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http://r3cseq.genereg.net/Site/index.html

An R/Bioconductor package to identify chromosomal interaction regions generated by chromosome conformation capture (3C) coupled to next-generation sequencing (NGS), a technique termed 3C-seq. It performs data analysis for a number of different experimental designs, as it can analyze 3C-seq data with or without a control experiment and it can be used to facilitate data analysis for experiments with multiple replicates. The r3Cseq package provides functions to perform data normalization, statistical analysis for cis/trans interactions and visualization in order to help scientists identify genomic regions that physically interact with the given viewpoints of interest. This tool greatly facilitates hypothesis generation and the interpretation of experimental results.

Proper citation: r3Cseq (RRID:SCR_003198) Copy   

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http://www.broadinstitute.org/scientific-community/science/programs/medical-and-population-genetics/haploview/haploview

A Java based software tool designed to simplify and expedite the process of haplotype analysis by providing a common interface to several tasks relating to such analyses. Haploview currently allows users to examine block structures, generate haplotypes in these blocks, run association tests, and save the data in a number of formats. All functionalities are highly customizable. (entry from Genetic Analysis Software) * LD & haplotype block analysis * haplotype population frequency estimation * single SNP and haplotype association tests * permutation testing for association significance * implementation of Paul de Bakker's Tagger tag SNP selection algorithm. * automatic download of phased genotype data from HapMap * visualization and plotting of PLINK whole genome association results including advanced filtering options Haploview is fully compatible with data dumps from the HapMap project and the Perlegen Genotype Browser. It can analyze thousands of SNPs (tens of thousands in command line mode) in thousands of individuals. Note: Haploview is currently on a development and support freeze. The team is currently looking at a variety of options in order to provide support for the software. Haploview is an open source project hosted by SourceForge. The source can be downloaded at the SourceForge project site.

Proper citation: Haploview (RRID:SCR_003076) Copy   

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https://sites.google.com/site/bctnet/datasets

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 5, 2023. This site has a collection of cortical connectivity datasets and modeling software components that can be downloaded and used for modeling of cortical circuits. The toolbox combines Matlab functions and neuroanatomical data sets useful in the analysis of structural or functional brain networks. Several people have made contributions and if you wish to contribute yourself with a new function or set of functions please contact osporns_at_indiana.edu.The following is a collection of commonly used large scale cortical connectivity data sets compiled from tract-tracing studies. Hence nodes represent cortical areas and links represent large cortico-cortical tracts. * macaque71.mat (BD network). Macaque cortical connectivity: 71 nodes 746 links. Reference: Young (1993). Contributor: OS. Used in e.g. Sporns (2002). * fve30.mat; fve32.mat (BD networks). Two version the macaque visual cortex. fve30.mat: 30 nodes 311 links. fve32.mat: 32 nodes 320 links. Reference: Felleman and van Essen (1991). Contributor: OS. Used in e.g. Sportns et al. (2000) Sporns and Kotter (2004). * macaque47.mat (BD network). Large scale cortico-cortical connectivity matrix of the visual and sensorimotor areas in the macaque. 47 nodes; 505 links. Used in e.g. Honey et al. (2007). Contributor: RK. * cat.mat (WD networks). Connection matrices of cat cortex. CIJall contains all cortical and thalamic areas: 95 nodes 2126 links. CIJctx contains only 52 cortical areas: 52 nodes 820 links. Reference: Scannell et al. (1999). Contributor: OS. Used in e.g. Sporns and Zwi (2004) Sporns and Kotter (2004). * DSIhumanctx.mat (WU networks).

Proper citation: Cortical connectivity data sets (RRID:SCR_003190) Copy   

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https://www.assays.co.il

Commercial organization that provides services for assay development, research histopathology, and early stage project consultation.

Proper citation: Smart Assays (RRID:SCR_003195) Copy   

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http://rsb.info.nih.gov/nih-image/index.html

Public image processing and analysis program for Macintosh.

Proper citation: NIH Image (RRID:SCR_003073) Copy   

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https://github.com/quwubin/MFEprimer/

A fast thermodynamics-based software program for checking PCR primer specificity against genomic DNA and mRNA/cDNA sequence databases.

Proper citation: MFEprimer (RRID:SCR_003066) Copy   

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http://sourceforge.net/projects/mipe/

A XML format that enables genomics researchers to store critical information on PCR experiments. Accompagnying perl scripts are written to read from (dbSTS) or write to a MIPE XML file.

Proper citation: MIPE (RRID:SCR_003065) Copy   

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https://grey.colorado.edu/emergent/index.php/PDP%2B%2B

THIS RESOURCE IS NO LONGER IN SERVICE, documented August 23, 2016. The PDP++ software is a neural-network simulation system written in C++. It represents the next generation of the PDP software originally released with the McClelland and Rumelhart Explorations in Parallel Distributed Processing Handbook, MIT Press, 1987. It is easy enough for novice users, but very powerful and flexible for research use. The new version of PDP++, released 8/21/07, is now called Emergent.

Proper citation: PDP++ Software Home Page (RRID:SCR_003064) Copy   

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https://code.google.com/p/mpprimer/

A software program for reliable multiplex PCR primer design. It employs the widely used primer design program Primer3 and the primer specificity evaluation program MFEprimer to design and evaluate the candidate primers based on genomic or transcript DNA database, followed by careful examination to avoid primer dimerization. The graph-expanding algorithm derived from the greedy algorithm was used to determine the optimal primer set combinations (PSCs) for multiplex PCR. In addition, it provides a virtual electrophotogram to help users choose the best PSC. It is a valuable tool for designing specific, no dimer formation and amplicons size constrained PSCs to improve the multiplex PCR experiments.

