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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
http://www.poldracklab.org/software
The Poldrack lab has developed software tools for fMRI data analysis (links on the site), experimental design, and informatics, in collaboration with several other groups. * pubbrain.org: Developed in collaboration with the UCLA Consortium for Neuropsychiatric Phenomics, this site is an automatic meta-analytic search aid that allows for visualizing PubMed searches based on published neuroanatomic findings. * LONI Probabilistic Atlas: Developed in collaboration with the UCLA Laboratory of Neuroimaging and Center for Cognitive Phenomics, this project provides free and open access to a probabilistic atlas of cortical structures in 40 healthy individuals, including all raw data. * fmripower.org: Software developed by Jeanette Mumford in the Poldrack lab for statistical power analysis for fMRI studies. * Automated ICA-based denoising: Toolbox developed by Jussi Tohka at the Tampere University of Technology in Finland in collaboration with our laboratory and the UCLA Laboratory of Neuroimaging. * Raw data diagnostics - An R program that reads in a 4-D data file and provides a diagnostic report. * Code to run various tasks used in the lab - all of these require MATLAB and the MATLAB Psychophysics toolbox: * - Stop signal task (for behavioral testing outside the scanner) * - File Stop signal task (for use in the scanner) * - File mixed gambles task (demo and scanning script)
Proper citation: Poldracklab Portal (RRID:SCR_002712) Copy
Public research university in Ohio that offers degree programs in a variety of fields such as business, music and arts, and medical and human service.
Proper citation: University of Cincinnati; Ohio; USA (RRID:SCR_002833) Copy
Public university in New Zealand that offers degree programs in fields such as art, commerce, engineering, forestry, health sciences, and social work.
Proper citation: University of Canterbury; Christchurch; New Zealand (RRID:SCR_002711) Copy
Private research university in Chicago, Illinois.
Proper citation: University of Chicago; Illinois; USA (RRID:SCR_002832) Copy
http://www.phalanxbiotech.com/
Group service that provides expression profiling products and services. They manufacture DNA microarrays for gene expression and microRNA profiling.
Proper citation: Phalanx Biotech Group (RRID:SCR_002717) Copy
http://www.bioconductor.org/packages/release/bioc/html/chimera.html
A Bioconductor package that organizes, annotates, analyses and validates fusions reported by different fusion detection tools. The current implementation can deal with output from bellerophontes, chimeraScan, deFuse, fusionCatcher, FusionFinder, FusionHunter, FusionMap, mapSplice, Rsubread, tophat-fusion, tophat-fusion-post and STAR. The core of Chimera is a fusion data structure that can store fusion events detected with any of the aforementioned tools.
Proper citation: Chimera (RRID:SCR_002959) Copy
http://proteininformationresource.org/
Integrated public bioinformatics resource to support genomic, proteomic and systems biology research and scientific studies. Provides databases and protein sequence analysis tools to scientific community, including Protein Sequence Database which grew out from the Atlas of Protein Sequence and Structure. Conducts research in biomedical text mining and ontology, computational systems biology, and bioinformatics cyberinfrastructure. In 2002 PIR, along with its international partners, EBI (European Bioinformatics Institute) and SIB (Swiss Institute of Bioinformatics), were awarded a grant from NIH to create UniProt, a single worldwide database of protein sequence and function, by unifying the PIR-PSD, Swiss-Prot, and TrEMBL databases. Currently, PIR major activities include: i) UniProt (Universal Protein Resource) development, ii) iProClass protein data integration and ID mapping, iii) PRO protein ontology, and iv) iProLINK protein literature mining and ontology development. The FTP site provides free download for iProClass, PIRSF, and PRO.
