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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Specification URL Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
Human Splicing Finder
 
Resource Report
Resource Website
500+ mentions
Human Splicing Finder (RRID:SCR_005181) HSF analysis service resource, service resource, data analysis service, production service resource Software tool to help study pre-mRNA splicing and to better understand intronic and exonic mutations leading to splicing defects. To calculate the consensus values of potential splice sites and search for branch points, new algorithms were developed. Furthermore, they have integrated all available matrices to identify exonic and intronic motifs, as well as new matrices to identify hnRNP A1, Tra2-? and 9G8. splicing, mutation, splicing signal, sequence, transcript, nucleotide, exon, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
is related to: Ensembl
has parent organization: National Institute of Health and Medical Research; Rennes; France
PMID:19339519 Acknowledgement requested biotools:human_splicing_finder, OMICS_00176 https://bio.tools/human_splicing_finder http://www.umd.be/HSF/ SCR_005181 2026-07-27 09:32:13 963
ADGO
 
Resource Report
Resource Website
1+ mentions
ADGO (RRID:SCR_006343) ADGO analysis service resource, service resource, data analysis service, production service resource A web-based tool that provides composite interpretations for microarray data comparing two sample groups as well as lists of genes from diverse sources of biological information. It provides multiple gene set analysis methods for microarray inputs as well as enrichment analyses for lists of genes. It screens redundant composite annotations when generating and prioritizing them. It also incorporates union and subtracted sets as well as intersection sets. Users can upload their gene sets (e.g. predicted miRNA targets) to generate and analyze new composite sets. microarray, gene, annotation, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
PMID:21624890 Acknowledgement requested OMICS_02229, biotools:adgo https://bio.tools/adgo SCR_006343 2026-07-27 09:32:31 3
HMM-TM
 
Resource Report
Resource Website
1+ mentions
HMM-TM (RRID:SCR_006186) HMM-TM analysis service resource, service resource, data analysis service, production service resource A web tool using the Hidden Markov Model method for the topology prediction of alpha-helical membrane proteins that incorporates experimentally derived topological information. Hidden Markov Models (HMMs) have been extensively used in computational molecular biology, for modelling protein and nucleic acid sequences. In many applications, such as transmembrane protein topology prediction, the incorporation of limited amount of information regarding the topology, arising from biochemical experiments, has been proved a very useful strategy that increased remarkably the performance of even the top-scoring methods. However, no clear and formal explanation of the algorithms that retains the probabilistic interpretation of the models has been presented so far in the literature. We present here, a simple method that allows incorporation of prior topological information concerning the sequences at hand, while at the same time the HMMs retain their full probabilistic interpretation in terms of conditional probabilities. We present modifications to the standard Forward and Backward algorithms of HMMs and we also show explicitly, how reliable predictions may arise by these modifications, using all the algorithms currently available for decoding HMMs. A similar procedure may be used in the training procedure, aiming at optimizing the labels of the HMM''s classes, especially in cases such as transmembrane proteins where the labels of the membrane-spanning segments are inherently misplaced. We present an application of this approach developing a method to predict the transmembrane regions of alpha-helical membrane proteins, trained on crystallographically solved data. We show that this method compares well against already established algorithms presented in the literature, and it is extremely useful in practical applications. hidden markov model, topology, prediction, alpha-helical membrane protein, protein, transmembrane, transmembrane alpha-helical protein, bio.tools is listed by: Debian
is listed by: bio.tools
has parent organization: University of Athens Biophysics and Bioinformatics Laboratory
PMID:16597327 Free for academic use nlx_151731, biotools:hmm-tm https://bio.tools/hmm-tm SCR_006186 HMM-TM: Prediction of Transmembrane Alpha-Helical Proteins 2026-07-27 09:32:29 6
PRED-LIPO
 
Resource Report
Resource Website
10+ mentions
PRED-LIPO (RRID:SCR_006187) PRED-LIPO analysis service resource, service resource, data analysis service, production service resource A web tool using the Hidden Markov Model method for the prediction of lipoprotein signal peptides of Gram-positive bacteria, trained on a set of 67 experimentally verified lipoproteins. The method outperforms LipoP and the methods based on regular expression patterns, in various data sets containing experimentally characterized lipoproteins, secretory proteins, proteins with an N-terminal TM segment and cytoplasmic proteins. The method is also very sensitive and specific in the detection of secretory signal peptides and in terms of overall accuracy outperforms even SignalP, which is the top-scoring method for the prediction of signal peptides. hidden markov model, lipoprotein signal peptide, gram-positive bacteria, lipoprotein, prediction, peptide, protein, signal peptide, bio.tools is listed by: Debian
is listed by: bio.tools
has parent organization: University of Athens Biophysics and Bioinformatics Laboratory
National Scholarships Foundation of Greece PMID:19367716 Free nlx_151732, biotools:pred-lipo https://bio.tools/pred-lipo SCR_006187 PRED-LIPO: Prediction of Lipoprotein and Secretory Signal Peptides in Gram-positive Bacteria with Hidden Markov Models 2026-07-27 09:32:29 17
PRED-SIGNAL
 
