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http://www.ra-map.com/p/about-project.html

RA MAP is a public-private collaborative project into early Rheumatoid Arthritis (RA). Our goal is to: identify the key predictors of clinical response and remission in RA patients, and identify those individuals at high risk of developing RA. By understanding the human immune system in RA through the study of biological samples from RA patients we plan to develop an ''immunological toolkit'' measuring the immune status of healthy individuals and patients.

Proper citation: RA MAP (RRID:SCR_010492) Copy   

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http://ecvam.jrc.it/

ECVAM was created by a Communication from the Commission to the Council and the Parliament in October 1991*, pointing to a requirement in Directive 86/609/EEC** on the protection of animals used for experimental and other scientific purposes, which requires that the Commission and the Member States should actively support the development, validation and acceptance of methods which could reduce, refine or replace the use of laboratory animals: Article 7.2: An experiment shall not be performed if another scientifically satisfactory method of obtaining the result sought, not entailing the use of an animal, is reasonably and practicably available. Article 23: The Commission and Member States should encourage research into the development and validation of alternative techniques which could provide the same level of information as that obtained in experiments using animals, but which involve fewer animals or which entail less painful procedures, and shall take such other steps as they consider appropriate to encourage research in this field. ECVAM has been established in 1992 as a unit of the Environment Institute, part of the Joint Research Centre, and has been transferred to, at that time, newly formed Institute for Health and Consumer Protection in Ispra, Italy in 1998 of which ECVAM is still part of. Duties of ECVAM As defined in the Communication of the European Commission to Council and the European Parliament in October 1991*: 1. To coordinate the validation of alternative test methods at the European Union level. 2. To act as a focal point for the exchange of information on the development of alternative test methods. 3. To set up, maintain and manage a data base on alternative procedures. 4. To promote dialogue between legislators, industries, biomedical scientists, consumer organisations and animal welfare groups, with a view to the development, validation and international recognition of alternative test methods. Moreover, ECVAM should help to expand the JRC''s role in prenormative research. ECVAM thus seeks to promote the scientific and regulatory acceptance of alternative methods which are of importance to the biosciences, through research, new test development and validation, and the establishment of specialised databases, with the aim of contributing to the replacement, reduction and refinement of laboratory animal precedures (in accordance with the 3Rs concept of Russell & Burch***) Due to the political sensitivity of its duties, ECVAM, uniquely at the JRC, has its own Scientific Advisory Committee (ESAC) with participation from all Member States, relevant industrial associations, academic toxicology, the animal welfare movement, as well as other Commission services with interest in the alternatives topic area. The Validation Process Validation is the process by which the reliability and relevance of a procedure are established for a specific purpose. In 1995, based upon experience gained during several recent large-scale validation studies, and in consultation with various international experts (including members of ERGATT), ECVAM published recommendations concerning the practical and logistical aspects of validating alternative test methods (ECVAM workshop report 5). Five main stages in the evolution of new test methods were identified: test development; prevalidation; validation (involving a formal interlaboratory study with the testing of coded chemicals); independent assessment; and progression toward regulatory acceptance. ECVAM has implemented a prevalidation scheme, which includes three main phases: protocol refinement, protocol transfer, and protocol performance. The objective of the prevalidation process is to ensure that any method included in a formal validation study adequately fulfills the criteria defined for inclusion in such a study, so that financial and human resources are used more efficiently, and so that there is a greater likelihood that the expectations of those in the scientific, regulatory and animal welfare communities, who seek the replacement of current animal tests by relevant and reliable alternative methods, will be met. In 2004, ECVAM has published the Modular Approach to the ECVAM Principles on Test Validity (select from the top-menu bar the sector Publications followed by ECVAM Selected Articles) that makes the validation process more flexible, by breaking down the various steps in validation into indipendent modules, and defining for each module the information needed for assessing test validity. Collaborations ECVAMs activities are undertaken in collaboration with numerous laboratories and organisations in the EU Member States, and all over the world. ECVAM also works in close collaboration with other Commission services, such as DG Environment, DG Enterprise, DG Research and DG Health and Consumer Protection. Sponsor. This is a Five years project funded by DG RTD that aims to develop a testing strategy to improve the prediction of oral acute toxicity using non-animals based systems.

