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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Specification URL Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
Down Syndrome Research and Treatment Foundation
 
Resource Report
Resource Website
Down Syndrome Research and Treatment Foundation (RRID:SCR_006637) DSRTF institution The Down Syndrome Research and Treatment Foundation is dedicated to finding a treatment to improve cognition including learning, memory and speech for individuals with Down syndrome. Since our founding in 2004 we have become the leading private source of funding in the United States for Down syndrome cognition research. The mission of DSRTF is to stimulate biomedical research that will accelerate the development of treatments to significantly improve cognition, including memory, learning and speech, for individuals with Down syndrome in order that they: * participate more successfully in school; * lead more active and independent lives; * and avoid the early onset of Alzheimer''s Disease. DSRTF is funding research that applies the information, tools and techniques resulting from the genome project along with recent advances in brain research to the study of cognition in Down syndrome. Our goal is the development of treatments that will improve learning, memory, and speech, and therefore enhance the lives of those with Down syndrome and their families. The majority of individuals with Down syndrome fall into the mild to moderate range of cognitive impairment. For many of these individuals, a 10%-20% improvement in cognitive ability would provide them with the ability to live independently, hold a job and be fully integrated within their communities. grid.478821.0, ISNI: 0000 0004 5902 2167, nlx_143653, Crossref funder ID: 100006836 https://ror.org/02m0a5h24 SCR_006637 2026-08-15 11:23:25 0
Ribosomal Database Project
 
Resource Report
Resource Website
1000+ mentions
Ribosomal Database Project (RRID:SCR_006633) RDP data or information resource, resource, database A database which provides ribosome related data services to the scientific community, including online data analysis, rRNA derived phylogenetic trees, and aligned and annotated rRNA sequences. It specifically contains information on quality-controlled, aligned and annotated bacterial and archaean 16S rRNA sequences, fungal 28S rRNA sequences, and a suite of analysis tools for the scientific community. Most of the RDP tools are now available as open source packages for users to incorporate in their local workflow. microbiome, database, rrna gene sequence, rrna, ribosome, genome browser, high-throughput sequencing, bacteria, archaea, fungi, FASEB list is listed by: OMICtools
is listed by: Human Microbiome Project
has parent organization: Michigan State University; Michigan; USA
is parent organization of: RDPipeline
DOE DE-FG02-99ER62848;
DOE DE-SC0004601;
DOE DE-FC02-07ER64494;
NIEHS P42 ES004911;
NSF DBI-0328255;
USDA 2008-35107-04542;
NHLBI U01HL098961;
NIDDK UH3 DK083993
PMID:24288368
PMID:17586664
Open source r3d100012372, nif-0000-03404, OMICS_01513 https://doi.org/10.17616/R3C087 SCR_006633 Ribosomal Database Project 2026-08-15 11:23:26 1724
Ligand Expo
 
Resource Report
Resource Website
Ligand Expo (RRID:SCR_006636) data or information resource, resource, database An integrated data resource for finding chemical and structural information about small molecules bound to proteins and nucleic acids within the structure entries of the Protein Data Bank. Tools are provided to search the PDB dictionary for chemical components, to identify structure entries containing particular small molecules, and to download the 3D structures of the small molecule components in the PDB entry. A sketch tool is also provided for building new chemical definitions from reported PDB chemical components. element, fingerprint, formula, amino acid, aromatic ring, atom, bound, carbon, chemical, component, depot, ligand, molecular, molecule, nitrogen, nucleic acid, nucleotide, pharmaceutical, protein, small molecule, structure, macromolecule, model uses: Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB)
uses: Worldwide Protein Data Bank (wwPDB)
has parent organization: Rutgers University; New Jersey; USA
has parent organization: Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB)
NSF ;
NIGMS ;
DOE ;
NLM ;
NCI ;
NCRR ;
NIBIB ;
NINDS ;
NIDDK
PMID:15059838 nif-0000-21237, OMICS_02751 http://ligand-depot.rutgers.edu/ SCR_006636 Ligand Depot 2026-08-15 11:23:21 0
NiftySim
 
