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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
http://go.princeton.edu/cgi-bin/GOTermFinder
The Generic GO Term Finder finds the significant GO terms shared among a list of genes from an organism, displaying the results in a table and as a graph (showing the terms and their ancestry). The user may optionally provide background information or a custom gene association file or filter evidence codes. This tool is capable of batch processing multiple queries at once. GO::TermFinder comprises a set of object-oriented Perl modules GO::TermFinder can be used on any system on which Perl can be run, either as a command line application, in single or batch mode, or as a web-based CGI script. This implementation, developed at the Lewis-Sigler Institute at Princeton, depends on the GO-TermFinder software written by Gavin Sherlock and Shuai Weng at Stanford University and the GO:View module written by Shuai Weng. It is made publicly available through the GMOD project. The full source code and documentation for GO:TermFinder are freely available from http://search.cpan.org/dist/GO-TermFinder/. Platform: Online tool, Windows compatible, Mac OS X compatible, Linux compatible, Unix compatible
Proper citation: Generic GO Term Finder (RRID:SCR_008870) Copy
APID Interactomes (Agile Protein Interactomes DataServer) provides information on the protein interactomes of numerous organisms, based on the integration of known experimentally validated protein-protein physical interactions (PPIs). The interactome data includes a report on quality levels and coverage over the proteomes for each organism included. APID integrates PPIs from primary databases of molecular interactions (BIND, BioGRID, DIP, HPRD, IntAct, MINT) and also from experimentally resolved 3D structures (PDB) where more than two distinct proteins have been identified. This collection references protein interactors, through a UniProt identifier.
Proper citation: Agile Protein Interactomes DataServer (RRID:SCR_008871) Copy
http://plantgrn.noble.org/LegumeIP/
LegumeIP is an integrative database and bioinformatics platform for comparative genomics and transcriptomics to facilitate the study of gene function and genome evolution in legumes, and ultimately to generate molecular based breeding tools to improve quality of crop legumes. LegumeIP currently hosts large-scale genomics and transcriptomics data, including: * Genomic sequences of three model legumes, i.e. Medicago truncatula, Glycine max (soybean) and Lotus japonicus, including two reference plant species, Arabidopsis thaliana and Poplar trichocarpa, with the annotation based on UniProt TrEMBL, InterProScan, Gene Ontology and KEGG databases. LegumeIP covers a total 222,217 protein-coding gene sequences. * Large-scale gene expression data compiled from 104 array hybridizations from L. japonicas, 156 array hybridizations from M. truncatula gene atlas database, and 14 RNA-Seq-based gene expression profiles from G. max on different tissues including four common tissues: Nodule, Flower, Root and Leaf. * Systematic synteny analysis among M. truncatula, G. max, L. japonicus and A. thaliana. * Reconstruction of gene family and gene family-wide phylogenetic analysis across the five hosted species. LegumeIP features comprehensive search and visualization tools to enable the flexible query on gene annotation, gene family, synteny, relative abundance of gene expression.
Proper citation: LegumeIP (RRID:SCR_008906) Copy
NeuroImaging laboratory focused on detecting early brain changes associated with cognitive decline and dementia that manages the neuroimaging component of all studies at the Layton Aging and Alzheimer's Center including acquisition and archival services, as well as volumetric analysis of anonymized MRI scans. Assistance with resulting data is also available, including statistical analysis, and preparation of materials for presentation and publication. The Layton Center also manages a library of thousands of digitized MRI scans, including what is believed to be the largest collection of longitudinal MRI scans of cognitively intact elderly subjects. The OADC Neuroimaging Lab conducts MRI studies on both 3 and 7T MRI systems using advanced sequences, employing a multimodal approach to brain imaging research.