Proper citation: European Centre for the Validation of Alternative Methods (RRID:SCR_008504) Copy   

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http://eurobonet.pathobiology.eu/cd/

Integration objectives Training and education Standardisation in technology Share of material Web based sharing of information and communication Translational research Spreading excellence objectives Coordinated by Treviso Courses on bone pathology and molecular biology Standard Operation Protocols Web-based discussion forums Research objectives Work packages on: Cartilaginous Tumours (Leiden) Osteogenic Tumours (Munster) Giant Cell Tumours (Oxford) Ewing Sarcoma (Bologna)

Proper citation: Eurobonet (RRID:SCR_008503) Copy   

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http://ccr.coriell.org/Sections/Collections/CSCB/Default.aspx

Biospecimen repository that provides scientists with the opportunity to bank their pluripotent stem cell lines and develops in-house induced pluripotent stem cell (iPSC) lines for distribution. They have developed core capabilities to maintain, characterize, bank, and distribute important stem cell resources. The SCB performs extensive identification and characterization testing for all submitted human induced pluripotent stem cell (iPSC) and mouse embryonic stem cell (mES) lines. The identification and quality control measures include karyotype analysis, microsatellite analysis for parental cell line identity matching, sterility testing, and assessment of viability after cryopreservation. Pluripotency characterizations performed by SCB vary depending upon the distributing repository. * NIGMS iPSCs: Surface antigen expression, Embryoid body formation, Pluritest Gene Expression assay * NINDS iPSCs: Surface antigen expression, Embryoid body formation * NIA mES: Surface antigen expression, Embryoid body formation, Transgene induction Each characterized human iPSC line and mES line released for distribution is provided with a Certificate of Analysis, which includes information regarding characterization and quality of the line, images and links to original publications. The human iPSCs distributed by Coriell are strictly for research purposes and cannot be used in human subjects. All terms described in the Material Transfer Agreement (NIGMS and NINDS Repositories) or Assurance Form (NIA Repository) for the stem cell line must be agreed to prior to using stem cell lines from Coriell.

Proper citation: Coriell Institute Stem Cell Biobank (RRID:SCR_008745) Copy   

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http://ctn.uwaterloo.ca/index.html

The Centre for Theoretical Neuroscience (CTN) was recently established at the University of Waterloo. The Centre is a growing research initiative of the University. The Centre consists of several labs focused on various areas of theoretical neuroscience (aka computational neuroscience). At present, the Centre consists of faculty members from Applied Mathematics, Biology, Psychology, Engineering, Philosophy, Statistics, Computer Science, and their students. The Centre has established a unique Graduate Program in theoretical neuroscience and hosts a regular academic colloquium series. The Centre also hosts the annual public Waterloo Brain Day lectures. The Centre is currently expanding, running searches for additional core faculty. The distinguished faculty of the Centre include two Canada Research Chairs and a fellow of the Royal Society of Canada. In addition, the Centre has a number of student researchers, both graduate and undergraduate, and hosts postdocs and visiting researchers. The Centre also hosts a graduate program for students wishing to obtain an officially recognized specialization in theoretical neuroscience. Faculty at the Centre pursue work on purely theoretical questions regarding the foundational principles guiding the function of neural systems, as well as constructing detailed neurobiological models of specific brain areas.

Proper citation: Center for Theoretical Neuroscience; University of Waterloo (RRID:SCR_008747) Copy   

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http://www.cytopathology-foundation.org/

Cytopathology Foundation is a non-profit organization dedicated to the health care for the advancement of art and science of Cytopathology dealing with study of cells for proper disease management especially cancer. Cytopathology is a well established diagnostic sub-specialty of pathology. Instead of using surgically removed tissue to arrive at a diagnosis it attempts to identify diagnostic and prognostic information from dispersed cells obtained by non-invasive or minimally invasive techniques. An example, and its greatest success story thus far, is the role it has played in the battle with cervical cancer. The introduction of the Pap smear has contributed immensely to the early diagnosis and significantly decreased mortality of cervical cancer. Activities of the foundation 1. Support the mission statement in general. 2. Support the editorial and publication expenses of CytoJournal. 3. Future activities may include publication and marketing of cytopathology related literature, to generate funds. 4. Support any other scholarly activities in Cytopathology and related areas.

Proper citation: Cytopathology Foundation (RRID:SCR_008467) Copy   

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http://www.cienciasecognicao.org

Portal for scientific dissemination, teaching and interdisciplinary research that includes the integration of the sciences of mind, brain and education in Brazil. The contents are in Portuguese. English version coming soon.

