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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
http://sunnybrook.ca/research/?page=sri_core_tbank_home
Sunnybrook Research Institute''s tumour bank provides a mechanism for the optimal collection, storage and distribution of human tissue for investigative purposes. We collect both freshly frozen and formalin-fixed paraffin-embedded tumour and normal samples, retrospectively and prospectively (informed consent and confidential consent is obtained from patients before sample collection). We offer the 1. Distribution of tissue and data to interested investigators after approval from the institutional research ethics board and 2. Collaboration with various research investigators. Our mandate is to design, implement and manage the structures and processes to ensure the timely provision of tissue samples and associated data. We are currently building bank on four disease sites: breast, prostate, colorectal, gynecological. We are also creating and maintaining a database with a tissue tracking and inventory system, using TissueMetrix software.
Proper citation: Sunnybrook Tumour Bank (RRID:SCR_004138) Copy
http://www.lerner.ccf.org/gmi/gmb/
A biorepository is a place where investigators can deposit and store biological material, in this case samples derived from patients. Moreover, the Genomic Medicine Institute (GMI) takes this basic concept and elevates it to make the Genomic Medicine Biorepository (GMB) a full-service processing and banking laboratory that serves as the foundation for evidence-based research for the GMI, the Cleveland Clinic, and our collaborators. The process relies on a team of multi-disciplinary professionals coordinating their efforts in order to streamline medical research. This begins with dedicated physicians and genetic counselors identifying individuals with specific medical conditions indicating the possibility of genetic involvement. Once identified, biological material (e.g. blood, tissue, or saliva) is collected under the care of the patient''s doctor or by our clinicians and sent to the GMB. Once in the lab, the patient and their samples are assigned a unique identifier (to protect the patient''s personal information) and logged into a central database. This unique identifier accompanies all samples processed and banked for that individual. The specimens are then processed into research-relevant samples using proven laboratory techniques and state-of-the-art quality control practices. These samples include the isolation of DNA and RNA from white blood cells for genetic studies; collection of plasma for proteomic studies; and initiated immortalized cell lines from lymphocytes for in-vitro studies and biochemical research. These cell lines are able to be indefinitely stored in cryogenic suspension and are invaluable as a renewable resource for genetic and biochemical research. The GMB also processes genetic material from various tissues (both fresh and archived). Charis Eng, MD, PhD, Chair and Director of the GMI, has been the faculty oversight person of a human biorepository for the last eight years. Since then, our biorepository has received, cataloged, processed, and banked, in excess of 25,000 specimens. These samples are of numerous tissue types from patients and their family members located all over the world. Our biorepository has managed samples that have resulted in more than 150 original peer reviewed articles and greater than $25 million total direct costs in extramural funding over the last four years alone.
Proper citation: Cleveland Clinic Genomic Medicine Biorepository (RRID:SCR_004136) Copy
https://www.bips-institut.de/en/research/biobank.html
Biobank that contains more than 50,000 blood, urine and saliva samples as well as tissue materials from epidemiological field studies. The samples and DNA collected in various studies are increasingly being used for the investigation of genetic, environmental and life-style associated factors in the etiology and prognosis of cancer and other chronic diseases such as obesity, diabetes and metabolic syndrome.
Proper citation: Leibniz Institute for Prevention Research and Epidemiology Biobank (RRID:SCR_004094) Copy
Framework for discovery of, and interoperability between, distributed data and analytical resources. It combines GET/POST-based Web Services with standards from the W3C Semantic Web initiative. The objective is to make it easy for data and analytical tool providers to make their resources available on the Semantic Web with minimal disruption to their usual practices. It simply defines an open set of best-practices and conventions, within the spectrum of existing standards, that allow for a high degree of semantic discoverability and interoperability between participating services.
Proper citation: Semantic Automated Discovery and Integration (RRID:SCR_004130) Copy
http://www.mouseconnectome.org/
Three-dimensional digital connectome atlas of the C57Black/6J mouse brain and catalog of neural tracer injection cases, which will eventually cover the entire brain. Serial sections of each case are available to view at 10x magnification in the interactive iConnectome viewer. The Image Gallery provides a glimpse into some of the highlights of their data set. Representative images of multi-fluorescent tracer labeling can be viewed, while more in depth examination of these and all other cases can be performed in the iConnectome viewer. Phase 1 of this project involves generating a physical map of the basic global wiring diagram by applying proven, state of the art experimental circuit tracing methods systematically, uniformly, and comprehensively to the structural organization of all major neuronal pathways in the mouse brain. Connectivity imaging data for the whole mouse brain at cellular resolution will be presented within a standard 3D anatomic frame available through the website and accompanied by a comprehensive searchable online database. A Phase 2 goal for the future will allow users to view, search, and generate driving direction-like roadmaps of neuronal pathways linking any and all structures in the nervous system. This could be looked on as a pilot project for more ambitious projects in species with larger brains, such as human, and for providing a reliable framework for more detailed local circuitry mapping projects in the mouse.
