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| Resource Name | Proper Citation | Abbreviations | Resource Type |
Description |
Keywords | Resource Relationships | |||||||||||||
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National Kidney Disease Education Program Resource Report Resource Website 10+ mentions |
National Kidney Disease Education Program (RRID:SCR_006527) | NKDEP | data or information resource, narrative resource, training material, resource | Educational resource to increase awareness of kidney disease and its risk factors, improve early detection of chronic kidney disease (CKD), reduce the burden of CKD, facilitate identification of patients at greatest risk for progression to kidney failure, stress the importance of testing those at risk, promote evidence-based interventions to slow progression of CKD, and support the coordination of Federal responses to CKD. Target audiences include individuals at risk, particularly those with diabetes, high blood pressure, and a family history of kidney disease, and primary care providers. | kidney, risk factor, treatment, prevention, kidney failure, chronic kidney disease, nutrition, pediatric, intervention, disease-related portal |
is related to: NIDDK Information Network (dkNET) has parent organization: NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases is parent organization of: Creatinine Standardization Program is parent organization of: Glomerular Filtration Rate Calculators |
Kidney disease, Chronic kidney disease | NIDDK | nlx_152712 | SCR_006527 | NKDEP: National Kidney Disease Education Program | 2026-08-13 09:27:39 | 37 | ||||||
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George M. O'Brien Kidney Center at Yale Human Genetics and Clinical Research Core Resource Report Resource Website |
George M. O'Brien Kidney Center at Yale Human Genetics and Clinical Research Core (RRID:SCR_015298) | core facility, resource, service resource, access service resource | Core that provides infrastructure support for several key steps in translational research, including development of HIC protocols, patient recruitment, patient DNA extraction and archiving, tools for high throughput SNP genotyping and DNA sequencing, and analysis of genetic linkage and linkage disequilibrium. | human genetics, kidney clinical research, translational research |
is listed by: NIDDK Information Network (dkNET) has parent organization: Yale School of Medicine; Connecticut; USA has parent organization: George M. O'Brien Kidney Center at Yale is organization facet of: George M. O'Brien Kidney Center at Yale |
NIDDK P30DK079310 | Available to the research community | SCR_015298 | 2026-08-13 09:29:22 | 0 | |||||||||
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George M. O'Brien Kidney Research Core Center - UT Southwestern Medical Center Clinical and Translational Core Resource Report Resource Website |
George M. O'Brien Kidney Research Core Center - UT Southwestern Medical Center Clinical and Translational Core (RRID:SCR_015295) | core facility, resource, service resource, access service resource | Core whose aim is to translate basic science research into effective diagnostic and therapeutic strategies that will improve the lives of patients by interrupting the pathogenesis of chronic kidney disease and its attendant high risk of cardiovascular disability and death. It combines comprehensive human genetics with phenotyping of subjects. | clinical, translational research, kidney disease, cardiovascular disease |
is listed by: NIDDK Information Network (dkNET) has parent organization: University of Texas Southwestern Medical Center; Texas; USA has parent organization: George M. O'Brien Kidney Research Core Center - UT Southwestern Medical Center is organization facet of: George M. O'Brien Kidney Research Core Center - UT Southwestern Medical Center |
kidney disease | NIDDK P30DK079328 | Available to the research community, Fee for service | SCR_015295 | 2026-08-13 09:29:21 | 0 | ||||||||
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Pittsburgh Center for Kidney Research Resource Report Resource Website |
Pittsburgh Center for Kidney Research (RRID:SCR_015286) | topical portal, data or information resource, disease-related portal, resource, service resource, access service resource, portal | Center whose focus is to advance knowledge of normal kidney function, cellular mechanisms that contribute to kidney disease, and the myriad altered cellular functions that occur in the setting of renal insufficiency. | kidney research, kidney disease and function, renal research |