Resource Report
Resource Website
1+ mentions
NiftySim (RRID:SCR_006591) NiftySim software resource A high-performance nonlinear finite element solver. A key feature is the option of GPU-based execution, which allows the solver to significantly out-perform equivalent commercial packages. pet, spect is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)
has parent organization: University College London; London; United Kingdom
BSD License nlx_155900 http://www.nitrc.org/projects/niftysim SCR_006591 Nifty Sim 2026-08-15 11:23:25 3
LexGrid
 
Resource Report
Resource Website
1+ mentions
LexGrid (RRID:SCR_006627) LexGrid software resource LexGrid (Lexical Grid) provides support for a distributed network of lexical resources such as terminologies and ontologies via standards-based tools, storage formats, and access/update mechanisms. The Lexical Grid Vision is for a distributed network of terminological resources. It is the foundation of the National Center for Biomedical Ontology BioPortal interface and web-services, and can parse OBO format, as well as other formats such as OWL. Currently, there are many terminologies and ontologies in existence. Just about every terminology has its own format, its own set of tools, and its own update mechanisms. The only thing that most of these pieces have in common with each other is their incompatibility. This makes it very hard to use these resources to their full potential. We have designed the Lexical Grid as a way to bridge terminologies and ontologies with a common set of tools, formats and update mechanisms. The Lexical Grid is: * accessible through a set of common APIs * joined through shared indices * online accessible * downloadable * loosely coupled * locally extendable * globally revised * available in web-space on web-time * cross-linked The realization of this vision requires three interlocking components, which are: * Standards - access methods and formats need to be published and openly available * Tools - standards based tools must be readily available * Content - commonly used terminologies have to be available for access and download Platform: Windows compatible, Mac OS X compatible, Linux compatible, Unix compatible software library, parse, ontology is listed by: BioPortal
is listed by: Gene Ontology Tools
is related to: Gene Ontology
is related to: OBO
has parent organization: European Bioinformatics Institute
has parent organization: National Cancer Institute
NIH ;
Cancer Biomedical Informatics Grid ;
NLM LM07319
PMID:19261933 Free for academic use nlx_149194 http://www.lexgrid.org/ SCR_006627 Lexical Grid 2026-08-15 11:23:25 1
ALEXA-Seq
 
Resource Report
Resource Website
1+ mentions
ALEXA-Seq (RRID:SCR_006700) ALEXA-Seq software resource A method for using massively parallel paired-end transcriptome sequencing for ''alternative expression analysis''. is listed by: OMICtools OMICS_01328 SCR_006700 2026-08-15 11:23:26 6
SpliceGrapher
 
Resource Report
Resource Website
10+ mentions
SpliceGrapher (RRID:SCR_006657) SpliceGrapher software resource Software that predicts alternative splicing patterns and produces splice graphs that capture in a single structure the ways a gene''s exons may be assembled. It enhances gene models using evidence from next-generation sequencing and EST alignments. is listed by: OMICtools
has parent organization: SourceForge
PMID:22293517 OMICS_01266 SCR_006657 2026-08-15 11:23:26 22
ChIPXpress
 
Resource Report
Resource Website
1+ mentions
ChIPXpress (RRID:SCR_006653) ChIPXpress software resource A R package designed to improve ChIP-seq and ChIP-chip target gene ranking using publicly available gene expression data. It takes as input predicted transcription factor (TF) bound genes from ChIPx data and uses a corresponding database of gene expression profiles downloaded from NCBI GEO to rank the TF bound targets in order of which gene is most likely to be functional TF target. gene expression, chip-seq, chip-chip, transcription factor, target gene, gene, gene expression profile is listed by: OMICtools
is related to: Gene Expression Omnibus
has parent organization: Bioconductor
GNU General Public License, v2 or greater OMICS_00516 SCR_006653 ChIPXpress: enhanced transcription factor target gene identification from ChIP-seq and ChIP-chip data using publicly available gene expression profiles 2026-08-15 11:23:26 2
Promega
 
Resource Report
Resource Website
10000+ mentions
Promega (RRID:SCR_006724) commercial organization An Antibody supplier nlx_152434 SCR_006724 2026-08-15 11:23:26 93363
Web Game for Collaborative Labeling
 
