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http://www.bsc.gwu.edu/dpp/index.htmlvdoc

Multicenter clinical research study aimed at discovering whether modest weight loss through dietary changes and increased physical activity or treatment with the oral diabetes drug metformin (Glucophage) could prevent or delay the onset of type 2 diabetes in study participants. At the beginning of the DPP, all 3,234 study participants were overweight and had blood glucose levels higher than normal but not high enough for a diagnosis of diabetesa condition called prediabetes. In addition, 45 percent of the participants were from minority groups-African American, Alaska Native, American Indian, Asian American, Hispanic/Latino, or Pacific Islander-at increased risk of developing diabetes. The DPP found that participants who lost a modest amount of weight through dietary changes and increased physical activity sharply reduced their chances of developing diabetes. Taking metformin also reduced risk, although less dramatically. In the DPP, participants from 27 clinical centers around the United States were randomly divided into different treatment groups. The first group, called the lifestyle intervention group, received intensive training in diet, physical activity, and behavior modification. By eating less fat and fewer calories and exercising for a total of 150 minutes a week, they aimed to lose 7 percent of their body weight and maintain that loss. The second group took 850 mg of metformin twice a day. The third group received placebo pills instead of metformin. The metformin and placebo groups also received information about diet and exercise but no intensive motivational counseling. A fourth group was treated with the drug troglitazone (Rezulin), but this part of the study was discontinued after researchers discovered that troglitazone can cause serious liver damage. The participants in this group were followed but not included as one of the intervention groups. In the years since the DPP was completed, further analyses of DPP data continue to yield important insights into the value of lifestyle changes in helping people prevent type 2 diabetes and associated conditions. For example, one analysis confirmed that DPP participants carrying two copies of a gene variant, or mutation, that significantly increased their risk of developing diabetes benefited from lifestyle changes as much as or more than those without the gene variant. Another analysis found that weight loss was the main predictor of reduced risk for developing diabetes in DPP lifestyle intervention group participants. The authors concluded that diabetes risk reduction efforts should focus on weight loss, which is helped by increased exercise.

Proper citation: Diabetes Prevention Program (RRID:SCR_001501) Copy   

•   Source: SciCrunch Registry
  

https://amstar.ca/

Guide tool to assess methodological quality of systematic reviews. Used to evaluate systematic reviews of randomised trials. AMSTAR 2 enables more detailed assessment of systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both.

Proper citation: AMSTAR (RRID:SCR_023194) Copy   

•   Source: SciCrunch Registry
  

https://cinema.ispm.unibe.ch/

Web application that simplifies evaluation of confidence in findings from network meta analysis.

Proper citation: Confidence in network meta analysis (RRID:SCR_023193) Copy   

•   Source: SciCrunch Registry
  

https://www.standardbio.com/products-services/instruments/hyperion

Imaging system enables comprehensive analysis of cellular phenotypes. Allows access to single cell insights. This includes deeper understanding of intricate spatial relationships of cells, pathways and phenotypes in tissue microenvironment.

Proper citation: Fluidigm: Hyperion Imaging System (RRID:SCR_023195) Copy   

•   Source: SciCrunch Registry
  

https://rth.dk/resources/risearch/

Software tool for prediction of RNA–RNA, RNA–DNA, and DNA–DNA interactions. Both RIsearch1 and RIsearch2 enable quick localisation of potential near complementary interactions between given query and target sequences. RIsearch1 performs computation with whole sequences. RIsearch2 focuses on perfect complementary seed regions and extends them on both ends. User defined seed and extension constraints makes RIsearch2 applicable to all kinds of interaction predictions (e.g., siRNA and Cas9–gRNA off-target predictions).

Proper citation: RIsearch (RRID:SCR_023503) Copy   

•   Source: SciCrunch Registry
  

http://www.ugr.es/local/abfr/tiempojm/

Web application that records the time devoted to each of the actions that are performed while playing motor games or active games. This recording system has applications in physical activity research and physical education.

Proper citation: Time in Motor Games (Tiempo en Juegos Motores) (RRID:SCR_015819) Copy   

•   Source: SciCrunch Registry
  

https://kosis.kr/

Republic of Korea e-Government platform for major domestic, international and North Korean statistics. Web service provides official statistics produced by statistical agencies covering more than 500 subject matters as well as the latest data on international finance and economy from international organizations i.e. IMF, World Bank, OECD.

Proper citation: Korea Statistical Information Service (RRID:SCR_023565) Copy   

•   Source: SciCrunch Registry
  

http://crispor.tefor.net

Web application that helps design, evaluate and clone guide sequences for the CRISPR/Cas9 system. This sgRNA design tool assists with guide selection in a variety of genomes and pre-calculated results for all human coding exons as a UCSC Genome Browser track.