is listed by: NIDDK Information Network (dkNET) is parent organization of: Pittsburgh Center for Kidney Research Biostatistical Analysis Services is parent organization of: Pittsburgh Center for Kidney Research Kidney Imaging is parent organization of: Pittsburgh Center for Kidney Research Model Organisms is parent organization of: Pittsburgh Center for Kidney Research Single Nephron and Metabolomics is parent organization of: Pittsburgh Center for Kidney Research Cellular Physiology has organization facet: Pittsburgh Center for Kidney Research Cellular Physiology has organization facet: Pittsburgh Center for Kidney Research Single Nephron and Metabolomics has organization facet: Pittsburgh Center for Kidney Research Kidney Imaging has organization facet: Pittsburgh Center for Kidney Research Model Organisms has organization facet: Pittsburgh Center for Kidney Research Biostatistical Analysis Services is organization facet of: O'Brien Kidney Centers |
kidney disease | NIDDK P30DK079307; University of Pittsburgh School of Medicine; Pennsylvania; USA ; Icahn School of Medicine at Mount Sinai; New York; USA |
Available to the research community | SCR_015286 | 2026-08-13 09:29:21 | 0 | ||||||||
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Duke O'Brien Center for Kidney Research Animal Models Core Resource Report Resource Website |
Duke O'Brien Center for Kidney Research Animal Models Core (RRID:SCR_015267) | core facility, resource, service resource, access service resource | Core facility that provides access to a range of experimental models of kidney, heart and vascular diseases. It also provides comprehensive phenotyping services for kidney functions, blood pressure and other cardiovascular functions. | animal model, experimental kidney model, experimental heart model, experimental vascular model |
is listed by: NIDDK Information Network (dkNET) has parent organization: Duke O'Brien Center for Kidney Research has parent organization: Duke University School of Medicine; North Carolina; USA has parent organization: Duke University; North Carolina; USA is organization facet of: Duke O'Brien Center for Kidney Research |
kidney disease, heart disease, hypertension, muscle disease | NIDDK P30DK096493 | Available to the research community | SCR_015267 | 2026-08-13 09:29:10 | 0 | ||||||||
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Pittsburgh Center for Kidney Research Cellular Physiology Resource Report Resource Website |
Pittsburgh Center for Kidney Research Cellular Physiology (RRID:SCR_015284) | core facility, resource, service resource, access service resource | Core that provides investigators with in vitro systems for the study of transport processes at the molecular, cell, and epithelial levels. | cellular physiology, membranes, cell function and structure, cell biology |
is listed by: NIDDK Information Network (dkNET) has parent organization: Pittsburgh Center for Kidney Research is organization facet of: Pittsburgh Center for Kidney Research |
NIDDK P30DK079307; University of Pittsburgh School of Medicine; Pennsylvania; USA ; Icahn School of Medicine at Mount Sinai; New York; USA |
Available to the research community | SCR_015284 | 2026-08-13 09:29:16 | 0 | |||||||||
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Pittsburgh Center for Kidney Research Single Nephron and Metabolomics Resource Report Resource Website |
Pittsburgh Center for Kidney Research Single Nephron and Metabolomics (RRID:SCR_015285) | core facility, resource, service resource, access service resource | Core that offers functional (in vitro microperfusion of isolated segments, measurements of transepithelial ion/solute fluxes, fluorescence functional imaging of single tubular cells), biochemical (microassays of enzyme/transporter activity), molecular (quantitation and analysis of RNA and protein), and analytical (targeted renal metabolomics of interrelated networks of small molecules) strategies applied to microdissected tubules, single cells, and urinary exosomes to address relevant questions proposed by users. It also provides analytical services for determining concentrations of exogenous pharmacological agents and molecular probes achieved within the tissue of interest. | single nephron, metabolomics, renal cells, cell analysis and function |
is listed by: NIDDK Information Network (dkNET) has parent organization: Pittsburgh Center for Kidney Research is organization facet of: Pittsburgh Center for Kidney Research |