Proper citation: Protein Information Resource (RRID:SCR_002837) Copy
Web service that tags gene, protein, and small molecule names in any web page. Clicking on a tagged term opens a small popup showing summary information, and allows the user to quickly link to more detailed information. For each protein or gene, Reflect provides domain structure, sub-cellular localization, 3D structure, and interaction partners. For small molecules, it provides the chemical structure and interaction partners. Reflect can be installed as a plugin to Firefox or Internet Explorer, or can be used by entering a URL in the field provided. It can also be accessed programmatically via a REST or SOAP API, and a Reflect button can easily be added to any web page using Javascript or using a CGI proxy. Reflect was first-prize winner out of over 70 submissions in the Elsevier Grand Challenge, an international competition for systems that improve the way scientific information is communicated and used. Reflect can be edited and improved by the community.
Proper citation: Reflect (RRID:SCR_002714) Copy
http://engels.genetics.wisc.edu/amplify/
A freeware Macintosh program for simulating and testing polymerase chain reactions (PCRs) that can also be used as a tool for designing primers by evaluating candidates. It's a program to simulate the polymerase chain reaction. You specify a target sequence and primers, and it predicts the result. It's useful for planning experiments, testing primers and teaching about PCR. Amplify draws a diagram of the predicted results showing all expected primer matches and amplified fragments. Clicking on any of these objects gives additional information about them.
Proper citation: Amplify (RRID:SCR_002956) Copy
Curated, open-source, integrated data resource for comparative functional genomics in crops and model plant species to facilitate the study of cross-species comparisons using information generated from projects supported by public funds. It currently hosts annotated whole genomes in over two dozen plant species and partial assemblies for almost a dozen wild rice species in the Ensembl browser, genetic and physical maps with genes, ESTs and QTLs locations, genetic diversity data sets, structure-function analysis of proteins, plant pathways databases (BioCyc and Plant Reactome platforms), and descriptions of phenotypic traits and mutations. The web-based displays for phenotypes include the Genes and Quantitative Trait Loci (QTL) modules. Sequence based relationships are displayed in the Genomes module using the genome browser adapted from Ensembl, in the Maps module using the comparative map viewer (CMap) from GMOD, and in the Proteins module displays. BLAST is used to search for similar sequences. Literature supporting all the above data is organized in the Literature database. In addition, Gramene now hosts a variety of web services including a Distributed Annotation Server (DAS), BLAST and a public MySQL database. Twice a year, Gramene releases a major build of the database and makes interim releases to correct errors or to make important updates to software and/or data. Additionally you can access Gramene through an FTP site.
Proper citation: Gramene (RRID:SCR_002829) Copy
A software package that anayzes the structral details of RNA molecules through rapid quantification of a footprinting gel. By automating many of the steps involved in gel analysis, approximately one entire gel with thousands of bands can be quantified in less than 10 minutes using SAFA. In general, all the automated features have a manual override, such that even difficult or exceptional gels can be analyzed with the package.
Proper citation: SAFA Footprinting Software (RRID:SCR_002707) Copy
https://omictools.com/cross-platform-transcriptome-analysis-tool
Software package for analyzing transcriptome sequencing data from different sequencing platforms.
Proper citation: CPTRA (RRID:SCR_002944) Copy
http://www.fda.gov/nctr/science/centers/toxicoinformatics/maqc/
The National Center for Toxicological Research (NCTR), FDA's internationally recognized research center, plays a critical role in FDA's mission. The unique scientific expertise of NCTR is critical in supporting FDA product centers and their regulatory roles. The NCTR is an important research component of the FDA that plays a critical role in the missions of FDA and DHHS to promote and protect public health. * NCTRin partnership with researchers from government, academia, and industrydevelops, refines, and applies current and emerging technologies to improve safety evaluations of FDA-regulated products. * NCTR fosters national and international collaborations to improve and protect public health and enhance the quality of life for the American people. Through the training of scientists from around the world, as well as FDA staff, NCTR researchers spread the principles of regulatory science globally. * NCTR conducts FDA research with the goal to develop a scientifically sound basis for regulatory decisions and reduce risks associated with FDA-regulated products. NCTR represents the FDA on key committees of the National Toxicology Program (NTP), a program that evaluates the effects of chemicals on health. Over the past 30 years, the NTP and NCTR have conducted studies on FDA-nominated compounds, providing data to support science-based regulatory decisions.
