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http://www.scienceexchange.com/facilities/nucleic-acids-core-facility

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 15,2024. Nucleic Acids Core Facility offers automated DNA sequencing with data analysis, custom DNA synthesis, genome project services, gene amplification services, and robotic application custom projects. These services are provided to researchers at the HSC and others in the surrounding scientific community. Our mission is to offer high quality synthesis and sequencing services to researchers through cutting edge instrumentation and a service-oriented and knowledgeable staff.

Proper citation: UTHSCSA Nucleic Acids Core Facility (RRID:SCR_012614) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/ontario-cancer-biomarker-network

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 14,2024. OCBN is a not-for-profit corporation that was established in 2005 with a grant from the Ontario Institute for Cancer Research and the Ontario Ministry of Research and Innovation for the purpose of advancing biomarker research. The OCBN is designed to enable the co-ordination and amplification of the proteomic and genomic biomarker research efforts throughout the province of Ontario to better service academia and industry, whether provincially, nationally or internationally. As such, OCBN is much more than simply an academic research consortium. Residing at the core of the network is the OCBN Central Facility, located at the MaRS Incubator www.marsdd.com in the heart of the biomedical research community in Toronto, one of the most vibrant research hubs in the world. The Central Facility functions as the nexus for the network and its academic and industry partners by providing numerous support services for their clinical and basic research scientists in the conduct of their research.

Proper citation: Ontario Cancer Biomarker Network (RRID:SCR_012616) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/waisman-biomanufacturing

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 15,2024. With broad and comprehensive capabilities, Waisman Biomanufacturing is uniquely situated and highly qualified to lead clients through the complex process of bringing a novel therapeutic into the clinic. Integral to any product campaign is a well thought-out product development plan. You can rely on our business manager and team of project leaders to work closely with you to maintain an on-going flow of communication and develop a time and cost effective plan that meets your needs. Utilizing our expertise in both Quality Assurance/Control and Process Development/Manufacture we can translate your bench top process to a large scale manufacturing process. Using this strategy Waisman routinely produces cGMP grade material qualified for clinical trials for a wide variety of applications.

Proper citation: Waisman Biomanufacturing (RRID:SCR_012583) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/immune-monitoring-core-facility-usc

The mission of the USC Arnold and Mabel Beckman Center for Immune Monitoring is to provide the USC community and external customers with the highest quality support for clinical trials for immunotherapy of human cancers; facilitate basic, translational, and clinical research with an immunological monitoring component; and provide immunological assay training and education. The IM core provides quality assessments of immunological function necessary for the study of pathogenesis, treatment, and prevention of cancer and other human diseases. Supporting clinical trials for immunotherapy of human cancer: For physicians involved in clinical trials for immunotherapy of human cancer, the Beckman Center for Immune Monitoring Core offers several assays to assess patient immune responses. Such assays provide a highly sensitive and quantitative means of measuring the efficacy of an experimental treatment as a surrogate endpoint or as a correlative to clinical responses. It can help establish proof of principle that a treatment works, and suggest changes to adapt a standard treatment protocol to individual patient needs. Besides the Gold Standard of Immune monitoring: the ELISPOT assay for detection of cytokines released by activated T cells, we also perform intracellular cytokine staining and can detect tumor specific T cells by MHC tetramer analysis. Helper and killer T cells can be separated, and proliferative and cytotoxic responses are quantified in radioactive assays. The monitoring protocol of choice is tailor made to fit the needs and the possibilities of each treatment protocol. The core offers freezing and storage capacity for clinical samples and full analytical support for monitoring assays. It is also possible to send in samples for post-assay analysis using our state-of-the-art ELISPOT reader. Facilitating research with an immune monitoring component: For researchers within travel distance of our facility, we offer equipment and technical assistance for performance and/or analysis of ELISPOT assays, flow cytometry-based assays, radioisotope-based proliferation and cytotoxicity assays, multiplexing ELISA assays, and molecular-based quantitative PCR assays. Our lab has equipment for controlled rate freezing and storage of cryopreserved peripheral blood cells, tissue culture facilities and an ELISPOT reader to analyze your 96 well plates. Assays and technical support are also available to support translational projects that utilize in-vitro systems and in vivo animal models.

Proper citation: USC Immune Monitoring Core Facility (RRID:SCR_012672) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/bwh-confocal-microscopy-core-facility-harvard

Our facility provides equipment and training for researchers interested in using widefield & confocal microscopy, photobleaching, and live cell imaging studies.