NIDDK P30DK079307; University of Pittsburgh School of Medicine; Pennsylvania; USA ; Icahn School of Medicine at Mount Sinai; New York; USA |
Available to the research community | SCR_015285 | 2026-08-13 09:29:11 | 0 | |||||||||
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Duke O'Brien Center for Kidney Research Clinical and Translational Core Resource Report Resource Website |
Duke O'Brien Center for Kidney Research Clinical and Translational Core (RRID:SCR_015272) | core facility, resource, service resource, access service resource | Core facility which investigates the connections between chronic kidney disease, cardiovascular disease, and hypertension. It focuses specifically on investigating the pathophysiology, epidemiology, and therapeutic response in on-going studies or existing datasets of one of the three diseases with the aim of relating data from individual diseases to each other. | translational kidney research, translational cardiovascular research, translational hypertension research |
is listed by: NIDDK Information Network (dkNET) has parent organization: Duke O'Brien Center for Kidney Research has parent organization: Duke University School of Medicine; North Carolina; USA has parent organization: Duke University; North Carolina; USA is organization facet of: Duke O'Brien Center for Kidney Research |
kidney disease, heart disease, hypertension, muscle disease | NIDDK P30DK096493 | Available to the research community | SCR_015272 | 2026-08-13 09:29:16 | 0 | ||||||||
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George M. O'Brien Kidney Center at Yale Resource Report Resource Website |
George M. O'Brien Kidney Center at Yale (RRID:SCR_015294) | topical portal, data or information resource, disease-related portal, resource, service resource, access service resource, portal | Center that facilitates translational and clinical research that will advance the prevention and treatment of kidney diseases. | kidney disease, clinical research |
is listed by: NIDDK Information Network (dkNET) has parent organization: Yale School of Medicine; Connecticut; USA is parent organization of: George M. O'Brien Kidney Center at Yale Mouse Genetics and Cell Line Core is parent organization of: George M. O'Brien Kidney Center at Yale Human Genetics and Clinical Research Core is parent organization of: George M. O'Brien Kidney Center at Yale Renal Physiology Core has organization facet: George M. O'Brien Kidney Center at Yale Renal Physiology Core has organization facet: George M. O'Brien Kidney Center at Yale Mouse Genetics and Cell Line Core has organization facet: George M. O'Brien Kidney Center at Yale Human Genetics and Clinical Research Core is organization facet of: O'Brien Kidney Centers |
kidney disease | NIDDK P30DK079310 | Available to the research community | SCR_015294 | 2026-08-13 09:29:11 | 0 | ||||||||
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Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center Clinical and Translational Core Resource Resource Report Resource Website |
Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center Clinical and Translational Core Resource (RRID:SCR_015291) | core facility, resource, service resource, access service resource | Core facility that provides clinical applications and methods to make kidney research translational and applicable to care settings. | pkd, polycystic kidney disease, clinical research, translational research |
is listed by: NIDDK Information Network (dkNET) has parent organization: University of Maryland School of Medicine; Maryland; USA has parent organization: Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center is organization facet of: Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center |
Polycystic Kidney Disease | NIDDK P30DK090868 | Available to the research community | SCR_015291 | 2026-08-13 09:29:11 | 0 | ||||||||
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Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center Antibody Validation and Vector Core Resource Report Resource Website |
Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center Antibody Validation and Vector Core (RRID:SCR_015318) | core facility, resource, service resource, access service resource | Core which supports the work of the Baltimore Polycystic Kidney Disease research center by providing antibody validation services and vectors to researchers. | pkd, polycystic kidney disease, antibody validation |
