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https://medicine.iu.edu/research/support/service-cores/chemical-genomics

Core provides collection of diversity-oriented, drug-like, and natural small molecules in non-redundant libraries, variety of automated liquid handling and assay detection systems such as EnVision Multiplate reader and ArrayScan HCA System, modern equipment for medicinal and analytical chemistry including NMR, LC-QTOF MS, HPLC, Peptide Synthesizer, and sophisticated chemoinformatics tools. Besides traditional high-throughput screening and hit compound optimization services, newly adapted technologies include arrayed CRISPR screening, phage display, and SAR by NMR.

Proper citation: Indiana University School of Medicine Chemical Genomics Core Facility (RRID:SCR_018785) Copy   

•   Source: SciCrunch Registry

http://www.pasteur.fr/biophysics

Provides services and instrumentation for characterization of biological macromolecules with technical and methodological expertise. Provides characterization of macromolecules including shape, folding, stability auto-association,and they interactions including stoichiometry,thermodynamic and kinetic parameters.

Proper citation: Pasteur Institute Biophysics of Macromolecules and their Interactions Core Facility (RRID:SCR_018267) Copy   

•   Source: SciCrunch Registry

https://grcf.jhmi.edu/

Established to produce immortalized cell lines from human blood (EBV transformations). Offers genomics applications for single cells, including RNA-seq, gene expression profiling by qPCR and DNA amplification for whole-genome or targeted (exome or PCR-based analysis) through 10x Genomics Chromium platform (similar to Drop Seq). Offers custom genotyping to analyze short tandem repeats, variable number tandem repeats and single nucleotide polymorphisms.

Proper citation: Johns Hopkins University School of Medicine Genetic Resources Core Facility (RRID:SCR_018669) Copy   

•   Source: SciCrunch Registry

https://animalcare.umich.edu/business-services/ulam-pathology-core/

Our core is affiliated with the Unit for Laboratory Animal Medicine (ULAM) at the University of Michigan-Ann Arbor. We provide animal pathology services in support of non-GLP preclinical, translational, or basic science studies. Services include histology preparation, immunohistochemistry, animal hematology and serum chemistry assays, digital slide scanning/image analysis, and pathology interpretation by board-certified veterinary pathologists. Our core mission is to reduce bias and increase rigor within non-GLP animal research by providing high quality, documented, pathology support that may not be otherwise accessible within individual laboratories. Our laboratory maintains internal SOPs, documented quality control practices, and accountability/chain-of-custody records for all submissions. Additionally, we participate in an external quality control program through the Veterinary Laboratory Association.

Proper citation: University of Michigan ULAM Pathology Core Facility (RRID:SCR_018823) Copy   

•   Source: SciCrunch Registry

https://childrenshospital.corefacilities.org/service_center/show_external/3145

Core with advanced instrumentation in Light and Electron Microscopy.Core provides confocal, multiphoton microscopy,electron microscopy,image analysis.

Proper citation: Harvard Medical School PCMM Microscopy Core Facility (RRID:SCR_018822) Copy   

•   Source: SciCrunch Registry

https://vbrn.org/proteomics-services/

Provides central resource of mass spectrometry based proteomics technologies to identify, characterize and quantify target proteins in various biological and biomedical samples. Provides mass spectrometry expertise for analyzing proteins and peptides for proteomics studies, support for data analysis from proteomics measurements, training in proteomics methods, and experimental design.

Proper citation: Vermont University Proteomics Core Facility (RRID:SCR_018667) Copy   

•   Source: SciCrunch Registry

https://www.colorado.edu/lmcf/

Provides access to instruments and training. Instruments including Dell Precision 7910 Analysis PC,Leica DMRXA Upright Widefield Microscope, Nikon E600 Upright Widefield Microscope, Nikon N-SIM structured illumination super-resolution and A1 laser scanning confocal microscope, Nikon Inverted Spinning Disk Confocal Microscope, Zeiss 510 Laser Scanning Confocal Microscope.

Proper citation: Colorado University at Boulder Light Microscopy Core Facility (RRID:SCR_018993) Copy   

•   Source: SciCrunch Registry

http://www.ohsu.edu/mcc

Core helps researchers investigate interactions between small molecules and biological systems by providing medicinal chemistry and chemical biology expertise and organic synthesis support.

Proper citation: Oregon Health and Science University Medicinal Chemistry Core Facility (RRID:SCR_019048) Copy   

•   Source: SciCrunch Registry

https://www.danforthcenter.org/our-work/core-facilities/phenotyping/

Core provides instruments including Scanalyzer 3D platform which consists of multiple digital imaging chambers connected to controlled environment Conviron growth house by conveyor belt system, resulting in continuous imaging loop and enables repeatedly image plants at multiple points throughout time.RGB imaging allows visualization and quantification of plant color and structural morphology. Near-infrared (NIR) enables visualization and quantification of plant water-use efficiency.Watering and weighing stations are customizable to deliver water and nutrients on specified schedule by volume or weight. Standard phenotyping services include operation and maintenance of LemnaTec Scanalyzer system, as well as technical support and troubleshooting.

Proper citation: Donald Danforth Plant Science Center Phenotyping Core Facility (RRID:SCR_019049) Copy   

•   Source: SciCrunch Registry

http://www.dartmouth.edu/~dartlab/

Offers services in customized end point assays using human WB/PBMCs for clinical trials, ELISPOT, multiplex cytokine analysis, cell energy analysis, blood processing and cryopreservation,up to 20 color flow cytometry phenotyping and up to 11color FACS cell subset sorting. Provides consultation, data analysis, and Flow Cytometry training course.

