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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Specification URL Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
XPN
 
Resource Report
Resource Website
1+ mentions
XPN (RRID:SCR_008845) XPN software resource Merging Two Gene Expression Studies via Cross Platform Normalization. bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: University of North Carolina at Chapel Hill; North Carolina; USA
OMICS_00863, biotools:xpn https://bio.tools/xpn SCR_008845 2026-09-19 12:51:46 2
MuSiC
 
Resource Report
Resource Website
100+ mentions
MuSiC (RRID:SCR_008792) MuSiC software resource A set of tools aimed at determining the significance of somatic mutations discovered within a given cohort of cancer samples, incorporating the cohort''s alignment data, variant lists and any relevant clinical data., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Washington University in St. Louis; Missouri; USA
PMID:22759861 THIS RESOURCE IS NO LONGER IN SERVICE biotools:MuSiC2, OMICS_00152 https://bio.tools/MuSiC2, https://github.com/ding-lab/MuSiC2/blob/master/README.md SCR_008792 Mutational Significance In Cancer 2026-09-19 12:51:45 485
GMAP
 
Resource Report
Resource Website
500+ mentions
GMAP (RRID:SCR_008992) GMAP alignment software, data processing software, image analysis software, software application, software resource, source code THIS RESOURCE IS NO LONGER IN SERVICE, documented August 29, 2016. A software program for mapping and aligning cDNA sequences to a genome. The program maps and aligns a single sequence with minimal startup time and memory requirements, and provides fast batch processing of large sequence sets. The program generates accurate gene structures, even in the presence of substantial polymorphisms and sequence errors, without using probabilistic splice site models. Methodology underlying the program includes a minimal sampling strategy for genomic mapping, oligomer chaining for approximate alignment, sandwich DP for splice site detection, and microexon identification with statistical significance testing. mrna, est sequence, expressed sequence tag, sequence, cdna sequence, genome, cdna, bio.tools is used by: deFuse
is listed by: Debian
is listed by: bio.tools
has parent organization: Genentech
PMID:15728110 THIS RESOURCE IS NO LONGER IN SERVICE OMICS_15072, biotools:gmap, nlx_152505 https://bio.tools/gmap, https://sources.debian.org/src/gmap/ SCR_008992 2026-09-19 12:51:47 599
SeqSaw
 
Resource Report
Resource Website
SeqSaw (RRID:SCR_009185) SeqSaw software resource A package for mapping of spliced reads and unbiased detection of novel splice junctions from RNA-seq data. bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
PMID:21575597 biotools:seqsaw, OMICS_01250 https://bio.tools/seqsaw SCR_009185 SeqSaw - Short Spliced Sequence Mapping Tool 2026-09-19 12:51:48 0
BARS
 
Resource Report
Resource Website
10+ mentions
BARS (RRID:SCR_009123) BARS software application, software resource Software application that is a statistical method that bridges the gap between single-locus and haplotype-based tests of association. It is based on the non-parametric regression techniques embodied by Bayesian Adaptive Regression Splines. (entry from Genetic Analysis Software), THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. gene, genetic, genomic, r, linux, bio.tools is listed by: Genetic Analysis Software
is listed by: bio.tools
is listed by: Debian
THIS RESOURCE IS NO LONGER IN SERVICE nlx_154204, biotools:bars, nlx_154228, SCR_009106 https://bio.tools/bars SCR_009123 Bayesian Adaptive Regression Splines 2026-09-19 12:51:48 39
NetOGlyc
 
Resource Report
Resource Website
500+ mentions
NetOGlyc (RRID:SCR_009026) NetOGlyc analysis service resource, data analysis service, production service resource, service resource, software application, software resource Server that produces predictions of mucin-type GalNAc O-glycosylation sites in mammalian proteins. neural network, predict, mucin, galnac, o-glycosylation site, protein, o-glycosylation, glycoprotein, o-glycoproteome, glycosite, proteome, bio.tools is listed by: Debian
is listed by: bio.tools
has parent organization: CBS Prediction Servers
PMID:23584533 Acknowledgement requested nlx_153864, biotools:netoglyc https://bio.tools/netoglyc SCR_009026 NetOGlyc Server 2026-09-19 12:51:48 643
elastix
 