Resource Report
Resource Website
1+ mentions
Web Game for Collaborative Labeling (RRID:SCR_006685) Web Game for Collaborative Labeling software resource Web game that provides an innovative infrastructure for labeling to enable an alternative to expert raters for medical image labeling through statistical analysis of the collaborative efforts of many, minimally-trained raters. Statistical atlases of regional brain anatomy have proven to be extremely useful in characterizing the relationship between the structure and function of the human nervous system. Typically, an expert human rater manually examines each slice of a three-dimensional volume. This approach can be exceptionally time and resource intensive, so cost severely limits the clinical studies where subject-specific labeling is feasible. Methods for improved efficiency and reliability of manual labeling would be of immense benefit for clinical investigation into morphological correlates of brain function. magnetic resonance, labeling, crowdsourcing is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC) GNU Lesser General Public License nlx_156019 http://www.nitrc.org/projects/webmill SCR_006685 2026-08-15 11:23:26 2
SoftSearch
 
Resource Report
Resource Website
1+ mentions
SoftSearch (RRID:SCR_006683) SoftSearch software resource A sensitive structural variant (SV) detection software tool for Illumina paired-end next-generation sequencing data. It simultaneously utilizes soft-clipping and read-pair strategies for detecting SVs to increase sensitivity. Soft clips are proxies for split-reads that indicate part of the read maps to the reference genome, but the other part is not localized at the same place (e.g. breakpoint spanning reads). Discordant read-pairs refer to a read and its mate, where the insert size is greater (or less than) the expected distribution of the dataset ? or ? where the mapping orientation of the reads is unexpected (e.g. both on the same strand). SoftSearch looks for areas with soft-clipping in the genome that have discordant read pairs supporting the anomaly. Once areas with both these conditions are identified, the read and mate information is extracted directly from the BAM file containing the discordant reads, obviating the need for time-consuming and error-prone complex alignment strategies. Only a small number of soft-masked bases discordant read-pairs are necessary to identify an SV, which on their own would not be sufficient to make an SV call, thus highlighting SoftSearch?s improved sensitivity. SoftSearch is well suited to be ?plugged in? to most sequence analysis workflows, since it requires standard file inputs, such as a BAM file using almost any aligner and a reference genome FASTA file. Because SoftSearch requires soft-masked bases, the only requirement is that the aligner must have this functionality, which is usually turned on by default by many standard aligners (e.g. BWA, Novoalign, etc). illumina, structural variant, next-generation sequencing, perl, academic is listed by: OMICtools
has parent organization: Google Code
GNU General Public License, v2 OMICS_00322 SCR_006683 SoftSearch - Detecting Structural Variations Using Split Reads and Discordant Read Pairs 2026-08-15 11:23:26 5
GREC Corpus
 
Resource Report
Resource Website
1+ mentions
GREC Corpus (RRID:SCR_006719) GREC training set A semantically annotated corpus of 240 MEDLINE abstracts (167 on the subject of E. coli species and 73 on the subject of the Human species) intended for training information extraction (IE) systems and/or resources which are used to extract events from biomedical literature. The corpus has been manually annotated with events relating to gene regulation by biologists. Each event is centered on either a verb (e.g. transcribe) or nominalized verb (e.g. transcription) and annotation consists of identifying, as exhaustively as possible, the structurally-related arguments of the verb or nominalized verb within the same sentence. Each event argument is then assigned the following information: * A semantic role from a fixed set of 13 roles which are tailored to the biomedical domain. * A biomedical concept type (where appropriate). The corpus in available for download in 2 formats: * A standoff format, based on the BioNLP'09 Shared Task format * An XML format, based on the GENIA event annotation format annotation, information extraction, text mining, semantic role, semantic search, gene, computational linguistics, gene regulation is listed by: FORCE11
is related to: MEDLINE
has parent organization: National Centre for Text Mining
JISC PMID:19852798 Creative Commons Attribution-NonCommercial-ShareAlike License, v3 Unported, For Copyright of abstracts refer to PubMed. nif-0000-06688 SCR_006719 Gene Event Regulation Corpus 2026-08-15 11:23:26 3
InnateDB
 
