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https://www.wistar.org/resources/imaging-facility/

Core facility that provides the following services: Live-cell time-lapse microscopy, Low magnification and photomacrography? service, Confocal microscopy service, Two-photon microscopy, Small animal whole body luminescence and fluorescence imaging?, 2, 3, 4, and 5D image analysis, Imaging consultation service, Imaging equipment, image processing, and image analysis training, In-lab microscopy assistance and maintenance service, Imaging Facility instrument access. The Imaging Facility is a shared resource with the primary goal of providing exceptional microscopy and imaging services, as well as individual access to a variety of state-of-the-art imaging resources for members of the Wistar research community. The imaging systems have been designed to be extremely flexible to reflect a broad range of challenging scientific questions and specimens. Each system provides a combination of illumination, optics and image capture options. Diverse subjects ranging from fluorescently tagged live cell cultures and stained tissue sections, to 3D tumor spheroids and low magnification explanted tissues, can be accommodated with available systems. Current equipment includes standard upright and inverted fluorescence microscopes, a customized live-cell time lapse microscope capable of 6D imaging, a laser scanning confocal microscope, a 2-photon microscope designed for in vivo imaging, a small animal, whole body luminescence and fluorescence imager, special low magnification (photomacrography) systems as well as a variety of traditional photographic cameras, lenses and lighting equipment. Users of the facility may be trained for unassisted use of all core assets, or they may elect assisted service with the facility staff performing the imaging. The Imaging staff also provides assistance to researchers with additional aspects of their imaging requirements. Ideal approaches to specimen documentation are often unique to the experiment and the staff can help design the most effective imaging protocols to answer a particular question. On-site assistance is available to help investigators get the most out of their own systems. Image analysis and specialized Photoshop training, creative imaging for journal covers, and guidance on digital imaging ethics help to round out the services available from the facility.

Proper citation: Wistar Imaging Core Facility (RRID:SCR_010207) Copy   

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http://harvard.eagle-i.net/i/0000013e-5708-120e-7db7-114480000000

The Core''s capabilities include six Computer Numerical Control (CNC) milling centers (one of which is a five-axis micro-milling machine), two 3D printers, a waterjet cutter, a laser cutter, and a sinker Electrical Discharge Machining (EDM) tool. The Core has three full time machinists with experience in both industrial and academic machine shops, creating prototypes for varied applications. In addition to fabrication, these experts help researchers during the design phase, enabling development from a simple concept into real prototypes.

Proper citation: Wyss Institute Machine Shop / 3D Prototyping Core (RRID:SCR_010212) Copy   

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http://harvard.eagle-i.net/i/00000137-b920-a047-d807-77a880000000

The Wyss Institute Materials Characterization Core is dedicated to promoting leading edge biologically inspired research by providing users with a wide range of state-of-the-art materials characterization equipment and analysis software. These tools help support the characterization of a material?s unique physical, chemical, and mechanical properties. The Materials Characterization Core team provides exceptional hands on training, method development, and technical expertise. We also proactively stride to introduce the latest innovations in materials characterization to the Wyss Institute community and our affiliated partners. Our current techniques include chromatography, mass spectrometry, UV-Vis spectroscopy, particle sizing, quartz crystal microbalance, electrochemical testing, rheology, and nanoindentation.

Proper citation: Wyss Institute Materials Characterization Core (RRID:SCR_010213) Copy   

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http://xula.eagle-i.net/i/00000139-25f8-4557-8dd7-9ade80000000

Core facility that provides the following services: Drug Dosage Form Development. The center is focused on understanding and overcoming barriers to efficient oral, colonic, parenteral, pulmonary and vaginal delivery of drugs in the hopes of developing new treatments for chronic diseases such as cancer. Numerous new technologies are coming out of the Center as relationships have been formed with small, advanced technology businesses.

Proper citation: XULA Center for Nanomedicine and Drug Delivery (RRID:SCR_010215) Copy   

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http://xula.eagle-i.net/i/00000134-fc0b-ad1d-77e4-a45080000000

Core facility that provides the following services: X-ray crystallography service. A Molecular Structure and Modeling Core laboratory has been established to provide technical services to support faculty researchers involved in cancer research and drug design at Xavier University. Drug design methods use molecular structure information and modeling methods to determine structure patterns among active and inactive compounds, identify and compare potential active sites, and screen databases to identify new leads. X-ray crystallography provides structure coordinates for druglike, organic compounds and small peptides. The goal of this core laboratory is to provide small molecule X-ray crystallographic services as well as to support ligand-based and structure-based drug design projects at any stage. The long term goal is to develop resources in order to enhance cancer related biomedical research capability at Xavier University. To achieve this goal, the Molecular Structure and Modeling Core Laboratory has set the following specific aims: 1. To provide salary support for a Core Scientist to provide molecular modeling services and training in support of Xavier faculty research projects 2. To establish new collaborations with faculty at other local and RCMI institutions who might benefit from molecular modeling services 3. To provide small molecule x-ray crystallography services 4. To provide support and maintenance costs for equipment in the MSM Core