is listed by: NIDDK Information Network (dkNET) has parent organization: University of Maryland School of Medicine; Maryland; USA has parent organization: Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center is organization facet of: Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center |
Polycystic Kidney Disease | NIDDK P30DK090868 | Available to the research community, Fee for service | SCR_015318 | 2026-08-13 09:29:11 | 0 | ||||||||
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Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease Resource Report Resource Website 1+ mentions |
Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (RRID:SCR_000690) | CRISP | clinical trial, resource | A five-year prospective cohort study following 240 patients who have autosomal-dominant polycystic kidney disease (PKD) to determine whether changes in anatomic characteristics of their kidneys as measured by magnetic resonance imaging will be useful in providing surrogate measures for disease progression. CRISP's overall goal is to develop methods that would facilitate shortening the observation period necessary to determine efficacy of treatment interventions in PKD patients. Specific goals of this study are to: * Quantify cyst growth and ascertain severity of renal parenchymal involvement by sequential measurement of total kidney volume and the ratio of intact parenchyma to renal parenchyma occupied by cysts over time * Establish useful clinical correlations of imaging data with other markers of disease progression * Identify and test other potential markers or indices of disease progression, for example, assessment of loss of heterozygosity of renal cells shed in the urine, or other markers, in cohorts of patients with PKD * Gain information about the cost-effectiveness, patient acceptability, and advantages and disadvantages of different imaging techniques used serially in patients with PKD. Some experience has been gained in establishing that repeat imaging of the same PKD patient, using these techniques, yields reproducible estimates of kidney size and the proportion of renal parenchyma occupied by cysts. MRI may also have the advantage of permitting simultaneous estimation of GFR. Ultrasound has the advantage of being more cost-effective and perhaps more acceptable to patients for repetitive studies, but the measurements may be less accurate and reproducible. Nonetheless, there is very limited experience in applying these techniques to follow progression of the renal disease. Development of improved, reproducible imaging methods that assess cyst growth and provide markers of disease progression could markedly improve the feasibility of clinical trials. Participating clinical centers are Emory University, the Mayo Clinic, University of Kansas, and the University of Alabama at Birmingham. The data coordinating and imaging analysis center is at Washington University. (PI has since moved to University of Pittsburgh) The study found that kidney enlargement resulting from the expansion of cysts is continuous, quantifiable, and associated with the decline of renal function. Cystic expansion occurs at a consistent rate per individual, although it is heterogeneous in the population, and that larger kidneys are associated with more rapid decrease in renal function. These anatomic characteristics of patient kidneys may provide useful surrogate measures for disease progression, and hence enhance the development of targeted therapies for autosomal dominant PKD. CRISP III is a five-year prospective cohort study to follow ~170 remaining autosomal dominant polycystic kidney disease (ADPKD) patients who were part of the original CRISP cohort study. CRISP III will verify and extend the preliminary observations of CRISP to determine the extent to which quantitative (kidney volume and blood flow, and hepatic and kidney cyst volume) or qualitative (cyst distribution and character) structural parameters predict renal insufficiency and develop and test new metrics to quantify and monitor disease progression. Urine metabolites and the genome will be correlated with the progression of disease to look for new, predictive disease biomarkers. This information from CRISP III will help determine if the kidney enlargement, blood flow, cyst distribution, or urine metabolites can function as an informative surrogate measure for disease progression. | mri, kidney volume, cyst volume, kidney, renal function, disease progression, measure, blood flow, hepatic cyst volume, kidney cyst volume, renal insufficiency, urine metabolite, surrogate measure, clinical, intervention |