Proper citation: BWH Confocal Microscopy Core Facility (RRID:SCR_012679) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/flow-cytometry-core-harvard

The cell sorting and analysis lab provides access to the most sophisticated flow cytometers presently available. The core is able to analyze and physically separate cells based upon features detectable with fluorescently labeled monoclonal antibodies. The Simches site is located in the newly constructed space located in room 3.434 in the Simches Building. Major Equipment (Simches): Analytic Seven Laser LSR configured with 355 nm, 407 nm, 488 nm, 532 nm, 594 nm, 633 nm, and 780 nm air cooled lasers providing a wide range of excitation possibilities. Modified Digital Vantage cell sorter with 2 water-cooled argon, 2 krypton and one air cooled 633 nm laser. The CNY site is located in the newly constructed space located in room 6.307 in Building 149, 13th Street, Charlestown Navy Yard. Major Equipment (CNY): Analytic three Laser LSR II configured with 405 nm, 488 nm, and 633 nm air cooled lasers providing a wide range of excitation possibilities. A four laser FACS Aria II cell sorter configured with 405 nm, 488 nm, 594 nm and 633 nm air cooled lasers providing a wide range of excitation and sorting possibilities.

Proper citation: MGH Flow Cytometry Core (RRID:SCR_012678) Copy   

•   Source: SciCrunch Registry

http://www.neurodiscovery.harvard.edu/research/lddn_2.html

Core facility that provides the following services: Assay design and development service. The NeuroDiscovery Center''''s Laboratory for Drug Discovery in Neurodegeneration (LDDN) was established to discover chemical agents from which we and others will develop a new generation of drugs to treat neurodegenerative diseases (including degenerative diseases of the eye and ear). To accomplish this goal, LDDN has recruited a permanent staff of industry-seasoned scientists with expertise in assay development, laboratory automation, informatics, and medicinal chemistry, to work in close collaboration with principal investigators from the academic neuroscience community. In this way, LDDN helps transform discoveries in the basic biology of neurodegeneration into opportunities for drug discovery. (While priority is given to members investigating neurodegenerative diseases and the central nervous system, we welcome inquiries from all investigators.)

Proper citation: HNDC Drug Discovery in Neurodegeneration (RRID:SCR_012680) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/brains-on-line

Our mission at Brains On-Line is to provide preclinical research services to facilitate the development of new drugs that target the central nervous system. Brains On-Line benefits from its intimate connections with academia, as well as with several associated contract research organizations (CRO). Using our expertise, we aim to give full insight in the possibilities of your compound.

Proper citation: Brains On-Line (RRID:SCR_012565) Copy   

•   Source: SciCrunch Registry

https://rhslab.pitt.edu/services

Research Histology Services is located in the Thomas E. Starzl Biomedical Science Tower at the University of Pittsburgh. RHS lab serves as the Core Liver and Kidney Laboratory for the Immune Tolerance Network (ITN) and the Core Heart Lab for the Clinical Trials in Organ Transplantation in Children (CTOTC04), providing histology services for ongoing clinical patient research studies throughout the United States and Canada. Provides range of histological research techniques that include decalcification, standard tissue processing, biopsy processing, paraffin embedding, OCT embedding of frozen tissues, serial sectioning, step/level sectioning, and cryostat sectioning. A wide spectrum of assays is available in addition to the routine hematoxylin and eosin (H&E) stain. Special histochemical stains routinely provided include; Masson Trichrome, PAS (periodic acid Schiff), Prussian Blue (Iron), Verhoff''''s Elastin Stain, Cresyl Violet, Toluidine Blue, and Luxol Fast Blue; additional histochemical staining is done upon request. Wide arrays of Immunoperoxidase and Immunofluorescent staining and apoptosis/ tunel stains are also available. Our goal is to return quality work in the shortest time possible.

Proper citation: University of Pittsburgh Research Histology Services Core Facility (RRID:SCR_012648) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/respiratory-disease-immunology-core-laboratory-rdicl-uc-davis

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 24,2024. Respiratory Disease Immunology Core Laboratory is to provide technical expertise and resources to investigators interested in the immunological evaluation of rhesus macaque models for lung disease. Studies are primarily carried out in conjunction with the Inhalation Exposure Core and the Computational Imaging Core at UCDavis, in order to provide a comprehensive evaluation of pathophysiological responses in the lung. Services provided by the RDICL include assistance with experimental design, allergen characterization and preparation (through Resource Services), evaluation of allergen-specific IgE and IgG, and quantitation of histamine. We also provide technical support for sample processing, including bronchoalveolar lavage, lung tissue, and blood. Flow cytometry and molecular analysis of lung and blood samples are coordinated with the Flow Cytometry Core Laboratory and the Infectious Disease Immunology Core Laboratory. In addition to immunological evaluation, the Respiratory Disease Immunology Core Laboratory can provide investigators with primary cell isolates and in vitro culture of rhesus lung epithelial cells and fibroblasts. The Core does not conduct studies with human lung cultures. Please inquire for additional assays that are in development. In the future, immunohistochemistry of lung samples will be offered in conjunction with the Computational Imaging Core at UCDavis.

