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http://www.nature.com/nature/supplements/collections/

This website provides summary collections written for a broad audience highlighting some of the significant advances in a particular field. These are not scientific articles although they may reference scientific work. Sponsors: This resource is supported by Nature.com

Proper citation: Nature Supplements: Collections archive (RRID:SCR_008337) Copy   

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http://www.ini.uzh.ch/

The mission of the Institute is to discover the key principles by which brains work and to implement these in artificial systems that interact intelligently with the real world. The Institute of Neuroinformatics is built of many people covering a wide range of disciplines and research areas. The major research projects and areas are listed below. - Behavior and Cognition: At the Institute of Neuroinformatics researchers investigate in Behavior and Cognition on various levels, ranging from neuronal circuit models of learning and adaptation over psychophysical experiments for color constancy up to modeling complex behavioral tasks such as exploration and goal-directed navigation. - Computation in Neural Circuits: By examining the brains of cats, rats and monkeys, and by making simulations of the cortex, INI hopes to learn how this circuit performs such widely different tasks. This knowledge might lead to advances in how computers are designed, and will certainly lead to advances in the subtlety and power of medical neuroscience. - Neurotechnologies: INI aims to harness the principles of biological computation, which can be expected to have a major impact on the technology market as autonomous intelligence pervades equipment, vehicles, buildings, utilities and clothing. Sponsors: INI is supported by European Union (EU), Gerbert Ruf Stiftung, Neuroscience Center (ZNZ), Swiss Confederation (KTI), Swiss Federal Institute of Technology Zurich (ETH), Swiss National Science Foundation (SNF), University of Zurich (UZH), and VW Stiftung

Proper citation: Institute of Neuroinformatics (RRID:SCR_008331) Copy   

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http://www.rulesbasedmedicine.com/

Rules-Based Medicine (RBM) uses proprietary Multi-Analyte Profiling (MAP) technology to make life science research and drug and diagnostic development programs more efficient and effective. Whether measuring hundreds of biomarkers or simply a few, our approach provides reproducible, quantitative immunoassay data from a small sample volume at a cost-effective price. RBM is CLIA certified and supports GLP studies. * Quality: All immunoassays are validated to clinical laboratory standards. This means complete validation for the clinic, not fit for purpose validation which at RBM means inferior validation. Learn More * Content: We have the most comprehensive menu of biomarker immunoassays available. * Small Sample Volumes: Multiplexing provides you with more data using a smaller sample volume. * Cost Effective: Multiplexing and automation combine to deliver high quality data at reasonable prices. * Ease of use: Ship us your samples and get results within 2 weeks. Rules-Based Medicine (RBM), the worlds leading multiplexed biomarker testing laboratory, provides comprehensive protein biomarker products and services based on its Multi-Analyte Profiling (MAP) technology platform. RBMs biomarker testing service provides pre-clinical and clinical researchers with reproducible, quantitative, multiplexed immunoassay data for hundreds of proteins in a cost-effective manner, from a small sample volume and from multiple species. Our biomarker testing laboratory is CLIA certified and supports GLP studies. Most diseases and drug effects manifest themselves in abnormal levels of specific biomarkers found in the peripheral blood. By providing multiplexed, quantitative, and reproducible tests for hundreds of biomarkers, RBM enables research that historically was not available due to sample volume requirements and associated costs. Use of our testing services can identify the sources of both the positive and negative effects of drugs during pre-clinical research and clinical trials. Biomarker testing results identify patients most likely to respond to a given therapy and the biochemical reason for that response, making clinical trials more successful and effective. Through its wholly owned subsidiary EDI GmbH, RBM provides Human Organo-Typic (HOT) cell culture systems. These co-culture systems consist of multiple primary cell types grown in a 3-D architecture that closely mimic particular human organs and are an ideal platform for ex vivo studies of drug safety and efficacy. RBM combines EDIs cell culture systems with its HumanMAP biomarker testing services to provide researchers with an unprecedented view of the physiological and biochemical impact of a new drug compound or consumer product prior to testing in a human subject. RBM also performs custom assay development, participates in co-sponsored research programs, and pursues in-licensing of novel high-value assays.