is listed by: NIDDK Information Network (dkNET) has parent organization: University of Pittsburgh; Pennsylvania; USA |
Polycystic kidney disease, Autosomal dominant polycystic kidney disease | NIDDK 5U01DK056961 | THIS RESOURCE IS NO LONGER IN SERVICE | nlx_152795 | SCR_000690 | Consortium of Radiologic Imaging Study of PKD | 2026-08-13 09:26:13 | 3 | |||||
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Autosomal Recessive Polycystic Kidney Disease Mutation Database Resource Report Resource Website 10+ mentions |
Autosomal Recessive Polycystic Kidney Disease Mutation Database (RRID:SCR_002290) | data or information resource, database, service resource, data repository, storage service resource | Catalog of all changes detected in PKHD1 (Polycystic Kidney and Hepatic Disease 1) in a locus specific database. Investigators are invited to submit their novel data to this database. These data should be meaningful for clinical practice as well as of relevance for the reader interested in molecular aspects of polycystic kidney disease (PKD). There are also some links and information for ARPKD patients and their parents. Autosomal recessive polycystic kidney disease (ARPKD/PKHD1) is an important cause of renal-related and liver-related morbidity and mortality in childhood. This study reports mutation screening in 90 ARPKD patients and identifies mutations in 110 alleles making up a detection rate of 61%. Thirty-four of the detected mutations have not been reported previously. Two underlying mutations in 40 patients and one mutation in 30 cases are disclosed, and no mutation was detected on the remaining chromosomes. Mutations were found to be scattered throughout the gene without evidence of clustering at specific sites. PKHD1 mutation analysis is a powerful tool to establish the molecular cause of ARPKD in a given family. Direct identification of mutations allows an unequivocal diagnosis and accurate genetic counseling even in families displaying diagnostic challenges. | clinical, gene, genetic, mutation, protein, recessive, renal | has parent organization: RWTH Aachen University; Aachen; Germany | Autosomal recessive polycystic kidney disease, Polycystic kidney disease | PMID:16199545 PMID:11919560 |
Permission required, Terms of use | nif-0000-21038 | http://www.humgen.rwth-aachen.de/index.asp?subform=database.html&nav=database_nav.html | SCR_002290 | Mutation Database Autosomal Recessive Polycystic Kidney Disease (ARPKD/PKHD1) | 2026-08-13 09:26:32 | 14 | |||||
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Kidney and Urinary Pathway Knowledge Base Resource Report Resource Website 1+ mentions |
Kidney and Urinary Pathway Knowledge Base (RRID:SCR_001746) | KUPKB | data or information resource, analysis service resource, production service resource, service resource, data repository, storage service resource, data analysis service, data set | A collection of omics datasets (mRNA, proteins and miRNA) that have been extracted from PubMed and other related renal databases, all related to kidney physiology and pathology giving KUP biologists the means to ask queries across many resources in order to aggregate knowledge that is necessary for answering biological questions. Some microarray raw datasets have also been downloaded from the Gene Expression Omnibus and analyzed by the open-source software GeneArmada. The Semantic Web technologies, together with the background knowledge from the domain's ontologies, allows both rapid conversion and integration of this knowledge base. SPARQL endpoint http://sparql.kupkb.org/sparql The KUPKB Network Explorer will help you visualize the relationships among molecules stored in the KUPKB. A simple spreadsheet template is available for users to submit data to the KUPKB. It aims to capture a minimal amount of information about the experiment and the observations made. | kidney, urinary, urine, pathway, molecule, visualizer, gene, protein, mirna, metabolite, mrna, microarray, ortholog, rdf, renal cell, anatomy, animal model, disease, sparql, proteomics, ontology, biomarker, gene expression, physiology, pathology |
is related to: NIDDK Information Network (dkNET) is related to: Gene Expression Omnibus is related to: Gene Ontology is related to: KEGG has parent organization: University of Manchester; Manchester; United Kingdom has parent organization: National Institute of Health and Medical Research; Rennes; France |
Kidney disease | European Union ; FP7 ; ICT-2007.4.4 e-LICO project |
PMID:21624162 | THIS RESOURCE IS NO LONGER IN SERVICE. | nlx_154134 | http://www.e-lico.eu/kupkb | SCR_001746 | Kidney & Urinary Pathway Knowledge Base | 2026-08-13 09:26:26 | 2 | |||