Proper citation: UC Davis Respiratory Disease Immunology Core Laboratory (RRID:SCR_012647) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/division-of-comparative-pathology-miami

The Division of Comparative Pathology is a full service veterinary pathology laboratory with both clinical pathology and histology services. Routine hematology and serum biochemistry testing is available for multiple species; we work well with low volume samples. Specialized testing is available or can be implemented as needed. Routine histology services including processing, embedding, and sectioning are available with many routine and special staining options.

Proper citation: UM Miller School of Medicine Division of Comparative Pathology (RRID:SCR_012492) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/institute-for-behavioral-genetics

The Institute for Behavioral Genetics (IBG) is an organized research unit of the University of Colorado Graduate School dedicated to conducting and facilitating research on the genetic and environmental bases of individual differences in behavior. Founded in 1967, IBG is one of the top research facilities in the world for genetic research on behavior. Data collection and analysis is ongoing for several internationally renowned studies including the Colorado Adoption Project, the Colorado Twin Registry, the National Youth Survey Family Study, the Colorado Learning Disabilities Research Center, and the National Longitudinal Study of Adolescent Health. IBG is home to one of the nation''''s largest DNA repositories for research on human behavior, as well as housing a wide array of behaviorally and genetically defined lines of selected, recombinant inbred, transgenic, and knockout-gene mice. Current research includes studies of aging ( The Johnson Lab, The Link Lab), psychopathology, reading disability, cognition, substance abuse, behavioral development, and evolution. In addition to our research, we provide training opportunities for graduate students in affiliated programs at the University of Colorado campuses in Boulder and Denver. IBG receives funding from several federal agencies, principally through the National Institutes of Health, as well as a broad spectrum of Associations, Foundations and Programs. Welcome to our site, please feel free to contact us with any questions about our research or programs.

Proper citation: CU Boulder Institute for Behavioral Genetics (RRID:SCR_012495) Copy   

•   Source: SciCrunch Registry

https://www.mayo.edu/research/core-resources/proteomics-core/overview

Proteomics involves analysis and identification of protein structure and function. Through Proteomics Core, investigators at Mayo Clinic and elsewhere have access to a broad range of proteomics services, technologies and guidance to help them answer scientific questions. Toward a goal of improving patient care, the core offers services and conducts research in the areas of mass spectrometry-based differential proteomics, peptide synthesis, protein and peptide purification, and protein identification, characterization and expression.

Proper citation: Mayo Clinic Proteomics Core Facility (RRID:SCR_012653) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/genomics-and-epigenomics-shared-resource-gesr-georgetown

The Genomics & Epigenomics Shared Resource (GESR) provides services for various high throughput experiments including gene expression profiling, SNP genotyping, CNV analysis, DNA methylation, microRNA expression profiling, siRNA screening, DNA/RNA isolation, RNA quality assessment, DNA plating and assay preparation, DNA sequencing, and fragment analysis. GESR uses state-of-the-art instruments and assays to provide these services. These include Affymetrix Microarray System, Agilent Microarray System, Applied Biosystems TaqMan assays, Illumina BeadXpress, Qiagen PyromarkMD, Qiagen Qiacube, Agilent Bioanalyzer, Beckman Multimek NXP Robotic Liquid Handling System, and Applied Biosystems Sequence Analyzer. In addition, GESR houses several user-operated specialized instruments for which the shared resource personnel provide technical support and training.

Proper citation: Georgetown Genomics and Epigenomics Shared Resource (RRID:SCR_012498) Copy   

•   Source: SciCrunch Registry

https://siperg.las.iastate.edu/stable-isotope-lab-sil/

Core performes continuous flow isotopic and elemental analyses of carbon, nitrogen, oxygen and hydrogen in organic and inorganic substrates (solids, liquids, and gases). Supports research in oceanography, paleoclimatology, geology, ecology, agronomy, and chemistry. Laboratory consists of ThermoFinnigan Delta Plus XL mass spectrometer coupled with several sample introduction systems, including GasBench II with CombiPal autosampler, Costech elemental analyzer and TC/EA with Conflo III interface. Additionally, the SIL operates Picarro L2130-i Isotopic Liquid Water Analyzer with autosampler for rapid measurements of deuterium and oxygen.

