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Software for short-read mapping to accurately map reads from the next-generation sequencing technology. It can map reads with or without error probability information (quality scores) and supports paired-end reads or bisulfite-treated reads mapping. There is no limitaions on read widths or number of mismatches. RMAP can now map more than 8 million reads in an hour at full sensitivity to 2 mismatches.
Proper citation: RMAP (RRID:SCR_000695) Copy
https://github.com/iontorrent/TMAP
Alignment software for short and long nucleotide sequences produced by next-generation sequencing technologies.
Proper citation: TMAP (RRID:SCR_000687) Copy
https://projects.propublica.org/nonprofits/organizations/364298517
Non-profit charitable organization that benefits philanthropy, voluntarism and grantmaking foundations, focusing specifically on private independent foundations programs. (http://non-profit-organizations.findthebest.com/l/558154/Makray-Family-Foundation)
Proper citation: Makray Family Foundation (RRID:SCR_000916) Copy
A commercial vendor of chemicals that provides custom synthesis of a wide variety of organic compounds. Frontier Scientific has capabilities for custom work in organoborons, organotins, porphyrins, silanes, halogenations, catalysts and cross couplings using Suzuki, Stille, and Kumada processes.
Proper citation: Frontier Scientific Chemical Supplier (RRID:SCR_000914) Copy
http://purl.bioontology.org/ontology/PHYLONT
Ontology for Phylogenetic Analysis
Proper citation: Phylogenetic Ontology (RRID:SCR_000912) Copy
http://purl.bioontology.org/ontology/ATO
A taxonomy of Amphibia
Proper citation: Amphibian Taxonomy Ontology (RRID:SCR_000906) Copy
http://www.ced.co.uk/pru.shtml?spk7wglu.htm
THIS RESOURCE IS NO LONGER IN SERVICE.Documented on September 23,2022. A data acquisition and analysis software package for electrophysiology data. Spike2 software offers multi-channel continuous data acquisition and analysis with a multitude of options. This offers flexible usage from a simple chart recorder to complex applications requiring stimulus generation, data capture, scrolling or triggered displays, control of external equipment, and custom analysis. Spike2 software can be used in many fields such as electrophysiology, neurophysiology, cardiovascular and respiratory studies, sports science and pharmacology.
Proper citation: Spike2 Software (RRID:SCR_000903) Copy
http://purl.bioontology.org/ontology/PATHLEX
A comprehensive lexicon - a unified language of anatomic pathology terms - for standardized indexing and retrieval of anatomic pathology information resources.
Proper citation: Anatomic Pathology Lexicon (RRID:SCR_000907) Copy
http://purl.bioontology.org/ontology/HIV
Ontology that encompasses all knowledge about HIV
Proper citation: HIV ontology (RRID:SCR_000908) Copy
http://www.medscape.org/medscapetoday
A portal with listings of continuing medical education opportunities such as radiology, pediatrics, and HIV/AIDS specializations.
Proper citation: Medscape Education - Medscape CME/CE (RRID:SCR_000936) Copy
http://code.google.com/hosting/
Project Hosting on Google Code provides a free collaborative development environment for open source projects.
Proper citation: Google Project Hosting (RRID:SCR_000811) Copy
A non-profit organization that supports the advance of healthy aging through biomedical research.