Proper citation: Science and Cognition Organization (RRID:SCR_009436) Copy   

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http://www.biobancusa.com/

BioBancUSA is a leading biotechnology company specializing in white blood cell collection, processing, cryopreservation and storage service. BioBancUSA, a private company headquartered in Monterey, California, is the exclusive licensee of the original patent for the collection, processing and cryopreservation technology of white blood cells, giving you the assurance of both technical integrity and legal legitimacy that you can count on. BioBancUSA is dedicated to providing our clients with the highest quality immune cell preservation for their future medical use. We are committed to the most advanced technology, exceptional, personalized service and leading-edge innovation to benefit our customers, health care providers, shareholders and employees.

Proper citation: Biobanc USA (RRID:SCR_010622) Copy   

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http://tronolab.epfl.ch

Retroelements constitute important evolutionary forces for the genome of higher organisms, yet their uncontrolled spread, whether from endogenous loci or within the context of viral infections, can cause diseases such as cancer, hepatitis and AIDS. Correspondingly, a variety of host-encoded activities limit this process, belonging to a line of defense commonly called intrinsic or innate immunity, which notably contributes to taming endogenous retroelements and to restricting the cross-species transmission of retroviruses. Our work aims at characterizing the relationship between retroelements and their hosts, which has recently led us to become more generally interested in epigenetic mechanisms regulating the expression of mammalian genomes.

Proper citation: Tronolab (RRID:SCR_008580) Copy   

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http://www.rucdr.org/

RUCDR is a biobank and a service organization that maintains human blood, serum, saliva, tissue and the genetic products derived from those. Services include technical consultation and logistical support for biobanking. Researchers can order biomaterials and apply for phenotypic / genotypic data.

Proper citation: Rutgers Cell and DNA Repository (RRID:SCR_010624) Copy   

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http://www.ntnu.edu/hunt

International biobank storing whole blood and DNA from 200,000 individuals, serum and plasma samples from more than 100,000 individuals as well as urine, RNA tubes, cells, buffy coat and Na-heparin tubes for environmental analysis for as many as 50,000 individuals. All bio-specimens from the HUNT surveys are collected, processed and stored at the HUNT Biobank in Levanger. The National CONOR Biobank is located on the same site, where it serves as a central research repository for DNA samples from all the largest Norwegian health surveys. These make up the Cohorts of Norway (CONOR), which include samples from more than 200,000 individuals. * HUNT 1 was carried out in 1984-1986 to establish the health history of 75,000 people. * HUNT 2, carried out in 1995-1997, focused on the evolution of the health history of 74,000 people. This included blood sample collection from 65,000 people. The data that accompany biospecimens in the biobank are stored in secured computer systems that run complex database management and analysis software. * HUNT 3 was completed in June 2008. 93,210 people were invited to participate in the study, and as of the 6th of June, 2008, 48,289 people participated (52% participation rate). The data, collected by means of questionnaires, interviews, clinical examinations and collection of blood and urine samples, will be ready for analysis in January 2009. * Young-HUNT is the adolescent part of HUNT including participants aged 13-19 years. Young-HUNT1 (1995-97) was conducted as part of HUNT2, 9141 adolescents participated (90% response rate). Young-HUNT2 (2000-01) was a follow-up study of Young-HUNT1, 2400 students participated in both studies (77% of the invited). Young-HUNT3 (2006-08) was a new cross-sectional study as part of HUNT3. This time 8677 adolescents participated (87% response rate). Data collection included self-reported questionnaires, structured interviews, clinical measurements and, in Young-HUNT3, buccal smears. All institutions with research expertise can apply for access to analyze HUNT data. Projects must have recommendations from The Regional Committee for Medical Research in Norway (REK) and be registered with The Norwegian Social Science Data Services (NSD).