Resource Report
Resource Website
500+ mentions
InnateDB (RRID:SCR_006714) InnateDB data or information resource, database Publicly available database of the genes, proteins, experimentally-verified interactions and signaling pathways involved in the innate immune response of humans, mice and bovines to microbial infection. The database captures coverage of the innate immunity interactome by integrating known interactions and pathways from major public databases together with manually-curated data into a centralized resource. The database can be mined as a knowledgebase or used with the integrated bioinformatics and visualization tools for the systems level analysis of the innate immune response. Although InnateDB curation focuses on innate immunity-relevant interactions and pathways, it also incorporates detailed annotation on the entire human, mouse and bovine interactomes by integrating data (178,000+ interactions & 3,900+ pathways) from several of the major public interaction and pathway databases. InnateDB also has integrated human, mouse and bovine orthology predictions generated using Ortholgue software. Ortholgue uses a phylogenetic distance-based method to identify possible paralogs in high-throughput orthology predictions. Integrated human and mouse conserved gene order and synteny information has also been determined to provide further support for orthology predictions. InnateDB Capabilities: * View statistics for manually-curated innate immunity relevant molecular interactions. New manually curated interactions are submitted weekly. * Search for genes and proteins of interest. * Search for experimentally-verified molecular interactions by gene/protein name, interaction type, cell type, etc. * Search genes/interactions belonging to 3,900 pathways. * Visualize interactions using an intuitive subcellular localization-based layout in Cerebral. * Upload your own list of genes along with associated gene expression data (from up to 10 experimental conditions) to interactively analyze this data in a molecular interaction network context. Once you have uploaded your data, you will be able to interactively visualize interaction networks with expression data overlaid; carry out Pathway, Gene Ontology and Transcription Factor Binding Site over-representation analyses; construct orthologous interaction networks in other species; and much more. * Access curated interaction data via a dedicated PSICQUIC webservice. gene, immune response, pathway, protein, signaling pathway, interaction, immune, signaling response, gene, orthology prediction, orthology, ortholg, annotation, interactome, gene expression, molecule, protein-protein interaction, molecular interaction, visualization, nucleic acid-protein, nucleic acid, network, web service, transcription factor binding site, software resource, FASEB list is listed by: re3data.org
is related to: IMEx - The International Molecular Exchange Consortium
is related to: Interaction Reference Index
is related to: ConsensusPathDB
is related to: IMEx - The International Molecular Exchange Consortium
is related to: PSICQUIC Registry
is related to: PSICQUIC Registry
is related to: Gene Ontology
is related to: IntAct
has parent organization: Simon Fraser University; British Columbia; Canada
has parent organization: University of British Columbia; British Columbia; Canada
works with: IMEx - The International Molecular Exchange Consortium
Microbial infection, Allergy, Asthma Michael Smith Foundation for Health Research ;
AllerGen 12ASI1;
AllerGen 12B&B2;
Teagasc RMIS6018;
European Union PSIMEx project contract FP7-HEALTH-2007-223411
PMID:23180781
PMID:18766178
Free, Freely available nif-0000-20808, r3d100010676 https://doi.org/10.17616/R36S43 SCR_006714 A Knowledge Resource for Innate Immunity Interactions and Pathways, InnateDB: Systems Biology of the Innate Immune Response, InnateDB - A Knowledge Resource for Innate Immunity Interactions and Pathways 2026-08-15 11:23:27 571
University of Quebec Hospital Centre; Quebec; Canada
 
Resource Report
Resource Website
University of Quebec Hospital Centre; Quebec; Canada (RRID:SCR_006740) CHUQ university Network of three teaching hospitals affiliated with the medical school of Université Laval and several specialized institutions in Quebec City. is related to: Cancer Research Network of the FRSQ
has parent organization: Laval University; Quebec; Canada
Wikidata:Q3145390, nlx_158566, grid.417661.3, ISNI:0000 0001 2190 0479 https://ror.org/034sbqc84 SCR_006740 University of Quebec Hospital Center, University of Quebec Hospital Centre, CHU de Qu�bec, Centre hospitalier universitaire de Quebec, CHU de Quebec, Centre hospitalier universitaire de Qu�bec 2026-08-15 11:23:27 0
EDASeq
 
Resource Report
Resource Website
100+ mentions
EDASeq (RRID:SCR_006751) EDASeq software resource Software for numerical and graphical summaries of RNA-Seq read data. Within-lane normalization procedures to adjust for GC-content effect (or other gene-level effects) on read counts: loess robust local regression, global-scaling, and full-quantile normalization (Risso et al., 2011). Between-lane normalization procedures to adjust for distributional differences between lanes (e.g., sequencing depth): global-scaling and full-quantile normalization (Bullard et al., 2010)., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. data analysis, normalization, rna-seq is listed by: OMICtools
has parent organization: Bioconductor
has parent organization: National Cancer Institute
THIS RESOURCE IS NO LONGER IN SERVICE OMICS_01231 SCR_006751 EDASeq: Exploratory Data Analysis and Normalization for RNA-Seq data 2026-08-15 11:23:22 255
POLGUI - Matlab Polhemus Interface
 
