox framework. Additionally numerous organizations with industry, regulatory or expert interests are active in providing guidance and direction. The goal is to expand OpenTox as a community project enabling additional expert and user participants to be involved in developments in as timely a manner as possible. To this end, our mission is to carry out developments in an open and transparent manner from the early days of the project, and to open up discussions and development to the global community at large, who may either participate in developments or provide user perspectives. Cooperation on data standards, data integration, ontologies, integration of algorithm predictions from different methods, and testing and validation all have significant collaboration opportunities and benefits for the community. OpenTox is working to meet the requirements of the REACH legislation using alternative testing methods to contribute to the reduction of animal experiments for toxicity testing. Relevant international authorities (e.g., ECB, ECVAM, US EPA, US FDA) and industry organizations participate actively in the advisory board of the OpenTox project and provide input for the continuing development of requirement definitions and standards for data, knowledge and model exchange. OpenTox actively supports the development and validation of in silico models and algorithms by improving the interoperability between individual systems (common standards for data and model exchange), increasing the reproducibility of in silico models (by providing a quality source of structures, toxicity data and algorithms) and by providing scientifically sound and easy-to-use validation routines. OpenTox is committed to the support and integration of alternative testing methods using in vitro assay approaches, systems biology, stem cell technology, and the mining and analysis of human epidemiological data. Hence the framework design must take into account extensibility to satisfy a broad range of scientific developments and use cases.
Proper citation: OpenTox Framework (RRID:SCR_008686) Copy
http://psychiatry.stanford.edu/alzheimer/
Portal for gerontology research with a variety of clinical, research and educational programs, with the aim of improving the lives of those affected by Alzheimer's Disease and memory losses associated with normal aging. The Center investigates the nature of Alzheimer's Disease, its progression over time, its response to treatments, and problems patients and caregivers experience in dealing with the changes that occur. It also conducts studies that look at changes that occur over the course of normal aging and have a Normal Aging Brain Donor Program. The Aging Clinical Research Center puts out a newsletter that showcases various projects and includes informative articles on dementia.
Proper citation: Stanford/VA Aging Clinical Research Center (RRID:SCR_008678) Copy
http://en.wikibooks.org/wiki/Main_Page
Community wiki for an open-content textbooks collection that anyone can improve or add to, start new books, and join project-related discussions in the reading rooms. Contributors maintain the property rights to their contributions, while the Creative Commons Attribution-ShareAlike License and the GNU Free Documentation License makes sure that the submitted version and its derivative works will always remain freely distributable and reproducible. Categories include: Computing, Engineering, Humanities, Languages, Mathematics, Miscellaneous, Science, Social sciences, All subjects. Wikibooks has two sub-projects; Wikijunior which is aimed at children and the Cookbook which is a collection of recipes and culinary topics. * 2,440 books with 40,746 pages (March 2012)
Proper citation: Wikibooks (RRID:SCR_008799) Copy
http://www.med.upenn.edu/cndr/index.shtml
A research institution which conducts clinical research to understand brain dysfunction and degeneration in Alzheimer's disease (AD), Parkinson's disease (PD), Frontotemporal disease (FTD), Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's disease), and other age-related neurodegenerative disorders. This organization also houses a general training program that has a focus on drug discovery. This program teaches trainees in etiology, pathogenesis, and diagnosis and treatment of Alzheimer's disease, Parkinson's disease, frontotemporal dementias, motor neuron disease and related disorders. This program also trains Ph.D and M.D/Ph.D students, as well scientists, physicians, and veterinarians who have already completed their advanced degree and are looking for a postdoctoral research fellowship. The program is designed to give a solid background in basic and translational neuroscience, and related disciplines.
Proper citation: University of Pennsylvania Center for Neurodegenerative Disease Research (RRID:SCR_008798) Copy
PathoNet is a virtual meeting place for pathologists from all over the world. They can use it as a virtual pathology laboratory in which they can exchange their views on their cases. Join us and share your experience. Special or rare cases maybe very useful in the diagnostic practice. Everybody who would like to use digital microscopy in human, veterinary or forensic pathology; in laboratory medicine, in human anatomy; in experimental research, and when teaching can benefit from this resource. Additionally, practicing physicians, students, tutors, experts and researchers can all contribute and benefit from PathoNet. Sponsors: This resource is supported by 3DHISTECH Ltd.
Proper citation: PATHONET (RRID:SCR_008674) Copy
http://www.scioncorp.com/pages/product_prices.htm#Software
THIS RESOURCE IS NO LONGER IN SERVICE, documented on July 17, 2013. Commercial software vendor.
Proper citation: Scion Image (RRID:SCR_008673) Copy
http://code.google.com/p/drgap/
Designed to identify Driver Genes and Pathways in cancer genome sequencing studies.
Proper citation: DrGaP (RRID:SCR_008670) Copy
http://www.raetschlab.org/suppl/qpalma
An alignment tool targeted to align spliced reads produced by Next Generation sequencing platforms such as Illumina Solexa or 454.
Proper citation: QPALMA (RRID:SCR_008791) Copy
Provides support for the Apache community of open-source software projects. The Apache projects are characterized by a collaborative, consensus based development process, open and pragmatic software license, and a desire to create high quality software that leads the way in its field.
Proper citation: Apache Software Foundation (RRID:SCR_008588) Copy
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