Proper citation: Iowa State University SIPERG Stable Isotope Lab Core Facility (RRID:SCR_012541) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/gene-expression-core

The Gene Expression Core (GEC), part of the Advanced Genomics Technology Center at Mayo Clinic, provides comprehensive services and technical support for the measurement of gene expression in clinical and nonclinical samples. The GEC serves customers from both inside and outside Mayo Clinic. The GEC utilizes multiple state-of-the-art platforms _������������ including microarray-based technologies from Affymetrix, Illumina and Agilent, and quantitative polymerase chain reaction (qPCR) instrumentation from Fluidigm and Applied Biosystems _������������ for a variety of gene expression analyses. Services are also available for sample preparation for whole-genome messenger RNA (mRNA) and microRNA (miRNA) profiling by next-generation sequencing. The GEC currently provides whole-transcriptome and miRNA expression analyses of RNA derived from fresh-frozen tissues; formalin-fixed, paraffin-embedded tissues; laser-capture microdissected cells; and cell lines.

Proper citation: Mayo Clinic Gene Expression Core (RRID:SCR_012664) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/waksman-institute-of-microbiology

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 10, 2023. Our mission is to conduct research in microbial molecular genetics, developmental molecular genetics, plant molecular genetics, and structural and computational biology. We also provide a catalyst for general university initiatives, a life science infrastructure, undergraduate and graduate education, and a public service function for the State of New Jersey. The Institute employs faculty teams that concentrate on certain classes of organisms amenable to genetic analysis such as bacteria and fungi (E. coli and yeast), animal systems (e.g., Drosophila), and plants (Arabidopsis, tobacco, and maize). Although the Institute focuses on basic questions in microbial, animal, and plant research, it continues to engage in extensive technology transfer of its basic discoveries.

Proper citation: Rutgers Waksman Institute of Microbiology Labs and Facilities (RRID:SCR_012728) Copy   

•   Source: SciCrunch Registry

http://ocs.med.nyu.edu/immunohistochemistry

The Immunohistochemistry Core, a component of the Experimental Pathology Shared Resource, is located in Bellevue Hospital within the NYULMC Department of Pathology''s Anatomic Pathology clinical space. The laboratory serves as an immunohistochemical antibody repository with a catalog of over 900 antibodies. Antibodies are in stock and available for use in the core laboratory for the collection of experimental immunohistochemistry data. The laboratory develops immunohistochemical protocols for new antibodies (commercial or proprietary) that have not been tested in fresh, frozen, fixed human or animal tissues and cells. In addition to performing manual labeling, the laboratory is equipped with two Ventana NEXES and one Discovery automated immunohistochemical staining instruments. The laboratory uses human and animal tissue micro-arrays for validation and employs a wide variety of antigen retrieval methods for protocol development. The core offers tyramide and polymer amplification methods (manual) and single or two color chromogenic immunohistochemistry. The laboratory has also commenced developing protocols and validating antibodies for immunoflorescence in frozen and FFPE tissue samples. The laboratory faculty and staff are available to provide hands-on informal training, as well as guidance and support for the design and execution of experiments involving histopathology and immunohistochemistry of human and animal cells and tissues. In conjunction with the Histopathology Core Laboratory, the Immunohistochemistry Laboratory can also assist investigators with routine and advanced histopathologic services for tissue and cell specimens (including guidance on initial processing steps: grossing/tissue preparation, processing, embedding, paraffin/frozen microtomy) for samples destined for histopathological interpretation and analysis. In addition, we offer extensive options for special and routine histochemical and immunohistochemical labeling of both human and animal model cells and tissues.

Proper citation: NYU Immunohistochemistry Core (RRID:SCR_012721) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/high-throughput-screening-service-uc-irvine

With the completion of the genome sequence, that offers us a variety of new genes to study, and advances in combinatorial chemistry, that delivers large numbers of synthetic compounds to test, high__������throughput screening (HTS) is becoming a necessary research endeavor. We specialize in HTS of G protein__������coupled receptors (GPCRs). Ligand recognition is quantified in binding experiments or monitored by second messenger responses. One technology that we use is the FLIPR technology that allows for real__������time fluorescent measurements.

Proper citation: UC Irvine High Throughput Screening Service (RRID:SCR_012725) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/macromolecular-x-ray-crystallography-core-facility

The Macromolecular X-ray Crystallography Core Facility of Scripps FL offers state-of-the-art equipment and resources to scientists inside and outside of the Scripps FL campus by providing crystallographic analysis of their chosen biological macromolecules. The core facility offers and operates as a full service core by performing protein crystallization, X-ray diffraction data collection (both in-house and at Argonne National Laboratory) and processing, phasing, crystallographic refinement, model building, and visualization. The structural data obtained by the core will provide scientists with a wealth of information including but not limited to biological functions, 3D-folding, ligand binding (small molecule or protein), or mutational effect of target macromolecules of their interests.

Proper citation: Scripps Florida Macromolecular X-ray Crystallography Core Facility (RRID:SCR_012727) Copy   

•   Source: SciCrunch Registry