Proper citation: Mouse Connectome Project (RRID:SCR_004096) Copy
http://www.lionseyeinstitute.org/about-us/
A nonprofit ocular research center with the largest eye bank in the world that provides eye tissue for research and transplantation to ophthalmic specialists and surgeons nationwide. They empower researchers to conduct real-time studies of healthy and diseased ocular tissue leading to a greater understanding of the events that lead to blindness. Their mission is to improve visual outcomes and quality of life for those who are blind or visually impaired through innovative ocular endeavors.
Proper citation: Lions Eye Institute for Transplant and Research (RRID:SCR_004008) Copy
http://www.alabamaorgancenter.org
The Alabama Organ Center (AOC) is the federally designated organ procurement organization for the state of Alabama. We work with all of the hospitals in the state to coordinate their donation services. Like all organ procurement organizations, the AOC is a non-profit organization. We provide a variety of services: * Hospital education * Public education * Screening of potential donors * Coordination of the donation process * Family support The AOC is committed to providing a better quality of life for those who require an organ or tissue transplant, while respecting the families who share the gift of life.
Proper citation: Alabama Organ Center (RRID:SCR_004721) Copy
THIS RESOURCE IS NO LONGER IN SERVICE, documented May 10, 2017. A pilot effort that has developed a centralized, web-based biospecimen locator that presents biospecimens collected and stored at participating Arizona hospitals and biospecimen banks, which are available for acquisition and use by researchers. Researchers may use this site to browse, search and request biospecimens to use in qualified studies. The development of the ABL was guided by the Arizona Biospecimen Consortium (ABC), a consortium of hospitals and medical centers in the Phoenix area, and is now being piloted by this Consortium under the direction of ABRC. You may browse by type (cells, fluid, molecular, tissue) or disease. Common data elements decided by the ABC Standards Committee, based on data elements on the National Cancer Institute''s (NCI''s) Common Biorepository Model (CBM), are displayed. These describe the minimum set of data elements that the NCI determined were most important for a researcher to see about a biospecimen. The ABL currently does not display information on whether or not clinical data is available to accompany the biospecimens. However, a requester has the ability to solicit clinical data in the request. Once a request is approved, the biospecimen provider will contact the requester to discuss the request (and the requester''s questions) before finalizing the invoice and shipment. The ABL is available to the public to browse. In order to request biospecimens from the ABL, the researcher will be required to submit the requested required information. Upon submission of the information, shipment of the requested biospecimen(s) will be dependent on the scientific and institutional review approval. Account required. Registration is open to everyone., documented on August 17, 2021.Biospecimens and support services to advance translational research including a wide range of specimen types, including matched sets of normal and diseased tissue, Formalin-Fixed, Paraffin-Embedded (FFPE), blood, and serum, focusing primarily on cancer. They stock a wide range of sample formats to help meet research goals quickly and on budget. Collections are preformed to be ideal for a wide range of studies including genomic, proteomic, molecular and histologic analysis. ILSbio provides tissue and tissue derivatives that are high quality, cost effective and procured in compliance with current and anticipated regulations. The company obtains its clinical specimens under strict IRB approved protocols with informed consent and the utmost attention to issues of patient safety, anonymity and confidentiality. Clinical and pathological data is available for all specimens. Researchers use the tissue products at all levels of scientific study ranging from large pharma and biotech organizations to small labs and university research facilities. They also participate in wholesale distribution to other bio-banking organizations.
Proper citation: ILSbio (RRID:SCR_004682) Copy
The Louisiana Organ Procurement Agency (LOPA) is the federally-designated organ procurement organization for the State of Louisiana. The agency focuses on educating the medical community and the general public about organ and tissue donation issues, working with families through the donation process, recovering donated organs and tissue, and placing the organs and tissue for transplant. Our mission is to save and enhance lives through organ and tissue donation. We envision a world in which no one suffers due to a lack of donor organs or tissues. LOPA has its main office in Metairie, with regional offices in Lafayette, and Shreveport. Additionally, LOPA has representatives in Baton Rouge, Alexandria, Lake Charles, and Monroe.