Resource Report
Resource Website
100+ mentions
elastix (RRID:SCR_009619) elastix data processing software, image analysis software, registration software, software application, software resource, software toolkit THIS RESOURCE IS NO LONGER IN SERVICE. Documented on February 23,2023. Software toolbox for rigid and nonrigid registration of images. elastix is open source software, based on the well-known Insight Segmentation and Registration Toolkit (ITK). The software consists of a collection of algorithms that are commonly used to solve (medical) image registration problems. The modular design of elastix allows the user to quickly configure, test, and compare different registration methods for a specific application. A command-line interface enables automated processing of large numbers of data sets, by means of scripting. A paper describing elastix contains more details: S. Klein, M. Staring, K. Murphy, M.A. Viergever, J.P.W. Pluim, elastix: a toolbox for intensity based medical image registration,; IEEE Transactions on Medical Imaging, vol. 29, no. 1, pp. 196 - 205, January 2010., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. reusable library, analyze, c++, console (text based), domain independent, nifti, nrrd, os independent, philips par/rec, registration, resampling, spatial transformation, bio.tools is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)
is listed by: Debian
is listed by: bio.tools
is related to: Insight Segmentation and Registration Toolkit
has parent organization: Utrecht University; Utrecht; Netherlands
PMID:19923044 THIS RESOURCE IS NO LONGER IN SERVICE nlx_155845, biotools:elastix http://www.nitrc.org/projects/elastix, https://bio.tools/elastix, https://sources.debian.org/src/elastix/ SCR_009619 2026-09-19 12:51:50 175
Supersplat
 
Resource Report
Resource Website
1+ mentions
Supersplat (RRID:SCR_009826) Supersplat software resource An application for discovering potential splice junctions in high throughput sequencing (HTS) data. bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
OMICS_01256, biotools:supersplat https://bio.tools/supersplat SCR_009826 2026-09-19 12:51:51 2
ERANGE
 
Resource Report
Resource Website
10+ mentions
ERANGE (RRID:SCR_005240) ERANGE software resource Software for Mapping and Quantifying Mammalian Transcriptomes by RNA-Seq. Its functions are to (i) assign reads that map uniquely in the genome to their site of origin and, for reads that match equally well to several sites (''multireads''), assign them to their most likely site(s) of origin; (ii) detect splice-crossing reads and assign them to their gene of origin; (iii) organize reads that cluster together, but do not map to an already known exon, into candidate exons or parts of exons; and (iv) calculate the prevalence of transcripts from each known or newly proposed RNA, based on normalized counts of unique reads, spliced reads and multireads. The new candidate RNA regions produced can be thought of as ESTs, and, like ESTs, some are provisionally appended to existing gene models if they meet several additional criteria. Remaining unassigned candidate transcribed regions (labeled RNAFAR features) can then be used in conjunction with other confirming data to develop new or revised gene models. transcriptome, rna-seq, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
PMID:18516045 OMICS_01274, biotools:erange https://bio.tools/erange SCR_005240 Enhanced Read Analysis of Gene Expression 2026-09-19 12:50:50 30
RNA-SeQC
 
Resource Report
Resource Website
100+ mentions
RNA-SeQC (RRID:SCR_005120) RNA-SeQC software resource Java software which computes a series of quality control metrics for RNA-seq data and can compare sequencing quality across different samples or experiments to evaluate different experimental parameters. The input can be one or more BAM files, and the output consists of HTML reports and tab delimited files of metrics data. java, bam file, html, sequence comparison, rnaseq, rna sequence, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Broad Institute
PMID:22539670 Acknowledgement requested, Public biotools:rna-seqc, OMICS_01234 https://bio.tools/rna-seqc SCR_005120 2026-09-19 12:50:48 214
READSCAN
 
Resource Report
Resource Website
1+ mentions
READSCAN (RRID:SCR_005204) READSCAN software resource A highly scalable parallel software program to identify non-host sequences (of potential pathogen origin) and estimate their genome relative abundance in high-throughput sequence datasets. pathgen, genome, sequence, high-throughput sequence, align, read, host, microbe, virus, taxon, simulation, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: King Abdullah University of Science and Technology; Makkah Province; Saudi Arabia
PMID:23193222 OMICS_00222, biotools:readscan https://bio.tools/readscan SCR_005204 2026-09-19 12:50:49 5
VirusSeq
 
