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https://medschool.cuanschutz.edu/corefacilities/cryo-em

Provides equipment, expert technical assistance and image analysis expertise to enable all aspects of macromolecular structure determination by single particle cryo-electron microscopy.

Proper citation: University of Colorado Anschutz Medical Campus Cancer Center Structural Biology Shared Resource CryoEM Core Facility (RRID:SCR_021999) Copy   

•   Source: SciCrunch Registry

https://micron.hms.harvard.edu/

Light microscopy core is open to HMS researchers, including Affiliated hospitals. Supports imaging modalities ranging from wide field, TIRF, spinning disk and single point scanning confocal, multiphoton, FLIM and supper resolution. Microscopes are embedded within Departments of Microbiology, Immunology, and Genetics, housed in five microscope rooms on five floors of NRB and HIM.

Proper citation: Harvard Medical School Microscopy Resources On the North Quad Core Facility (RRID:SCR_022209) Copy   

•   Source: SciCrunch Registry

https://medschool.cuanschutz.edu/corefacilities/nmr/home

Core enables study of biomolecular structure, dynamics and interactions in solution at atomic level. Provides NMR spectrometers from 600 MHz to 900 MHz equipped for biomolecular NMR studies. Equipment include 900 MHz Bruker Avance Neo with Oxford 21 T magnet - TCI Cryoprobe 600 MHz Bruker Avance Neo with Bruker Sample Jet (2024) - TCI Cryoprobe 600 MHz Varian Inova with HCN cryoprobe.

Proper citation: University of Colorado Anschutz Medical Campus Cancer Center Structural Biology Shared Resource NMR Core Facility (RRID:SCR_021997) Copy   

•   Source: SciCrunch Registry

https://medschool.cuanschutz.edu/corefacilities/x-ray-crystallography

Core performs all aspects of structure determination of large biomolecules such as proteins and nucleic acids including macromolecular crystallization, crystal screening, molecular structure and model building.

Proper citation: University of Colorado Anschutz Medical Campus Cancer Center Structural Biology Shared Resource X Ray Crystallography Core Facility (RRID:SCR_021998) Copy   

•   Source: SciCrunch Registry

https://www.biomedicas.unam.mx/servicios/unidad-de-microscopia/

Core is specialized in stereology techniques, live cell imaging, CLSM (confocal microscopy), and STORM. Provided instruments include CONFOCAL microscopes Zeiss LSM 5 Pascal, Olympus BX51-WI,Olympus IX71 inverted microscope, Nikon Labophot-2 microscope,Nikon Optiphot 2 microscope.

Proper citation: National Autonomous University of Mexico Microscopy Core Facility (RRID:SCR_022204) Copy   

•   Source: SciCrunch Registry

http://www.cemib.unicamp.br

Core produces mice and rats for biomedical research. Provides services for customers are researchers from Unicamp and other Institutions from Brazil.

Proper citation: State University of Campinas Multidisciplinary Center for Biological Investigantion on Laboratory Animals Science Core Facility (RRID:SCR_022203) Copy   

•   Source: SciCrunch Registry

https://vtpb.tamu.edu/flow-cytometry/

Provides flow cytometry experimental design, data collection, data analysis and cell sorting services; training for flow cytometers, imaging flow cytometer, and data analysis using IDEAS and FlowJo software;staff assisted flow cytometry and imaging flow cytometry data acquisition, cell sorting, and data analysis, experimental design and consultation services. FCF currently has Beckman Coulter Moflo Astrios cell sorter, Luminex/Amnis Image Stream X Mark II, Luminex/Amnis Cell Stream, and Becton Dickinson Accuri C6 flow cytometer. Astrios cell sorter is housed in ClassII BSC and has 3 lasers (405nm, 488nm, 642nm) and 11 detectors and can sort up to 6 populations simultaneously. Image Stream X Mark II is equipped with 20x, 40x, 60x objectives, 4 lasers (405nm, 488nm, 561nm, 642nm), 10 detection channels, EV mode for small particle detection, and an autosampler.Cell Stream is equipped with 3 lasers (405nm, 488nm, 642nm), 13 detection channels, EV mode for small particle detection, and autosampler. Accuri C6 is equipped with 2 lasers (488nm, 642nm), and 4 detection channels.

