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https://rnainnovation.med.upenn.edu/scientific-groups/mrna-core/

Core focuses on exploring mRNA technology and lipid nanoparticles for various applications including tissue and cell targeting. Offers Optimization and production of in vitro transcribed mRNA, Small scale production of sequence optimized in vitro transcribed mRNA, Incorporation of modified nucleosides to modulate activity, Off the shelf in vitro transcribed mRNA encoding reporter genes or cancer antigens,Labelled mRNA for nanoparticle tracking and microscopy, Encapsulation into commercially available proprietary and non proprietary lipid nanoparticles through LNP core.

Proper citation: University of Pennsylvania Institute for RNA Innovation Engineered mRNA and Targeted Nanomedicine Core Facility (RRID:SCR_023665) Copy   

•   Source: SciCrunch Registry

https://uclouvain.be/en/technology-platforms/pgen.html

Core provides services including Sequencing (Sanger, NGS); Genotyping (micro array, fragment analysis); Molecular karyotyping (micro array); Bioinformatics (exomes [WES], genomes [WGS], gene panels [panels], transcriptome [RNAseq]). Equipment includes Illumina MiSeq sequencer;Ion Torrent Ion Proton sequencer and an Ion Chef for sample preparation;HPC cluster for bioinformatics processing of NGS data (WES, WGS, panels, RNASeq);Affymetrix microarray platform;Sanger sequencer and fragment analyser;Contracts for outsourcing WES, WGS and RNAseq, according to public procurement regulations;Highlander software, developed in-house, for variant analysis from NGS data.

Proper citation: Catholic University of Louvain Genomics platform Core Facility (RRID:SCR_023707) Copy   

•   Source: SciCrunch Registry

https://sqi.northwestern.edu/core-facilities/antec/

Facility houses research equipment for evaluating materials and biological preparations, and offers 3D printing and 3D scientific illustration services. Available instruments include Cytation3 Automated Microscope Plate Reader, BioTek Inc.; Zetasizer Nano ZSP, Malvern Inc.; Lyophilizers FreeZone 6 and 6 Plus, Labconco; Azure300, Chemiluminescent Gel Imager, Azure Biosystems; Real-Time PCR I-cycler CFX-Connect, Bio-Rad Laboratories; Centrifuge Sorvall X1R, ThermoFisher; MCR302 Rheometer, Anton Paar Inc.; Plasma Cleaner, Harrick Plasma; NanoSight300, Malvern Instruments (Evanston); IncuCyte Live Cell Analysis System, Sartorius; Piuma Nanoindenter, Optics 11; Freezer/Mill, SPEX Sample Prep; J-1500 Circular Dichroism Spectrometer, JASCO.

Proper citation: Northwestern University Analytical BioNanoTechnology Equipment Core Facility (RRID:SCR_023706) Copy   

•   Source: SciCrunch Registry

https://research.arizona.edu/university-arizona-phenotyping-core-uapc

Core provides resources to investigate phenotypes of genetically altered mice and small animal models of disease. Offers investigators full service support of in vivo cardiovascular and physiology studies in normal and diseased states through surgical models, imaging techniques, and functional physiological assessments.Core provides services to assist researchers with phenotyping of small laboratory animals including mice, rats, guinea pigs, rabbits with focus on cardiovascular neuromuscular and respiratory function, and exercise tolerance. Services include Experiments with cardiovascular ultrasound, plethysmography, exercise studies, small animal surgeries LAD-ligation, transaortic constriction, and data analysis; Training with equipment, small animal surgeries or data analysis; Equipment rent to measure cardiovascular, neuromuscular, respiratory function, and exercise tolerance;Consultation on experimental design, physiological data-collection, analysis, interpretation and IACUC protocols, grant- and manuscript writing.

Proper citation: University of Arizona Phenotyping Core Facility (RRID:SCR_023879) Copy   

•   Source: SciCrunch Registry

https://my.creighton.edu/researchservices/corefacilities/ibif/

Provides instruments for performing widefield light microscopy, multiphoton microscopy, and confocal microscopy. Offers software for analyzing imaging data.