Proper citation: Layton Center NeuroImaging Laboratory (RRID:SCR_008823) Copy
Aggregator of blogs about new developments in science and other fields that allows readers to easily find blog posts about serious peer-reviewed research, instead of just news reports and press releases. If you''re a blogger who writes about serious research, Research Blogging offers you a way to distinguish your serious posts from news, politics, family, bagpipes, and so on. They can direct your regular readers - and new readers - to the posts you''ve worked the hardest to create. All you need to get started is a blog and a peer-reviewed research report that you''d like to discuss. How it works * Bloggers -- often experts in their field -- find exciting new peer-reviewed research they''d like to share. They write thoughtful posts about the research for their blogs. * Bloggers register and use a simple one-line form to create a snippet of code to place in their posts. This snippet not only notifies this site about their post, it also creates a properly formatted research citation for their blog. * Their software automatically scans registered blogs for posts containing their code snippet. When it finds them, it indexes them and displays them on their front page -- thousands of posts from hundreds of blogs, in one convenient place, organized by topic. * Their editors identify the notable posts in each major discipline, publishing the results on their news page. * Other services like PubGet index their database as well, so every time readers search for a journal article, they can also locate blog posts discussing the article. * The quality of the posts listed on their site is monitored by the member bloggers. If a post doesn''t follow their guidelines, it is removed from their database. Borderline cases may be discussed publicly on the blog as well. Bloggers are also provided with an icon they can use to show when they''re talking about a peer-reviewed work that they''ve read and analyzed closely. There are already over seven thousand blog posts using the icon, and now it''s easier than ever to find them.
Proper citation: Research Blogging (RRID:SCR_008786) Copy
http://www.sfn.org/index.aspx?pagename=brainfacts
Brain Facts is a 74-page primer on the brain and nervous system, published by SfN. Designed for a lay audience as an introduction to neuroscience, Brain Facts is also a valuable educational resource used by high school teachers and students who participate in Brain Awareness Week. The 2008 edition updates all sections and includes new information on brain development, learning and memory, language, neurological and psychiatric illnesses, potential therapies, and more. Download the full book (PDF) or download individual sections. All downloads are PDFs. Educators, request a copy of the Brain Facts book (paperback or CD) - contact [email protected].
Proper citation: Brain Facts (RRID:SCR_008788) Copy
http://www.ohsu.edu/xd/research/centers-institutes/neurology/alzheimers/
An aging and Alzheimer's disease research center that conducts studies of treatments, technologies for patient support, genetics, neuroimaging, and pathology. The Center's clinical research focuses on understanding differing rates of progression and cognitive decline as compared to optimal cognitive health in the elderly and are currently studying methods of gauging the progression of Alzheimer’s disease through research in genetics, neuroimaging, and cerebrospinal fluid biomarkers. Clinical trials performed at the Center include drugs targeted to ameliorate the symptoms of memory failure and slow the progression of disease.
Proper citation: OHSU Layton Aging and Alzheimer's Disease Center (RRID:SCR_008821) Copy
http://www.med.upenn.edu/cndr/biosamples-brainbank.html
A brain and tissue bank that contains human brain samples from patients with Alzheimer's disease (AD), Parkinson's disease (PD) and other related neurodegenerative dementias and movement disorders. This brain bank serves as a resource for scientists and researchers, providing access to tissue samples for further research. While priority is given to University of Pennsylvania researchers, this bank will provide requests to researchers not associated with the University of Pennsylvania. This tissue bank accepts donations from those seeing a University of Pennsylvania physician or collaborator.
Proper citation: University of Pennslyvania Brain Bank (RRID:SCR_008820) Copy
http://www.nia.nih.gov/research/dgcg/clinical-research-study-investigators-toolbox
The purpose of the NIA Clinical Research Toolbox is to provide a Web-based information repository for investigators and staff involved in clinical research. The Toolbox contains templates, sample forms, guidelines, regulations and information materials to assist investigators in the development and conduct of high quality clinical research studies.
Proper citation: Clinical Research Study Investigators Toolbox (RRID:SCR_008815) Copy
http://www.lifetechnologies.com/
Vendor for life sciences products and services ranging from instruments to antibodies.
Proper citation: Life Technologies (RRID:SCR_008817) Copy
http://mayoresearch.mayo.edu/mayo/research/udall_center/
A research program associated with bringing together researchers from various disciplines to study the genetic and molecular basis of Parkinson's disease. The program focuses on epidemiological and longitudinal studies of Parkinson's disease, dementia with Lewy bodies, and aging and dementia. It also provides clinical materials for other research projects. This program provides faculty research funds, invited speaker seminar series, sponsorship of movement disorder fellowships, pilot research grants, and support for faculty travel to promote intra-institutional collaborations.
