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Center for the study of non-human primates. Its mission is the study and use of non-human primates as models for studies of social and biological interactions and for the discovery of methods of prevention, diagnosis and treatment of diseases that afflict humans. Through the stewardship of three unique facilities—Cayo Santiago Field Station, Sabana Seca Field Station, and the Laboratory of Primate Morphology supports a diverse range of research programs that enhance understanding of primate biology and behavior, with direct applications in biomedical and translational research.
Proper citation: Caribbean Primate Research Center (RRID:SCR_008345) Copy
Griffin (G-protein-receptor interacting feature finding instrument) is a high-throughput system to predict GPCR - G-protein coupling selectively with the input of GPCR sequence and ligand molecular weight. This system consists of two parts: 1) HMM section using family specific multiple alignment of GPCRs, 2) SVM section using physico-chemical feature vectors in GPCR sequence. G-protein coupled receptors (GPCR), which is composed of seven transmembrane helices, play a role as interface of signal transduction. The external stimulation for GPCR, induce the coupling with G-protein (Gi/o, Gq/11, Gs, G12/13) followed by different kinds of signal transduction to inner cell. About half of distributed drugs are intending to control this GPCR - G-protein binding system, and therefore this system is important research target for the development of effective drug. For this purpose, it is necessary to monitor, effectively and comprehensively, of the activation of G-protein by identifying ligand combined with GPCR. Since, at present, it is difficult to construct such biochemical experiment system, if the answers for experimental results can be prepared beforehand by using bioinformatics techniques, large progress is brought to G-protein related drug design. Previous works for predicting GPCR-G protein coupling selectivity are using sequence pattern search, statistical models, and HMM representations showed high sensitivity of predictions. However, there are still no works that can predict with both high sensitivity and specificity. In this work we extracted comprehensively the physico-chemical parameters of each part of ligand, GPCR and G-protein, and choose the parameters which have strong correlation with the coupling selectivity of G-protein. These parameters were put as a feature vector, used for GPCR classification based on SVM.
Proper citation: G protein receptor interaction feature finding instrument (RRID:SCR_008343) Copy
http://www.xiphophorus.txstate.edu/
Supplier of xiphophorus (platyfish or swordtails) from pedigreed parental lines, representing variety of species. In addition to supplying strains and providing consultation on husbandry and genetic questions, the XGSC produces custom interspecies hybrids (both first generation F1, and backcross hybrid generation BC1) for a variety of projects.
Proper citation: Xiphophorus Genetic Stock Center (RRID:SCR_008340) Copy
http://www.nature.com/nature/supplements/collections/
This website provides summary collections written for a broad audience highlighting some of the significant advances in a particular field. These are not scientific articles although they may reference scientific work. Sponsors: This resource is supported by Nature.com
Proper citation: Nature Supplements: Collections archive (RRID:SCR_008337) Copy
The mission of the Institute is to discover the key principles by which brains work and to implement these in artificial systems that interact intelligently with the real world. The Institute of Neuroinformatics is built of many people covering a wide range of disciplines and research areas. The major research projects and areas are listed below. - Behavior and Cognition: At the Institute of Neuroinformatics researchers investigate in Behavior and Cognition on various levels, ranging from neuronal circuit models of learning and adaptation over psychophysical experiments for color constancy up to modeling complex behavioral tasks such as exploration and goal-directed navigation. - Computation in Neural Circuits: By examining the brains of cats, rats and monkeys, and by making simulations of the cortex, INI hopes to learn how this circuit performs such widely different tasks. This knowledge might lead to advances in how computers are designed, and will certainly lead to advances in the subtlety and power of medical neuroscience. - Neurotechnologies: INI aims to harness the principles of biological computation, which can be expected to have a major impact on the technology market as autonomous intelligence pervades equipment, vehicles, buildings, utilities and clothing. Sponsors: INI is supported by European Union (EU), Gerbert Ruf Stiftung, Neuroscience Center (ZNZ), Swiss Confederation (KTI), Swiss Federal Institute of Technology Zurich (ETH), Swiss National Science Foundation (SNF), University of Zurich (UZH), and VW Stiftung
Proper citation: Institute of Neuroinformatics (RRID:SCR_008331) Copy
Center that supports studies of nonhuman primate models of human diseases, including common chronic diseases and infectious diseases and the effects that genetics and the environment have on physiological processes and disease susceptibility. SNPRC encourages the use of its resources by investigators from the national and international biomedical research communities.