Proper citation: Dartmouth Geisel School of Medicine Immunoassay and Flow Cytometry Core Facility (RRID:SCR_019165) Copy   

•   Source: SciCrunch Registry

https://www.colorado.edu/sharedinstrumentation/core-facilities/intermountain-neuroimaging-consortium

Magnetic resonance imaging research facility. Provides Tesla Siemens MAGNETOM Prismafit MRI scanner, located at Center for Innovation and Creativity (CINC) on CU Boulder campus.

Proper citation: Colorado University at Boulder Intermountain Neuroimaging Consortium Core Facility (RRID:SCR_018990) Copy   

•   Source: SciCrunch Registry

https://www.colorado.edu/lab/massspec/

Offers analytical and instructional expertise in mass spectrometry with practical training and access to instrumentation.Located in room C1B90 of Jennie Smoly Caruthers Biotechnology Building houses six mass spectrometry systems.Instruments are interfaced with chromatographic system in order to separate complex mixture samples. Offers training for open access to some instruments including Thermo ISO LT GCMS, Synapt G2 HDMS, Agilent 6120 LCMS, and 4000 Q-trap QQQ instruments.

Proper citation: Colorado University at Boulder Central Analytical Mass Spectrometry Core Facility (RRID:SCR_018992) Copy   

•   Source: SciCrunch Registry

https://dentistry.musc.edu/research/gcohr

Core offers investigators opportunity to address research questions that require use of gnotobiotic animals. Standard services provide germ free mice (e.g. BALB/c, C57BL/6), deriving new strains of mice into germ free state by caesarean section, tissue collection and/or fluid from mice that have not received treatment or manipulations, exporting germ free mice in sterile transporters to other institutions. Non-Standard Services include maintaining and breeding newly derived germ free mice, administration of specialized diets, administration of compounds as therapeutic or disease-inducing agents, tissue collection and/or fluid from mice that have received treatment or manipulations.

Proper citation: Medical University of South Carolina College of Dental Medicine Gnotobiotic Animal Core Facility (RRID:SCR_018884) Copy   

•   Source: SciCrunch Registry

https://www.unh.edu/research/welcome-university-instrumentation-center

University wide core facility offers NMR,SEM including FIB, EBS, EBSD, Tensile Stage,Confocal,X-Ray Photoelectron Spectroscopy,X-Ray Microscope aka Micro CT, Expert analysis of research and industrial samples,Training in scientific instrument operation and data analysis, Maintenance, repair, and calibration of instruments,Specialty instrument engineering design and application services,Facilitation of access to scientific instruments throughout the university.

Proper citation: University of New Hampshire University Instrumentation Center Core Facility (RRID:SCR_021101) Copy   

•   Source: SciCrunch Registry

https://www.lsi.umich.edu/science/centers-technologies/center-structural-biology

Comprehensive structural biology resource.Provides high throughput protein laboratory for protein engineering, protein purification facilities for small- and large-scale protein production, macromolecular crystallization and crystallography laboratories for solving crystal structures of biological molecules, and X-ray facility with access to high energy synchrotron radiation. Provides expert guidance to researchers through every stage of project, collaborating and consulting with researchers who use the facilities. Service categories are Chemical, Material and Protein Characterization, Molecular Biology. Services include Cloning, Crystallization, Differential thermal analysis, Drug development, NMR (small molecule), PCR, Protein crystallography, Protein engineering, Protein production, Structure determination, Xray.

Proper citation: University of Michigan Center for Structural Biology Core Facility (RRID:SCR_021065) Copy   

•   Source: SciCrunch Registry

https://www.colorado.edu/geologicalsciences/resources/research-facilities/raman-microspectroscopy-lab

Core research facility housed in Department of Geological Sciences for fast, non-destructive characterization and chemical imaging of diverse materials spanning minerals (thin sections and powders), biological samples, fluids, dissolved gases, and much more.

Proper citation: University of Colorado Boulder Raman Microspectroscopy Lab Core Facility (RRID:SCR_019305) Copy   

•   Source: SciCrunch Registry

https://www.colorado.edu/lab/biocore/

Purpose is to connect MCDB, EBIO, and IPHY researchers to campus research resources.

Proper citation: University of Colorado Boulder BioCore Core Facility (RRID:SCR_019302) Copy   

•   Source: SciCrunch Registry

https://www.colorado.edu/geologicalsciences/resources/research-facilities/u-thhe-thermochronology-lab

Fully equipped (U-Th)/He thermochronology facility.

Proper citation: University of Colorado Boulder CU Thermochronology Research and Instrumentation Lab Core Facility (RRID:SCR_019303) Copy   

•   Source: SciCrunch Registry

https://www.colorado.edu/geologicalsciences/resources/research-facilities/earth-systems-stable-isotope-laboratory

Designed to measure relative abundance of stable isotopes of light elements and molecules.

Proper citation: University of Colorado Boulder Earth Systems Stable Isotope Lab Core Facility (RRID:SCR_019300) Copy   

•   Source: SciCrunch Registry

https://cami.northwestern.edu/

Provides access to range of preclinical imaging modalities and support services. These include MRI, nuclear imaging (PET, SPECT, and CT), in vivo bioluminescence and fluorescence imaging, animal housing and prep spaces, and tissue culture. Image analysis services are available, as are software packages (JIM, Amira, Matlab) and a workstation for users to perform their own data analysis. Imaging services can be provided for investigators' own animal models, or animal models can be supplied by the Developmental Therapeutics Core.

Proper citation: Northwestern University Center for Advanced Molecular Imaging Core Facility (RRID:SCR_021192) Copy   

•   Source: SciCrunch Registry