Proper citation: Rules Based Medicine (RRID:SCR_008575) Copy   

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http://www.nimblegen.com

Roche NimbleGen, Inc. is a leading innovator, manufacturer and supplier of a proprietary suite of DNA microarrays, consumables, instruments and services. Roche NimbleGen uniquely produces high-density arrays of long oligo probes that provide greater information content and higher data quality necessary for studying the full diversity of genomic and epigenomic variation. Roche NimbleGen is enabling a new era of High-Definition Genomics by providing scientists with cost-effective, high-throughput tools for extracting and integrating complex data on important forms of genomic and epigenomic variation not previously accessible on a genome-wide scale. Scientists can thus obtain a clearer understanding of genomic and epigenomic structure and function and how they impact biology and medicine. This improved performance is made possible by Roche NimbleGen''s proprietary Maskless Array Synthesis (MAS) technology, which uses digital light processing and rapid, high-yield photochemistry to synthesize long oligo, high-density DNA microarrays with extreme flexibility. NimbleGen Systems was established in 1999. The MAS technology is the result of research collaborations between the departments of biotechnology, genetics, physics, and semiconductor engineering at the University of Wisconsin - Madison. Roche NimbleGen has the exclusive worldwide license to the MAS technology from the Wisconsin Alumni Research Foundation (WARF).

Proper citation: Roche NimbleGen (RRID:SCR_008571) Copy   

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http://www.brainvoyager.de/BV2000OnlineHelp/BrainVoyagerWebHelp/Talairach_brain_atlas.htm

The Talairach brain atlas visualized via BrainVoyager (Commercial software) can be used to visualize Brodmann areas as they were defined for the Talairach brain (Talairach & Tournaux, 1988) and to compare regions of subjects with respect to the Brodmann areas. The demarcated areas are based on the Talairach demon, which is a digitized version of the Talairach atlas and which has been transferred into BrainVoyager VOI files by Matthias Ruf, Mannheim. Using the Brodman.voi file you may ask questions like the following: What is the signal time course of subject N in experiment A within Brodmann area X ?. Note, however, that the defined areal boundaries should be used only as a rough guideline for determining the location of activated regions: There is substantial variation of histologically defined areas between subjects. Since cytoarchitectonically defined Brodmann areas are not available in vivo, we advise to use the provided information with care. The TalairachBrain.vmr file is located in the same folder as your BrainVoyager executable file. It can be loaded as any VMR project by using the Open... item in the File menu (or the Open icon). The TalairachBrain.vmr file is also loaded automatically when using the glass brain visualization tool.

Proper citation: BrainVoyager: Talairach Brain Atlas (RRID:SCR_008800) Copy   

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http://tigger.uic.edu/~cjeffery/

The moonlighting protein database is not yet available publicly. Stay tuned. Moonlighting proteins have multiple, seemingly unrelated functions not due to gene fusions or alternative splicing. Like PGI, which is a cytosolic enzyme and an extracellular cytokine, dozens of other proteins have been found to moonlight. Connie coined the term moonlighting proteins and has written several review articles that develop the idea of moonlighting proteins and describe additional moonlighting proteins from the literature, how they switch between functions, how they might have evolved, and how they might benefit the cell. She is currently writing two additional invited articles and planning computational studies of the sequences and structures of known moonlighting proteins.

Proper citation: MoonProt (RRID:SCR_008803) Copy   

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http://www.cumc.columbia.edu/dept/taub/index.html

An institute which conducts research of Alzheimer's, Parkinson's and other age-related brain diseases. This organization also provides clinical evaluations to patients with memory problems, Alzheimer's disease or other types of dementia. Furthermore, the institute leads multi-center clinical trials for the treatment and prevention of Alzheimer's, Parkinson's and other age-related brain diseases. There is a brain donation program for enrolled/examined patients. The Education Core of the Taub Institute sponsors community events and Continuing Medical Education programs, as well as the distribution of periodic newsletters and brochures highlighting research developments and other Alzheimer's topics.