Proper citation: Southwest National Primate Research Center (RRID:SCR_008292) Copy
Catalog of published genome-wide association studies. Genome-wide set of genetic variants in different individuals to see if any variant is associated with trait and disease. Database of genome-wide association study (GWAS) publications including only those attempting to assay single nucleotide polymorphisms (SNPs). Publications are organized from most to least recent date of publication. Studies are identified through weekly PubMed literature searches, daily NIH-distributed compilations of news and media reports, and occasional comparisons with an existing database of GWAS literature (HuGE Navigator). Works with HANCESTRO ancestry representation.
Proper citation: GWAS: Catalog of Published Genome-Wide Association Studies (RRID:SCR_012745) Copy
http://www.scienceexchange.com/facilities/lifetein
LifeTein LLC, located in South Plainfield, New Jersey, was founded for its global custom peptide synthesis services, antibody production services and chemical services. LifeTein offers a wide range of custom research services and a staff of scientists with the first-hand campus-core-facility experience necessary to understanding the role of peptide and protein services in large research projects. LifeTein is the only peptide synthesis manufacturer to have developed its own line of PeptideSyn platform for peptide synthesis and AdjuBooster for antibody production.
Proper citation: LifeTein (RRID:SCR_012626) Copy
http://www.brain.northwestern.edu/index.html
The Cognitive Neurology and Alzheimer's Disease Center (CNADC) is a multidisciplinary organization dedicated to conducting research to discover how the brain coordinates mental functions such as memory, language, attention, and emotion; transferring the benefits of this research to patients with brain diseases that impair cognitive function; and training researchers and clinicians who want to work in this field. The CNADC's mission is to investigate the neurological basis of cognitive function, to elucidate causes of dementia, and to ensure that the patients and their families are the beneficiaries of resultant discoveries. * Clinical Services: Neurobehavior and Memory Health Clinical Services * Annual Grant Opportunities: Annual Core Pilot Project Funding Opportunities * Research Areas & Faculty: Alzheimer's Disease / Primary Progressive Aphasia / Frontal Dementia, Brain Endowment (Brains are permanently stored, and requests for tissue for research purposes are submitted to Dr. Bigio for review by the Northwestern Alzheimer's Disease Center); Cognitive Brain Mapping Group, Volunteer For A Study * Fellowships: Neuropathology Fellowship, Behavioral Neurology & Neuropsychiatry Fellowship * Training Programs: Mechanisms of Aging and Dementia (M.A.D.) Training Program; Training Program in the Neuroscience of Human Cognition
Proper citation: Northwestern University Cognitive Neurology and Alzheimers Disease Center (RRID:SCR_012747) Copy
http://www.scienceexchange.com/facilities/intrepid-bioinformatics
Core offers a repository from which researchers can drag and drop genetic sequence data into another application. Core offers a feature-surface to surface interoperation-that enables the system to be the hub for a network of applications researchers need to perform their work; LIMS, analytic tools, content management, workflow engines, visualization, etc. The core's system is optimized for cloud-based operations, and doesn't require users to re-download data.
Proper citation: Intrepid Bioinformatics (RRID:SCR_012625) Copy
Software suite of automated docking tools. Designed to predict how small molecules, such as substrates or drug candidates, bind to receptor of known 3D structure. AutoDock consist of AutoDock 4 and AutoDock Vina. AutoDock 4 consists of autodock to perform docking of ligand to set of grids describing target protein, and autogrid to pre calculate these grids.