Proper citation: American Federation for Aging Research (RRID:SCR_000806) Copy
http://www.yandell-lab.org/software/index.html
Sequenced genomes contain a treasure trove of information about how genes function and evolve. Getting at this information, however, is challenging and requires novel approaches that combine computer science and experimental molecular biology. My lab works at the intersection of both domains, and research in our group can be summarized as follows: generate hypotheses concerning gene function and evolution by computational means, and then test these hypotheses at the bench. This is easier said than done, as serious barriers still exist to using sequenced genomes and their annotations as starting points for experimental work. Some of these barriers lie in the computational domain, others in the experimental. Though challenging, overcoming these barriers offers exciting training opportunities in both computer science and molecular genetics, especially for those seeking a future at the intersection of both fields. Ongoing projects in the lab are centered on genome annotation and comparative genomics; exploring the relationships between sequence variation and human disease; and high-throughput biological image analysis. Current software tools available: VAAST (the Variant Annotation, Analysis & Search Tool) is a probabilistic search tool for identifying damaged genes and their disease-causing variants in personal genome sequences. VAAST builds upon existing amino acid substitution (AAS) and aggregative approaches to variant prioritization, combining elements of both into a single unified likelihood-framework that allows users to identify damaged genes and deleterious variants with greater accuracy, and in an easy-to-use fashion. VAAST can score both coding and non-coding variants, evaluating the cumulative impact of both types of variants simultaneously. VAAST can identify rare variants causing rare genetic diseases, and it can also use both rare and common variants to identify genes responsible for common diseases. VAAST thus has a much greater scope of use than any existing methodology. MAKER 2 (updated 01-16-2012) MAKER is a portable and easily configurable genome annotation pipeline. It's purpose is to allow smaller eukaryotic and prokaryotic genomeprojects to independently annotate their genomes and to create genome databases. MAKER identifies repeats, aligns ESTs and proteins to a genome, produces ab-initio gene predictions and automatically synthesizes these data into gene annotations having evidence-based quality values. MAKER is also easily trainable: outputs of preliminary runs can be used to automatically retrain its gene prediction algorithm, producing higher quality gene-models on seusequent runs. MAKER's inputs are minimal and its ouputs can be directly loaded into a GMOD database. They can also be viewed in the Apollo genome browser; this feature of MAKER provides an easy means to annotate, view and edit individual contigs and BACs without the overhead of a database. MAKER should prove especially useful for emerging model organism projects with minimal bioinformatics expertise and computer resources. RepeatRunner RepeatRunner is a CGL-based program that integrates RepeatMasker with BLASTX to provide a comprehensive means of identifying repetitive elements. Because RepeatMasker identifies repeats by means of similarity to a nucleotide library of known repeats, it often fails to identify highly divergent repeats and divergent portions of repeats, especially near repeat edges. To remedy this problem, RepeatRunner uses BLASTX to search a database of repeat encoded proteins (reverse transcriptases, gag, env, etc...). Because protein homologies can be detected across larger phylogenetic distances than nucleotide similarities, this BLASTX search allows RepeatRunner to identify divergent protein coding portions of retro-elements and retro-viruses not detected by RepeatMasker. RepeatRunner merges its BLASTX and RepeatMasker results to produce a single, comprehensive XML-based output. It also masks the input sequence appropriately. In practice RepeatRunner has been shown to greatly improve the efficacy of repeat identifcation. RepeatRunner can also be used in conjunction with PILER-DF - a program designed to identify novel repeats - and RepeatMasker to produce a comprehensive system for repeat identification, characterization, and masking in the newly sequenced genomes. CGL CGL is a software library designed to facilitate the use of genome annotations as substrates for computation and experimentation; we call it CGL, an acronym for Comparitive Genomics Library, and pronounce it Seagull. The purpose of CGL is to provide an informatics infrastructure for a laboratory, department, or research institute engaged in the large-scale analysis of genomes and their annotations.