Proper citation: CRISPOR (RRID:SCR_015935) Copy   

•   Source: SciCrunch Registry
  

https://omsf.io/

Nonprofit organization with mission to advance molecular sciences by building open source software and sustainable communities for research software development. Focuses on working with hosted projects to support their software development and provide operational support, while also pursuing own community-service and community-building projects. Uses fiscal sponsorship as business model available to nonprofit organizations to assemble resources, provide support and advance open source projects in molecular sciences aligned with charitable purpose and general public interest.

Proper citation: Open Molecular Software Foundation (RRID:SCR_023440) Copy   

•   Source: SciCrunch Registry
  

https://github.com/lucadellasantina/ObjectFinder

Software image analysis package for 3D object recognition in volumetric images developed for neuroscience research purposes. MATLAB application to recognize small structures in large volumetric image, plot their statistics and perform quantitative analysis such as nearest neighbor and colocalization analysis. Used to detect fluorescently labeled synapses in neuronal image stacks acquired using confocal or super resolution microscopes.

Proper citation: ObjectFinder (RRID:SCR_023319) Copy   

•   Source: SciCrunch Registry
  

https://neuromorpho.org/xyz2swc/ui/

Web service that converts all 30 reconstruction formats (and 65 variations) described in scientific literature into SWC standard. Service is available open-source through user-friendly browser interface and Application Programming Interface.

Proper citation: xyz2swc (RRID:SCR_023317) Copy   

•   Source: SciCrunch Registry
  

https://github.com/PedroBarbosa/DeepIntronic_Benchmark

Repository of code, data, and documentation to reproduce computational evaluation performed to identify the best tools/models to predict genetic variation in deep intronic regions of human genome.

Proper citation: Benchmark of human deep intronic variation (RRID:SCR_023315) Copy   

•   Source: SciCrunch Registry
  

https://github.com/PedroBarbosa/VETA

Software tool that analyses performance of several variant prediction methods at different levels. Used to benchmark variant effect predictors from VCF files.

Proper citation: Variant Prediction Tools Evaluation (RRID:SCR_023314) Copy   

•   Source: SciCrunch Registry
  

https://precisionhealth.umich.edu/our-research/michigangenomics/

Collaborative research effort among physicians, researchers, and patients at the University of Michigan with goal of combining patient electronic health record data with corresponding genetic data to gain novel biomedical insights. Biobank linking genotypes and electronic clinical records in Michigan Medicine patients. MGI participants agree to provide study team with access to EHR data for clinical information and biospecimen including blood or saliva.

Proper citation: Michigan Genomics Initiative (RRID:SCR_023556) Copy   

•   Source: SciCrunch Registry
  

https://github.com/frlender/DendroX

Web application for multi-level multi-cluster selections in dendrogram. Provides interactive visualization of dendrogram in which users can divide dendrogram at any level and into any number of clusters.

Proper citation: DendroX (RRID:SCR_023434) Copy   

•   Source: SciCrunch Registry
  

https://github.com/CompSynBioLab-KoreaUniv/FunGAP

Software tool to predict protein coding genes in fungal genome assembly. Performs gene prediction on given genome assembly and RNA-seq reads. Runs multiple gene predictors, evaluates all predicted genes, and assembles gene models that are highly supported by homology to known sequences.

Proper citation: FunGAP (RRID:SCR_023213) Copy   

•   Source: SciCrunch Registry
  

https://pypi.org/project/roifile/

Software Python package to read, write, create, and plot ImageJ ROI format, an undocumented and ImageJ application specific format to store regions of interest, geometric shapes, paths, text, and whatnot for image overlays.

Proper citation: roifile (RRID:SCR_023331) Copy   

•   Source: SciCrunch Registry
  

https://www.gmi-inc.com/product/nuaire-labgard-es-nu-425-biosafety-cabinet-series-2/

Designed for laboratory safety, proper ergonomics, and energy efficiency.Models available from GMI are 2-ft. NU-425-200, 3-ft. NU-425-300, 4-ft. NU-425-400, and 6-ft. NU-425-600. LabGard NU-425 biosafety cabinets feature control system to control blower, lights, and outlets, Minihelic gauge that measures plenum performance, and Attenumount vibration control system for attenuation of sound and vibration. Cabinets are equipped with highly efficient, energy-saving motor/blower to increase filter life and cut electricity costs.

Proper citation: NuAire: LabGard ES NU-425-600E Biosafety Cabinet (RRID:SCR_023448) Copy   

•   Source: SciCrunch Registry
  

https://github.com/sapporo-wes/yevis-web

Web application for browsing Yevis workflow registry.

Proper citation: Yevis web (RRID:SCR_023205) Copy   

•   Source: SciCrunch Registry
  

http://cell-innovation.nig.ac.jp/maser/AllPipelines/P000001138_en.html

Software pipeline that visualizes mapping results (in BAM format) on Genome Explorer.

Proper citation: loadBAM2ge_db (RRID:SCR_015951) Copy   

•   Source: SciCrunch Registry