Proper citation: AutoDock (RRID:SCR_012746) Copy
http://www.scienceexchange.com/facilities/altabioscience
Founded in 1973, AltaBioscience* is recognised world-wide as a leading manufacturing laboratory providing analysis and synthesis of DNA, proteins and other biochemical molecules to researchers in academia, pharmaceutica and the food industry. *An ISO 9001: 2008 certified UK based laboratory offering CD analysis.
Proper citation: AltaBioscience (RRID:SCR_012593) Copy
http://www.scienceexchange.com/facilities/university-of-western-sydney
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 15,2024. Portal, Core facility
Proper citation: University of Western Sydney Labs and Facilities (RRID:SCR_012590) Copy
http://www.bioconductor.org/packages/release/bioc/html/ExiMiR.html
R functions for the normalization of Exiqon miRNA array data.
Proper citation: ExiMiR (RRID:SCR_012753) Copy
http://sourceforge.net/projects/cnv/
Software for a web-enabled platform for analyzing genome variation such as copy number variation (CNV).
Proper citation: CNV Workshop (RRID:SCR_012635) Copy
A global evaluation of the conservation status of plant and animal species. The IUCN Red List plays a prominent role in guiding conservation activities of governments, NGOs and scientific institutions. The introduction in 1994 of a scientifically rigorous approach to determine risks of extinction that is applicable to all species, has become a world standard. In order to produce The IUCN Red List of Threatened Species, the IUCN Global Species Programme working with the IUCN Survival Commission (SSC) and with members of IUCN draws on and mobilizes a network of scientists and partner organizations working in almost every country in the world, who collectively hold what is likely the most complete scientific knowledge base on the biology and conservation status of species. The IUCN Red List is underpinned by information management tools (the Species Information Service) which facilitate the collection, management and processing of species data from workshop to publication on The IUCN Red List.
Proper citation: IUCN (RRID:SCR_012758) Copy
https://www.scienceexchange.com/labs/virginia-bioinformatics-institute-vt
THIS RESOURCE IS NO LONGER IN SERVCE, documented January 23, 2019. Core functions as a multi-user resource dedicated to the development and application of various high-throughput technologies to aid in the discovery of biological macromolecules. Core provides analysis platforms for DNA (sequencing and genotyping), RNA (gene expression analysis) and proteins (proteomics). They also offer a selection of molecular biology applications (colony picking, cloning, DNA/RNA isolations).
Proper citation: Virginia Bioinformatics Institute (RRID:SCR_012636) Copy
http://www.scienceexchange.com/facilities/sylvester-comprehensive-cancer-center-miami
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 23,2024. With more than 250 physicians and scientists dedicated to cancer care and research, Sylvester is leading the search for a cancer cure. Every day, our physicians and scientists within the cancer center''''s site disease groups and multidisciplinary research programs, are discovering exciting new breakthroughs that are quickly transforming the way cancer patients are diagnosed and treated.
Proper citation: UM Sylvester Comprehensive Cancer Center Labs and Facilities (RRID:SCR_012720) Copy
http://www.bioconductor.org/packages/release/bioc/html/motifRG.html
Software tools for discriminative motif discovery using regression methods.
Proper citation: motifRG (RRID:SCR_012602) Copy
http://www.scienceexchange.com/facilities/advanced-analytical-testing-service
Advanced Analytical Testing Service (AATS) is dedicated to providing premium testing services for food, dietary supplement, biotechnology and cosmetic industries. AATS is established on our clients'' greatest satisfaction with our sample processing, testing method development and post-testing consultation. Our goal is to report authentic and accurate testing results with optimal quality and minimum turnover time. AATS is FDA registered independent analytical testing provider that is familiar with cGMP, USP and ISO standards. AATS has established full quality system on personnel, training, sample receipt and handling, testing, quality control and documentation. We provide testing results of high quality, because we have a strong quality system built in our testing facilities.
Proper citation: Advanced Analytical Testing Service (RRID:SCR_012723) Copy
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