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Assessment Serial Evaluation and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) Resource Report Resource Website |
Assessment Serial Evaluation and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) (RRID:SCR_014386) | ASSESS-AKI | data or information resource, data set, resource | A study which recruits patients with and without an episode of acute kidney injury during a hospitalization, and follows them longitudinally for major cardiac, renal and mortality events. An important aspect of the study is the prospective evaluation of potential biomarkers for renal and cardiac outcomes. | study, acute kidney injury, longitudinal, major cardiac event, major renal event, major mortality event, biomarker |
is listed by: NIDDK Research Resources is listed by: NIDDK Information Network (dkNET) |
NIDDK | Account required | http://www.niddk.nih.gov/research-funding/research-resources/Pages/default.aspx | SCR_014386 | Assessment Serial Evaluation and Subsequent Sequelae in Acute Kidney Injury | 2026-08-13 09:29:01 | 0 | ||||||
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Translational Polycystic Kidney Disease (PKD) Center at Mayo Clinic Rochester Molecular Genetics and Biomarker Core Resource Report Resource Website |
Translational Polycystic Kidney Disease (PKD) Center at Mayo Clinic Rochester Molecular Genetics and Biomarker Core (RRID:SCR_015308) | core facility, resource, service resource, access service resource | Core services include mutation screening of cell lines derived from ADPKD patients, mutation screening of large, typical ADPKD populations, genetic screening of atypical PKD families, cystic Kidney and Liver Disease Biobank (CKLBB) from ADPKD patients, and urine collection and fractionation. | molecular genetics, biomarker, mutation screening, PKD |
is listed by: NIDDK Information Network (dkNET) has parent organization: Mayo Clinic Minnesota; Minnesota; USA has parent organization: Translational Polycystic Kidney Disease (PKD) Center at Mayo Clinic Rochester is organization facet of: Translational Polycystic Kidney Disease (PKD) Center at Mayo Clinic Rochester |
Polycystic Kidney Disease | NIDDK P30DK090728 | Available to the research community | SCR_015308 | 2026-08-13 09:29:17 | 0 | ||||||||
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Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center Cell Culture and Engineering Resource Report Resource Website |
Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center Cell Culture and Engineering (RRID:SCR_015323) | core facility, resource, service resource, access service resource | Core faiclity that provides researchers with cell culturing and engineering services. | pkd, polycystic kidney disease, cell culture, cell engineering |
is listed by: NIDDK Information Network (dkNET) has parent organization: University of Maryland School of Medicine; Maryland; USA has parent organization: Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center is organization facet of: Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center |
Polycystic Kidney Disease | NIDDK P30DK090868 | Available to the research community | SCR_015323 | 2026-08-13 09:29:17 | 0 | ||||||||
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UAB-UCSD Core Center for Acute Kidney Injury Research Bioanalytical Core Resource Report Resource Website |
UAB-UCSD Core Center for Acute Kidney Injury Research Bioanalytical Core (RRID:SCR_015280) | core facility, resource, service resource, access service resource | Core that provides bioenergetics, oxidative stress analysis and metabolite analysis support for AKI research. It includes protocols and technology for bioanalytical analysis of oxidative stress and cellular bioenergetics as well as post-translational modifications. | bioenergetics, bioanalytical analysis, spectrometry, oxidative stress |
is listed by: NIDDK Information Network (dkNET) has parent organization: University of Alabama at Birmingham School of Medicine; Alabama; USA has parent organization: University of California San Diego School of Medicine; California; USA has parent organization: UAB-UCSD Core Center for Acute Kidney Injury Research is organization facet of: UAB-UCSD Core Center for Acute Kidney Injury Research |
NIDDK P30DK079337 | Available to the research community | SCR_015280 | 2026-08-13 09:29:21 | 0 | |||||||||