Proper citation: Creighton University Integrated Biomedical Imaging Core Facility (RRID:SCR_023806) Copy   

•   Source: SciCrunch Registry

https://www.creighton.edu/medicine/departments/biomedical-sciences/translational-hearing-center/technology

Core was established to provide infrastructure to support Research Project Leaders and principle investigators associated with the Dr. Richard J. Bellucci Translational Hearing Center to conduct auditory and vestibular research across the full range of experimental model systems, from single molecule analysis to whole organism models. We also offer access to our services and instruments to outside users.

Proper citation: Creighton University Auditory and Vestibular Technology Core Facility (RRID:SCR_023866) Copy   

•   Source: SciCrunch Registry

https://www.huck.psu.edu/core-facilities/metabolomics-core-facility

Core for conducting metabolomics studies on variety of biofluids and tissue extracts from plant and animal sources. Provided instruments include Agilent 5975C series GC-MSD, Bruker NEO 600 NMR, Thermo Exactive Plus, Thermo Orbitrap Exploris 120, Thermo Orbitrap Exploris 240, Thermo TSQ Quantis Plus, Thermo Orbitrap Fusion Lumos Tribrid.

Proper citation: Pennsylvania State University Huck Institutes of Life Sciences Metabolomics Core Facility (RRID:SCR_023864) Copy   

•   Source: SciCrunch Registry

https://www.sdstate.edu/biology-and-microbiology/functional-genomics-core-facility

Core provides access and training on range of instruments in areas of genomics, molecular biology, imaging, and chemical/metabolite analysis to support research on the SDSU campus.

Proper citation: South Dakota State University Functional Genomics Core Facility (RRID:SCR_023786) Copy   

•   Source: SciCrunch Registry

https://www.unmc.edu/vcr/cores/vcr-cores/animal-behavior/index.html

Provides investigators with expertise, equipment, and space that is required to conduct innovative acoustic, behavioral, and cognitive research with focus on rigor, reproducibility, and maintaining the highest standards of animal welfare.

Proper citation: University of Nebraska Medical Center Animal Behavior Core Facility (RRID:SCR_018830) Copy   

•   Source: SciCrunch Registry

https://cibr.umaryland.edu/service_center/show_external/4322?name=flow-cytometry-and-mass-cytometry-core-cvd

Core provides researchers with flow cytometry and mass cytometry services and equipment and help from highly trained and experienced staff.

Proper citation: Maryland University School of Medicine Flow Cytometry and Mass Cytometry Core Facility (RRID:SCR_018835) Copy   

•   Source: SciCrunch Registry

https://www.labx.com/product/sciex-api-5000

Triple quadrupole liquid chromatography mass spectrometer for analysis of bioanalytical samples. It can be used for DMPK and ADME studies.API 5000 LC/MS/MS System delivers the lowest limits of detection for the most demanding DMPK and ADME studies.

Proper citation: SCIEX:: API 5000 Triple Quadrupole Liquid Chromatography Mass Spectrometer System (RRID:SCR_018437) Copy   

•   Source: SciCrunch Registry

https://www.claflin.edu//academics-research/schools-departments/school-of-natural-sciences-and-mathematics/facilities

Core facility is equipped with instrumentation to support proteomic and metabolomic research, as well as equipment for materials characterization. Key instruments include a Bruker 700MHz NMR, two Bruker XRDs (Powder and Crystal), and Bruker Micro ToF mass spectrometer.

Proper citation: Claflin University Molecular Science Research Center Core Facility (RRID:SCR_018836) Copy   

•   Source: SciCrunch Registry

http://tools.thermofisher.com/content/sfs/manuals/cms_041850.pdf

Automated peptide synthesizer for chain assembly steps in solid phase peptide synthesis or FastMoc chemistry. Data is based on conductance or ultraviolet UV absorbance of reagent, solutions, and solvents in the synthesis cycle.

Proper citation: Thermo Fisher: Applied Biosystems: 433A Peptide Sequencer (RRID:SCR_018440) Copy   

•   Source: SciCrunch Registry

https://fralinlifesci.vt.edu/core-services/mass-spectrometry-incubator.html

Facility supports Virginia Tech's research infrastructure as mass spectrometry analysis and education center. Provides training in sample preparation, instrument operation and data analysis, with strong emphasis on metadata and analytical requirements for publication of metabolomic and proteomic results.