Proper citation: Udall Center of Excellence in Parkinson's Disease Research (RRID:SCR_008778) Copy
An endowment that offers funding for neuroscience research, especially as it may apply to Minnesota, agriculture, or if the researchers are based in Minnesota. The McKnight Foundation, a Minnesota-based family foundation, seeks to improve the quality of life for present and future generations through grantmaking, collaboration, and strategic policy reform in the following areas: arts, education and learning, environment, the region and communities, agricultural research, and neuroscience research. The McKnight Foundation assists nonprofit organizations and public agencies to improve the quality of life for all people, particularly those in need. Through grantmaking, coalition-building, and encouragement of strategic policy reform, we aim to build and maintain vibrant communities; enrich people''s lives through the arts; encourage protection of the natural environment; and promote research in selected fields. The Foundation had assets of approximately $1.8 billion and gave about $98 million in grants in 2009. Generally speaking, McKnight supports nonprofit organizations in Minnesota, U.S., only. McKnight''s primary geographic focus in grantmaking is to nonprofit organizations located within the state of Minnesota. We do not provide funding outside Minnesota, with five important programmatic exceptions: * Collaborative Crop research: International. * East Africa: Tanzania and Uganda only. * Mississippi River: 10 states bordering or encompassing the Mississippi River. * Neuroscience research: National. * Southeast Asia: Cambodia, Laos, and Vietnam only. Each program is different. Please consult the specific guidelines appropriate to your project or organization for funding details. With very few exceptions, McKnight funds nonprofit organizations only. To be eligible for a grant, applicants must be classified by the Internal Revenue Service as tax-exempt, nonprofit organizations. We discourage the use of fiscal agents.
Proper citation: McKnight Foundation (RRID:SCR_008776) Copy
Platform for sharing data, with very large storage capability for electrophysiological data, EEG data is included. This service is provided for neuroscientists to facilitate data access, data storage, data analysis and data sharing. This service is developed and maintained by the German Node of the International Neuroinformatics Coordinating Facility. The global scale of neuroinformatics offers unprecedented opportunities for scientific collaborations between and among experimental and theoretical neuroscientists. To fully harvest these possibilities, coordinated activities are required to improve key ingredients of neuroscience: data access, data storage, and data analysis, together with supporting activities for teaching and training. Focusing on the development and free distribution of tools for handling and analyzing neurophysiological data, G-Node aims at addressing these aspects as part of the International Neuroinformatics Coordination Facility (INCF) and the German Bernstein Network for Computational Neuroscience (NNCN). G-Node also serves as an international forum for Computational Neuroscientists that are interested in sharing experimental data and tools for data analysis and modeling. G-Node is funded through the German Federal Ministry of Education and Research and hosted by Ludwig-Maximilians-Universit-Munchen.
Proper citation: G-node portal electrophysiology data sharing (RRID:SCR_008893) Copy
This comprehensive free collection of multimedia resources and inquiry-based activities tied to the National Science Education Standards help teachers and students learn about the structure, function and cognitive aspects of the human brain. The packet includes a teacher's manual, student manual, DVD of videos, and a CDROM of accompanying materials.
Proper citation: Brain's Inner Workings: Activities for Grades 9 through 12 (RRID:SCR_008842) Copy
http://en.wikibooks.org/wiki/Main_Page
Community wiki for an open-content textbooks collection that anyone can improve or add to, start new books, and join project-related discussions in the reading rooms. Contributors maintain the property rights to their contributions, while the Creative Commons Attribution-ShareAlike License and the GNU Free Documentation License makes sure that the submitted version and its derivative works will always remain freely distributable and reproducible. Categories include: Computing, Engineering, Humanities, Languages, Mathematics, Miscellaneous, Science, Social sciences, All subjects. Wikibooks has two sub-projects; Wikijunior which is aimed at children and the Cookbook which is a collection of recipes and culinary topics. * 2,440 books with 40,746 pages (March 2012)
Proper citation: Wikibooks (RRID:SCR_008799) Copy
http://www.med.upenn.edu/cndr/index.shtml
A research institution which conducts clinical research to understand brain dysfunction and degeneration in Alzheimer's disease (AD), Parkinson's disease (PD), Frontotemporal disease (FTD), Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's disease), and other age-related neurodegenerative disorders. This organization also houses a general training program that has a focus on drug discovery. This program teaches trainees in etiology, pathogenesis, and diagnosis and treatment of Alzheimer's disease, Parkinson's disease, frontotemporal dementias, motor neuron disease and related disorders. This program also trains Ph.D and M.D/Ph.D students, as well scientists, physicians, and veterinarians who have already completed their advanced degree and are looking for a postdoctoral research fellowship. The program is designed to give a solid background in basic and translational neuroscience, and related disciplines.