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UAB-UCSD Core Center for Acute Kidney Injury Research Pre-Clinical Studies of AKI Resource Report Resource Website |
UAB-UCSD Core Center for Acute Kidney Injury Research Pre-Clinical Studies of AKI (RRID:SCR_015278) | core facility, resource, service resource, access service resource | Core that provides services such as expertise in development and training in the use of rodent models of AKI, specifically in the setting of ischemia/reperfusion (I/R) injury, sepsis and renal transplantation, gamma-ray imaging (gamma camera, microSPECT/CT, microPET/CT), metabolic assessments of kidney O2 consumption, and technical expertise in isolation of primary renal and vascular cell in culture. | AKI, pre-clinical studies, murine models, imaging |
is listed by: NIDDK Information Network (dkNET) has parent organization: University of Alabama at Birmingham School of Medicine; Alabama; USA has parent organization: University of California San Diego School of Medicine; California; USA has parent organization: UAB-UCSD Core Center for Acute Kidney Injury Research is organization facet of: UAB-UCSD Core Center for Acute Kidney Injury Research |
NIDDK P30DK079337 | Available to the research community | SCR_015278 | 2026-08-13 09:29:16 | 0 | |||||||||
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AASK Clinical Trial and Cohort Study Resource Report Resource Website |
AASK Clinical Trial and Cohort Study (RRID:SCR_006985) | AASK Cohort Study | topical portal, data or information resource, disease-related portal, resource, clinical trial, research forum portal, portal | Clinical trial investigating whether a specific class of antihypertensive drugs (beta-adrenergic blockers, calcium channel blockers, or angiotensin converting enzyme inhibitors) and/or the level of blood pressure would influence progression of hypertensive kidney disease in African Americans. The initiative consisting of 21 clinical centers and a data-coordinating center is followed by a Continuation of AASK Cohort Study to investigate the environmental, socio-economic, genetic, physiologic, and other co-morbid factors that influence progression of kidney disease in a well-characterized cohort of African Americans with hypertensive kidney disease. Only patients who were previously in the randomized trial are eligible for the cohort study. A significant discovery was made in the treatment strategy for slowing kidney disease caused by hypertension. Angiotensin-converting enzyme (ACE) inhibitors, compared with calcium channel blockers, were found to slow kidney disease progression by 36 percent, and they drastically reduced the risk of kidney failure by 48 percent in patients who had at least one gram of protein in the urine, a sign of kidney failure. ACE inhibitors have been the preferred treatment for hypertension caused by diabetes since 1994; however, calcium channel blockers have been particularly effective in controlling blood pressure in African Americans. The AASK study now recommends ACE inhibitors to protect the kidneys from the damaging effects of hypertension. The Continuation of AASK Cohort Study will be followed at the clinical centers. The patients will be provided with the usual clinical care given to all such patients at the respective centers. Baseline demographic information, selected laboratory tests, and other studies are being obtained at the initiation of the Continuation Study. The patients will be seen quarterly at the centers, and some selected studies done at these visits. Samples will be obtained and stored for additional studies and analyses at a later date. | african american, blood pressure, beta-adrenergic blocker, calcium channel blocker, angiotensin converting enzyme inhibitor, environment, socio-economic, genetic, physiology, co-morbid factor, gene, adult human, antihypertensive drug, clinical, treatment, longitudinal, demographics, laboratory test, biospecimen, biomaterial supply resource |
is listed by: One Mind Biospecimen Bank Listing is related to: NIDDK Information Network (dkNET) is related to: Chronic Renal Insufficiency Cohort Study |
End-stage renal disease, Kidney failure, Kidney disease, Hypertension, Hypertensive kidney disease | NIDDK | nlx_152750 | SCR_006985 | African American Study of Kidney Disease and Hypertension (AASK) Clinical Trial and Cohort Study, African American Study of Kidney Disease and Hypertension Clinical Trial and Cohort Study, Continuation of AASK Cohort Study, African American Study of Kidney Disease and Hypertension | 2026-08-13 09:27:41 | 0 |
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