Resource Report
Resource Website
1+ mentions
POLGUI - Matlab Polhemus Interface (RRID:SCR_006752) POLGUI software resource An interface between MATLAB and the Polhemus Fastrak digitizer used to digitize fiducial locations and scalp EEG electrode locations. There are 5 versions all of which work under MATLAB R14 (on both linux and windows platforms), # polgui_ver1_r14 : works with 1 receiver (stylus pen) # polgui_ver2_r14 : works with 2 receivers (including the pen) # polgui_ver3_r14 : works with 3 receivers(including the pen) # polgui_ver4_r14 : works with 4 receivers (including the pen) # polgui_ver5_r14 : Generic version which works with 1/2/3/4 receivers (WARNING: Ver 5 might be buggy; not fully tested) Requirements: MATLAB R14 (Linux/Windows) eeg, meg, electrocorticography, linux, matlab, microsoft, magnetic resonance, posix/unix-like, win32 (ms windows), windows is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)
has parent organization: SourceForge
BSD License nlx_155915 http://www.nitrc.org/projects/polgui SCR_006752 POLGUI - Matlab GUI for Polhemus Fastrak 2026-08-15 11:23:27 5
mubiomics
 
Resource Report
Resource Website
1+ mentions
mubiomics (RRID:SCR_006785) mubiomics software resource A set of scripts (mostly python) for processing reads generated by the Roche 454 or Illumina next-gen sequencing platforms. Included are quality control, read demultiplexing and microbiome characterisation scripts for use with usearch, pplacer and RDP classifier. is listed by: OMICtools
has parent organization: SourceForge
OMICS_01059 SCR_006785 mubiomics - Scripts for processing next-gen sequencing data 2026-08-15 11:23:23 4
ShortRead
 
Resource Report
Resource Website
100+ mentions
ShortRead (RRID:SCR_006813) ShortRead software resource Software package for input, quality assessment and exploration of high-throughput sequence data. Used for input, quality assurance, and basic manipulation of `short read'' DNA sequences such as those produced by Solexa, 454, and related technologies, including exible import of common short read data formats. high throughput sequence data, short read, DNA sequences, short read data is listed by: OMICtools
is listed by: Debian
is listed by: SoftCite
has parent organization: Bioconductor
PMID:19654119 Free, Available for download, Freely available OMICS_01076 https://sources.debian.org/src/r-bioc-shortread/ SCR_006813 ShortRead - Classes and methods for high-throughput short-read sequencing data. 2026-08-15 11:23:23 235
mutationSeq
 
Resource Report
Resource Website
10+ mentions
mutationSeq (RRID:SCR_006815) mutationSeq software resource A software suite using feature-based classifiers for somatic mutation prediction from paired tumour/normal next-generation sequencing data. mutationSeq has the advantages of integrating different features (e.g., base qualities, mapping qualities, strand bias, and tailed distance features), and validated somatic mutations to make predictions. Given paired normal/tumour bam files, mutationSeq will output the probability of each candidate site being somatic. next-generation sequencing, somatic mutation, tumor, normal is listed by: OMICtools
is related to: JointSNVMix
has parent organization: BC Cancer Agency
Tumor, Normal PMID:22084253 OMICS_00086 SCR_006815 2026-08-15 11:23:28 24
University of Rostock; Mecklenburg-Vorpommern; Germany
 
Resource Report
Resource Website
1+ mentions
University of Rostock; Mecklenburg-Vorpommern; Germany (RRID:SCR_006816) university Public university located in Rostock, Mecklenburg-Vorpommern, Germany. Founded in 1419. is parent organization of: neuroVIISAS
is parent organization of: SysZNF - C2H2 Zinc Finger genes
nlx_151399, grid.10493.3f, Wikidata:Q159895, ISNI:121858338 https://ror.org/03zdwsf69 SCR_006816 Universit�t Rostock, University of Rostock, Universitat Rostock 2026-08-15 11:23:23 1

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