Resource Report
Resource Website
10+ mentions
VirusSeq (RRID:SCR_005206) VirusSeq software resource An algorithmic software tool for detecting known viruses and their integration sites using next-generation sequencing of human cancer tissue. VirusSeq takes FASTQ files (paired-end reads) as input. next-generation sequencing, virus, integration site, cancer tissue, genome, rna-seq, whole genome sequencing, fastq, paired-end read, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: University of Texas MD Anderson Cancer Center
Cancer OMICS_00227, biotools:virusseq https://bio.tools/virusseq SCR_005206 2026-09-19 12:50:49 23
MethPipe
 
Resource Report
Resource Website
100+ mentions
MethPipe (RRID:SCR_005168) MethPipe software resource A computational pipeline for analyzing bisulfite sequencing data. bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: University of Southern California; Los Angeles; USA
PMID:24324667 biotools:methpipe, OMICS_00603 https://bio.tools/methpipe SCR_005168 2026-09-19 12:50:48 108
SnpEff
 
Resource Report
Resource Website
5000+ mentions
SnpEff (RRID:SCR_005191) SnpEff software resource Genetic variant annotation and effect prediction software toolbox that annotates and predicts effects of variants on genes (such as amino acid changes). By using standards, such as VCF, SnpEff makes it easy to integrate with other programs. genome, genetic variant, annotation, effect, variant, gene, cancer variant, gatk, hgsv, single nucleotide polymorphisms, genome sequence, java, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is related to: Galaxy
is related to: GATK
has parent organization: SourceForge
has parent organization: Wayne State University; Michigan; USA
works with: SnpSift
Cancer PMID:22728672 Free, Freely available biotools:snpeff, OMICS_00186 https://bio.tools/snpeff, https://sources.debian.org/src/snpeff/ SCR_005191 SnpEff - Genetic variant annotation and effect prediction toolbox 2026-09-19 12:50:49 5640
SimRare
 
Resource Report
Resource Website
1+ mentions
SimRare (RRID:SCR_005226) SimRare software resource A stand-alone executable software with user-friendly graphical interface implemented in Python/C++ for rare variant association studies. It is designed as a unified simulation framework to provide an unbiased and easy manner to evaluate association methods, including novel methods, under a broad range of choice of biological contexts. It consists of three modules, variant data simulator, genotype/phenotype generator and association method evaluator. SimRare generates variant data for gene regions using forward-time simulation which incorporates realistic population demographic and evolutionary scenarios. For phenotype data it is capable of generating both case-control and quantitative traits. The phenotypic effects of variants can be detrimental, protective or non-causal. SimRare has a graphical user interface which allows for easy entry of genetic and phenotypic parameters. Simulated data can be written into external files in a standard format. For novel association method implemented in R it can be imported into SimRare, which has been equipped built in functions to evaluate performance of new method and visually compare it with currently available ones in an unbiased manner. statistical genetics, simulation framework, gui, association test, sequencing, rare variant, python, c++, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Google Code
has parent organization: Baylor University; Texas; USA
PMID:22914216 Acknowledgement requested, GNU General Public License, v3 OMICS_00257, biotools:simrare https://bio.tools/simrare SCR_005226 SimRare - A program to generate and analyze sequence-based data for rare variant association studies of quantitative and qualitative traits 2026-09-19 12:50:49 2
PHAge Search Tool
 
Resource Report
Resource Website
100+ mentions
PHAge Search Tool (RRID:SCR_005184) PHAST analysis service resource, data analysis service, data or information resource, data set, production service resource, service resource A web server designed to rapidly and accurately identify, annotate and graphically display prophage sequences within bacterial genomes or plasmids. It accepts either raw DNA sequence data or partially annotated GenBank formatted data and rapidly performs a number of database comparisons as well as phage cornerstone feature identification steps to locate, annotate and display prophage sequences and prophage features. Relative to other prophage identification tools, PHAST is up to 40 times faster and up to 15% more sensitive. It is also able to process and annotate both raw DNA sequence data and Genbank files, provide richly annotated tables on prophage features and prophage quality and distinguish between intact and incomplete prophage. PHAST also generates downloadable, high quality, interactive graphics that display all identified prophage components in both circular and linear genomic views. Databases available for download include Virus DB, Prophage and virus DB, Bacteria DB, and PHAST result DB. Pre-calculated genomes for viewing are also available. prophage sequence, genome, prophage, sequence, bacterial genome, plasmid, dna sequence, graph, phage, annotate, virus, nucleotide sequence, fasta, annotated genome, genbank, bio.tools, FASEB list is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: University of Alberta; Alberta; Canada
PMID:21672955 Acknowledgement requested biotools:phast, OMICS_00180 https://bio.tools/phast SCR_005184 PHAST - PHAge Search Tool 2026-09-19 12:50:49 243
Breakpointer
 