Proper citation: Taub Institute for Research on Alzheimers Disease and the Aging Brain (RRID:SCR_008802) Copy   

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http://crezoo.crt-dresden.de/crezoo/

Database of helpful set of CreERT2 driver lines expressing in various regions of the developing and adult zebrafish. The lines have been generated via the insertion of a mCherry-T2A-CreERT2 in a gene trap approach or by using promoter fragments driving CreERT2. You can search the list of all transgenic lines or single entries by insertions (gene) or expression patterns (anatomy/region). In most cases the CreERT2 expression profile using in situ hybridization at 24 hpf and 48 hpf is shown, but also additional information (e.g. mCherry or CreERT2 expression at adult stages, transactivation of a Cre-dependent reporter line) is displayed. Currently, not all insertions have been mapped to a genomic location but the database will be regularly updated adding newly generated insertions and mapping information. Your help in improving and broadening the database by giving your opinion or knowledge of expression patterns is highly appreciated.

Proper citation: CreZoo (RRID:SCR_008919) Copy   

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http://clipserve.clip.ubc.ca/topfind

An integrated knowledgebase focused on protein termini, their formation by proteases and functional implications. It contains information about the processing and the processing state of proteins and functional implications thereof derived from research literature, contributions by the scientific community and biological databases. It lists more than 120,000 N- and C-termini and almost 10,000 cleavages. TopFIND is a resource for comprehensive coverage of protein N- and C-termini discovered by all available in silico, in vitro as well as in vivo methodologies. It makes use of existing knowledge by seamless integration of data from UniProt and MEROPS and provides access to new data from community submission and manual literature curating. It renders modifications of protein termini, such as acetylation and citrulination, easily accessible and searchable and provides the means to identify and analyse extend and distribution of terminal modifications across a protein. The data is presented to the user with a strong emphasis on the relation to curated background information and underlying evidence that led to the observation of a terminus, its modification or proteolytic cleavage. In brief the protein information, its domain structure, protein termini, terminus modifications and proteolytic processing of and by other proteins is listed. All information is accompanied by metadata like its original source, method of identification, confidence measurement or related publication. A positional cross correlation evaluation matches termini and cleavage sites with protein features (such as amino acid variants) and domains to highlight potential effects and dependencies in a unique way. Also, a network view of all proteins showing their functional dependency as protease, substrate or protease inhibitor tied in with protein interactions is provided for the easy evaluation of network wide effects. A powerful yet user friendly filtering mechanism allows the presented data to be filtered based on parameters like methodology used, in vivo relevance, confidence or data source (e.g. limited to a single laboratory or publication). This provides means to assess physiological relevant data and to deduce functional information and hypotheses relevant to the bench scientist. TopFIND PROVIDES: * Integration of protein termini with proteolytic processing and protein features * Displays proteases and substrates within their protease web including detailed evidence information * Fully supports the Human Proteome Project through search by chromosome location CONTRIBUTE * Submit your N- or C-termini datasets * Contribute information on protein cleavages * Provide detailed experimental description, sample information and raw data

Proper citation: TopFIND (RRID:SCR_008918) Copy   

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http://bioinformatics.fccc.edu/software/OpenSource/FGDP/FGDP.shtml

A Java-based, Microarray or Genechip data analysis system.

Proper citation: FGDP (RRID:SCR_008910) Copy   

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http://code.google.com/p/elk-reasoner/

ELK is an ontology reasoner with the goal of supporting the OWL 2 EL profile. ELK is a specialized reasoner for the lightweight ontology language OWL EL. The practical utility of ELK is in its combination of high performance and comprehensive support for language features. At its core, ELK employs a consequence-based reasoning engine that can take advantage of multi-core and multi-processor systems. A modular architecture allows ELK to be used as a stand-alone application, Protege plug-in, or programming library (either with or without the OWL API).