Resource Report
Resource Website
10+ mentions
PRED-SIGNAL (RRID:SCR_006181) PRED-SIGNAL analysis service resource, service resource, data analysis service, production service resource A web tool for prediction of signal peptides in archaea. Computational prediction of signal peptides (SPs) and their cleavage sites is of great importance in computational biology; however, currently there is no available method capable of predicting reliably the SPs of archaea, due to the limited amount of experimentally verified proteins with SPs. We performed an extensive literature search in order to identify archaeal proteins having experimentally verified SP and managed to find 69 such proteins, the largest number ever reported. A detailed analysis of these sequences revealed some unique features of the SPs of archaea, such as the unique amino acid composition of the hydrophobic region with a higher than expected occurrence of isoleucine, and a cleavage site resembling more the sequences of gram-positives with almost equal amounts of alanine and valine at the position-3 before the cleavage site and a dominant alanine at position-1, followed in abundance by serine and glycine. Using these proteins as a training set, we trained a hidden Markov model method that predicts the presence of the SPs and their cleavage sites and also discriminates such proteins from cytoplasmic and transmembrane ones. signal peptide, prediction, protein, bio.tools is listed by: Debian
is listed by: bio.tools
has parent organization: University of Athens Biophysics and Bioinformatics Laboratory
State Scholarships Foundation of Greece PMID:18988691 Free for academic use biotools:pred-signal, nlx_151728 https://bio.tools/pred-signal SCR_006181 PRED-SIGNAL - Prediction of Signal Peptides in Archaea with Hidden Markov Models 2026-07-27 09:32:28 14
FuncAssociate: The Gene Set Functionator
 
Resource Report
Resource Website
10+ mentions
FuncAssociate: The Gene Set Functionator (RRID:SCR_005768) FuncAssociate analysis service resource, service resource, data analysis service, production service resource A web-based tool that accepts as input a list of genes, and returns a list of GO attributes that are over- (or under-) represented among the genes in the input list. Only those over- (or under-) representations that are statistically significant, after correcting for multiple hypotheses testing, are reported. Currently 37 organisms are supported. In addition to the input list of genes, users may specify a) whether this list should be regarded as ordered or unordered; b) the universe of genes to be considered by FuncAssociate; c) whether to report over-, or under-represented attributes, or both; and d) the p-value cutoff. A new version of FuncAssociate supports a wider range of naming schemes for input genes, and uses more frequently updated GO associations. However, some features of the original version, such as sorting by LOD or the option to see the gene-attribute table, are not yet implemented. Platform: Online tool gene, gene ontology, statistical analysis, web service, bio.tools is listed by: Gene Ontology Tools
is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
is related to: Gene Ontology
has parent organization: Roth Laboratory
NIH ;
Canadian Institute for Advanced Research ;
NINDS NS054052;
NINDS NS035611;
NHLBI HL081341;
NHGRI HG0017115;
NHGRI HG004233;
NHGRI HG003224
PMID:19717575
PMID:14668247
Free for academic use, Acknowledgement requested biotools:funcassociate, OMICS_02264, nlx_149233 http://llama.mshri.on.ca/cgi/func/funcassociate, https://bio.tools/funcassociate SCR_005768 2026-07-27 09:32:22 36
WEGO - Web Gene Ontology Annotation Plot
 
Resource Report
Resource Website
100+ mentions
WEGO - Web Gene Ontology Annotation Plot (RRID:SCR_005827) WEGO analysis service resource, service resource, data analysis service, production service resource Web Gene Ontology Annotation Plot (WEGO) is a simple but useful tool for plotting Gene Ontology (GO) annotation results. Different from other commercial software for chart creating, WEGO is designed to deal with the directed acyclic graph (DAG) structure of GO to facilitate histogram creation of GO annotation results. WEGO has been widely used in many important biological research projects, such as the rice genome project and the silkworm genome project. It has become one of the useful tools for downstream gene annotation analysis, especially when performing comparative genomics tasks. Platform: Online tool visualization, gene ontology, gene, annotation, comparative genomics, histogram, directed acyclic graph, genomics, genome, ontology or annotation visualization, bio.tools is listed by: Gene Ontology Tools
is listed by: Debian
is listed by: bio.tools
is related to: Gene Ontology
has parent organization: BGI; Shenzhen; China
Zhejiang University ;
Chinese Academy of Sciences ;
Danish Basic Research Foundation ;
Ministry of Science and Technology 2002AA104250;
Ministry of Science and Technology CNGI-04-15-7A;
National Natural Science Foundation of China 30399120;
National Natural Science Foundation of China 90208019;
National Natural Science Foundation of China 30200163;
National Natural Science Foundation of China 90403130
PMID:16845012 Free for academic use biotools:wego, nlx_149334 https://bio.tools/wego SCR_005827 BGI WEGO - Web Gene Ontology Annotation Plotting, Web Gene Ontology Annotation Plot 2026-07-27 09:32:23 386
SNPsandGO
 
