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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
https://ldi.upenn.edu/fellows/fellows-resources/data-and-analytics-support/
Provides secure environment for investigators analyzing protected health information. �It coordinates acquisition, storage, and analysis of data from private and government sources (e.g., Medicare, Medicaid, and others) and facilitates their use by researchers who seek to answer important questions regarding health policy and health care.�
Proper citation: University of Pennsylvania Leonard Davis Institute of Health Economics Health Services Research Data Center Core Facility (RRID:SCR_022439) Copy
https://www.vet.upenn.edu/research/core-resources-facilities/comparative-pathology-core
Provides support to investigators utilizing animal models to study disease. Comparative Pathology Core, Abramson Cancer Center shared resource, provides expert pathological characterization and validation of mouse and other animal models used in biomedical research by offering expertise of board certified veterinary pathologists and access to histology, immunohistochemistry, and digital pathology services.
Proper citation: University of Pennsylvania Penn Vet Comparative Pathology Core Facility (RRID:SCR_022438) Copy
https://ldi.upenn.edu/fellows/fellows-resources/data-and-analytics-support/
Provides LDI affiliated investigators access to high quality, skilled data analysts. HEDAP recruits, trains, and manages group of masters level and PhD level statistical analysts. These analysts work with multi disciplinary investigators across funded projects using statistical software packages such as SAS, Stata, and R to manipulate and analyze health care data under guidance of investigators and other collaborators.
Proper citation: University of Pennsylvania Leonard Davis Institute of Health Economics Data Analyst Pool Core Facility (RRID:SCR_022437) Copy
https://www.vet.upenn.edu/research/core-resources-facilities/imaging-core
Provides access to optical imaging capabilities for researchers at the University of Pennsylvania, Perelman School of Medicine, Children's Hospital of Philadelphia, and Wistar Institute. Provides instruments and expertise to perform widefield, confocal, multiphoton/intravital imaging, fluorescence lifetime imaging, high content live cell screening, long term single cell imaging, second harmonic imaging, structured illumination super resolution, and total internal reflection fluorescence microscopy, as well as software tools for image analysis. Core has adjacent (in and out) ULAR approved facility to house animals for long term live animal studies.
Proper citation: University of Pennsylvania Penn Vet Imaging Core Facility (RRID:SCR_022436) Copy
https://www.vet.upenn.edu/research/core-resources-facilities/animal-model-core-corl
Supports discovery to invention to innovation in medical translation.Provides animal model development to enhance scientific rigor during in vivo studies in experimental or naturally occurring disease models. Studies can start on small scale leading towards pivotal non-clinical IND/IDE-enabling trials in support of FDA or OUS-FDA submissions. Core hosts PIs, trainees and sponsors during clinical procedures to support and enrich their experience in cross functional team setting.
Proper citation: University of Pennsylvania Animal Model Core Facility (RRID:SCR_022435) Copy
https://www.cardiff.ac.uk/biosciences/research/technology-research-hubs/bioimaging-unit
Provides advanced light microscopy imaging modalities and histological services. Offers training and application support in experimental design, sample preparation, data generation and analysis through to scientific publication and grant assistance.
Proper citation: Cardiff University Bioimaging Hub Core Facility (RRID:SCR_022556) Copy
https://med-upenn.corefacilities.org/service_center/5129/?tab=about
Offers Illumina sequencing and bioinformatic expertise to assist researchers�with gene therapy trial evaluations, viral integration profiling,�CRISPR off-target�analyses. Assists with bioinformatic analyses including RNAseq transcription profiling�and 16S taxonomic assignments.�
Proper citation: University of Pennsylvania Perelman School of Medicine Viral Molecular High Density Sequencing Core Facility (RRID:SCR_022433) Copy
https://www.ohsu.edu/integrated-genomics-laboratory
Lab houses three cores providing support and services from nucleic acid isolation through data generation on multiple genomic and molecular analysis platforms. Nucleic acid extraction, qPCR, and Nanostring profiling services are available through the Gene Profiling Shared Resource for gene expression profiling, microRNA profiling, DNA genotyping and copy number analysis, and DNA methylation analyses. Currently running QuantStudio real-time PCR system. Comprehensive RNA and DNA extraction and quality assessment services available. Massively parallel sequencing (NGS) services, including library preparation, are available through Massively Parallel Sequencing Shared Resource on Illumina NovaSeq 6000 and NextSeq platforms. 10x Genomics single-cell and single-nuclei analysis services available. Cell line authentication, DNA plating, and custom oligo services are available through DNA Services Core.