Proper citation: National Center for Toxicological Research (RRID:SCR_002943) Copy
Only worldwide authority that provides standardized nomenclature, i.e. gene names and symbols (short form abbreviations), for all known human genes, and stores all approved symbols in the HGNC database. Approved human gene nomenclature. Database of gene symbols and names. Manually curated genes into groups based on shared characteristics such as homology, function or phenotype. Data for protein-coding genes, pseudogenes and non-coding RNAs.
Proper citation: HGNC (RRID:SCR_002827) Copy
https://simtk.org/home/foldvillin
An archive of hundreds of all-atom, explicit solvent molecular dynamics simulations that were performed on a set of nine unfolded conformations of a variant of the villin headpiece subdomain (HP-35 NleNle). It includes scripts for accessing the archive of villin trajectories as well as a VMD plug-in for viewing the trajectories. In addition, all starting structures used in the trajectories are also provided. The simulations were generated using a distributed computing method utilizing the symmetric multiprocessing paradigm for individual nodes of the Folding_at_home distributed computing network. The villin trajectories in the archive are divided into two projects: PROJ3036 and PROJ3037. PROJ3036 contains trajectories starting from nine non-folded configurations. PROJ3037 contains trajectories starting from the native (folded) state. Runs 0 through 8 (in PROJ3036) correspond to starting configurations 0 through 8 discussed in the paper in J. Mol. Biol. (2007) 374(3):806-816 (see the publications tab for a full reference), whereas RUN9 uses the same starting configuration as RUN8. Each run contains 100 trajectories (named clone 0-99), each with the same starting configuration but different random velocities. Trajectories vary in their length of time and are subdivided into frames, also known as a generation. Each frame contains around 400 configurational snapshots, or timepoints, of the trajectory, with the last configurational snapshot of frame i corresponding to the first configurational snapshot of generation i+1. The goal is to allow researchers to analyze and benefit from the many trajectories produced through the simulations.
Proper citation: Molecular Simulation Trajectories Archive of a Villin Variant (RRID:SCR_002704) Copy
Private, non-profit university in Utah. The university is a part of the Latter-day Saints Church Educational System.
Proper citation: Brigham Young University; Utah; USA (RRID:SCR_002825) Copy
http://www.pbrc.edu/default.asp
Research institute which investigates chronic disease and its triggers.
Proper citation: Pennington Biomedical Research Center (RRID:SCR_002946) Copy
http://www.schlaganfallcentrum.de/index.php?id=147
Stroke research group that performs disease-oriented basic research, clinical research, epidemiology and health services research.
Proper citation: Center for Stroke Research Berlin (RRID:SCR_002742) Copy
http://www.medical-neurosciences.de
Program integrates basic laboratory research and the clinic in terms of faculty, students, course content and infrastructure. This university's rigorous and comprehensive Master program provides a structured education in basic neuroscience to medical students and trains students of the life sciences in medical topics and approaches concerning the central and peripheral nervous system. Besides in depth theoretical training, the MSc program emphasizes state-of-the art practical lab experience, preparing graduates for continued research as PhD students. The PhD program places a high emphasis on scientific excellence, provides a multidisciplinary research and learning environment and offers extensive supervision and tutoring allowing students to complete their projects within 3 years. The supervised research project stands in the center of the PhD program, complemented by colloquia, workshops and training in professional skills. Our PhD students are member of the undefined Humboldt-Graduate-School providing an excellent service and training in transferable skills.
Proper citation: International Graduate Program Medical Neurosciences (RRID:SCR_002740) Copy
http://pfind.ict.ac.cn/software/pNovo/index.html
A de novo peptide sequencing algorithm using complementary higher-energy collisional dissociation (HCD) and electron transfer dissociation (ETD) tandem mass spectra.
Proper citation: pNovo+ (RRID:SCR_002860) Copy
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