Proper citation: elk-reasoner (RRID:SCR_008913) Copy   

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http://www.pdbj.org/

PDBj (Protein Data Bank Japan) maintains a centralized PDB archive of macromolecular structures and provides integrated tools, in collaboration with the RCSB, the BMRB in USA and the PDBe in EU.

Proper citation: PDBj - Protein Data Bank Japan (RRID:SCR_008912) Copy   

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http://developer.yahoo.com/yui/

The YUI Library is a set of utilities and controls, written with JavaScript and CSS, for building richly interactive web applications using techniques such as DOM scripting, DHTML and AJAX. YUI is available under a BSD license and is free for all uses. YUI is proven, scalable, fast, and robust. Built by frontend engineers at Yahoo! and contributors from around the world, it''s an industrial-strength JavaScript library for professionals who love JavaScript.

Proper citation: Yahoo Developer Network (RRID:SCR_008594) Copy   

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http://www.aquatichabitats.com

Aquatic Habitats (AHAB) is the worlds largest manufacturer of housing systems for aquatic research animals. We are biologists first and engineers second, so we understand the complexity of aquatic life and how to sustain it. Our turnkey systems are secure, efficient and as fail-safe as possible.

Proper citation: Aquatic Habitats (RRID:SCR_008597) Copy   

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http://www.ltp-program.com

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on Jan 16th 2025. WinLTP is a stimulation, data acquisition and on-line analysis electrophysiological software for studying Long-Term Potentiation (LTP), Long-term Depression (LTD), and related phenomena. WinLTP is multitasking and simultaneously runs 1) LTP stimulus/acquisition/analyzing sweeps with protocol scripting, and 2) continuous acquisition saving Axon Binary Files (abf). WinLTP runs on Windows PCI bus computers and uses National Instruments PCI M-Series boards and Axon Instruments'' Digidata 1320A and 1322A data acquisition boards. Other software that can use the M-Series boards includes Axograph Scientific''s AxoGraph X, WaveMetrics'' IGOR, National Instruments'' LabView, John Dempster''s Strathclyde Electrophysiology Suite (WinWCP and WinEDR), Silver lab''s Nclamp, and QUB data acquisition., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Proper citation: WinLTP (RRID:SCR_008590) Copy   

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http://www.mcmillenfoundation.org/

A foundation that offers grants for researchers in cardiology, lipid and organ transplant in Washington and Alaska. The Robert B McMillen Foundation is a non-profit charitable foundation established to; promote research in the areas of cardiology, lipid and organ transplant, support education at the university and college level in the states of Washington and Alaska and provide funding for social service organizations. What we fund: * MEDICAL: 50% of our annual giving is earmarked for medical research. We will consider making grants to non-profit organizations involved in researching cardiology, lipid and organ transplants. * EDUCATION: 25% of our annual giving is earmarked for Education at the University level in the states of Washington and Alaska. Funding will be provided to support the art departments of post secondary schools who offer a degree in the visual arts. * SOCIAL: 25% of our annual giving is earmarked for social areas including, but not limited to, Goodwill, Salvation Army & United Way. Preference is given to organizations and/or programs that use art as the vehicle to impact communities and change individual lives.

Proper citation: McMillen Foundation (RRID:SCR_008908) Copy   

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http://www.icpsr.umich.edu/icpsrweb/NACDA/studies/09915/version/3