Proper citation: Oregon Health and Science University Integrated Genomics Laboratory Core Facility (RRID:SCR_022651) Copy
https://www.sfu.ca/fhs/research/research-centres-labs/flow-cytometry-laboratory.html
Offers high speed cell sorting and bench top flow cytometric analysis services as well as training and support to research community.Instruments include BD FACSAria Fusion Cell Sorter,4-Laser | 16-Colour (2B/3R/5YG/6V) within Class II Type A2 BioSafety Cabinet and BD LSRFortessa X-20 Cell Analyzer 4-laser | 16-Colour (2B/3R/5YG/6V).
Proper citation: Simon Fraser University Flow Cytometry Lab Core Facility (RRID:SCR_022492) Copy
https://www.cincinnatichildrens.org/research/cores/mmac
Provides solutions in areas of study design, bioinformatic processing of amplicon and shotgun metagenomic sequencing data, integration of metagenomic and clinical data structures, and statistical analyses of microbial community samples. MMAC works closely with Microbial Genomics and Metagenomics Laboratory to streamline workflows for metagenomic sequencing, bioinformatic processing, and statistical analysis of microbiome projects.
Proper citation: Cincinnati Children's Hospital Microbial Metagenomics Analysis Center Microbial Genomics and Metagenomics Core Facility (RRID:SCR_022649) Copy
Facilitates scientific research of nervous system function to enhance development and testing of novel therapeutic strategies for treatment of nervous system disorders. Provides resource capacity typically unavailable or impractical in individual laboratory. Major areas of specialization include surgical approaches to model production and assessment, behavior testing of sensorimotor functions, in vivo electrophysiological recording (EEG, EMG, ERP). Procedures are intended for mice and rats. Procedures can be developed based on client interests.
Proper citation: University of Texas Southwestern Medical Center Neuro Models Core Facility (RRID:SCR_022529) Copy
https://bauercore.fas.harvard.edu/
Helps to advance research efforts in life sciences that cannot readily be accomplished in the traditional academic laboratory because of need for expensive instrumentation or automation, scientific or organizational infrastructure, or multidisciplinary expertise. Provides expertise and hands-on training and use of instrumentation for nominal fee. Researchers can sign up to use instrumentation through on-line scheduling system and conduct their experiments independently.
Proper citation: Harvard University Bauer Core Facility (RRID:SCR_022656) Copy
Genomics and transcriptomics core at the UCD Genome Center provides high throughput sequencing, genotyping, single-cell multi-omics and spatial transcriptomics services, training and consultation. Initial consultations are free. The lab uses liquid handling robots to minimize sample handling variation and to provide fast turnaround times.
Proper citation: University of California Davis DNA Technologies and Expression Analysis Core Facility (RRID:SCR_017740) Copy
https://web.uri.edu/riinbre/mic/
Core provides sequencing and bioinformatics support for INBRE and non-INBRE researchers. Provides data science services adjacent to traditional bioinformatics; access to computational and software resources for INBRE network institutions, particularly primarily undergraduate institutions; training for students and faculty in data science methods. Maintains professional network with other core and user facilities in Rhode Island and beyond to maximize resources available to our users.Utilizes novel technologies such as virtual/augmented reality for use in teaching and research.
Proper citation: Rhode Island INBRE Molecular Informatics Core Facility (RRID:SCR_017685) Copy
https://core.bioinformatics.udel.edu
CBCB Bioinformatics Data Science Core builds upon infrastructure of the Center for Bioinformatics and Computational Biology. Delaware Biotechnology Institute , Delaware Data Science Institute, and Protein Information Resource. Core helps with planning your research or analyzing your current data. Services:Consultation and Collaboration, Proposal Assistance,Training, Bioinformatics Software, Computational Hardware, Database and Web Services, Next Gen Analysis, Custom Analysis.