Proper citation: Louisiana Organ Procurement Agency - LOPA (RRID:SCR_004442) Copy
http://www.hgsc.bcm.tmc.edu/content/hapmap-3-and-encode-3
Draft release 3 for genome-wide SNP genotyping and targeted sequencing in DNA samples from a variety of human populations (sometimes referred to as the HapMap 3 samples). This release contains the following data: * SNP genotype data generated from 1184 samples, collected using two platforms: the Illumina Human1M (by the Wellcome Trust Sanger Institute) and the Affymetrix SNP 6.0 (by the Broad Institute). Data from the two platforms have been merged for this release. * PCR-based resequencing data (by Baylor College of Medicine Human Genome Sequencing Center) across ten 100-kb regions (collectively referred to as ENCODE 3) in 712 samples. Since this is a draft release, please check this site regularly for updates and new releases. The HapMap 3 sample collection comprises 1,301 samples (including the original 270 samples used in Phase I and II of the International HapMap Project) from 11 populations, listed below alphabetically by their 3-letter labels. Five of the ten ENCODE 3 regions overlap with the HapMap-ENCODE regions; the other five are regions selected at random from the ENCODE target regions (excluding the 10 HapMap-ENCODE regions). All ENCODE 3 regions are 100-kb in size, and are centered within each respective ENCODE region. The HapMap 3 and ENCORE 3 data are downloadable from the ftp site.
Proper citation: HapMap 3 and ENCODE 3 (RRID:SCR_004563) Copy
Founded in 1977, California Cryobank (CCB) is a full-service sperm bank providing a comprehensive resource for frozen donor sperm, private semen cryopreservation, and specialized reproductive services (including egg and embryo storage and artificial insemination guidance). We are extremely proud of our 30 years of reproductive success. The demand for expert services has grown exponentially as discussion of reproductive challenges has continued to become more mainstream. At California Cryobank we understand that regardless of how much information and education you bring to the process, there can still be significant apprehension accompanying such big steps as sperm donation and donor insemination. CCB''s commitment to making our clients as comfortable as possible is what sets us apart and makes us so much more than just another sperm bank. Our services are entirely patient-centric; from the education that we provide����??answering questions and providing step-by-step timetables that let patients know what to expect in the weeks and months to come from donor sperm selection through insemination����??to the guidance that we offer. Our team is comprised of physicians, lab technicians, genetic counselors, Client Service Consultants, and Donor Matching Consultants. Every facet of our services is completely and expertly led by one of our experienced and compassionate team members. And while our sperm donor program is the foundation of our service, California Cryobank provides a full range of services for our clients including cord blood banking and access to our CCB Sibling Registry.
Proper citation: California Cryobank, Inc. (RRID:SCR_004684) Copy
Established in 1970, the University of Miami Tissue Bank (UMTB) is the oldest academic institution of its kind in the United States. UMTB came about and evolved in an effort to provide safe and effective bone and soft tissue grafts to patients long before allograft bone transplantation was widely accepted. UMTB has always been focused on safety and the advancement of knowledge in allograft use. More scientific peer-reviewed articles, book chapters and innovations have come from UMTB either directly or indirectly than from any other organization of its kind. UMTB continues to be a leader in transplantation research and has maintained an impeccable safety record. As the only university-run tissue bank, UMTB works closely with surgeons and basic science investigators to advance the field of bone and soft tissue transplantation. Our scientific endeavors include clinical trials to confirm and improve graft efficacy for oral surgery, orthopedic tumor and spine surgery, and sports injuries. When warranted, we engage commercial entities for these studies. As a multidisciplinary organization of surgeons, pathologists, scientists and technicians, we have safely recovered, processed, distributed and implanted aseptically processed bone, cartilage and soft tissue grafts in thousands of patients. We make extraordinary efforts to ensure aseptic recovery and processing to protect the biologic activity, integrity, bio attributes, and safety of the graft. We believe that the American Association of Tissue Banks (AATB) has adopted appropriate guidelines for Tissue Banking in the United States and the University of Miami is a proud member of this organization.
Proper citation: University of Miami Tissue Bank (RRID:SCR_004560) Copy
http://www.cas.org/expertise/cascontent/registry/index.html
CAS REGISTRY, the gold standard for substance information, is the only integrated, comprehensive source of chemical information from a full range of disclosed material including patents, journals, and reputable web sources. When you need to positively identify a chemical substance, you can rely on the authoritative source for chemical names and structures of CAS REGISTRY. CAS databases are curated and quality-controlled by CAS scientists, and recognized by chemical and pharmaceutical companies, universities, government organizations, and patent offices around the world as authoritative. By combining these databases with advanced search and analysis technologies (SciFinder, STN, and Science IP products and services), CAS delivers the most current, complete, and cross-linked secure digital information environment for scientific discovery. You can identify your substance of interest by its CAS Registry Number, which is the best way to identify a substance, regardless of what name you have for it. You can also use CAS REGISTRY to locate * literature references to the substance * experimental and predicted property data (boiling and melting points, etc.) * commercial availability * preparative methods * spectra * regulatory information from international sources
Proper citation: CAS REGISTRY (RRID:SCR_004558) Copy
Established in 1987, LifeGift is a not-for-profit organ procurement organization that recovers organs and tissue for individuals needing transplants in 109 Texas counties in North, Southeast and West Texas. Our Role * Help grieving families consider the decision to give the gift of life. Inform families of registered donors of their loved ones����?? wishes to donate. * Coordinate the organ and tissue recovery process with surgeons, other transplant professionals and transplant centers. Collect data for use in transplantation research. * Partner with hospitals to continually develop effective, government-regulated donation systems to help increase the number of donated organs available for transplant. * Educate the public about the need for organ and tissue donation. Serve the African-American, Latino and Asian minority communities with specific educational programs. * Continue to support and maintain contact with donor families following the donation process, facilitating communication between recipients and donor families, if both parties desire.