Proper citation: XULA RCMI Molecular Structure and Modeling Core (RRID:SCR_010219) Copy   

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http://hawaii.eagle-i.net/i/0000012b-36ba-adb7-2f73-b43980000000

THIS RESOURCE IS NO LONGER IN SERVICE, documented January 24, 2019. Core aims to promote multidisciplinary collaboration, and enhance the research excellence and productivity of CRCH by providing access to biomedical informatics expertise and computational support to all members of the Center. The prime objective of the ISR is to facilitate the management, sharing, and integration of diverse data types in cancer research, as well as the synthesis and analysis of more focused data sets from the basic, clinical, genomics and population sciences. The bioinformatics group of the ISR supports a dedicated scientific computing network for computational cancer biology, and leads the development and application of advanced algorithms and software tools that enable Center investigators to take a more integrative approach to cancer research for the purpose of accelerating the translation of basic research results into the clinic.

Proper citation: University of Hawaii at Manoa Informatics Shared Resource (RRID:SCR_010100) Copy   

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http://eagle-i.itmat.upenn.edu/i/00000138-7c6f-afad-fbab-3b8480000000

The Cell Center Stockroom is a division of the Genetics Core Facilities (GCF). The GCF is a University service center, established in 1973 to provide consultation, training, and services in the areas of cell culture and hybridomas. Also, the GCF to provides a full range of cell culture media and molecular biology reagents needed by investigators to perform cell culture techniques in their own laboratories. The DNA Sequencing Facility, Genetic Diagnostic Laboratory and Transgenic/Chimeric Animal Facility are the remaining three divisions of the GCF. The Stockroom serves University of Pennsylvania investigators and affiliate institutions (Cancer Center, Chidren''s Hospital of Philadelphia, Hospital of the Unviersity of Pennsylvania, The Wistar Institute, Monell Chemical Senses Center, and Presbyterian Hospital) by coordinating relations with various suppliers of molecular biological research materials. This involves not only bulk purchasing of these products, but the negotiation of discounts and convenient delivery arrangements. There are over 1,400 products on-site for immediate delivery in the Stockroom. Special ordering of non-regularly stocked products is available from 24 bioreagent vendors with discounted pricing and overnight delivery. List of Stockroom Vendors: * Accutek Laboratories * Amaxa Biosystems * Ambion, Inc. * Applied Biosystems * Atlanta Biologicals * Bio-Rad Laboratories * Biowhittaker * Cell Center Services * Cell Signaling Technologies * Clontech Laboratories * Collaborative * Denville Scientific * Difco Laboratories * EMD Chemicals * Fermentas * Fisher (Thermo) Scientific * Fuji Film * GE/Amersham Bioscience * Gemini Bio-Products�� * Hyclone Laboratories * Integrated DNA Technologies * Invitrogen * ISC Bioexpress * Kodak * KPL, Inc. * Life Technologies * Lonz A* MediaTech * Millipore * New England Biolabs * Open Biosystems * Perkin Elmer Life Sciences * Promeg A* Qiagen * Rainin Instruments * Roche�� * Sigma-Aldrich * Stratagene/Agilent Technologies * TruMark Scientific * USB Corporation/Affymetrix * VWR International * Zen-Bio, Inc.

Proper citation: Penn Cell Center Stockroom (RRID:SCR_010003) Copy   

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http://upr.eagle-i.net/i/0000012b-00c0-e8b5-9e37-5ded80000000

Core facility that provides the following services: Training in STEM, Consulting service, Training in TEM, TEM and SEM service, Assistance with immunogold labeling, Maintenance of SEM, Training in SEM. This lab maintains and operates electron microscope facilities for the faculty, investigators and students of the Medical Sciences Campus for research, training and diagnosis. Service charges apply. Contact lab for details.

Proper citation: UPR Central Electron Microscopy Unit (RRID:SCR_010124) Copy   

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http://upr.eagle-i.net/i/0000012a-250b-de21-43fb-601a80000000

Core facility that provides the following services: Training in the use of FACSort instrumentation, Flow cytometry consulting service. The specific objectives of this unit are to provide access to flow cytometry technology resources to investigators, students, and technical personnel; to train users in the utilization of flow cytometry; instrumentation and in its multiple applications in biological research; to provide basic technical support in flow cytometry methodology to interested users of the facility, and to encourage the development of new methodology and applications in the area of flow cytometry. Provides specialized seminars in flow cytometry basic and clinical applications.