Resource Report
Resource Website
50+ mentions
SNPsandGO (RRID:SCR_005788) SNPs&GO analysis service resource, service resource, data analysis service, production service resource A server for the prediction of single point protein mutations likely to be involved in the insurgence of diseases in humans. prediction, protein, mutation, disease, single nucleotide polymorphism, bio.tools is used by: HmtVar
is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is related to: Gene Ontology
has parent organization: University of Bologna; Bologna; Italy
PMID:19514061 biotools:snps_go, OMICS_02219 https://bio.tools/snps_go SCR_005788 SNPs and GO 2026-07-27 09:32:22 58
PRINSEQ
 
Resource Report
Resource Website
1000+ mentions
PRINSEQ (RRID:SCR_005454) PRINSEQ analysis service resource, service resource, data analysis service, production service resource A publicly available tool that is able to filter, reformat and trim your genomic and metagenomic sequence data and provide you summary statistics for your sequence data. The interactive web interface facilitates visualizations of the results and export functionality for subsequent data processing. The standalone lite version is written in Perl and does not require any non-core Perl modules. The lite version is primarily designed for data preprocessing and does not generate summary statistics in graphical form., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. microbiome, data analysis, genomic sequence data, metagenomic sequence data, summary, perl, bio.tools is listed by: OMICtools
is listed by: Human Microbiome Project
is listed by: Debian
is listed by: bio.tools
has parent organization: San Diego State University; California; USA
PMID:21278185 THIS RESOURCE IS NO LONGER IN SERVICE OMICS_01068, biotools:prinseq http://prinseq.sourceforge.net, https://bio.tools/prinseq SCR_005454 PReprocessing and INformation of SEQuences, preprocessing and information of sequences 2026-07-27 09:32:17 1192
TMA Navigator
 
Resource Report
Resource Website
1+ mentions
TMA Navigator (RRID:SCR_005599) TMA Navigator analysis service resource, service resource, data analysis service, production service resource A free web-based service open to all users for analysis of tissue microarray (TMA) data and related information, accommodating categorical, semi-continuous and continuous expression scores. There is no login requirement. tissue microarray, network, analysis, visualization, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
PMID:23761446 Acknowledgement requested, Free biotools:tma_navigator, OMICS_00821 https://bio.tools/tma_navigator SCR_005599 2026-07-27 09:32:19 5
ExpressYourself
 
Resource Report
Resource Website
ExpressYourself (RRID:SCR_008881) ExpressYourself analysis service resource, service resource, data analysis service, production service resource A fully integrated platform for processing microarray data. bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
OMICS_00755, biotools:expressyourself https://bio.tools/expressyourself SCR_008881 ExpressYourself: microarray data processing platform, Express Yourself, Express Yourself: microarray data processing platform 2026-07-27 09:33:14 0
waviCGH
 
Resource Report
Resource Website
1+ mentions
waviCGH (RRID:SCR_006662) waviCGH analysis service resource, service resource, data analysis service, production service resource A versatile web-server application for the analysis and visualization of array-CGH data. genomic, copy number alteration, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
PMID:20507915 Acknowledgement requested OMICS_00739, biotools:wavicgh https://bio.tools/wavicgh SCR_006662 2026-07-27 09:32:37 4
Gene Array Analyzer
 
Resource Report
Resource Website
1+ mentions
Gene Array Analyzer (RRID:SCR_008323) GAA analysis service resource, service resource, data analysis service, production service resource Data analysis service that allows to process CEL files from Affymetrix, Inc. GeneChip Gene 1.0 ST Arrays to identify alternative splicing. bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
PMID:22123740 Acknowledgement requested OMICS_00759, biotools:gene_array_analyzer https://bio.tools/gene_array_analyzer SCR_008323 2026-07-27 09:33:03 5
GeMoMa
 