Proper citation: University of Pennsylvania Center for Neurodegenerative Disease Research (RRID:SCR_008798) Copy
http://www.muschealth.com/multimedia/Podcasts/index.aspx?type=main
The MUSChealth.com Podcast Library, featuring podcasts on a variety of topics related to your health and our services here at MUSC. These medical podcasts are hosted by MUSC faculty, physicians and special guests and are produced and directed by Linda Austin, M.D. Current topics include: * Academics and Education * Aging, Geriatrics and Caregiving * Alcohol and Drug Dependency * Allergies and Asthma * Ashley River Tower * Bones, Joints, Muscles and Spine * Cancer * Children''s Health * Cosmetic Surgery * Dental * Dermatology/Skin Problems * Diabetes, Endocrinology and Metabolism * Digestive Health * ENT: Ear, Nose and Throat * Executive Health * Eye Health * General Health and Wellness * Heart and Vascular Health * Hospice * Kohl''s Take a Minute for Kids * Lungs and Breathing * Men''s Health * Mental Health * MUSC News and Events * Neurological Health * Organ Transplant * Osteoporosis * Pregnancy - Week by Week * Pregnancy and Childbirth * Radiology * Research and Clinical Trials * SC Health, Leadership and Policy * Sports Medicine * Stroke * Urology * Weight Loss Surgery Follow-up * Weight Management * Women''s Health
Proper citation: MUSC Health Podcast Library (RRID:SCR_008827) Copy
Voluntary, non-profit organization dedicated to collecting and disseminating statistical data. Resource for gathering and disseminating epidemiologic data on all primary benign and malignant brain and other CNS tumors.
Proper citation: Central Brain Tumor Registry of the United States (RRID:SCR_008748) Copy
The WEB ATLAS contains photographs of dissected brains showing important structures. The diagrams folder contains drawings showing functionally important parts of the brain as well as drawings of dissections adapted from C.G. Smith. We are particularly pleased to make Nan Cheney''s medical illustrations of the brain and the head available. The STROKE MODEL portion of the website has syndromes associated with strokes of different vessels of the brain as well as extensive diagrams and tables about the vessels of the brain. The 3D RECONSTRUCTIONS featured on this website were made from MRI scans through the brain - where indicated the source material was from the NIH Visible Human Project. The website will also contain material important for the neuroanatomy labs for med students at UBC. Weekly quizzes will help you keep up with studying the material, the podcasts will help you review material presented in the labs, and the weekly wikis will help you share information with your peers.
Proper citation: Neuroanatomy at UBC (RRID:SCR_008744) Copy
http://meme.nbcr.net/meme/cgi-bin/gomo.cgi
Gene Ontology for Motifs (GOMO) is an alignment- and threshold-free comparative genomics approach for assigning functional roles to DNA regulatory motifs from DNA sequence. The algorithm detects associations between a user-specified DNA regulatory motif (expressed as a position weight matrix; PWM) and Gene Ontology terms. The original method for predicting the roles of transcription factors (TFs starts with a PWM motif describing the DNA-binding affinity of the TF. GOMO uses the PWM to score the promoter region of each gene in the genome for its likelihood to be bound by the TF. The resulting ''''affinity'''' scores are then used to test each term in the Gene Ontology for association with high-scoring genes. The algorithm was subsequently extended to leverage conserved signals using multiple, related species in a comparative approach, which greatly improves the resulting annotations. Platform: Online tool, Windows compatible, Mac OS X compatible, Linux compatible, Unix compatible
Proper citation: GOMO - Gene Ontology for Motifs (RRID:SCR_008864) Copy
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