Proper citation: LifeGift Organ Donation Center (RRID:SCR_004555) Copy
http://allograftinnovations.com/
Allograft Innovations was formed in 2006 to facilitate quality biologic grafts for surgery. We are committed to providing quality tissue to enhance patients'' health, mobility and quality of life nationwide and across the globe. Our goal is to provide the safest, most clinically effective allografts available. The health of tissue recipients is top priority to us, and we take every possible step to ensure safety and integrity during all processes. Allograft Innovations partners with federally designated OPO''s (Organ Procurement Organization), as well as Tissue recovery agencies that comply with all 21 CFR 1270 and 1271 FDA Standards, and have achieved AATB accreditation.
Proper citation: Allograft Innovations, LLC (RRID:SCR_004435) Copy
http://ehs.sph.berkeley.edu/holland/biorepository/
Established in 2004, SPH Biorepository was built to create a centralized facility for many research programs, as well as for new ones; more effective use of the available storage space; development of new database management tools; and quality control of sample processing and banking. While maintaining ultimate control of the samples accumulated in their research projects, PIs will have the assurance of competent handling of their biological samples, reliable access, safe storage, and expert advice from the Biorepository personnel. In the long-term, the Biorepository will provide: * Safe and orderly storage of banked samples * Samples diversification in case of a major disaster *Leverage for additional funding for the new projects Over 145,000 thousands of various biological and environmental samples have been stored and archived through the CHAMACOS, Vitamin, FACES, IBD, and other projects. The Biorepository (Holland - Director) has accumulated substantial expertise in the development of customized databases to barcode and monitor sample location, transfer, and use.
Proper citation: SPH Biorepository (RRID:SCR_004551) Copy
http://www.ebi.ac.uk/Tools/dbfetch/dbfetch
Dbfetch is an acronym for database fetch. Dbfetch provides an easy way to retrieve entries from various databases at the EBI in a consistent manner and allows you to retrieve up to 50 entries at a time from various up-to-date biological databases. It can be used from any browser as well as well as within a web-aware scripting tool that uses wget, lynx or similar. From the browser, follow these instructions... * Select a database: If you are using the first form to paste your search items: choose a database name from this form. If you are using the second form to upload your search items: the database name is included at the beginning of each line line of the upload file followed by a colon. * Enter search terms: These MUST BE in the appropriate database format, up to 200 search items can be queried in one run. If you are using the first form: separate search items with a comma or space. If you are using the second form: separate search items with a new line. * Choose an output format: Here you can choose the simpler fasta format, or the databases'''' default format for the chosen database. * Style: You can get your results as text or html. * Retrieve! - You are now ready to fetch your results, by pressing the Retrieve button.
Proper citation: EBI Dbfetch (RRID:SCR_004393) Copy
https://komentissuebank.iu.edu/
The goals of the Susan G. Komen for the Cure Tissue Bank at the IU Simon Cancer Center are to acquire biomolecule and tissue specimens from the entire continuum of breast development: puberty to menopause and to make these specimens or the digital data derived from them available and accessible to researchers across the globe.
Proper citation: Susan G. Komen Tissue Bank (RRID:SCR_004708) Copy
A tool for taxonomic classification of DNA fragments, as they are typically obtained in metagenome projects. The classification is based on taxon-specific DNA base composition characteristics (genomic signatures). Classification of query sequences is achieved by mapping the query sequences to the genomic signatures of sequences with known taxonomic affiliations. The mapping is done via the Self-Organizing Map (SOM) algorithm. TaxSOM offers two modes of operation: * mapping query sequences to a pre-calculated SOM * mapping query sequences to a custom SOM
Proper citation: TaxSOM (RRID:SCR_004669) Copy
LifeSource is the non-profit organization dedicated to saving lives through organ and tissue donation in the Upper Midwest. We serve more than 6 million people in communities across Minnesota, North Dakota, South Dakota and portions of western Wisconsin. As the federally-designated organization that manages organ and tissue donation in our region, we are dedicated to working with our hospital and community partners to support donor families, facilitate the donation of organs and tissues to transplant recipients and encourage the people in our communities to register as donors.
Proper citation: LifeSource (RRID:SCR_004702) Copy
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