Proper citation: Virginia Tech Mass Spectrometry Incubator Core Facility (RRID:SCR_017956) Copy   

•   Source: SciCrunch Registry

http://www.umass.edu/ials/mass-spectrometry

The mass spectrometry core facility offers instrumentation for characterizing elements and compounds across the entire mass range from quantitative metal analysis to intact protein mass measurement. Instrumentation is also available for proteomics, metabolomics, MALDI imaging and HDX-MS. Specialized mass spectrometers encompass variety of ionization techniques and separation devices to cover wide range of analytical capabilities. The facility accepts samples and will perform requested analysis. Staff can also offer training to conduct experimentation. Instrumentation include Bruker timsTOF fleX, Thermo Orbitrap Fusion, Bruker Microflex and ultrafleXtreme MALDI-TOF, Agilent GC-MS, Waters Xevo TQD with UPLC, Waters Synapt G2Si with full HDX automation, Perkin Elmer NexION ICP-MS

Proper citation: UMass Amherst Mass Spectrometry Core Facility (RRID:SCR_019063) Copy   

•   Source: SciCrunch Registry

http://www.pasteur.fr/biophysics

Provides services and instrumentation for characterization of biological macromolecules with technical and methodological expertise. Provides characterization of macromolecules including shape, folding, stability auto-association,and they interactions including stoichiometry,thermodynamic and kinetic parameters.

Proper citation: Pasteur Institute Biophysics of Macromolecules and their Interactions Core Facility (RRID:SCR_018267) Copy   

•   Source: SciCrunch Registry

https://grcf.jhmi.edu/

Established to produce immortalized cell lines from human blood (EBV transformations). Offers genomics applications for single cells, including RNA-seq, gene expression profiling by qPCR and DNA amplification for whole-genome or targeted (exome or PCR-based analysis) through 10x Genomics Chromium platform (similar to Drop Seq). Offers custom genotyping to analyze short tandem repeats, variable number tandem repeats and single nucleotide polymorphisms.

Proper citation: Johns Hopkins University School of Medicine Genetic Resources Core Facility (RRID:SCR_018669) Copy   

•   Source: SciCrunch Registry

https://animalcare.umich.edu/business-services/ulam-pathology-core/

Our core is affiliated with the Unit for Laboratory Animal Medicine (ULAM) at the University of Michigan-Ann Arbor. We provide animal pathology services in support of non-GLP preclinical, translational, or basic science studies. Services include histology preparation, immunohistochemistry, animal hematology and serum chemistry assays, digital slide scanning/image analysis, and pathology interpretation by board-certified veterinary pathologists. Our core mission is to reduce bias and increase rigor within non-GLP animal research by providing high quality, documented, pathology support that may not be otherwise accessible within individual laboratories. Our laboratory maintains internal SOPs, documented quality control practices, and accountability/chain-of-custody records for all submissions. Additionally, we participate in an external quality control program through the Veterinary Laboratory Association.

Proper citation: University of Michigan ULAM Pathology Core Facility (RRID:SCR_018823) Copy   

•   Source: SciCrunch Registry

https://childrenshospital.corefacilities.org/service_center/show_external/3145

Core with advanced instrumentation in Light and Electron Microscopy.Core provides confocal, multiphoton microscopy,electron microscopy,image analysis.

Proper citation: Harvard Medical School PCMM Microscopy Core Facility (RRID:SCR_018822) Copy   

•   Source: SciCrunch Registry

https://med.nyu.edu/research/scientific-cores-shared-resources/center-biospecimen-research-development

Assists researchers and clinicians with molecular and morphologic characterization of normal and disease tissues of interest in support of biomarker discovery and translational research. Offers both routine and advanced histology immunohistochemistry, in situ and whole slide scanning services.

Proper citation: New York University School of Medicine Center for Biospecimen Research and Development Histology Core Facility (RRID:SCR_018304) Copy   

•   Source: SciCrunch Registry