Proper citation: Yandell Lab Portal (RRID:SCR_000807) Copy
https://www.openbiosystems.com/
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. Open Biosystems offers products that span Genomics, RNAi and Antibodies. Building on the rapid sharing model that is at the core of the Human Genome Project, Open Biosystems collaborates with some of the most innovative life science investigators working today. We partner with them to bring to market new productsthey have often pioneered the new resources in their own lab, and we prepare it for widespread use and then provide access to the research community. Delivery of genetic content is our most recent technological breakthrough. Recently, we brought to market the Tranz-vector system, the safest human-based lentiviral delivery technology. Further supplementing our already strong line of RNA interference (RNAi) and complementary DNA (cDNA) products, this technology provides investigators with superior delivery capabilities for high-quality cellular screening. The combination or our unique Tranz-vector system and whole genome RNAi and cDNA content enables our customers to perform drug target validation on a large scale. With our genomics resources, Open Biosystems provides the content investigators utilize to unlock the functions of human genes and their relationships to normal and disease development. We offer the most complete gene library in the industry. This novel library consists of several full length cDNA and open reading frame collections. Most prominently among these is the Mammalian Gene Collection (MGC), the industry's gold standard gene catalog. The discovery of RNA interference has revolutionized the way investigators approach the studies of gene expression, regulation and interactions, particularly as it relates to drug development. Our collaboration with Drs. Greg Hannon (CSHL) and Steve Elledge (Harvard) has led the way in the evolution of the short hairpin RNA (shRNA) technologies to provide the life science community with whole genome resources for human, mouse and rat with a multitude of technology and delivery advantages.
Proper citation: Open Biosystems (RRID:SCR_000808) Copy
http://hcls.deri.org/atag/generator/
THIS RESOURCE IS NO LONGER IN SERVICE, documented on August 13, 2012. Snippets of HTML that capture the information that is most important in a machine-readable, interlinked format, making it easier to see the big picture. aTags work with any Web text and can store and connect any textual element that is highlighted in a browser. The structure of the embedded RDF/OWL is decidedly simple: a very short piece of human-readable text that is "tagged" with relevant ontological entities. An aTag generator can be easily added to any web browser and allows researchers to quickly generate aTags out of key statements from web pages, such as PubMed abstracts. The resulting aTags can be embedded anywhere on the web, for example on blogs, wikis, or biomedical databases. aTag demonstrates how the resulting statements that are distributed over the web can be searched, visualized and aggregated with Semantic Web / Linked Data tools, and discusses how aTags can be used to answer practically relevant biomedical questions even though their structure is very simple. aTags are based on Semantic Web standards and Linked Data practices. Specifically, they make use of RDFa, the SIOC vocabulary and various domain ontologies and taxonomies that are available in RDF/OWL format. The autocomplete functionality is based on Apache Solr. Reference: Simple, ontology-based representation of biomedical statements through fine-granular entity tagging and new web standards Matthias Samwald and Holger Stenzhorn. Bio-Ontologies 2009., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.
Proper citation: aTag Generator (RRID:SCR_000801) Copy
A higher education institute for advanced undergraduate and graduate studies in France. The institute has fourteen teaching and research departments that span the humanities and sciences.
Proper citation: Ecole Normale Superieure; Paris; France (RRID:SCR_000960) Copy
https://www.thermofisher.com/order/catalog/product/4474950
A software that gives the user the ability to basecall, trim, display, edit, and print data for the entire line of capillary DNA sequencing instruments for data analysis and quality control. This software benefits from being able to obtain longer read lengths, greater accuracy on the 5' end, and the ability to filter out low-quality sequence ends.
Proper citation: Sequencing Analysis Software (RRID:SCR_000718) Copy
http://psychiatry.stanford.edu/
A Stanford-affiliated organization which is primarily concerned with the study and treatment of sleep disorders, the treatment of psychological illnesses, and the training of medical students, residents and research fellows in psychiatry and sleep medicine.
Proper citation: Stanford University Psychiatry and Behavioral Sciences (RRID:SCR_000719) Copy
An Italian private research university that offers undergraduate, graduate and postdoctoral level degrees in both Italian and English.
Proper citation: Catholic University of the Sacred Heart; Milan; Italy (RRID:SCR_000958) Copy
http://www.scrippscollege.edu/academics/department/neuroscience/index.php
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on August 14,2025. A neuroscience program that prepares the student for graduate work in biology, psychology, neuroscience, or preparation for medical school or a career in the health services.
Proper citation: Scripps Women's College, Neuroscience Department (RRID:SCR_000717) Copy
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