Proper citation: Texas A and M University College of Veterinary Medicine and Biomedical Sciences Flow Cytometry Core Facility (RRID:SCR_022169) Copy   

•   Source: SciCrunch Registry

https://mcf.tamu.edu/

Core provides access to instrumentation essential for studies of surface and interfacial properties of materials, such as ion and electron based spectroscopies, electron, optical and scanning probe microscopies. Core provides training to students and faculty on instrumentation as well as consolation of measurements needs and data interpretation, supports educational activities involving lab tours, workshops, hands on demonstrations, outreach and broader impact related activities through our open house and lunchtime seminar series.Supports collaborative research projects with outside industrial users.

Proper citation: Texas A and M University Materials Characterization Core Facility (RRID:SCR_022202) Copy   

•   Source: SciCrunch Registry

https://www.med.upenn.edu/idom/drc/cores/rodent.html

Core (RMPC, formerly MPPMC) is metabolic core. Offers technology and phenotyping services to allow investigators to study metabolism in pre-clinical rodent models. Services include measurements of body composition (fat and lean mass) using NMR and DEXA, energy balance (food intake, locomotor activity, energy expenditure) using indirect calorimetry in either Columbus Instruments CLAMS system or Sable Systems Promethion System (with optional gas analyzer), and other in vivo metabolic phenotyping services (glucose clamps, insulin and glucose tolerance tests, telemetric monitoring of blood glucose or blood pressure, bomb calorimetry).

Proper citation: University of Pennsylvania Perelman School of Medicine Rodent Metabolic Phenotyping Core Facility (RRID:SCR_022427) Copy   

•   Source: SciCrunch Registry

https://www.med.upenn.edu/ipsccore/

Provides resources for disseminating human pluripotent stem cell technology within UPenn and surrounding research communities. �Our services include derivation of patient specific iPSCs, genome engineering of stem cell lines using CRISPR/Cas9 technology, and lineage specific differentiation of iPSCs/hESCs in 2D and 3D organoid culture.�Core has large collection of patient derived iPSC lines and cell lines of gastrointestinal tract (esophageal, pancreatic and intestinal) available to users.�Committed to training investigators in stem cell culture techniques and providing quality tested stem cell reagents to users.

Proper citation: University of Pennsylvania Perelman School of Medicine Induced Pluripotent Stem Cell Core Facility (RRID:SCR_022426) Copy   

•   Source: SciCrunch Registry

https://www.biotech.cornell.edu/core-facilities-brc/facilities/genomics-innovation-hub

Core complements services provided by BRC Genomics Facility.Working on collaborative model, protocol and method development by early adopters pave the way for larger scale production services.

Proper citation: Cornell University BRC Genomics Innovation Hub Core Facility (RRID:SCR_022547) Copy   

•   Source: SciCrunch Registry

https://www.med.upenn.edu/ris/

Shared resource machine shop serving various University of Pennsylvania Schools and Departments. Assists researchers to design and construct both laboratory and clinical instruments.

Proper citation: University of Pennsylvania Perelman School of Medicine Research Instrumentation Shop Core Facility (RRID:SCR_022424) Copy   

•   Source: SciCrunch Registry

https://www.dental.upenn.edu/research/core-facilities/

Provides Becton Dickinson LSR II flow cytometer equipped with four lasers.Blue laser can be used to detect forward and side scatter and 4 colors (eg., FITC/Alexa 488, PE, PerCP-CY55, PE-CY7), red laser can be used to detect 2 colors (e.g., APC and APC-CY7), violet laser can be used to detect 2 colors (e.g., Pacific blue, Am cyan) and a UV laser which can also be used to detect 2 colors (e.g., INDO1 blue, Indo1-violet/DAPI). The instrument is located in Room 330 in the Levy Building (240 South 40th Street).