A collection of data that describes and identifies predictors of mortality, hospitalization, and placement in long-term care facilities and investigates risk factors for chronic diseases and loss of functioning. The EPESE project consisted of baseline and annual follow-up surveys on approximately 14,000 noninstitutionalized persons aged 65 and older in four geographically-defined communities: East Boston, Massachusetts; Iowa and Washington counties, Iowa; New Haven, Connecticut (started in 1982-1983); and a five-county-wide region in north-central North Carolina (started in 1986). Half of the participants in the North Carolina EPESE are African-American. The baseline data cover demographic characteristics (age, sex, race, height, weight, income, education, marital status, number of children, employment, and religion); social and physical functioning; chronic conditions; related health problems; health habits; self-reported use of dental, hospital, and nursing home services. More detailed descriptions of the Iowa and North Carolina surveys follow in this document (Iowa 65+ Rural Health Study and PHSE Ten-Year Follow-up of North Carolina EPESE). Data Availability: Data from the baseline and the first 6 years of follow-up are available as ICPSR Study No. 9915. Information from death certificates obtained for deaths occurring in the first 6 years of follow-up is also available. * Dates of Study: 1981-1993 * Study Features: Longitudinal, Minority Oversamples, Anthropometric Measures * Sample Size: ** 1981: 14,458 (Baseline) ** 1982: 14,070 (First follow-up) ** 1983: 13,382 (Second follow-up) ** 1984: 12,381 (Third follow-up) ** 1985: 11,657 (Fourth follow-up) ** 1986: 10,998 (Fifth follow-up) ** 1987: 9,998 (Sixth follow-up) Link * ICPSR: http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/09915

Proper citation: Established Populations for Epidemiologic Studies of the Elderly (RRID:SCR_008909) Copy   

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http://plantgrn.noble.org/LegumeIP/

LegumeIP is an integrative database and bioinformatics platform for comparative genomics and transcriptomics to facilitate the study of gene function and genome evolution in legumes, and ultimately to generate molecular based breeding tools to improve quality of crop legumes. LegumeIP currently hosts large-scale genomics and transcriptomics data, including: * Genomic sequences of three model legumes, i.e. Medicago truncatula, Glycine max (soybean) and Lotus japonicus, including two reference plant species, Arabidopsis thaliana and Poplar trichocarpa, with the annotation based on UniProt TrEMBL, InterProScan, Gene Ontology and KEGG databases. LegumeIP covers a total 222,217 protein-coding gene sequences. * Large-scale gene expression data compiled from 104 array hybridizations from L. japonicas, 156 array hybridizations from M. truncatula gene atlas database, and 14 RNA-Seq-based gene expression profiles from G. max on different tissues including four common tissues: Nodule, Flower, Root and Leaf. * Systematic synteny analysis among M. truncatula, G. max, L. japonicus and A. thaliana. * Reconstruction of gene family and gene family-wide phylogenetic analysis across the five hosted species. LegumeIP features comprehensive search and visualization tools to enable the flexible query on gene annotation, gene family, synteny, relative abundance of gene expression.

Proper citation: LegumeIP (RRID:SCR_008906) Copy   

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http://www.ohsu.edu/xd/research/centers-institutes/neurology/alzheimers/research/data-tissue/neuro-imaging.cfm

NeuroImaging laboratory focused on detecting early brain changes associated with cognitive decline and dementia that manages the neuroimaging component of all studies at the Layton Aging and Alzheimer's Center including acquisition and archival services, as well as volumetric analysis of anonymized MRI scans. Assistance with resulting data is also available, including statistical analysis, and preparation of materials for presentation and publication. The Layton Center also manages a library of thousands of digitized MRI scans, including what is believed to be the largest collection of longitudinal MRI scans of cognitively intact elderly subjects. The OADC Neuroimaging Lab conducts MRI studies on both 3 and 7T MRI systems using advanced sequences, employing a multimodal approach to brain imaging research.

Proper citation: Layton Center NeuroImaging Laboratory (RRID:SCR_008823) Copy   

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http://www.ohsu.edu/xd/research/centers-institutes/neurology/alzheimers/

An aging and Alzheimer's disease research center that conducts studies of treatments, technologies for patient support, genetics, neuroimaging, and pathology. The Center's clinical research focuses on understanding differing rates of progression and cognitive decline as compared to optimal cognitive health in the elderly and are currently studying methods of gauging the progression of Alzheimer’s disease through research in genetics, neuroimaging, and cerebrospinal fluid biomarkers. Clinical trials performed at the Center include drugs targeted to ameliorate the symptoms of memory failure and slow the progression of disease.

Proper citation: OHSU Layton Aging and Alzheimer's Disease Center (RRID:SCR_008821) Copy   

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