Proper citation: University of Delaware CBCB Bioinformatics Data Science Core Facility (RRID:SCR_017696) Copy
Core provides services, access to instruments, and training to facilitate production of animal tissue samples for morphological and molecular analyses. Supports multiplex immunofluorescence staining, RNA in situ hybridization (ISH), and imaging analysis. Services include tissue preparation, processing, and sectioning, as well as histochemistry and immunohistochemistry of fresh, frozen, and fixed animal tissues, can optimize and validate commercial or proprietary antibodies for chromogenic or fluorescence-based immunohistochemistry including seven-color multiplexing.Provides access to database listing antibodies that have been tested in lab to date and are currently in stock.Offers basic imaging resources and digital whole-slide scanning of stained tissue sections, which allows researchers to view their slides online at their convenience.Researchers can also rent our self-service instruments. These include embedding station, microtome, cryostat, and vibratome. Provides access to brightfield and fluorescence upright and dissecting microscopes,laser capture microdissection scope, and high-throughput multispectral imaging system.To reserve time on instrument, faculty, staff, and investigators must be registered in iLab.
Proper citation: New York University School of Medicine Langone Health Experimental Pathology Research Laboratory Core Facility (RRID:SCR_017928) Copy
Core provides central hub to help leverage bioinformatics and data science methods in research projects. Services include Transcriptomics: bulk RNA-Seq, single-cell RNA-Seq, and spatial RNA-Seq; Genomics: SNP, structural variants (SV), and copy number variation (CNV) analyses; Regulatory genomics: ChIP-Seq, ATAC-Seq, CUT&RUN, and Hi-C; Functional genomics: CRISPR-based loss-of-function screens;Image and metadata analysis: AI/ML-based approaches including knowledge graphs. Offers training, education, collaboration, consultation,custom guidance on study design and analysis approaches. Provides classroom and custom training sessions on computational, data science, bioinformatics topics, tailored workshops for requested specialized topics. Offers technical infrastructure and support, computing resource optimization and facilitation, bioinformatics software deployment (conda environments and Docker containers), version control and reproducible science (Git repositories), data management support and submission to public repositories.
Proper citation: Koch Institute at MIT Data Science and Multimodal Integration Core Facility (RRID:SCR_017894) Copy
https://coreimmunology.ucsf.edu/services
Provides immunology assays, expert consultation, and education to UCSF and global research community. CIL specializes in developing immunology research tools, and initiating and stimulating innovative research projects to address emerging questions in immunologic diseases including HIV pathogenesis.Services include:Isolation of PBMC for staining, cell sorting, or viable cryopreservation;Isolation of mucosal mononuclear cells (MMC) from mucosal tissue biopsies;Immunomagnetic bead isolation of untouched cell populations for functional studies;Immunophenotyping of whole blood, PBMC, MMC and cerebrospinal fluid for: NK, B and T cells percentages, and their subsets, including maturation, trafficking, senescence, activation, in vivo proliferation and chemokine receptor expression;Flow cytometric functional assays, including NK cell function, antigen-specific CD4+ and CD8+ T cell cytokine expression, degranulation and proliferation;Evaluation of T cell signaling by phosflow using monoclonal antibodies specific for phosphorylated protein;Training and Support;Flow Cytometry Training Course;Three-hour lecture and lab course designed to cover basics of flow cytometry including:Fluorescence emission and detection,Fluidics,Operation,Panel design,Controls.
Proper citation: University of California at San Francisco Immunology Lab Core Facility (RRID:SCR_017906) Copy
https://www.wpiinc.com/var-2273-constant-current-stimulus-isolator
Automated bipolar pulsing for zero net charge on biological preparations. Includes Constant current, Unipolar and bipolar stimulation modes, Built-in non-compliance alarm, Optically isolated input Standard TTL triggering, DC test mode. Powered by 9 V alkaline or rechargeable batteries.
Proper citation: WPI: Constant Current Stimulus Isolator (RRID:SCR_022660) Copy
https://www.fluidigm.com/products-services/instruments/biomark-hd
Automated, high performance PCR/qPCR system that uses microfluidics technology to process samples at nanoliter scale volumes for gene expression, genotyping, sample identification, copy number variation analysis and digital PCR. With wide range of integrated fluidic circuit (IFC) formats available, scaling from mid to high throughput on single system.
Proper citation: Standard BioTools: Biomark HD system (RRID:SCR_022658) Copy
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