Proper citation: Hunt Biobank (RRID:SCR_010626) Copy   

•   Source: SciCrunch Registry

http://www.sabc.murdoch.edu.au/

The SABC is the collaborative university Centre for R&D in agricultural and veterinary biotechnology in Western Australia. It provides platform technologies and world class equipment and facilities for R&D in agricultural biotechnology to researchers from universities, state government and industry. More than 20 research groups and companies rent space and use the SABC facilities. It is based at Murdoch University in Perth. Our Vision To be an eminent, internationally recognized centre for research and development in agriculture and veterinary biotechnology Our Mission To provide state-of-the-art facilities and equipment enabling multi disciplinary research in biotechnology which under pins the agricultural and veterinary industry, for the benefit of the community. This will be achieved by being recognised as the centre for agricultural biotechnology in WA providing national and international research links and collaborations fostering establishment of national centres in leading edge technologies Characteristics of the SABC * The SABC is a multi-user centre with a research spend of about $9 million pa * There is a critical mass of more than 225 researchers * The SABC combines university, state government and industry researchers in one cost-effective centre * The SABC operates as a ''Research Hotel'' in which different groups rent common laboratory space and access to platform technologies * The SABC supports incubation and co-location of new ag biotech companies in WA * The SABC promotes collaborative research, undertakes contract research, and provides many local, national and international linkages * SABC researchers are members of eight agricultural Cooperative Centres (CRCs) Research Focus The research focus is on molecular activities that involve or promote primary production of commercial livestock, crop plants or microbes, or their subsequent processing for added value. The SABC also supports research in biomedical sciences, and environmental biotechnology. Deliverables and Outcomes SABC researchers have an outstanding track record of outputs and outcomes. These include the provision of co-located, state-of-the art, well run platform technologies for all WA researchers plant breeding support leading to improved crop varieties (molecular markers, yield, resistance to diseases and pests, better quality, variety ID, diagnostics), improved productivity and health of livestock, and biomedical diagnostics. Facilities and platform technologies The SABC provides the most comprehensive set of equipment and facilities for biotechnology R&D in WA, with full facilities for: cell and molecular biology, robotics, high throughput agricultural genetic analyses and diagnostics, structural, comparative and functional genomics, microarray technologies, proteomics and mass spectroscopy and bioinformatics support via the (CBBC). Training and Mentoring The SABC plays a major role in advanced training in ag biotech. There are about 100 Honours and PhD students in the research complement. The SABC also runs a series of hands on short courses in molecular biology, gene mapping, diagnostics, proteomics and bioinformatics. In 2005 new postgraduate certificate and diploma courses on Application of Molecular Technologies was established at Murdoch University, run by internationally qualified SABC researchers. These provide advanced education at the Postgraduate Certificate, Diploma and MSc levels, for local and international participants. click here for details The SABC runs the following hands-on training workshops: * Introduction to Molecular Biology * Molecular Mapping Techniques in Diagnostic Biotechnology * High Throughput Genetic Analysis * Introduction to Proteomics * Advanced Proteomics * Bioinformatics (with the CBBC) Competitive Advantages The SABC: * combines crop, veterinary and biomedical research in biotechnology in one centre * is multidisciplinary and inclusive * provides enabling facilities, platform technologies and common laboratories * is highly cost effective Researcher Groups Using the SABC * Division of Health Sciences (Murdoch)/Veterinary Sciences * Division of Science and Engineering (Murdoch)/Biological Sciences and Biotechnology * UWA (Natural Resources and Agriculture, Biochemistry) * Curtin University (Molecular Biotechnology, Horticulture) * Edith Cowan University (Human Genetics) * WA Dept of Agriculture (animal, plant, microbial) * Fisheries * Perth Zoo * Plant Biotechnology Research Group * Australian Centre for Necrotrophic Fungal Pathogens (ACNFP) * Rumen Biotechnology * Centre for High Throughput Agricultural Genetic Analysis (CHAGA) * Veterinary Virology, Parasitology, Microbiology * Saturn Biotech Pty Ltd * Grain Biotech Australia Pty Ltd * Proteomics International * Lighthouse Laboratories Pty Ltd * ID PLUS Pty Ltd * Royal Perth Hospital * Fremantle Hospital * Australian Neuromuscular Research Institute (ANRI) Partnering Opportunities The SABC can provide full facilities for contract R&D, start up companies or co-location of existing companies in agricultural, veterinary and biomedical sciences via its incubation program. Contact the Director for further information. Partnering Needs Investors interested in commercializing outputs of SABC researchers.