Resource Report
Resource Website
100+ mentions
GeMoMa (RRID:SCR_017646) software application, simulation software, software resource Software tool as homology based gene prediction program that predicts gene models in target species based on gene models in evolutionary related reference species. Utilizes amino acid sequence conservation, intron position conservation, and RNA-seq data to accurately predict protein-coding transcripts. Supports combination of predictions based on several reference species allowing to transfer high quality annotation of different reference species to target species. Homology, based, gene, prediction, model, target, evolutionary, related, reference, species, sequence, conservation, intron, position, RNAseq, data, protein, coding, transcript, bio.tools is listed by: bio.tools
is listed by: Debian
works with: GUSHR
PMID:31020559 Free, Available for download, Freely available biotools:gemoma https://bio.tools/gemoma SCR_017646 Gene Model Mapper 2026-07-27 09:35:32 135
MB-GAN
 
Resource Report
Resource Website
1+ mentions
MB-GAN (RRID:SCR_019289) software application, simulation software, software resource Software tool as deep learning simulation framework for simulating realistic microbiome data. Can automatically learn from given microbial abundances and compute simulated abundances that are indistinguishable from it. Metagenomics, deep learning, generative adversarial network, microbiome data simulation, bio.tools is listed by: bio.tools
is listed by: Debian
has parent organization: University of Texas at Dallas; Texas; USA
DOI:10.1101/863977 Free, Available for download, Freely available biotools:mb-gan https://bio.tools/mb-gan SCR_019289 Microbiome Simulation via Generative Adversarial Network 2026-07-27 09:35:55 1
ProP Server
 
Resource Report
Resource Website
50+ mentions
ProP Server (RRID:SCR_014936) web application, software resource Web application which predicts arginine and lysine propeptide cleavage sites in eukaryotic protein sequences using an ensemble of neural networks. Furin-specific prediction is the default. It is also possible to perform a general proprotein convertase prediction. web application, prediction, arginine, lysine, cleavage, propeptide, eukaryotic, protein, sequence, bio.tools is listed by: Debian
is listed by: bio.tools
DOI:10.1093/protein/gzh013 Open source biotools:prop, BioTools:prop https://bio.tools/prop, https://bio.tools/prop, https://bio.tools/prop SCR_014936 ProP, ProP 1.0 Server, ProP 1.0 2026-07-27 09:34:46 75
Composition Profiler
 
Resource Report
Resource Website
10+ mentions
Composition Profiler (RRID:SCR_014630) web application, software resource Web tool for discovery and visualization of differences in amino acid composition. Two samples of amino acid sequences serve as input and a bar chart composed of twenty data points is output. web tool, web application, amino acid, amino acid composition, sequence, bar chart, bio.tools is listed by: Debian
is listed by: bio.tools
PMID:17578581 Source code available, Acknowledgement requested biotools:composition_profiler https://bio.tools/composition_profiler SCR_014630 2026-07-27 09:34:44 32
GeneWise
 
Resource Report
Resource Website
1000+ mentions
GeneWise (RRID:SCR_015054) web application, software resource Gene alignment tool from the EBI which predicts gene structure using similar protein sequences. See also the associated GenomeWise tool. gene alignment, dna sequence, protein sequence, bio.tools is listed by: Debian
is listed by: bio.tools
has parent organization: European Bioinformatics Institute
PMID:15123596 Freely available, Available for download biotools:wise https://bio.tools/wise SCR_015054 2026-07-27 09:34:53 1017
ChromImpute
 
Resource Report
Resource Website
ChromImpute (RRID:SCR_023990) software application, simulation software, software resource Software tool for large scale systematic epigenome imputation. ChromImpute takes existing compendium of epigenomic data and uses it to predict signal tracks for mark-sample combinations not experimentally mapped or to generate a potentially more robust version of data sets that have been mapped experimentally. systematic epigenome imputation, epigenomic data, predict signal tracks, mark-sample combinations, not experimentally mapped data, is listed by: Debian Free, Available for download, Freely available OMICS_11185 https://sources.debian.org/src/chromimpute/ SCR_023990 chromimpute 2026-07-27 09:37:02 0
InSilicoSeq
 
Resource Report
Resource Website
1+ mentions
InSilicoSeq (RRID:SCR_024041) software application, simulation software, software resource Software tool as sequencing simulator producing realistic Illumina reads. Primarily intended for simulating metagenomic samples, it can also be used to produce sequencing data from a single genome. producing realistic Illumina reads, simulating metagenomic samples, is listed by: Debian PMID:30016412 Free, Available for download, Freely available, OMICS_31218 https://sources.debian.org/src/insilicoseq/, https://insilicoseq.readthedocs.io/en/latest/ SCR_024041 insilicoseq, InSilicoSeq- A sequencing simulator 2026-07-27 09:37:02 7

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