Proper citation: MPprimer (RRID:SCR_003063) Copy   

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http://creskolab.uoregon.edu/stacks/

A software pipeline for building loci from short-read sequences, such as those generated on the Illumina platform. It was developed to work with restriction enzyme-based data, such as RAD-seq, for the purpose of building genetic maps and conducting population genomics and phylogeography.

Proper citation: Stacks (RRID:SCR_003184) Copy   

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http://www.bioconductor.org/packages/release/bioc/html/triplex.html

Software package that provides functions for identification and visualization of potential intramolecular triplex patterns in DNA sequence. The main functionality is to detect the positions of subsequences capable of folding into an intramolecular triplex (H-DNA) in a much larger sequence. The potential H-DNA (triplexes) should be made of as many canonical nucleotide triplets as possible. The package includes visualization showing the exact base-pairing in 1D, 2D or 3D.

Proper citation: Triplex (RRID:SCR_003061) Copy   

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http://purl.bioontology.org/ontology/ICNP

Ontology of the international classification for nursing practice.

Proper citation: International Classification for Nursing Practice (RRID:SCR_003099) Copy   

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http://www.wormbase.org

Central data repository for nematode biology including complete genomic sequence, gene predictions and orthology assignments from range of related nematodes.Data concerning genetics, genomics and biology of C. elegans and related nematodes. Derived from initial ACeDB database of C. elegans genetic and sequence information, WormBase includes genomic, anatomical and functional information of C. elegans, other Caenorhabditis species and other nematodes. Maintains public FTP site where researchers can find many commonly requested files and datasets, WormBase software and prepackaged databases.

Proper citation: WormBase (RRID:SCR_003098) Copy   

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http://www.nigms.nih.gov/Research/

NIGMS places great emphasis on the support of individual, investigator-initiated grants within its scientific mission areas. Most grants are for research projects (R01), but NIGMS also funds program projects (P01) as well as some research resources. The Institute encourages research in certain scientific areas through requests for applications and program announcements. This website has information for upcoming grants, minority grants as well as training opportunities in medical research in the following disciplines: cell biology, biophysics, genetics, developmental biology, pharmacology, physiology, biological chemistry, bioinformatics, and computational biology.

Proper citation: National Institute of General Medical Sciences: Research Funding (RRID:SCR_003096) Copy   

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http://genome.ucsc.edu/cgi-bin/hgPcr?command=start

Tool that searches a sequence database with a pair of PCR primers, using an indexing strategy for fast performance. When successful, the search returns a sequence output file in fasta format containing all sequence in the database that lie between and include the primer pair. The fasta header describes the region in the database and the primers. The fasta body is capitalized in areas where the primer sequence matches the database sequence and in lower-case elsewhere. Sources and executables to run batch jobs on your own server are available free for academic, personal, and non-profit purposes. Non-exclusive commercial licenses are also available.

Proper citation: In-Silico PCR (RRID:SCR_003089) Copy   

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http://empress.har.mrc.ac.uk

Database of validated Standard Operating Procedures (SOPs) for screens to determine the phenotype of a mouse, developed by the EUMORPHIA consortium. The SOP's cover all of the main body systems including: clinical chemistry, hormonal and metabolic systems, cardiovascular, allergy and infection, renal function, sensory function, neurological and behavioral function, cancer, bone and cartilage, and respiratory function. In addition, there are generic SOPs in histology, necropsy, pathology and gene expression. EMPReSS is a platform of individual tests. These can be performed as individual tests or grouped together in sequences, recommended in the EMPReSS database, to give more information on particular phenotype. Quick List of Current Pipelines: * EUMODIC Pipeline 1 * EUMODIC Pipeline 2 * GMC Pipeline * MGP Pipeline * Additional Tests * EUMODIC Pipeline 3

Proper citation: European Mouse Phenotyping Resource of Standardised Screens (RRID:SCR_003087) Copy   

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http://elm.eu.org

Computational biology resource for investigating candidate functional sites in eukarytic proteins. Functional sites which fit to the description linear motif are currently specified as patterns using Regular Expression rules. To improve the predictive power, context-based rules and logical filters are being developed and applied to reduce the amount of false positives. The current version of the ELM server provides core functionality including filtering by cell compartment, phylogeny, globular domain clash (using the SMART/Pfam databases) and structure. In addition, both the known ELM instances and any positionally conserved matches in sequences similar to ELM instance sequences are identified and displayed (see ELM instance mapper). Although the ELM resource contains a large collection of functional site motifs, the current set of motifs is not exhaustive.

Proper citation: Eukaryotic Linear Motif (RRID:SCR_003085) Copy   

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http://sourceforge.net/projects/gemi/

Automated software tool to design polymerase chain reaction (PCR) primers. It accepts multiple aligned and long sequences with degenerated nucleotides. It can be used for quantitative/real-time PCR, conventional and Sanger sequencing. Gemi accepts DNA and RNA sequences with degenerate nucleotide (non-A/C/G/T bases). The programs are as the following: # The first program is to design PCR primers from multiple sequence alignment. # Program to convert ClustalW format (.aln), Phylip (.phy) and (.gde) formats to Fasta format. # Reverse and/or complement program is to find the reverse and complement counterpart of single or multiple sequences.

Proper citation: Gemi (RRID:SCR_003211) Copy   

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http://sourceforge.net/projects/vtontology/

A controlled vocabulary for the description of traits (measurable or observable characteristics) pertaining to the morphology, physiology, or development of vertebrate organisms.

Proper citation: Vertebrate Trait Ontology (RRID:SCR_003214) Copy   

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http://www.popgen.dk/software/index.php/NgsAdmix

A tool for finding admixture proportions from next generation sequencing (NGS) data that is based on genotype likelihoods. It is a multithreaded c/c++ program.

Proper citation: NGSadmix (RRID:SCR_003208) Copy   

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