Proper citation: UPR Flow Cytometry Unit (RRID:SCR_010126) Copy   

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http://upr.eagle-i.net/i/0000012f-9804-0f16-f2e2-7b7e80000000

An Core facility

Proper citation: UPR Infectious and Global Diseases Program (RRID:SCR_010127) Copy   

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http://eagle-i.itmat.upenn.edu/i/00000138-ba8f-c231-9cd7-d7e280000000

Core facility that provides the following services: Cryopreservation, Clinical Cell and Vaccine Production Facility quality control and quality assurance services, Clinical Cell and Vaccine Production Facility quality control training, Conjugation of proteins or antibodies to magnetic beads and quality control, Clinical Cell and Vaccine Production Facility vaccine preparation service, Enrichment of lymphocytes or monocytes from apheresis collection, WBC, lymphocyte and monocyte count, Conversion of patient/donor plasma to serum, Depletion of cell subpopulation from apheresis or lymphocytes, Clinical Cell and Vaccine Production Facility quality control testing. The Clinical Cell and Vaccine Production Facility (CVPF) is a GMP facility accredited by the Foundation for the Accreditation of Cellular Therapy (FACT) and a Department of Pathology/Lab Medicine and NCI approved Abramson Cancer Center Shared Resource. The CVPF provides focused scientific, technical and regulatory support for investigator initiated investigational new drug applications (INDs) in cell and gene therapy. Under compliance of FDA 21 CFR Parts 210 and 211, the CVPF performs cell processing on a range of different cell types, to include bone marrow derived CD4+ and CD8+ T lymphocytes, dendritic cells, and marrow stromal cells (aka mesenchymal stem cells). In each of these cases, cells are expanded ex vivo with or without genetic modification to the cells before being reintroduced back into the patient, either alone or in combination with other therapies such as vaccines. The overall mission of the Clinical Cell and Vaccine Production Facility is to help translate insights into novel cellular therapies.

Proper citation: Penn Clinical Cell and Vaccine Production Facility (RRID:SCR_010007) Copy   

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http://eagle-i.itmat.upenn.edu/i/00000141-5b51-0e1d-91c7-0c6080000000

Core facility that provides the following services: Community engagement and research consultation services. Mission: The purpose of the Community Engagement and Research Core in the Penn CTSA is to facilitate community-based research and community engagement, especially community-based participatory research, and enhance the translation of research and technological developments to key public health and community stakeholders. Goals: 1. Foster community-based participatory research projects through developing training programs and integrating lectures into existing academic programs 2. Determine community health needs and priorities 3. Promote community-based research within the area of health disparities through seminar series 4. Continue the involvement in community outreach and education events to engage the community 5. Fund the conduct of CEAR Core pilot studies 6. Facilitate the use of academic-community partnerships to aid in the recruitment of subjects

Proper citation: Penn Community Engagement and Research Core (RRID:SCR_010008) Copy   

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http://eagle-i.itmat.upenn.edu/i/0000013f-631e-6095-a468-831a80000000

Core facility that provides the following services: Body composition measurements, Resting energy expenditure analysis. Nutrition plays a vital role in health at all ages. The Clinical and Translational Research Center offers a Bionutrition Research Unit (BRU) to facilitate and implement clinical and translational research services. Research dietitians assist investigators with research design, implementation, data collection and analysis in study protocols. The Dietary Assessment Unit of the Nutrition Core provides a broad range of nutrition-related research services to investigators at the Children''s Hospital of Philadelphia, the Hospital of the University of Pennsylvania (HUP) and Penn Presbyterian Medical Center (PMC).

Proper citation: Penn/CHOP CTRC Bionutrition Research Core Dietary Assessment (RRID:SCR_010009) Copy   

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http://eagle-i.itmat.upenn.edu/i/00000138-9b9e-1bb6-9cd7-d7e280000000

Core facility that provides the following services: Biological specimen sample preparation for transmission electron microscopy, Phenotypic characterization and ultrastructural analysis of biological specimens, Consultation for transmission electron microscopy experiments, usage, and data presentation, Transmission electron microscopy image construction tomography service, Training in transmission electron microscope operation, Scanning electron microscopy service, Transmission electron microscope access. Structural organization is underlies nearly all cellular, molecular and biochemical processes in biological systems. The Electron Microscopy Resource Laboratory (EMRL) at Penn is dedicated to analysis of biological samples by electron microscopy (EM). The primary goal of the EMRL is to promote biomedical research by offering high quality EM imaging services at a low cost. With a team of experienced professional staff and state-of-the-art imaging equipment, the EMRL offers users a full spectrum of both transmission EM and scanning EM services. These services include: specimen preparation (including fixation, embedding, and sectioning of cells and tissues or preparation of non-cellular materials), operation of equipment, data acquisition, data interpretation, and free instruction on all aspects of EM analysis. We also offer free assistance on the preparation of manuscript and grant applications that incorporate various forms of EM analysis. For most users, the Core will perform a complete analysis from sample preparation through collection of data, most often with the user present during data collection. More experienced users can perform the work themselves, with the Core providing guidance and assistance as needed. The Core staff and affiliated Scientific Advisory Committee members are always available for consulting on the morphological aspects of a project, and the Core staff is willing to custom-design services to fit any investigator''s needs.