Resource Report
Resource Website
10+ mentions
Breakpointer (RRID:SCR_005254) Breakpointer software resource A fast tool for locating sequence breakpoints from the alignment of single end reads (SE) produced by next generation sequencing (NGS). It adopts a heuristic method in searching for local mapping signatures created by insertion/deletions (indels) or more complex structural variants(SVs). With current NGS single-end sequencing data, the output regions by Breakpoint mainly contain the approximate breakpoints of indels and a limited number of large SVs. Notably, Breakpointer can uncover breakpoints of insertions which are longer than the read length. Breakpointer also can find breakpoints of many variants located in repetitive regions. The regions can be used not only as a extra support for SV predictions by other tools (such as by split-read method), but also can serve as a database for searching variants which might be missed by other tools. Breakpointer is a command line tool that runs under linux system. Breakpointer takes advanage of two local mapping features of single-end reads as a consequence of indel/SVs: 1) non-uniform read distribution (depth skewness) and 2) misalignments at the boundaries of indel/SVs. These features are summarized as breakpoint signature. Breakpointer proceeds in three stages in capturing this signature. It is implemented in C++ and perl. Input is the file or files containing alignments of single-end reads against a reference genome (in .BAM format). Output is the predicted regions containing potential breakpoints of SVs (in .GFF format). To be able to read in .BAM files, Breakpointer requires bamtools API, which users should install beforehand. next-generation sequencing, c++, perl, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Max Planck Institute for Molecular Genetics; Berlin; Germany
GNU General Public License biotools:breakpointer, OMICS_00308 https://bio.tools/breakpointer SCR_005254 2026-09-19 12:50:50 10
G-Mo.R-Se
 
Resource Report
Resource Website
1+ mentions
G-Mo.R-Se (RRID:SCR_005273) G-Mo.R-Se software resource Software aimed at using RNA-Seq short reads to build de novo gene models. First, candidate exons are built directly from the positions of the reads mapped on the genome (without any ab initio assembly of the reads), and all the possible splice junctions between those exons are tested against unmapped reads : the testing of junctions is directed by the information available in the RNA-Seq dataset rather than a priori knowledge about the genome. Exons can thus be chained into stranded gene models. bio.tools, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
OMICS_01259, biotools:g-mo.r-se, biotools:gmorse https://bio.tools/g-mo.r-se, https://bio.tools/gmorse SCR_005273 Gene MOdeling using RNA-Seq, G-Mo.R-Se: Gene MOdeling using RNA-Seq 2026-09-19 12:50:50 1
inGAP
 
Resource Report
Resource Website
10+ mentions
inGAP (RRID:SCR_005261) inGAP software resource Software mining pipeline guided by a Bayesian principle to detect single nucleotide polymorphisms, insertion and deletions by comparing high-throughput pyrosequencing reads with a reference genome of related organisms. This pipeline is extended to identify and visualize large-size structural variations, including insertions, deletions, inversions and translocations. structural variation, genome, next-generation sequence, genome analysis, alignment, single nucleotide polymorphism, insertion, deletion, indel, inversion, translocation, windows, linux, macos/x, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: SourceForge
has parent organization: Fudan University; Shanghai; China
has parent organization: Chinese Academy of Sciences; Beijing; China
OMICS_00319, biotools:ingap https://bio.tools/ingap SCR_005261 inGAP-sv, inGAP-sv: structural variation detection and visualization, integrative next-generation genome analysis pipeline 2026-09-19 12:50:50 29
PEMer
 
Resource Report
Resource Website
1+ mentions
PEMer (RRID:SCR_005263) software resource Software package as computational framework with simulation-based error models for inferring genomic structural variants from massive paired-end sequencing data. Package is composed of three modules, PEMer workflow, SV-Simulation and BreakDB. PEMer workflow is a sensitive software for detecting SVs from paired-end sequence reads. SV-Simulation randomly introduces SVs into a given genome and generates simulated paired-end reads from novel genome. structural variation, genome, next-generation sequencing, bio.tools, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is related to: BreakDB
has parent organization: European Molecular Biology Laboratory
PMID:19236709 biotools:pemer, OMICS_00320 https://bio.tools/pemer, https://bio.tools/pemer SCR_005263 Paired-End Mapper 2026-09-19 12:50:50 7

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