Proper citation: Western Australian State Agricultural Biotechnology Centre (RRID:SCR_008577) Copy   

•   Source: SciCrunch Registry

http://www.mrli.ppdi.com

PPD is a leading global contract research organization (CRO), celebrating 25 years of providing drug discovery, development and lifecycle management services. Our clients and partners include pharmaceutical, biotechnology, medical device, academic and government organizations. With offices in 41 countries and more than 10,500 professionals worldwide, PPD applies innovative technologies, therapeutic expertise and a commitment to quality to help clients and partners accelerate the delivery of safe and effective therapeutics and maximize the returns on their R&D investments. Discovery Services: BioDuro, A PPD Company A drug discovery services company focused on integrated drug discovery programs Nonclinical development Preclinical services partners. Compound Partnering PPD''s compound partnering business is now Furiex Pharmaceuticals, Inc., an independent, publicly traded company. Collaboration with Merck Our strategic collaboration with Merck enabled us to acquire its vaccines and biologics infrastructure, broaden our therapeutic expertise and expand our existing relationship. Alliance with WHISCON We have expanded our post-approval safety expertise and risk management through an alliance with World Health Information Science Consultants. Partnership with PUL To meet growing client demand in Southeast Asia, we partnered with Peking Union Lawke Biomedical Development Limited (PUL) to establish our central lab services in China. Our e-Newsletter is your source for what is happening at PPD and in the CRO industry.

Proper citation: Clinical Trial Solutions with PPD (RRID:SCR_008457) Copy   

•   Source: SciCrunch Registry

http://www.medicine.iu.edu/

Medical school and medical research center connected to Indiana University. Its principal research and medical center is on Indiana University – Purdue University Indianapolis campus in Indianapolis.

Proper citation: Indiana University School of Medicine; Indiana; USA (RRID:SCR_012916) Copy   

•   Source: SciCrunch Registry

http://www.ed.ac.uk/schools-departments/vet/

At the vanguard of veterinary education since William Dick founded the School in 1823, the Royal (Dick) School of Veterinary Studies is one of the world''s most innovative and influential centers for clinical care and student education. Using outstanding clinical facilities, we provide veterinary services of the highest standards and a stimulating educational experience for our students, within an environment rich in high quality interdisciplinary research. Affectionately known as the ''Dick Vet'', the School is part of the College of Medicine and Veterinary Medicine at the University of Edinburgh, one of the top 15 centers of biomedical research in the world with annual research awards in excess of 100 million pounds. Our research spans all aspects of veterinary medicine, from molecules and genes through to animal and human populations. Our partnership with the Medical School is summed up in the ethos - One Health. Our vision is simple yet ambitious: we want to take the School''s work to a new level as a world leader in veterinary research and training. By 2011 we will have invested over 100 million pounds in building state-of-the-art teaching facilities, clinics and laboratories. We attract, and actively recruit, the world''s leading veterinary teachers, clinicians and researchers to maintain our customary high ranking in the UK league tables for international excellence in our teaching and research.

Proper citation: University of Edinburgh Royal (Dick) School of Veterinary Studies; Scotland; United Kingdom (RRID:SCR_012845) Copy   

•   Source: SciCrunch Registry

http://www.tsu.edu/

Proper citation: Texas Southern University; Texas; USA (RRID:SCR_012737) Copy   

•   Source: SciCrunch Registry

http://lucene1.neuinfo.org/nif_resource/monthly_results/current/

An automatic pipeline based on an algorithm that identifies new resources in publications every month to assist the efficiency of NIF curators. The pipeline is also able to find the last time the resource's webpage was updated and whether the URL is still valid. This can assist the curator in knowing which resources need attention. Additionally, the pipeline identifies publications that reference existing NIF Registry resources as this is also of interest. These mentions are available through the Data Federation version of the NIF Registry, http://neuinfo.org/nif/nifgwt.html?query=nlx_144509 The RDF is based on an algorithm on how related it is to neuroscience. (hits of neuroscience related terms). Each potential resource gets assigned a score (based on how related it is to neuroscience) and the resources are then ranked and a list is generated.

Proper citation: NIF Registry Automated Crawl Data (RRID:SCR_012862) Copy   

•   Source: SciCrunch Registry

http://www.phylotree.org/

A phylogenetic tree of global human mitochondrial DNA variation, based on both coding- and control-region mutations, and including haplogroup nomenclature.

Proper citation: PhyloTree.org (RRID:SCR_012948) Copy   

•   Source: SciCrunch Registry

http://www.mq.edu.au/

Proper citation: Macquarie University; Sydney; Australia (RRID:SCR_012796) Copy   

•   Source: SciCrunch Registry

http://www.informatics.jax.org/external/festing/mouse/STRAINS.shtml

A list of major inbred mouse strains from the Jackson laboratories. This list is not being actively maintained (found on Nov 27, 2013).

Proper citation: MGI strains (RRID:SCR_012950) Copy   

•   Source: SciCrunch Registry