Proper citation: Penn Electron Microscopy Resource Laboratory (RRID:SCR_010010) Copy   

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http://upr.eagle-i.net/i/0000012b-547c-89f8-0b67-095480000000

The Pharmaceutical Sciences Research Support Unit responds directly to the Chair of the Pharmaceutical Sciences Department. Its mission is to promote research by making available to offering our investigators instruments such as HPLCs, GC-MSs, NMR, among others and facilitating physical complementary spaces.

Proper citation: UPR Pharmaceutical Science Research Support Unit (RRID:SCR_010131) Copy   

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http://upr.eagle-i.net/i/0000012a-250d-df05-43fb-601a80000000

The Translational Proteomics Center provides training, resources, and tools for new and established investigators seeking to use innovative approaches of proteomics to their research, as well as to undergraduate and graduate students in the biomedical field. The Center fosters collaborations and partnerships among researchers aiming to reduce health disparities, including infectious diseases, cancer, and neurological/neurodegenerative diseases. Currently located at the second floor of the Comprehensive Cancer Center, Laboratory # 5.

Proper citation: UPR RCMI Translational Proteomics Center (RRID:SCR_010133) Copy   

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http://eagle-i.itmat.upenn.edu/i/0000013b-7127-463d-83a0-df0880000000

The Penn Gene Targeting Service (PGT) is run by the Penn Gene Targeting Core and Laboratory in collaboration with two other Penn Cores (DNA Sequencing Facility and the Transgenic and Chimeric Mouse Facility) and has the capability to generate from scratch almost any type of genetically modified mouse. This includes complete knockout of any gene, tissue-specific and/or drug-inducible knockout of any gene, targeted mutagenesis of any region of any gene (knockin), tissue-specific activation of an endogenous gene using loxP flanked stop cassettes, and tissue-specific and/or drug-inducible transgene expression from defined loci. For details regarding services and prices please consult the PGT home page of the Department of Genetics and/or directly contact Dr. Tobias Raabe. The Client lab does not need to be involved in any experimental step and only needs to breed the resulting mice. However, if desired, participation of the client lab in almost any experimental step is possible. PGT has an outstanding record of germ line transmission and so far over 32 targeted mice - more than 12 in the desirable C57BL6 background - have been made, starting either with molecular design and construction of the targeting vector or with electroporation of an existing targeting vector into ES cells.

Proper citation: Penn Gene Targeting Service (RRID:SCR_010013) Copy   

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http://upr.eagle-i.net/i/0000012c-9dd1-fddf-95a5-371e80000000

Core facility that provides the following services: Necropsy. The Sabana Seca Field Station (SSFS) is the administrative headquarters for the Caribbean Primate Research Center, or CPRC. This area contains offices, a clinic, and laboratories for reproductive biology and bone densitometry, necropsy and maintenance buildings. It houses rhesus monkeys from the CS colony or from the CS genetic line.

Proper citation: UPR Sabana Seca Field Station Caribbean Primate Research Center (RRID:SCR_010134) Copy   

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https://med-upenn.corefacilities.org/service_center/show_external/4515

Core provides full service whole genome and targeted molecular profiling of DNA and RNA on multiple platforms. The Facility offers a range of cost and performance options suitable for a variety of experimental projects. While the Facility staff performs most of the assays, investigator-performed studies are actively encouraged through the sharing of Facility procedures, individualized training of investigators or their technical staff, and use of core equipment.

Proper citation: University of Pennsylvania Molecular Profiling Facility (RRID:SCR_010014) Copy   

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http://upr.eagle-i.net/i/0000012c-2bf2-d33a-5b95-f21080000000

Core facility that provides the following services: RNA extraction, Immunofluoresence assay, Dendritic cell immunophenotyping, ELISA, Polymerase chain reaction service, Florescence activated cell sorting service, Western blot analysis service. Research interests include: immunogenicity and protective efficacy of multi-clade consensus ENV SHIV virus-like particle vaccine, cellular innate activation as a tactic to prevent HIV-1 transmission, molecular changes after serial DV infections in macaques, and immunization of rhesus macaques with a dengue vaccine candidate based on a Venezuelan Equine Encephalitis (VEE) replicon vector.

Proper citation: UPR Virology Laboratory (RRID:SCR_010136) Copy   

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