Proper citation: University of Pennsylvania Penn Dental Medicine Flow Cytometry Core Facility (RRID:SCR_022443) Copy   

•   Source: SciCrunch Registry

https://www.vet.upenn.edu/research/core-resources-facilities/referral-center-for-animal-models

Core mission is to discover, create, characterize, treat, and share naturally occurring hereditary disorders in dogs and cats that are orthologous to those found in human patients.�Provides expertise in discovering, characterizing, and developing therapies for genetic disease in dogs and cats, which serve as models of same diseases that occur in children.�Specializes in molecular discovery of mutations, clinical phenotyping, biochemical and histological characterization, development of therapies which are translatable to human patients and preclinical trials in animal models of human disease.�

Proper citation: University of Pennsylvania Penn Vet Referral Center for Animal Models of Human Genetic Disease Core Facility (RRID:SCR_022440) Copy   

•   Source: SciCrunch Registry

https://www.vet.upenn.edu/research/centers-laboratories/center/center-for-host-microbial-interactions

Offers consultation and laboratory services for high-throughput sequencing (HTS) experiments, with particular expertise and interest in microbiome/metagenome and RNA-seq applications. Provides instrumentation, including Illumina NextSeq 2000 and single cell platforms from 10X genomics and 1CellBio. Offers full service options, as well as hands on instruction for trainees who want to learn best practices for wet lab aspects of genomics experiments. Offers consultation services for all phases of HTS studies, from study design to bioinformatics analysis.

Proper citation: University of Pennsylvania Penn Vet Center for Host Microbial Interactions Core Facility (RRID:SCR_022434) Copy   

•   Source: SciCrunch Registry

https://www.cincinnatichildrens.org/research/divisions/r/rips/research/pharmacy

Our Investigational Pharmacy team is responsible for dispensing both inpatient and outpatient investigational medication for industry-sponsored, grant-funded and investigator-initiated protocols. We provide pharmacy services customized to each research protocol conducted at Cincinnati Children�s.

Proper citation: Cincinnati Children's Hospital Investigational Pharmacy Core Facility (RRID:SCR_022650) Copy   

•   Source: SciCrunch Registry

https://www.cincinnatichildrens.org/research/cores/meg

Core facilitates study of normal and pathologic brain processes using magnetoencephalography.The purpose of the core is to make magnetoencephalography available to researchers across the institute.

Proper citation: Cincinnati Children's Hospital Magnetoencephalography Core Facility (RRID:SCR_022648) Copy   

•   Source: SciCrunch Registry

https://www.cincinnatichildrens.org/research/divisions/d/dev-biology/core

Offers comprehensive CRISPR services to generate gene edited rodents and cells, and helps generate transgenic and chimeric mice via our microinjection service, cryopreserving unique mouse lines, and recovering them from liquid nitrogen storage via IVF and embryo transfer services.

Proper citation: Cincinnati Children's Hospital Transgenic Animal and Genome Editing Core Facility (RRID:SCR_022642) Copy   

•   Source: SciCrunch Registry

https://www.med.upenn.edu/neuronsrus/

Core supplies suspensions of neuronal cells prepared from rodent brain for various downstream applications, including primary cell culture. Supplies rat or mouse cells isolated from cortex or hippocampus either in suspension or plates. Custom dissection services are available for other brain regions or for user supplied genetically modified mice.

Proper citation: University of Pennsylvania Perelman School of Medicine Neurons R Us Core Facility (RRID:SCR_022421) Copy   

•   Source: SciCrunch Registry

https://www.themiamiproject.org/research-resources/core-facilities/drug-discovery-core/

Core at Miami Project to Cure Paralysis leverages PerkinElmer Opera Phenix Plus high content screening system to provide assay development and phenotypic screening. Facility is also equipped with PerkinElmer Janus G3 liquid handler, featuring modular and variable dispense heads, to automate screening workflows and enhance throughput. Core supports phenotypic and target-based assays. Phenotypic assays range from 2D to 3D, widefield to confocal, and antibody to dye based. It collaborates with users to develop customized assays and analytical pipelines tailored to their specific needs. Current specializations include neurite tracing, lipid droplet quantification, cell viability, morphological and kinetic analyses, phagocytosis, cell marker detection, cell adhesion, among others.

Proper citation: Drug Discovery Core Facility (RRID:SCR_022542) Copy   

•   Source: SciCrunch Registry